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61. 发明授权

US5593972A Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US5593972A
公开(公告)日：1997-01-14
申请号：US125012
申请日：1993-09-21
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/16 , C12N15/87 , A61K45/05 , A61K31/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞蛋白质或与自身免疫疾病相关的蛋白质。在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。核酸分子不含病毒颗粒，能够在所述细胞中表达。细胞可以与细胞刺激剂接触细胞。公开了预防和治疗个体免受HIV感染的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

62. 发明授权

US5338829A Peptides derived from human immunodeficiency virus-1 GP160 失效
标题翻译：衍生自人类免疫缺陷病毒-1 GP160的肽
公开(公告)号：US5338829A
公开(公告)日：1994-08-16
申请号：US932078
申请日：1992-10-19
申请人： David B. Weiner , Mark I. Greene , William V. Williams
发明人： David B. Weiner , Mark I. Greene , William V. Williams
IPC分类号： A61K38/00 , A61K39/00 , C07K14/16 , C07K14/705 , C07K16/10 , A61K37/02 , C07K3/00 , C07K5/00 , C07K15/00
CPC分类号： C07K14/005 , C07K14/705 , C07K16/1063 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： This invention discloses novel polypeptides having an antigenic determinant or determinants immunologically cross-reactive with determinants of a glycoprotein having a molecular weight of approximately 41,000 daltons, and determinants of a glycoprotein having a molecular weight of approximately 160,000 daltons which are obtained from cells infected with human immunodeficiency virus-1. The invention further discloses novel polypeptides having an antigenic determinant or determinants specific for a glycoprotein having a molecular weight of approximately 41,000 daltons obtained from cells infected with human immunodeficiency virus-1, the polypeptides further having an antigenic determinant or determinants immunologically cross-reactive with at least one glycoprotein having a molecular weight of 25,000 to 35,000 daltons, 45,000 daltons to 60,000 daltons, 80,000 to 100,000 daltons or 180,000 or 220,000 daltons, which are obtained from HSB, St, HeLa and human cells. The novel polypeptides of the invention are useful in methods of interfering with the effects of HIV-1 upon host cells having cell surface polypeptides capable of binding HIV-1. Methods of assay for HIV-1 infection are also disclosed. The invention also discloses peptides having amino acid sequences of about 10 to about 50 amino acids that correspond to at least a portion of an epitope of HIV and methods for developing such biologically active peptides.
摘要翻译：本发明公开了具有与具有约41,000道尔顿分子量的糖蛋白的决定簇免疫交叉反应的抗原决定簇或决定簇的新型多肽，以及分子量约为160,000道尔顿的糖蛋白的决定簇，这些糖蛋白是从感染人的细胞获得的免疫缺陷病毒-1。本发明进一步公开了具有抗原决定簇或具有特异性的决定簇的新型多肽，该决定簇具有从感染人类免疫缺陷病毒-1的细胞获得的具有约41,000道尔顿的糖蛋白的特异性，所述多肽还具有抗原决定簇或与抗原决定簇免疫交叉反应的决定簇至少一种由HSB，St，HeLa和人细胞获得的分子量为25,000至35,000道尔顿，45,000道尔顿至60,000道尔顿，80,000至100,000道尔顿或180,000或220,000道尔顿的糖蛋白。本发明的新型多肽可用于干扰HIV-1对具有能够结合HIV-1的细胞表面多肽的宿主细胞的作用的方法。还公开了HIV-1感染的测定方法。本发明还公开了具有对应于HIV表位的至少一部分的约10至约50个氨基酸的氨基酸序列的肽和用于开发此类生物活性肽的方法。

63. 发明授权

US09993545B2 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom 有权
公开(公告)号：US09993545B2
公开(公告)日：2018-06-12
申请号：US14774356
申请日：2014-03-17
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , David B. Weiner , Jian Yan , Karuppiah Muthumani , Niranjan Y. Sardesai
发明人： David B. Weiner , Jian Yan , Karuppiah Muthumani , Niranjan Y. Sardesai
IPC分类号： C12N7/00 , A61K39/135 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/135 , A61K39/12 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2770/32134
摘要： The present invention relates to synthetic, consensus foot-and-mouth disease virus (FMDV) immunogenic proteins and nucleic acid molecule encoding such proteins, to vaccines against FMDV, to methods for inducing immune responses against FMVD, to methods for distinguishing between individuals infected with FMDV versus those vaccinated against FMDV, and methods of prophylactically and/or therapeutically immunizing individuals against FMDV.

64. 发明申请

US20150335726A1 Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same 有权
标题翻译：纤维病毒共识抗原，核酸构建体和疫苗，以及使用相同的方法
公开(公告)号：US20150335726A1
公开(公告)日：2015-11-26
申请号：US14391952
申请日：2013-04-12
申请人： David B. Weiner , Devon Shedlock
发明人： David B. Weiner , Devon Shedlock
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K38/20 , A61K38/208 , A61K38/2086 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/572 , A61K2039/70 , A61N1/327 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2760/14122 , C12N2760/14134 , C12N2760/14171 , C12N2760/14222 , C12N2760/14234 , C12N2760/14271
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.
摘要翻译：公开了包含一个或多个核酸序列的核酸分子和组合物，所述核酸序列编码包括共有的马尔堡病毒filov病毒糖蛋白MARV GP免疫原，共有的埃博病毒苏丹filovirus糖蛋白SEBOV GP免疫原和共有的埃博病毒扎伊尔糖蛋白ZEBOV GP免疫原的共有的病毒免疫原。编码序列任选地包括编码信号肽的可操作的连锁编码序列。公开了免疫调节方法和诱导针对病毒，尤其是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的免疫应答的方法。公开了防止病毒感染的方法，特别是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的感染，以及治疗感染了病毒感染的个体，特别是马尔堡病毒，埃博病毒苏丹和埃博拉病毒扎伊尔感染的方法。公知共识的病毒蛋白。

65. 发明申请

US20150328298A1 WT1 Vaccine 审中-公开
标题翻译： WT1疫苗
公开(公告)号：US20150328298A1
公开(公告)日：2015-11-19
申请号：US14651492
申请日：2013-12-13
申请人： David B. WEINER , Jian YAN , Jewell WALTERS , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , INOVIO PHARMACEUTICALS, INC.
发明人： David B. Weiner , Jian Yan , Jewell Walters
IPC分类号： A61K39/00 , C07K14/47
CPC分类号： A61K39/0011 , A61K2039/53 , C07K14/4748
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.
摘要翻译：本文公开了包含编码突变的WT1抗原的一个或多个核酸序列的核酸分子。公开了包含编码突变的WT1抗原的一个或多个核酸序列的载体，组合物和疫苗。公开了治疗具有WT1表达肿瘤的个体的方法和预防表达WT1的肿瘤的方法。公开了突变的WT1抗原。

66. 发明申请

US20130045180A9 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20130045180A9
公开(公告)日：2013-02-21
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和减毒活疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

67. 发明申请

US20120276142A1 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IGE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME 审中-公开
标题翻译：包含IGE信号肽和/或IL-15的核酸序列编码和组合物及其使用方法
公开(公告)号：US20120276142A1
公开(公告)日：2012-11-01
申请号：US13466015
申请日：2012-05-07
申请人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
发明人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
IPC分类号： A61K39/00 , C12N15/86 , A61K31/7088 , C07H21/04 , A61K39/285 , C12N15/85
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

68. 发明申请

US20120230945A1 TARGETED PARTICLES AND METHODS OF USING THE SAME 有权
标题翻译：目标颗粒及其使用方法
公开(公告)号：US20120230945A1
公开(公告)日：2012-09-13
申请号：US13422864
申请日：2012-03-16
申请人： David B. Weiner , Karuppiah Muthumani , Donghui Zhang , Mathura P. Ramanathan
发明人： David B. Weiner , Karuppiah Muthumani , Donghui Zhang , Mathura P. Ramanathan
IPC分类号： A61K39/395 , A61P37/02 , C07K16/18 , C12N5/02 , A61K38/20
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译：公开了递送组合物和递送化合物的方法。公开了免疫个体的疫苗和方法。公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。

69. 发明授权

US08202847B2 Mutant human CD80 and compositions for and methods of making and using the same 有权
标题翻译：突变人CD80及其制备方法及其制备和使用方法
公开(公告)号：US08202847B2
公开(公告)日：2012-06-19
申请号：US12211029
申请日：2008-11-10
申请人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
发明人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
IPC分类号： A61K31/713
CPC分类号： C07K14/70532 , A61K39/00
摘要： Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.
摘要翻译：公开了改进的疫苗和使用该疫苗的方法。公开了用于治疗患有自身免疫性疾病或移植物的个体的免疫抑制组合物及其使用方法。

70. 发明申请

US20120064116A9 INFLUENZA NUCLEIC ACID MOLECULES AND VACCINES MADE THEREFROM 有权
标题翻译：流感病毒核酸分子和疫苗
公开(公告)号：US20120064116A9
公开(公告)日：2012-03-15
申请号：US12694238
申请日：2010-01-26
申请人： David B. Weiner , Jian Yan , Matthew P. Morrow
发明人： David B. Weiner , Jian Yan , Matthew P. Morrow
IPC分类号： A61K39/145 , A61K39/00 , A61K31/7088 , C07H21/04 , C12N15/63
CPC分类号： A61K39/145 , A61K31/7088 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/54 , C12N2760/16134
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotypes using the vaccines that are provided.
摘要翻译：本文提供了编码HA血凝素的新的共有氨基酸序列以及表达序列的遗传构建体/载体和疫苗的核酸序列。本文还提供了使用所提供的疫苗产生针对一种或多种流感A血清型的免疫应答的方法。

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