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61. 发明授权

US06430435B1 Multiple state morphology-based system detecting ventricular tachycardia and supraventricular tachycardia 有权
标题翻译：多态态形态系统检测室性心动过速和室上性心动过速
公开(公告)号：US06430435B1
公开(公告)日：2002-08-06
申请号：US09716622
申请日：2000-11-20
申请人： William Hsu , Alan F. Marcovecchio
发明人： William Hsu , Alan F. Marcovecchio
IPC分类号： A61N1365
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3956
摘要： A system for detecting ventricular tachycardia and supraventricular tachycardia using a multiple stage morphology based system. Cardiac signals are sensed from a patient's heart and analyzed for the occurrence of a tachycardia event. When a tachycardia event is detected, the method and system analyzes a plurality of features of the sensed cardiac signals in two or more discrimination stages. Each of the two or more discrimination stages classify the tachycardia event as either a ventricular tachycardia or a candidate supraventricular tachycardia event. When a discrimination stage detects the occurrence of a ventricular tachycardia, therapy is delivered to the heart to treat the ventricular tachycardia.
摘要翻译：一种使用多阶段形态学系统检测室性心动过速和室上性心动过速的系统。从患者的心脏感测到心脏信号，并分析了心动过速事件的发生。当检测到心动过速事件时，该方法和系统在两个或更多个鉴别阶段中分析感测的心脏信号的多个特征。两个或多个歧视阶段中的每一个将心动过速事件分类为室性心动过速或候选室上性心动过速事件。当鉴别阶段检测到室性心动过速的发生时，将治疗传递给心脏以治疗室性心动过速。

62. 发明授权

US06321122B1 Single pass defibrillation/pacing lead with passively attached electrode for pacing and sensing 失效
标题翻译：单次除颤/起搏导联带有被动连接的电极用于起搏和感测
公开(公告)号：US06321122B1
公开(公告)日：2001-11-20
申请号：US09121018
申请日：1998-07-22
申请人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
发明人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
IPC分类号： A61N100
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.
摘要翻译：适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。引线包括具有第一导电表面的第一远端电极。引线体还具有具有第二导电表面的第二电极。第二电极适于定位并固定在心脏心房的壁上。被动固定元件可以用作第二电极的一部分。引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

63. 发明授权

US06295545B1 Reduction of execution times for convolution operations 失效
标题翻译：减少卷积运算的执行时间
公开(公告)号：US06295545B1
公开(公告)日：2001-09-25
申请号：US09192394
申请日：1998-11-12
申请人： William Hsu , Taiwei Yin
发明人： William Hsu , Taiwei Yin
IPC分类号： G06F1710
CPC分类号： H03H17/06
摘要： A convolution operation such as an FIR filter determines sums of products by loading first and second sequences of values into a register file of a processor, each value being in a separate register in the register file. The processor determines a sum of products, for example, by executing a series on multiply-and-accumulate instructions on the previously loaded values from the register file. For a next sum, one or more values is loaded into the register file to replace some or all of the values from the second sequence. The first sequence of values is left intact in the register file for use in calculating the next sum. For an FIR filter, only a single value from the second sequence is replaced, and the next sum uses most of the previously loaded second sequence. This reduces the number of required memory accesses and reduces processing time required for convolution operations. A sequence of sums of products for the FIR filter requires loading of only one new value per filtered value determined.
摘要翻译：诸如FIR滤波器的卷积操作通过将第一和第二序列序列加载到处理器的寄存器文件来确定乘积的总和，每个值在寄存器文件中的单独的寄存器中。处理器确定产品的总和，例如，通过对来自寄存器文件的先前加载的值的乘法和累加指令执行一系列的操作。对于下一个总和，将一个或多个值加载到寄存器文件中以替换第二个序列中的一些或全部值。值的第一个序列在寄存器文件中保持不变，用于计算下一个和。对于FIR滤波器，仅替换来自第二个序列的单个值，并且下一个和使用大部分先前加载的第二个序列。这减少了所需的存储器访问的数量，并缩短了卷积操作所需的处理时间。 FIR滤波器的乘积和序列需要每个滤波值确定一个新的值。

64. 发明授权

US06266554B1 System and method for classifying cardiac complexes 有权
标题翻译：心脏复合物分类系统及方法
公开(公告)号：US06266554B1
公开(公告)日：2001-07-24
申请号：US09249128
申请日：1999-02-12
申请人： William Hsu , Joseph Martin Smith
发明人： William Hsu , Joseph Martin Smith
IPC分类号： A61B50452
CPC分类号： A61B5/04525 , A61B5/7264 , A61N1/3622 , A61N1/3704
摘要： A system and a method for classifying cardiac complexes based on cardiac information derived from two or more cardiac signals. Two or more cardiac signals containing cardiac complexes are monitored. A cardiac complex in the two or more cardiac signals is isolated in an analysis window. The morphology of the cardiac complex in each of the two or more cardiac signals is then compared to the morphology of a template cardiac complex representing a predetermined cardiac condition. Based on this comparison, the cardiac complex is classified as either belonging or not belonging to the predetermined cardiac condition.
摘要翻译：基于从两个或更多个心脏信号导出的心脏信息对心脏复合物进行分类的系统和方法。监测含有心脏复合物的两个或更多个心脏信号。两个或更多个心脏信号中的心脏复合物在分析窗口中被隔离。然后将两个或更多个心脏信号中的每一个中的心脏复合物的形态与表示预定心脏状况的模板心脏复合体的形态进行比较。基于该比较，心脏复合物被归类为属于或不属于预定心脏病状态。

65. 发明授权

US06179865B2 Cross chamber interval correlation 有权
标题翻译：跨室间隔相关
公开(公告)号：US06179865B2
公开(公告)日：2001-01-30
申请号：US09283159
申请日：1999-04-01
申请人： William Hsu , Robert J. Sweeney
发明人： William Hsu , Robert J. Sweeney
IPC分类号： A61B50464
CPC分类号： A61N1/3622
摘要： A system and method for discriminating cardiac rhythms occurring in an antegrade direction from cardiac rhythms occurring in a retrograde direction. Atrial and ventricular contractions are sensed, from which atrial and ventricular cycle lengths are determined. Ventricular contractions are also analyzed to determine the occurrence of a tachycardia episode that has a one-to-one association of atrial contractions to ventricular contractions. During a tachycardia episode having a one-to-one association of atrial contractions to ventricular contractions, the atrial cycle lengths are paired with the ventricular cycle lengths, where for each of the atrial cycle lengths the atrial cycle length is paired with at least one ventricular cycle length started before the first atrial contraction of each of the atrial cycle lengths and paired with at least one ventricular cycle length started after the first atrial contraction of each of the atrial cycle lengths. A retrograde correlation coefficient is then determined for the atrial cycle lengths paired with the ventricular cycle lengths started before the first atrial contraction, and an antegrade correlation coefficient is determined for the atrial cycle lengths paired with the ventricular cycle lengths started after the first atrial contraction. The tachycardiac episode is then classified based on a comparison of the antegrade correlation coefficient and the retrograde correlation coefficient.
摘要翻译：用于区分沿逆行方向发生的心律的顺行方向发生的心律的系统和方法。感测到心房和心室收缩，确定心房和心室周期长度。还分析心室收缩以确定心房收缩与心室收缩具有一对一关联的心动过速发作的发生。在心房收缩与心室收缩有一对一关联的心动过速发作期间，心房周期长度与心室周期长度配对，其中对于心房周期长度中的每一个，心房周期长度与至少一个心室循环长度在每个心房周期长度的第一次心房收缩之前开始，并且与每个心房周期长度的第一次心房收缩之后开始的至少一个心室周期长度配对。然后确定与在第一次心房收缩之前开始的心室周期长度成对的心房周期长度的逆行相关系数，并且确定与在第一次心房收缩之后开始的心室周期长度配对的心房周期长度的顺行相关系数。然后根据顺行相关系数与逆行相关系数的比较对心动过速进行分类。

66. 发明授权

US6119043A Atrial and ventricular cardiac lead having a mechanical bias 失效
标题翻译：心房和心室心脏铅具有机械偏置
公开(公告)号：US6119043A
公开(公告)日：2000-09-12
申请号：US129348
申请日：1998-08-05
申请人： William Hsu , Jay A. Warren , Gerrard M. Carlson
发明人： William Hsu , Jay A. Warren , Gerrard M. Carlson
IPC分类号： A61N1/362 , A61N1/00
CPC分类号： A61N1/3622
摘要： A method and system for discriminating atrial and ventricular signal components from a single heart lead, and for using this information for identifying an arrhythmia condition as being atrial or ventricular in origin. The invention is effective in identifying P waves occurring in complex signal which includes relatively stronger R waves or other ventricular artifacts which mask the P waves. The contribution of the R wave signal to the complex signal is obtained by filtering, time windowing and transfer function estimation, then the R wave estimate is subtracted from the combined signal to leave the P wave. The ratio of P waves to R waves, P--P and R--R intervals, and their ratios to one another and to fixed values can be estimated, and used in a comparison to discriminate between atrial and ventricular arrhythmia, to thereby enable appropriate treatment.
摘要翻译：用于区分来自单个心脏引线的心房和心室信号分量的方法和系统，以及用于将该信息用于将心律失常状态识别为心房或心室起源的方法和系统。本发明有效地识别出复杂信号中出现的P波，其中包含相对较强的R波或掩蔽P波的其他心室伪像。通过滤波，时间窗口和传递函数估计得到R波信号对复信号的贡献，然后将R波估计从组合信号中减去离开P波。可以估计P波与R波，P-P和R-R间隔的比率以及它们彼此之间的比值和固定值，并用于比较以区分心房和心室心律不齐，从而使得能够进行适当的治疗。

67. 发明授权

US5776072A Discrimination of atrial and ventricular signals from a single cardiac lead 失效
公开(公告)号：US5776072A
公开(公告)日：1998-07-07
申请号：US579872
申请日：1995-12-28
申请人： William Hsu , Jay A. Warren , Gerrard M. Carlson
发明人： William Hsu , Jay A. Warren , Gerrard M. Carlson
IPC分类号： A61N1/362 , A61B5/046
CPC分类号： A61N1/3622
摘要： A method and system for discriminating atrial and ventricular signal components from a single heart lead, and for using this information for identifying an arrhythmia condition as being atrial or ventricular in origin. The invention is effective in identifying P waves occurring in complex signal which includes relatively stronger R waves or other ventricular artifacts which mask the P waves. The contribution of the R wave signal to the complex signal is obtained by filtering, time windowing and transfer function estimation, then the R wave estimate is subtracted from the combined signal to leave the P wave. The ratio of P waves to R waves, P--P and R--R intervals, and their ratios to one another and to fixed values can be estimated, and used in a comparison to discriminate between atrial and ventricular arrhythmia, to thereby enable appropriate treatment.

68. 发明授权

US08843197B2 Method and system to correct contractility based on non-heart failure factors 有权
标题翻译：基于非心力衰竭因子校正收缩性的方法和系统
公开(公告)号：US08843197B2
公开(公告)日：2014-09-23
申请号：US13049774
申请日：2011-03-16
申请人： Stuart Rosenberg , Cecilia Qin Xi , Jong Gill , Brian Jeffrey Wenzel , Yelena Nabutovsky , William Hsu
发明人： Stuart Rosenberg , Cecilia Qin Xi , Jong Gill , Brian Jeffrey Wenzel , Yelena Nabutovsky , William Hsu
IPC分类号： A61N1/365 , A61B5/02 , A61B5/042 , A61N1/362
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/042 , A61N1/3627 , A61N1/36507 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： A method for trending heart failure measures cardiogenic impedance (CI) and obtains signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The method identifies correction factors based on the signals and applies the correction factors to the contractility estimates. A system for trending heart failure includes a contractility module to determine contractility estimates from CI measurements taken along at least a first vector through a heart, and a collection module to receive signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The system further includes a factor module to identify correction factors based on the signals and a correction module to apply the correction factors to the contractility estimates.
摘要翻译：用于趋势性心力衰竭的方法测量心源性阻抗（CI）并且获得当获得CI测量时表示心脏体积和心脏压力中的至少一个的估计或直接测量的信号。该方法基于信号识别校正因子，并将修正因子应用于收缩率估计。用于趋向心力衰竭的系统包括收缩模块，用于根据通过心脏的至少第一载体进行的CI测量来确定收缩性估计，以及收集模块，用于接收代表心脏体积和压力中的至少一个的估计或直接测量的信号的CI测量值。该系统还包括一个因素模块，用于基于信号识别校正因子，以及一个校正模块，以将校正因子应用于收缩性估计。

69. 发明授权

US08548575B2 System for verifying the integrity of cardiac complex templates 有权
标题翻译：用于验证心脏复合物模板完整性的系统
公开(公告)号：US08548575B2
公开(公告)日：2013-10-01
申请号：US13208252
申请日：2011-08-11
申请人： Alan F. Marcovecchio , William Hsu
发明人： Alan F. Marcovecchio , William Hsu
IPC分类号： A61B5/04
CPC分类号： A61B5/04525
摘要： A method and system for verifying the integrity of normal sinus rhythm (NSR) templates and updating the NSR template after selected time intervals. At selected time intervals after establishing a NSR template, cardiac complexes are sensed and values for one or more cardiac parameters are measured. The values of the cardiac parameters are compared to predetermined value ranges for NSR cardiac complexes. When the values of the cardiac parameters fall within the predetermined value ranges, values for the differences between the values of the cardiac parameters for the cardiac complexes and the values for the cardiac parameters of the NSR cardiac complexes are calculated. When the values of the differences are greater than one or more threshold values, the NSR template is updated as a function of the sensed cardiac complexes.
摘要翻译：一种用于验证正常窦性心律（NSR）模板的完整性并在选定的时间间隔后更新NSR模板的方法和系统。在建立NSR模板之后的选定的时间间隔，感测心脏复合物并测量一个或多个心脏参数的值。将心脏参数的值与NSR心脏复合物的预定值范围进行比较。当心脏参数的值落在预定值范围内时，计算心脏复合物心脏参数值与NSR心脏复合物心脏参数值之差的值。当差异的值大于一个或多个阈值时，NSR模板被更新为感测的心脏复合物的函数。

70. 发明授权

US08295918B2 Systems and methods for activating and controlling impedance-based detection systems of implantable medical devices 有权
标题翻译：用于激活和控制可植入医疗设备的基于阻抗的检测系统的系统和方法
公开(公告)号：US08295918B2
公开(公告)日：2012-10-23
申请号：US13035773
申请日：2011-02-25
申请人： Stuart Rosenberg , Cecilia Q. Xi , Yelena Nabutovsky , Brian J. Wenzel , Jong Gill , William Hsu
发明人： Stuart Rosenberg , Cecilia Q. Xi , Yelena Nabutovsky , Brian J. Wenzel , Jong Gill , William Hsu
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61N1/3702 , A61N1/372
摘要： Techniques are provided for use with implantable medical devices for addressing encapsulation effects, particularly in the detection of cardiac decompensation events such as heart failure (HF) or cardiogenic pulmonary edema (PE.) In one example, during an acute interval following device implant, cardiac decompensation is detected using heart rate variability (HRV), ventricular evoked response (ER) or various other non-impedance-based parameters that are insensitive to component encapsulation effects. During the subsequent chronic interval, decompensation is detected using intracardiac or transthoracic impedance signals. In another example, the degree of maturation of encapsulation of implanted components is assessed using impedance frequency-response measurements or based on the frequency bandwidth of heart sounds or other physiological signals. In this manner, impedance-based HF/PE detection systems can be activated as soon as component encapsulation has matured, without necessarily waiting until completion of a preset post-implant maturation interval, often set to forty-five days or more.
摘要翻译：提供技术用于可植入医疗装置，用于解决封装效应，特别是在心脏代偿失调事件如心力衰竭（HF）或心源性肺水肿（PE）的检测中。在一个实例中，在装置植入后的急性期间，心脏使用心率变异性（HRV），心室诱发反应（ER）或对组件封装效应不敏感的各种其他基于非阻抗的参数来检测代偿失调。在随后的慢性间隔期间，使用心内或经胸阻抗信号检测代偿失调。在另一示例中，使用阻抗频率响应测量值或基于心脏声音或其他生理信号的频率带宽来评估植入部件的封装的成熟程度。以这种方式，一旦组件封装已经成熟，就可以激活基于阻抗的HF / PE检测系统，而不必等待直到完成植入后成熟间隔的预设，通常设置为四十五天或更长时间。

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