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61. 发明专利

AU5571300A Dna encoding sucrose pts enzyme ii 未知
公开(公告)号：AU5571300A
公开(公告)日：2001-01-22
申请号：AU5571300
申请日：2000-06-30
申请人： AJINOMOTO KK
发明人： IZUI MASAKO , SUGIMOTO MASAKAZU , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N9/12 , C12N15/54

62. 发明专利

AU5106800A Process for producing l-lysine 未知
公开(公告)号：AU5106800A
公开(公告)日：2001-01-02
申请号：AU5106800
申请日：2000-06-08
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , NAKAMURA JUN , IZUI HIROSHI , KIMURA EIICHIRO , ITO HISAO , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N1/21 , C12N9/12 , C12N15/54 , C12P13/08

63. 发明专利

AU3194200A Process for producing l-lysine 未知
公开(公告)号：AU3194200A
公开(公告)日：2000-10-09
申请号：AU3194200
申请日：2000-03-17
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , ITO HISAO , KURAHASHI OSAMU
IPC分类号： C12N15/09 , C12N1/21 , C12N9/90 , C12N15/61 , C12P13/08 , C12R1/13

64. 发明专利

BR9706058A 未知
公开(公告)号：BR9706058A
公开(公告)日：1999-10-05
申请号：BR9706058
申请日：1997-12-05
申请人： AJINOMOTO KK
发明人： HAYAKAWA ATSUSHI , SUGIMOTO MASAKAZU , YOSHIHARA YASUHIKI , NAKAMATSU TSUYOSHI
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/12 , C12N9/88 , C12N15/00 , C12N15/54 , C12N15/60 , C12P13/08 , C12R1/15 , C12N15/57 , C12N15/77 , C12R1/13
摘要： A recombinant DNA autonomously replicable in cells of coryneform bacteria, comprising a DNA sequence coding for an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, and a DNA sequence coding for a diaminopimelate decarboxylase; a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, and comprising an enhanced DNA sequence coding for a diaminopimelate decarboxylase; and a method for producing L-lysine comprising the steps of cultivating the coryneform bacterium in an appropriate medium to allow L-lysine to be produced and accumulated in a culture of the bacterium, and collecting L-lysine from the culture.

65. 发明专利

CA2256757A1 METHOD OF PRODUCING L-SERINE BY FERMENTATION 未知
公开(公告)号：CA2256757A1
公开(公告)日：1999-07-12
申请号：CA2256757
申请日：1999-01-11
申请人： AJINOMOTO KK
发明人： SUGA MIKIKO , ITO MIKA , OSUMI TSUYOSHI , SUGIMOTO MASAKAZU , NAKAMATSU TSUYOSHI , HIBINO WATARU
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/04 , C12N15/53 , C12P13/06 , C12R1/13
摘要： Disclosed is a coryneform bacterium having resistance to azaserine or .beta.-(2-thienyl)-DL-alanine and having L-serine productivity. Also, disclosed are D-3-phosphoglycerate dehydrogenase derived from a coryneform bacterium, in which feedback inhibition by L-serine is desensitized; the D-3-phosphoglycerate dehydrogenase, which is obtainable from a coryneform bacterium having resistance to azaserine or .beta.-(2-thienyl)-DL-alanine and having L-serine productivity; the D-3-phosphoglycerate dehydrogenase having an amino acid sequence depicted in SEQ ID NO : 12 in Sequence Listing or the sequence including substitution, addition or deletion of one or more amino acids, wherein an amino acid residue corresponding to the 325th glutamic acid residue of the amino acid sequence in the SEQ ID NO : 12 is replaced with an amino acid other than glutamic acid; the D-3-phosphoglycerate dehydrogenase that has an amino acid sequence depicted in SEQ ID NO : 11 in Sequence Listing; a DNA coding for the D-3-phosphoglycerate dehydrogenase described above; the DNA that has a base sequence depicted in SEQ ID NO : 13 in Sequence Listing; a coryneform bacterium which harbors a recombinant DNA containing the DNA; and a method of producing L-serine, comprising the steps of cultivating the bacterium described above in a medium to allow accumulation of L-serine in the medium, and collecting the L-serine from the medium.

66. 发明专利

FR2736066B1 未知
公开(公告)号：FR2736066B1
公开(公告)日：1998-11-20
申请号：FR9608127
申请日：1996-06-28
申请人： AJINOMOTO KK
发明人： MORIYA MIKA , MATSUI HIROSHI , YOKOZEKI KENZO , HIRANO SEIKO , HAYAKAWA ATSUSHI , IZUI MASAKO , SUGIMOTO MASAKAZU
IPC分类号： C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/67 , C12N15/77 , C12N15/87 , C12N15/90 , C12P13/04 , C12P13/08

67. 发明专利

CZ390397A3 RECOMBINANT DNA, BACTERIUM AND PROCESS FOR PREPARING L-LYSINE 未知
公开(公告)号：CZ390397A3
公开(公告)日：1998-06-17
申请号：CZ390397
申请日：1996-06-05
申请人： AJINOMOTO KK
发明人： OTSUNA SEIKO , SUGIMOTO MASAKAZU , IZUI MASAKO , HAYAKAWA ATSUSHI , NAKAMATSU TSUYOSHI , NAKANO EIICHI , KOBAYASHI MASAKI , YOSHIHARA YASUHIKO
IPC分类号： C12N1/21 , C12N9/06 , C12N9/12 , C12N9/88 , C12N15/31 , C12N15/52 , C12N15/77 , C12P13/08 , C12P19/34 , C12R1/15
摘要： The L-lysine-producing ability and the L-lysine-producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihydrodipicolinate reductase, DNA coding for a dihydrodipicolinate synthase, DNA coding for a diaminopimelate decarboxylase, and DNA coding for a diaminopimelate dehydrogenase.

68. 发明专利

HU9702361D0 METHOD FOR PRODUCING L-LYSINE 未知
公开(公告)号：HU9702361D0
公开(公告)日：1998-03-02
申请号：HU9702361
申请日：1997-12-05
申请人： AJINOMOTO KK
发明人： HAYAKAWA ATSUSHI , NAKAMATSU TSUYOSHI , SUGIMOTO MASAKAZU , YOSHIHARA YASUHIKO
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/12 , C12N9/88 , C12N15/00 , C12N15/54 , C12N15/60 , C12P13/08 , C12R1/15
摘要： A recombinant DNA autonomously replicable in cells of coryneform bacteria, comprising a DNA sequence coding for an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, and a DNA sequence coding for a diaminopimelate decarboxylase; a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, and comprising an enhanced DNA sequence coding for a diaminopimelate decarboxylase; and a method for producing L-lysine comprising the steps of cultivating the coryneform bacterium in an appropriate medium to allow L-lysine to be produced and accumulated in a culture of the bacterium, and collecting L-lysine from the culture.

69. 发明专利

AU682547B2 Variant phosphoenolpyruvate carboxylase, gene thereof, and process for producing amino acid 未知
公开(公告)号：AU682547B2
公开(公告)日：1997-10-09
申请号：AU8099194
申请日：1994-08-17
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , SUZUKI TOMOKO , MATSUI HIROSHI , IZUI KATSURA
IPC分类号： C12N9/88 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/14 , C12P13/20
摘要： A variant phosphoenolpyruvate carboxylase that is not substantially inhibited by aspartic acid is produced by introducing a variant phosphoenolpyruvate carboxylase gene, such as one wherein the 625th glutamic acid residue from the N-terminus of the carboxylase has been replaced by a lysine residue or one wherein the 438th arginine residue has been replaced by a cysteine residue, into Escherichia coli or a coryneform bacterium. An amino acid can efficiently be produced by using this carboxylase.

70. 发明专利

BR9407625A 未知
公开(公告)号：BR9407625A
公开(公告)日：1997-01-21
申请号：BR9407625
申请日：1994-08-17
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , SUZUKI TOMOKO , MATSUI HIROSHI , IZUI KATSURA
IPC分类号： C12N9/88 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/14 , C12P13/20
摘要： A variant phosphoenolpyruvate carboxylase that is not substantially inhibited by aspartic acid is produced by introducing a variant phosphoenolpyruvate carboxylase gene, such as one wherein the 625th glutamic acid residue from the N-terminus of the carboxylase has been replaced by a lysine residue or one wherein the 438th arginine residue has been replaced by a cysteine residue, into Escherichia coli or a coryneform bacterium. An amino acid can efficiently be produced by using this carboxylase.

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