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61. 发明授权

US3840524A Alpha-cycloalkylbenzyl lactamimides 失效
标题翻译：阿尔法 - 环丙基苄基乳糖苷
公开(公告)号：US3840524A
公开(公告)日：1974-10-08
申请号：US35444273
申请日：1973-04-25
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G
IPC分类号： C07D223/12 , C07D207/22 , C07D211/72 , C07D227/10 , C07D27/04 , C07D29/28 , C07D41/04
CPC分类号： C07D227/10 , Y10S514/866
摘要： 1. AN A-CYCLOALKYLBENZYL LACTAMIMIDE HAVING THE FORMULA ((X)M-PHENYL)-CH(-Y)-N=C

62. 发明授权

US3829433A Substituted piperidinoalkanone oxime derivatives 失效
标题翻译：取代的哌嗪酮氧化衍生物
公开(公告)号：US3829433A
公开(公告)日：1974-08-13
申请号：US22182272
申请日：1972-01-28
申请人： RICHARDSON MERRELL INC
发明人： CARR A , KINSOLVING C , MEYER D
IPC分类号： C07D211/14 , C07D211/22 , C07D211/70 , C07D409/06 , C07D29/28
CPC分类号： C07D211/70 , C07D211/14 , C07D211/22 , Y10S514/825 , Y10S514/957 , Y10S514/96 , Y10S514/962
摘要： NOVEL COMPOUNDS USEFUL AS ANTIHISTAMINE AGENTS, ANTIALLERGY AGENTS, AND BRONCHODILATORS ARE REPRESENTED BU THE FOLLOWING FORMULA

1-(Z-C(=N-OH)-(CH2)N-),4-R1,4-((DIPHENYL)-C(-R)-)-PIPERI

DINE

WHEREIN R REPRESENTS HYDROGEN OR HYDROXY; R1 REPRESENTS HYDROGEN; OR R AND R1 TAKEN TOGETHER FORM A SECOND BOND BETWEEN THE CARBON ATOMS BEARING R AND R1; N IS A POSITIVE WHOLE INTEGER OF FROM 1 TO 3; Z REPRESENTS THIENYL, PHENYL, OR SUBSTITUTED PHENYL WHEREIN THE SUBSTITUENTS ON THE SUBSTITUTED PHENYL MAY BE ATTACHED AT THE ORTHO, META, OR PARA POSITIONS OF THE PHENYL RING AND ARE SELECTED FROM HALOGEN, A STRAIGHT OR BRANCHED LOWER ALKYL CHAIN OF FROM 1 TO 4 CARBON ATOMS, A LOWER ALKOXY GROUP OF FROM 1 TO 4 CARBON ATOMS, A DI(LOWER)ALKYLAMINO GROUP, OR A SATURATED MONOCYCLIC HETEROCYCLIC GROUP SUCH AS PYRROLIDNO, PIPERIDINO, MORPHOLINO, OR N-(LOWER)ALKYLPIPERAZINO. PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND INDIVIDUAL GEOMETRIC ISOMERS OF COMPOUNDS OF THE ABOVE FORMULA ARE ALSO INCLUDED AS A PART OF THIS INVENTION.

63. 发明授权

US3818072A Alkyl substituted-benzoylacetates antilipemic agents 失效
标题翻译：烷基取代的苯甲酸酯抗生素
公开(公告)号：US3818072A
公开(公告)日：1974-06-18
申请号：US20386871
申请日：1971-12-01
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , JANSSENS W
IPC分类号： C07C69/95 , C07C69/76
CPC分类号： C07C69/95
摘要： Disclosed are novel compounds of the formula

WHEREIN R1 is lower alkyl of from one to four carbon atoms and R2 is a straight or branched chain alkyl of from eight to 14 carbon atoms which may be substituted on any position of the ring. The novel compounds are useful in the treatment of hyperlipemic states characterized by elevated blood lipid levels.
摘要翻译：公开了下式的新化合物，其中R 1是具有1至4个碳原子的低级烷基，R 2是可以在该环的任何位置被取代的8至14个碳原子的直链或支链烷基。新型化合物可用于治疗以血脂水平升高为特征的高脂血症。

64. 发明授权

US3808206A Bis-basic ketones of phenoxathiins and antiviral compositions thereof 失效
标题翻译：苯并噻唑类的双酚S基础组合物及其抗病毒组合物
公开(公告)号：US3808206A
公开(公告)日：1974-04-30
申请号：US15812271
申请日：1971-06-29
申请人： RICHARDSON MERRELL INC
发明人： FLEMING R , DE WITT SILL A
IPC分类号： A61K31/535 , C07D327/08 , A61K27/00 , C07D89/16
CPC分类号： A61K31/535 , C07D327/08
摘要： WHEREIN X IS OXYGEN OR NR4, IS HYDROGEN OR LOWER ALKYL OF FROM 1 TO 4 CARBON ATOMS; OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THESE COMPOUNDS CAN BE PREPARED BY SEVERAL DIFFERENT METHODS. ANTIVIRAL COMPOSITIONS AND METHODS OF INHIBITING OR INACTIVATING VIRUSES BY ADMINISTERING TO HOSTS AN ANTIVIRALLY EFFECTIVE QUANTITY OF AN ACTIVE INGREDIENT ARE DISCLOSED HEREIN.

BIS(Y-A-CO-)PHENOXATHIIN

WHEREIN A IS A STRAIGHT OR BRANCHED ALKYLENE CHAIN HAVING FROM 1 TO 6 CARBON ATOMS; AND EACH Y IS SELECTED FROM (A) THE GROUP

-N(-R1)-R2

WHEREIN R1 AND R2 ARE INDIVIDUALLY SELECTED FROM HYDROGEN, LOWER ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL OF FROM 3 TO 6 CARBON ATOMS AND HAVING THE VINYL UNSATURATION IN OTHER THAN THE I-POSITION OF THE ALKENYL GROUP; OR (B) THE GROUP

-N
WHEREIN N IS A WHOLE INTEGER OF FROM 4 TO 6 AND R3 IS SELECTED FROM HYDROGEN OR LOWER ALKYL OF FROM 1 TO 4 CARBON ATOMS AND CAN BE LINKED TO ANY ONE OF THE CARBON ATOMS OF THE HETEROCYCLIC GROUP; OR (C) THE GROUP
-N BIS-BASIC KETONES OF PHENOXATHIINS HAVE ANTIVIRAL ACTIVITY WHEN ADMINISTERED ORALLY AND PARENTERALLY. THE COMPOUNDS ARE REPRESENTED BY THE FOLLOWING FORMULA:

65. 发明授权

US3806526A 1-aroylalkyl-4-diphenylmethyl piperidines 失效
标题翻译： 1-二氧戊基-4-二苯基甲基哌啶
公开(公告)号：US3806526A
公开(公告)日：1974-04-23
申请号：US22182372
申请日：1972-01-28
申请人： RICHARDSON MERRELL INC
发明人： CARR A , KINSOLVING C
IPC分类号： C07D211/44 , A61K31/445 , C07D211/14 , C07D211/22 , C07D211/70 , C07D409/06 , C07D29/28
CPC分类号： A61K31/445 , C07D211/14 , C07D211/22 , C07D211/70 , Y10S514/826
摘要： NOVEL COMPOUNDS USEFUL AS ANTIHISTAMINE AGENTS, ANTIALLERGY AGENTS, AND BRONCHODILATORS ARE REPRESENTED BY THE FOLLOWING FORMULA

1-(Z-CO-(CH2)N-),4-((PHENYL)2-C(-R)-),4-R1-PIPERIDINE

WHEREIN R REPRESENTS HYDROGEN OR HYDROXY; R1 REPRESENTS HYDROGEN; OR R AND R1 TAKEN TOGETHER FROM A SECOND BOND BETWEEN THE CARBON ATOMS BEARING R AND R1; N IS A POSITIVE WHOLE INTEGER OF FROM 1 TO 3; Z REPRESENTS THIENYL, PHENYL, OR SUBSTITUTED PHENYL WHEREIN THE SUBSTITUENTS ON THE SUBSTITUTED PHENYL MAY BE ATTACHED AT THE ORTHO, META, OR PARA POSITIONS OF THE PHENYL RING AND ARE SELECTED FROM HALOGEN, A STRAIGHT BRANCHED LOWER ALKYL CHAIN OF FROM 1 TO 4 CARBON ATOMS, A LOWER ALKOXY GROUP OF FROM 1 TO 4 CARBON ATOMS, DI(LOWER) ALKYLAMINO, OR A SATURATED MONOCYCLIC HETEROCYLIC GROUP SUCH AS PYRROLIDINO, PIPERIDINO, MORPHOLINO, OR N-(LOWER) ALKYLPIPERAZINO. PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND INDIVIDUAL OPTICAL ISOMERS OF COMPOUNDS OF THE ABOVE FORMULA ARE ALSO INCLUDED AS A PART OF THIS INVENTION.

66. 发明授权

US3803170A 2-((1-benzylcyclopentyl)imino)pyrrolidine 失效
标题翻译： 2 - （（1-苄氧基）咪唑啉）吡咯烷
公开(公告)号：US3803170A
公开(公告)日：1974-04-09
申请号：US28004872
申请日：1972-08-11
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G , BLOHM T , ROBERTS E
IPC分类号： C07D207/22 , C07D27/00 , C07D27/02
CPC分类号： C07D207/22 , Y10S514/866
摘要： 2-(1 - BENZYLCYCLOPENTYL)IMINO)PYRROLIDINE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF POSSESS USEFUL HYPOLYCEMIC PROPERTIES.

67. 发明授权

US3737322A Treatment of arabinogalactan 失效
标题翻译：治疗阿拉伯糖化血红蛋白
公开(公告)号：US3737322A
公开(公告)日：1973-06-05
申请号：US3737322D
申请日：1971-03-17
申请人： RICHARDSON MERRELL INC
发明人： FREY R
IPC分类号： A23G1/00 , A23G1/40 , A23L1/052 , A23L1/308 , C08B37/14 , A23L1/26
CPC分类号： A23G1/40 , A23L29/206 , A23L33/21 , C08B37/006 , Y10S426/804
摘要： THE TENDENCY OF ARABINOGALACTAN, A LOW-CALORIE SUGAR SUBSTITUTE FOR USE IN FOODS, TO ABSORB FAT AND BECOME UNMANAGEABLE IN FOOD PROCESSING OPERATIONS MAY BE CONTROLLED BY TREATING THE ARABINOGALACTAN WITH SACCHARIDES AND OTHER EDIBLE POLYHYDROXY COMPOUNDS.

68. 发明授权

US3634183A Compacted regenerated cellulose sponges and method of preparing the same 失效
标题翻译：压缩再生纤维素海绵及其制备方法
公开(公告)号：US3634183A
公开(公告)日：1972-01-11
申请号：US3634183D
申请日：1970-05-15
申请人： RICHARDSON MERRELL INC
发明人： VIOLA LEONARD J , GANS EUGENE H
IPC分类号： A61K8/02 , A61Q15/00 , B29C44/00 , B29C67/20 , C09J5/00 , B32B3/26
CPC分类号： B29C44/00 , A61K8/0208 , A61Q15/00 , Y10S206/823 , Y10T428/24967 , Y10T428/249981 , Y10T428/31884
摘要： Stacks of individual thinly sliced sheets of regenerated cellulose may be compressed at pressures of 2,000-20,000 pounds per square inch to reduce the thickness thereof to 8-20 percent of the original stacked height to obtain a product which remains compressed and in which the individual thin sheets of regenerated cellulose adhere to each other so long as they are dry. The compressed sheets can be cut into desired shapes, packed in shipping boxes, transported and handled on automatic filling machines without falling apart. The individual units are useful in preparing cosmetic pads for cleaning, disinfecting and otherwise applying liquid medicaments to the skin.
摘要翻译：可以在2,000-20,000磅/平方英寸的压力下压缩单个薄片再生纤维素的片材以将其厚度减小到原始堆叠高度的8-20％，以获得保持压缩的产品，并且其中各个薄片再生纤维素片相互粘合，只要它们干燥即可。压缩片材可以切割成所需的形状，包装在运输箱中，在自动灌装机上运输和处理，而不会分离。单个单元可用于制备用于清洁，消毒和以其它方式将液体药物施用于皮肤的化妆品垫。

69. 发明授权

US3576865A Fluorenone-,fluorenol-,and fluorenebis-basic carboxamides 失效
标题翻译：荧光素，氟菊酯和氟代基础碳酰胺
公开(公告)号：US3576865A
公开(公告)日：1971-04-27
申请号：US3576865D
申请日：1968-10-11
申请人： RICHARDSON MERRELL INC
发明人： FLEMING ROBERT W , SILL ARTHUR D , SWEET FRANCIS WILLIAM
IPC分类号： C07D295/12 , A61K31/16 , B60K17/22 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/12 , C07C233/78 , C07C235/42 , C07C235/84 , C07C103/30
CPC分类号： A61K31/16 , B60K17/22 , C07C233/12 , C07C2603/18
摘要： NOVEL COMPOUNDS SELECTED FROM A BASE OF THE FORMULA

9-(X=),BIS(R3-N(-R2)-A-N(-R1)-CO-)FLUORENE

WHEREIN: X IS 0; H2; OR H,OH; EACH R1 IS HYDROGEN OR LOWER ALKYL; EACH A IS ALKYLENE OF 2 TO ABOUT 8 CARBON ATOMS AND SEPARATES ITS ADJACENT NITROGEN ATOMS BY AN ALKYLENE CHAIN OF AT LEAST 2 CARBON ATOMS; AND EACH R2 AND R3 IS HYDROGEN, LOWER ALKYL, CYCLOALKYL HAVING 3 TO ABOUT 6 RING CARBON ATOMS, ALKENYL OF 3 TO 6 CARBON ATOMS HAVING THE VINYL UNSATURATION IN OTHER THAN THE 1POSITON OF THE ALKENYL GROUP, OR EACH SET OF R2 AND R3 TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED IS A SATURATED MONOCYCLIC HETEROCYCLIC GROUP HAVING 4 OR 5 RING CARBON ATOMS IN SAID HETEROCYCLIC GROUP; OR AN ACID ADDITION SALT OF SAID BASE. THE COMPOUNDS CAN BE USED AS ANTI-INFECTIVE OR ANTIMICROBIAL AGENTS, SUCH AS ANTIVIRAL, ANTIBACTERIAL AND ANTIFUNGAL AGENTS.

70. 发明授权

US3440274A Trimethoxyphenylalkylamines and their carboalkoxy derivatives 失效
标题翻译：三甲氧基甲硅烷氧基及其碳氧烷衍生物
公开(公告)号：US3440274A
公开(公告)日：1969-04-22
申请号：US3440274D
申请日：1965-10-21
申请人： RICHARDSON MERRELL INC
发明人： PALOPOLI FRANK P , MICUCCI DOMINIC DONALD , ROSENSTOCK PAUL D
IPC分类号： C07C93/00 , C07C93/14

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