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1. 发明授权

US3829440A Xanthene derivatives 失效
标题翻译： XANTHENE衍生物
公开(公告)号：US3829440A
公开(公告)日：1974-08-13
申请号：US31714772
申请日：1972-12-21
申请人： RICHARDSON MERRELL INC
发明人： CARR A , GRUNWELL J
IPC分类号： C07D311/82 , C07D7/42 , C07D65/16
CPC分类号： C07D311/82 , Y10S514/825 , Y10S514/883
摘要： NOVEL 3,6-BIS BASIC ETHERS AND THIOETHERS OF 9(SUBSTITUTED)BENZYLIDENEXANTHENE, THEIR PREPARATION AND USE FOR THE PREVENTION AND INHIBITION OF VIRAL INFECTIONS ARE DISCLOSED.

2. 发明授权

US3829578A Antiviral compositions containing bis-basic ethers and thioethers of xanthene and xanthen-9-ones and methods of treating viruses therewith 失效
标题翻译：含有BIS基础物质和XENTHENE和XANTHEN-9-ONES的硫醇的抗病毒组合物及其治疗病毒的方法
公开(公告)号：US3829578A
公开(公告)日：1974-08-13
申请号：US30325572
申请日：1972-11-02
申请人： RICHARDSON MERRELL INC
发明人： FLEMING R , CARR A
IPC分类号： A23K1/16 , A61K27/00
CPC分类号： A23K20/121
摘要： Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an antivirally effective quantity of an active ingredient are disclosed herein. The active ingredients are those compounds having the formula

WHEREIN Z is oxygen or H2; each Y is oxygen or divalent sulfur; each A is a straight or branched alkylene chain of from two to four carbon atoms and which separates the amino nitrogen and Y by at least two carbon atoms; each R and R1 are individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, alkenyl of from three to six carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or each set of R and R1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino or N-(lower)alkylpiperazino; or pharmaceutically acceptable acid addition salts of said compounds.

3. 发明授权

US3795677A Aryl 4-piperidyl ketone derivatives 失效
标题翻译： ARYL 4-PIPERIDYL KETONE DERIVATIVES
公开(公告)号：US3795677A
公开(公告)日：1974-03-05
申请号：US3795677D
申请日：1971-11-09
申请人： RICHARDSON MERRELL INC
发明人： CARR A , MEYER D
IPC分类号： C07D211/32 , C07D211/62 , C07D29/20
CPC分类号： C07D211/32 , Y10S514/822
摘要： NOVEL COMPOUNDS HAVING THE FORMULA

4-(((R)N-PHENYL)-CO-)PIPERIDINE

WHEREIN N IS A POSITIVE WHOLE INTEGER OF FROM 1 TO 3; R REPRESENTS PHENYL, A STRAIGHT OR BRANCHED ALKYL CHAIN OF FROM 1 TO 4 CARBON ATOMS ATTACHED TO THE PHENYL RING AT THE ORTHO, META, OR PARA POSITIONS, OR A DIFUNCTIONAL 1,4-BUTADIENYLENE MOIETY WHICH TOGETHER WITH THE PHENYL RING FORMS A NAPHTHYL RING WITH THE PROVISO THAT WHEN R REPRESENTS A DIFUNCTIONAL 1,4-BUTADIENYLENE MOIETY, N IS EQUAL TO 1; OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF, ARE USEFUL AS ANALGESIC AND AS ANTICOAGULANT AGENTS.

4. 发明授权

US3852455A 4-{8 4({60 hydroxybenzyl)piperidino{9 -4-fluorobutyrophenone derivatives as tranquilizers 失效
标题翻译： 4- {8 4（{60羟基苄基）哌啶{9-4-氟代丁基酮衍生物作为交联剂
公开(公告)号：US3852455A
公开(公告)日：1974-12-03
申请号：US24988672
申请日：1972-05-03
申请人： RICHARDSON MERRELL INC
发明人： CARR A
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： Novel compounds which are neuroleptic agents useful as tranquilizers and having the formula WHEREIN R is hydrogen, halogen, such as chlorine, bromine or fluorine, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, thioalkoxy having from 1 to 3 carbon atoms, trifluoromethyl, phenyl or phenoxy and may be attached to the phenyl ring in the ortho, meta or para position or pharmaceutically acceptable acid addition salts thereof. The novel compounds are produced by reacting (substituted) Alpha phenyl-4-piperidinemethanols or salts thereof with 4''-fluoro-4halobutyrophenones.
摘要翻译：用作镇定剂并具有式WHEREIN R为氢，卤素如氯，溴或氟的卤素，具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，具有1至4个碳原子的烷氧基的新型化合物， 3个碳原子，三氟甲基，苯基或苯氧基，并且可以在其邻位，间位或对位或其药学上可接受的酸加成盐中连接到苯环上。该新化合物通过（取代的）α-苯基-4-哌啶基甲醇或其盐与4'-氟-4-卤代丁基酮反应制备。

5. 发明授权

US3829433A Substituted piperidinoalkanone oxime derivatives 失效
标题翻译：取代的哌嗪酮氧化衍生物
公开(公告)号：US3829433A
公开(公告)日：1974-08-13
申请号：US22182272
申请日：1972-01-28
申请人： RICHARDSON MERRELL INC
发明人： CARR A , KINSOLVING C , MEYER D
IPC分类号： C07D211/14 , C07D211/22 , C07D211/70 , C07D409/06 , C07D29/28
CPC分类号： C07D211/70 , C07D211/14 , C07D211/22 , Y10S514/825 , Y10S514/957 , Y10S514/96 , Y10S514/962
摘要： NOVEL COMPOUNDS USEFUL AS ANTIHISTAMINE AGENTS, ANTIALLERGY AGENTS, AND BRONCHODILATORS ARE REPRESENTED BU THE FOLLOWING FORMULA

1-(Z-C(=N-OH)-(CH2)N-),4-R1,4-((DIPHENYL)-C(-R)-)-PIPERI

DINE

WHEREIN R REPRESENTS HYDROGEN OR HYDROXY; R1 REPRESENTS HYDROGEN; OR R AND R1 TAKEN TOGETHER FORM A SECOND BOND BETWEEN THE CARBON ATOMS BEARING R AND R1; N IS A POSITIVE WHOLE INTEGER OF FROM 1 TO 3; Z REPRESENTS THIENYL, PHENYL, OR SUBSTITUTED PHENYL WHEREIN THE SUBSTITUENTS ON THE SUBSTITUTED PHENYL MAY BE ATTACHED AT THE ORTHO, META, OR PARA POSITIONS OF THE PHENYL RING AND ARE SELECTED FROM HALOGEN, A STRAIGHT OR BRANCHED LOWER ALKYL CHAIN OF FROM 1 TO 4 CARBON ATOMS, A LOWER ALKOXY GROUP OF FROM 1 TO 4 CARBON ATOMS, A DI(LOWER)ALKYLAMINO GROUP, OR A SATURATED MONOCYCLIC HETEROCYCLIC GROUP SUCH AS PYRROLIDNO, PIPERIDINO, MORPHOLINO, OR N-(LOWER)ALKYLPIPERAZINO. PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND INDIVIDUAL GEOMETRIC ISOMERS OF COMPOUNDS OF THE ABOVE FORMULA ARE ALSO INCLUDED AS A PART OF THIS INVENTION.

6. 发明授权

US3806526A 1-aroylalkyl-4-diphenylmethyl piperidines 失效
标题翻译： 1-二氧戊基-4-二苯基甲基哌啶
公开(公告)号：US3806526A
公开(公告)日：1974-04-23
申请号：US22182372
申请日：1972-01-28
申请人： RICHARDSON MERRELL INC
发明人： CARR A , KINSOLVING C
IPC分类号： C07D211/44 , A61K31/445 , C07D211/14 , C07D211/22 , C07D211/70 , C07D409/06 , C07D29/28
CPC分类号： A61K31/445 , C07D211/14 , C07D211/22 , C07D211/70 , Y10S514/826
摘要： NOVEL COMPOUNDS USEFUL AS ANTIHISTAMINE AGENTS, ANTIALLERGY AGENTS, AND BRONCHODILATORS ARE REPRESENTED BY THE FOLLOWING FORMULA

1-(Z-CO-(CH2)N-),4-((PHENYL)2-C(-R)-),4-R1-PIPERIDINE

WHEREIN R REPRESENTS HYDROGEN OR HYDROXY; R1 REPRESENTS HYDROGEN; OR R AND R1 TAKEN TOGETHER FROM A SECOND BOND BETWEEN THE CARBON ATOMS BEARING R AND R1; N IS A POSITIVE WHOLE INTEGER OF FROM 1 TO 3; Z REPRESENTS THIENYL, PHENYL, OR SUBSTITUTED PHENYL WHEREIN THE SUBSTITUENTS ON THE SUBSTITUTED PHENYL MAY BE ATTACHED AT THE ORTHO, META, OR PARA POSITIONS OF THE PHENYL RING AND ARE SELECTED FROM HALOGEN, A STRAIGHT BRANCHED LOWER ALKYL CHAIN OF FROM 1 TO 4 CARBON ATOMS, A LOWER ALKOXY GROUP OF FROM 1 TO 4 CARBON ATOMS, DI(LOWER) ALKYLAMINO, OR A SATURATED MONOCYCLIC HETEROCYLIC GROUP SUCH AS PYRROLIDINO, PIPERIDINO, MORPHOLINO, OR N-(LOWER) ALKYLPIPERAZINO. PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND INDIVIDUAL OPTICAL ISOMERS OF COMPOUNDS OF THE ABOVE FORMULA ARE ALSO INCLUDED AS A PART OF THIS INVENTION.

7. 发明专利

BE882703A NOUVEAUX DERIVES DE OMEGA-(4-DIPHENYLMETHYL-PIPERIDINO)-1-PHENYLALCANOLS ET LEUR PROCEDE DE PREPARATION. 未知
公开(公告)号：BE882703A
公开(公告)日：1980-07-31
申请号：BE200161
申请日：1980-04-09
申请人： RICHARDSON MERRELL INC
发明人： CARR A , DOLFINI J , WRIGHT G
IPC分类号： A61K31/445 , A61K31/451 , A61P11/08 , A61P37/08 , A61P43/00 , C07D211/22 , C07D , A61K

8. 发明专利

PH11250A (-ARYL-4)SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES,COMPOSITION AND METHOD OF USE THEREOF 未知
公开(公告)号：PH11250A
公开(公告)日：1977-10-28
申请号：PH16790
申请日：1975-02-10
申请人： RICHARDSON MERRELL INC
发明人： CARR A , KINSOLVING C
IPC分类号： C07D211/22 , C07D211/70 , C07D409/06 , A61K31/445 , C07D211/00
摘要： Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula WHEREIN R1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R2 represents hydrogen or hydroxy; R3 represents hydrogen, or R2 and R3 taken together form a second bond between the carbon atoms bearing R2 and R3; n is an integer of from 1 to 3; Z represents thienyl, naphthyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl may be attached at the ortho, meta or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, an alkoxy group of from 1 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)-alkylpiperazino with the proviso that when R1 is phenyl, Z is naphthyl or phenyl substituted with a straight or branched alkyl group of 5 or 6 carbon atoms, a lower alkoxy group of 5 or 6 carbon atoms, or a cycloalkyl group of from 3 to 6 carbon atoms. Pharmaceutically acceptable acid addition salts and individual optical and geometric isomers of compounds of the above formula are also included as a part of this invention.

9. 发明专利

ZA75894B PIPERIDINE DERIVATIVES 未知
公开(公告)号：ZA75894B
公开(公告)日：1976-01-28
申请号：ZA75894
申请日：1975-02-12
申请人： RICHARDSON MERRELL INC
发明人： CARR A , KINSLOVING C
IPC分类号： C08L67/00 , C07D211/14 , C07D211/22 , C07D211/70 , C07D

10. 发明专利

ZA7549B SUBSTITUTED PIPERIDINE DERIVATIVES 未知
公开(公告)号：ZA7549B
公开(公告)日：1976-01-28
申请号：ZA7549
申请日：1975-01-02
申请人： RICHARDSON MERRELL INC
发明人： KINSOLVING C , CARR A
IPC分类号： C07D211/22 , C07D211/70 , C07D409/06 , C07D
摘要： Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula WHEREIN R1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R2 represents hydrogen or hydroxy; R3 represents hydrogen; or R2 and R3 taken together form a second bond between the carbon atoms bearing R2 and R3; n is an integer of from 1 to 3; Z represents thienyl, naphthyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl may be attached at the ortho, meta or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, an alkoxy group of from 1 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)alkylpiperazino with the proviso that when R1 is phenyl, Z is naphthyl or phenyl substituted with a straight or branched alkyl group of 5 or 6 carbon atoms, a lower alkoxy group of 5 or 6 carbon atoms, or a cycloalkyl group of from 3 to 6 carbon atoms. Pharmaceutically acceptable acid addition salts and individual optical isomers of compounds of the above formula are also included as a part of this invention.

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