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1. 发明授权

US3803170A 2-((1-benzylcyclopentyl)imino)pyrrolidine 失效
标题翻译： 2 - （（1-苄氧基）咪唑啉）吡咯烷
公开(公告)号：US3803170A
公开(公告)日：1974-04-09
申请号：US28004872
申请日：1972-08-11
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G , BLOHM T , ROBERTS E
IPC分类号： C07D207/22 , C07D27/00 , C07D27/02
CPC分类号： C07D207/22 , Y10S514/866
摘要： 2-(1 - BENZYLCYCLOPENTYL)IMINO)PYRROLIDINE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF POSSESS USEFUL HYPOLYCEMIC PROPERTIES.

2. 发明授权

US3816457A Lactamimide derivatives 失效
标题翻译： LACTAMIMIDE衍生物
公开(公告)号：US3816457A
公开(公告)日：1974-06-11
申请号：US32116073
申请日：1973-01-05
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G , BLOHM T
IPC分类号： C07D307/00 , A61K31/395 , A61K31/435 , A61P3/08 , C07D307/52 , C07D405/12 , C07D409/12 , A61K27/00 , C07D63/12
CPC分类号： A61K31/395 , Y10S514/884
摘要： WHEREIN X REPRESENTS OXYGEN OR SULFUR; A REPRESENTS A BOND, OR A STRAIGHT OR BRANCHED SLKYLENE CHAIN OF FROM 1 TO 3 CARBON ATOMS; R REPRESENTS HYDROGEN, A STRAIGHT OR BRANCHED LOWER ALKYL GROUP OF 1 TO 4 CARBON ATOMS, A STRAIGHT OR BRANCHED LOWER ALKENYL GROUP OF FROM 3 TO 6 CARBON ATOMS, A CYCLOALKYL GROUP OF FROM 3 TO 6 CARBON ATOMS OR PHENYL; R1 REPRESENTS HYDROGEN OR A STRAIGHT OR BRANCHED LOWER ALKYL GROUP OF FROM 1 TO 4 CARBON ATOMS; N IS N INTEGER OF FROM 3 TO 11; AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND INDIVIDUAL OPTICAL ISOMERS OF THE COMPOUNDS WHERE APPLICABLE.

(-X-CH=CH-CH=)>C-A-CH(-R)-N=C
NOVEL COMPOUNDS USEFUL AS HYPOGLYCEMIC AGENTS ARE REPRESENTED BY THE FORMULA

3. 发明授权

US3712896A Allene polyamines 失效
标题翻译：艾伦聚氨酯
公开(公告)号：US3712896A
公开(公告)日：1973-01-23
申请号：US3712896D
申请日：1971-02-25
申请人： RICHARDSON MERRELL INC
发明人： TILFORD C , BLOHM T , MCKENZIE R
IPC分类号： C07C47/21 , C07D203/12 , C07D233/06 , C07D29/28
CPC分类号： C07D233/06 , C07C47/21 , C07D203/12
摘要： NOVEL COMPOUNDS WHICH HAVE ACTIVITY IN INHIBITING THE CLOTTING OF BLOOD ARE SELECTED FROM BASES OF THE FORMULA

R3-(R4-)C=C=C(-R5)-C(-R6)(-R7)-CH2-NH-A

WHEREIN: (A) R3 IS HYDROGEN, (LOWER)ALKYL OR (LOWER)ALKENYL; (B) R4 IS (LOWER)ALKYL OR (LOWER)ALKENYL; (C) R3 AND R4 TAKEN TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE ATTACHED IS CYCLOALKYL OF 5 TO 7 RING CARBON ATOMS; (D) R5 IS HYDROGEN OR (LOWER)ALKYL; (E) EACH OF R6 AND R7 IS (LOWER)ALKYL, (LOWER)ALLKENYL, OR R6 AND R7 TOGETHER WITH CARBON ATOMS TO WHICH THEY ARE ATTACHED IS (I) CYCLOALKYL OF 5 TO 7 RING CARBON ATOMS; (II) CYCLOALKENYL OF 5 TO 7 RING CARBON ATOMS; OR (III) BICYCLOALKYL SELECTED FROM BORNYL, NORBORNYL OR NORBORNENYL; (F) A IS THE GROUP (I)

-X-N(-R1)-R2

WHEREIN X IS ALKYLENE OF 2 TO ABOUT 8 CARBON ATOMS AND SEPARATES THE ADJACENT NITROGEN ATOMS BY AN ALKYLENE CHAIN OF AT LEAST 2 CARBON ATOMS, MONOHYDROXY ALKYLENE OF 3 TO ABOUT 8 CARBON ATOMS, AND SEPARATES THE ADJACENT NITROGEN ATOMS BY AN ALKYLENE CHAIN OF AT LEAST 3 CARBON ATOMS, OR A CYCLOALKYLSUBSTITUTED ALKYLENE GROUP OF THE FORMULA

(-CH2)V-C(-(CH2)U-)-(CH2)V''-

WHEREIN EACH OF V AND V'' IS AN INTEGER OF 0 TO 4, U WHEREIN EACH OF V AND V'' IS AN INTEGER OF 0 TO 4, U IS AN INTEGER OF 3 TO 5 PROVIDED THAT AT LEAST ONE OF V AND V'' IS 1, AND THE TOTAL OF V, V7 AND U IS NOT GREATER THAN 8, R1 IS HYDROGEN, (LOWER)ALKYL, PHENYL, HYDROXY(LOWER)ALKYL, CYCLOALKYL OF 4 TO 6 RING CARBON ATOMS, DI(LOWER)ALKYLAMINO(LOWER)ALKYL, PYRIDYL(LOWER)ALKYL, PIPERIDYL(LOWER)ALKYLAMINO(LOWER) ALKYL, OR PIPERIDYL(LOWER)ALKYL, R2 IS HYDROGEN, (LOWER)ALKYL OR HYDROXY(LOWER)ALKYL, OR R1 AND R2 TAKEN TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED IS PIPERAZINO, N-(LOWER)ALKYLPIPERAZINO, MORPHOLINO, PYRROLIDINO, AZIRIDINO, PIPERIDINO, (LOWER)ALKYLPIPERIDINO, (LOWER)ALKYLIMIDAZOLIDINO, OR (II) A IS

-(CH2)N-CH
WHEREIN N'' IS AN INTEGER OF 0 TO 3, M IS AN INTEGER OF 1 OR 2, R8 IS HYDROGEN, (LOWER)ALKYL, (LOWER) ALKENYL, HYDROXY(LOWER)ALKYL, PHENYL(LOWER)ALKYL, CYANO(LOWER)ALKYL, PIPERIDINO(LOWER)ALKYL, R9 IS (LOWER)ALKYL; AND N IS IN INTEGER OF 0 TO 4; OR PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS OF SAID BASES.

4. 发明授权

US3838151A Cycloalkyllactamimides 失效
标题翻译：环丙基乳糖
公开(公告)号：US3838151A
公开(公告)日：1974-09-24
申请号：US28004972
申请日：1972-08-11
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G , BLOHM T , ROBERTS E
IPC分类号： C07D223/12 , C07D207/22 , C07D211/72 , C07D225/02 , H04Q11/04 , C07D27/04 , C07D29/28 , C07D41/02
CPC分类号： H04Q11/04 , C07D207/22 , Y10S514/866
摘要： NOVEL COMPOUNDS OF THE FOLLOWING FORMULA ARE USEFUL AS HYPOGLYCEMIC AND ANTIVIRAL AGENTS.

R-N=C
WHEREIN R REPRESENTS NORBORNYL OR ADAMANTANYL AND N IS AN INTEGER OF FROM 3 TO 11.

5. 发明授权

US3783162A Hypoglycemic compositions containing benzhydryl-lactamimide derivatives 失效
标题翻译：含有苯甲酰赖氨酸衍生物的高分子化合物
公开(公告)号：US3783162A
公开(公告)日：1974-01-01
申请号：US3783162D
申请日：1971-09-13
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , BLOHM T
IPC分类号： A61K31/395 , A61K31/55 , C07D207/22 , C07D211/72 , A61K27/00
CPC分类号： A61K31/395 , A61K31/55 , C07D207/22 , C07D211/72
摘要： Pharmaceutical compositions with hypoglycemic and diuretic properties and methods for their use are disclosed herein. The active ingredients of the compositions are compounds of the formula

WHEREIN R is hydrogen or lower alkoxy of from one to six carbon atoms, and when R represents lower alkoxy the substituent alkoxy radical may be attached at the ortho-, meta- or para-position of the phenyl radical; R1 is hydrogen or lower alkyl of from one to four carbon atoms; n is a whole integer of from 3 to 11; or pharmaceutically acceptable acid addition salts of said compounds and individual optical isomers where applicable.
摘要翻译：具有低血糖和利尿性质的药物组合物及其使用方法在本文中公开。组合物的活性成分是下式的化合物，即：WHEREIN R是氢或1-6个碳原子的低级烷氧基，当R代表低级烷氧基时，取代基烷氧基可以在邻位，间位或对位连接的苯基; R1是氢或1-4个碳原子的低级烷基; n为3〜11的整数，或所述化合物的药学上可接受的酸加成盐和各种旋光异构体。

6. 发明专利

ZA8002452B NOVEL STEROID 5 ALPHA-REDUCTASE INHIBITORS 未知
公开(公告)号：ZA8002452B
公开(公告)日：1981-04-29
申请号：ZA8002452
申请日：1980-04-23
申请人： RICHARDSON MERRELL INC
发明人： BLOHM T , METCALF B
IPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , A61P13/02 , A61P15/00 , A61P17/00 , C07J1/00 , C07J3/00 , C07J7/00 , C07J9/00 , C07J17/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J51/00 , C12N9/99 , A61K , C07D
CPC分类号： C07J3/00 , C07J1/0011 , C07J3/005 , C07J9/00 , C07J9/005 , C07J17/00 , C07J21/00 , C07J31/006 , C07J41/0005 , C07J51/00

7. 发明专利

ZA7702084B TESTOSTERONE 5A-REDUCTASE INHIBITORS 未知
公开(公告)号：ZA7702084B
公开(公告)日：1978-06-28
申请号：ZA7702084
申请日：1977-04-05
申请人： RICHARDSON MERRELL INC
发明人： BENSON H , BLOHM T
IPC分类号： C07J9/00 , C07J21/00 , C07J31/00 , C07J41/00 , A61K , C07C
CPC分类号： C07J9/00 , C07J9/005 , C07J21/006 , C07J31/006 , C07J41/0061

8. 发明专利

ZA732922B PYRROLIDENE DERIVATIVE 未知
公开(公告)号：ZA732922B
公开(公告)日：1974-04-24
申请号：ZA732922
申请日：1973-04-30
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , ROBERTS E , CLAXTON G , BLOHM T
IPC分类号： C07D207/22 , C07D
摘要： 1367597 2-iminopyrrolidine derivative RICHARDSON-MERRELL Inc 30 April 1973 [11 Aug 1972] 20460/73 Heading C2C The novel compound, 2-[(1-benzylcyclopentyl)imino]pyrrolidine, and its pharmaceutically acceptable acid addition salts, are prepared by reacting an excess of a 2-(C 1-4 alkoxy or alkylthio)-1-pyrroline with 1-benzylcyclopentylamine, or its hydrochloride and optionally converting a free base obtained into an acid addition salt or vice versa. In acid addition salt form, the novel compound may in the tautomeric aminoform, i.e. as an acid addition salt of 2-[(1-benzylcyclopentyl)amino]pyrroline. Pharmaceutical compositions having hypoglycemic activity, for oral or parenteral administration, comprise the novel compound or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical diluent or carrier.

9. 发明专利

ZA7302927B CYCLOALKYLLACTAMIMIDES 未知
公开(公告)号：ZA7302927B
公开(公告)日：1974-03-27
申请号：ZA7302927
申请日：1973-04-30
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G , BLOHM T , ROBERTS E
IPC分类号： C07D223/12 , C07D207/22 , C07D211/72 , C07D225/02 , H04Q11/04 , A61K , C07C
CPC分类号： H04Q11/04 , C07D207/22 , Y10S514/866

10. 发明专利

ZA7302922B PYRROLIDENE DERIVATIVE 未知
公开(公告)号：ZA7302922B
公开(公告)日：1974-04-24
申请号：ZA7302922
申请日：1973-04-30
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , ROBERTS E , CLAXTON G , BLOHM T
IPC分类号： C07D207/22 , C07D
CPC分类号： C07D207/22 , Y10S514/866

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