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61. 发明申请

US20170292948A1 MULTIANALYTE MOLECULAR ANALYSIS USING APPLICATION-SPECIFIC RANDOM PARTICLE ARRAYS 审中-公开
公开(公告)号：US20170292948A1
公开(公告)日：2017-10-12
申请号：US15455375
申请日：2017-03-10
申请人： BioArray Solutions, Ltd.
发明人： Sukanta BANERJEE , Michael SEUL
IPC分类号： G01N33/543 , G01N27/74 , B01J19/00 , C12Q1/68 , G01N33/58
CPC分类号： G01N33/5434 , B01J19/0046 , B01J2219/005 , B01J2219/00545 , B01J2219/00576 , B82Y15/00 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/54326 , G01N33/54333 , G01N33/54346 , G01N33/587 , G01N33/588
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.

62. 发明申请

US20170088885A9 Optimization Of Gene Expression Analysis Using Immobilized Capture Probes 有权
公开(公告)号：US20170088885A9
公开(公告)日：2017-03-30
申请号：US14257294
申请日：2014-04-21
申请人： BIOARRAY SOLUTIONS, LTD.
发明人： Michael Seul , Sukanta Banerjee , Jiacheng Yang , Tatiana Vener
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , B01J2219/00459 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2565/501 , C12Q2565/507 , C12Q2533/101 , C12Q2565/514 , C12Q2565/519
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including a method of preventing a significant reduction in duplexes detectable in a hybridization assay involving (i) selecting probe lengths for sets of oligonucleotide probes, wherein probes include different subsequences such that at least one subsequence is complementary to a subsequence in a cognate target; wherein probes for longer cognate targets are longer in length than probes for shorter cognate targets, (ii) selecting, for each set of probes, a density of oligonucleotides probes attached per unit area on a solid phase carrier which is below a limit at which the significant reduction in detectable duplexes is predicated to take place, (iii) producing the probes and affixing them to different solid phase carriers at the selected density, and (iv) annealing targets to the probes, wherein signal intensities of probes and targets of different lengths are about the same.

63. 发明申请

US20160369066A1 Directed Assembly Of Functional Heterostructures 审中-公开
标题翻译：定向组装功能异质结构
公开(公告)号：US20160369066A1
公开(公告)日：2016-12-22
申请号：US15251159
申请日：2016-08-30
申请人： BioArray Solutions, Ltd.
发明人： Michael SEUL , Sukanta BANERJEE , Kairali PODUAL , Ye HONG
IPC分类号： C08J3/075 , G01N33/545 , G01N33/50 , C08J3/28 , C12Q1/68
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention. also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology:
摘要翻译：本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。本发明。还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。用于生成多功能薄膜的小型化格式。提供简单的设置来合成定制组合和形态的薄膜：

64. 发明申请

US20160321409A1 Transfusion registry and exchange network 审中-公开
公开(公告)号：US20160321409A1
公开(公告)日：2016-11-03
申请号：US15014688
申请日：2016-02-03
申请人： BioArray Solutions, Ltd.
发明人： Yi Zhang , Michael SEUL
IPC分类号： G06F19/00
CPC分类号： G16H40/20 , G06Q30/02 , G06Q30/0202 , G06Q50/22 , G06Q50/24
摘要： Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.

65. 发明申请

US20130210642A1 Hybridization-Mediated Analysis Of Polymorphisms 审中-公开
标题翻译：杂交介导的多态性分析
公开(公告)号：US20130210642A1
公开(公告)日：2013-08-15
申请号：US13845496
申请日：2013-03-18
申请人： BioArray Solutions, Ltd.
发明人： Ghazala HASHMI , Michael SEUL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/543 , C12Q2563/107 , C12Q2565/501
摘要： Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.
摘要翻译：描述了测定设计和测定图像校正的方法，其可用于使用探针对阵列（在一个方面中，其中一个成员与特定突变体互补的突变和多态性）的多重遗传筛选（包括CF相关突变体和多态性）多态等位基因和另一个成员与相应的野生型等位基因互补），其中探针与编码的颗粒结合（例如，珠粒），其中编码允许鉴定附着的探针。该方法涉及通过选择探针和扩增子来避免交叉杂交，以及分离某些探针和扩增子的反应，其中超过同源性阈值。还公开了使用背景图校正荧光图像的方法，其中颗粒还包含光编码系统。

66. 发明申请

US20130123146A1 METHOD OF MAKING A MICROBEAD ARRAY WITH ATTACHED BIOMOLECULES 失效
标题翻译：用连接的生物分子制备微阵列阵列的方法
公开(公告)号：US20130123146A1
公开(公告)日：2013-05-16
申请号：US13664953
申请日：2012-10-31
申请人： Bioarray Solutions, Ltd.
发明人： Michael Seul
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , B01L2400/0454 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/04 , G01N15/1468 , G01N27/447 , G01N33/54313 , G01N33/54386 , G01N33/6845 , G01N2015/149 , G01N2015/1497 , G02B3/0012 , G02B3/0056 , G02B3/0075 , H05H3/04 , Y10S435/808 , Y10S435/81 , Y10S435/814 , Y10S436/806 , Y10S436/808 , Y10S436/809 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
摘要翻译：一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。表面附近颗粒的光控电动组装取决于三个功能元件的组合：交流电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。

67. 发明申请

WO2009064280A3 A TRANSFUSION REGISTRY AND EXCHANGE NETWORK 审中-公开
标题翻译：转移注册和交换网络
公开(公告)号：WO2009064280A3
公开(公告)日：2009-07-02
申请号：PCT/US2007072193
申请日：2007-11-14
申请人： BIOARRAY SOLUTIONS LTD , ZHANG YI , SEUL MICHAEL
发明人： ZHANG YI , SEUL MICHAEL
IPC分类号： A61B5/00
CPC分类号： G06Q10/00 , G06Q50/22
摘要： Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors,
摘要翻译：公布了候选人输血捐助者的登记册，该登记处援引了库存管理政策，以创建和主动管理候选人捐助者名单，以便最大限度地减少多个地区和多个捐助者和接受者之间的需求与供应之间的不平衡。与基因分型实验室一起，注册管理机构确实针对招募潜在的捐赠者，这些捐赠者是针对一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变异体和可能的其他抗原如HLA 和HPA。注册管理机监测输血抗原基因型的输入需求，最好将需求分为一组代表稳定亚群体的类别，并将应用本文所披露的策略来调整候选捐献者名单的组成以匹配需求，从而避免过多和不必要的，候选人的打字，

68. 发明申请

WO2007121018A3 PROBE DENSITY CONSIDERATIONS AND ELONGATION OF SELF-COMPLEMENTARY LOOPED PROBES 审中-公开
标题翻译：探索密度考虑和自组织循环探测的延伸
公开(公告)号：WO2007121018A3
公开(公告)日：2008-12-04
申请号：PCT/US2007064118
申请日：2007-03-16
申请人： BIOARRAY SOLUTIONS LTD , SEUL MICHAEL , ZHANG YI , BANARJEE SUKANTA , YANG JIACHENG , CHAU CHIU
发明人： SEUL MICHAEL , ZHANG YI , BANARJEE SUKANTA , YANG JIACHENG , CHAU CHIU
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： This invention relates to a multiplexed assay method earned out in solution, wherein the solution contains nucleic aad targets and, wherein several different types of oligonucleotide probes are used to detect the nucleic acid targets The assay method includes a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, including (?) selecting a particular probe density on the surface of the bead, (??) selecting a solution having an ionic strength greater than a threshold, (??) selecting a target domain of a size less than a threshold, or (in) selecting target domains within a specified proximity to a terminal end of the targets
摘要翻译：本发明涉及在溶液中获得的多重测定方法，其中所述溶液含有核酸靶，并且其中使用几种不同类型的寡核苷酸探针来检测所述核酸靶。所述测定方法包括增加所述核酸靶的有效浓度的方法通过一个或多个以下步骤调节测定条件以增加可用于结合探针的靶标的有效浓度，包括（？）选择的寡核苷酸探针结合的珠粒表面上的核酸靶标选择具有大于阈值的离子强度的溶液，选择小于阈值的目标区域的（Δε）选择靶区域，在目标的终端的指定接近度内

69. 发明申请

WO2007081778A3 MULTIPLEXED DETECTION OF ANTI-RED CELL ALLOANTIBODIES 审中-公开
标题翻译：多重检测抗红细胞抗体
公开(公告)号：WO2007081778A3
公开(公告)日：2007-09-13
申请号：PCT/US2007000234
申请日：2007-01-04
申请人： BIOARRAY SOLUTIONS LTD , BANERJEE SUKANTA
发明人： BANERJEE SUKANTA
IPC分类号： G01N33/53
CPC分类号： G01N33/80 , Y10T436/106664 , Y10T436/13 , Y10T436/2525
摘要： Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection of clinically important allo-immune antibodies to blood group antigens. Specifically the method involves generating fluorescently encoded red blood cells or red blood cell ghosts with known antigen presentation and using them to detect the presence of antibody in serum/plasma with a fluorescent sandwich type immunoassay. The assay results can be read using flow cytometric or fluorescent microscope based imaging techniques.
摘要翻译：公开了用于检测样品中的抗体的方法，其中抗体靶向由红细胞或红细胞鬼影表达的抗原。本发明的方法不是检测特定抗原抗体对之间的结合事件（如在传统的基于凝集的测定中），而是允许对血型抗原的临床上重要的同种免疫抗体进行多重检测。具体而言，该方法涉及产生具有已知抗原呈递的荧光编码的红血细胞或红细胞重影，并使用它们通过荧光三明治型免疫测定来检测血清/血浆中抗体的存在。可以使用基于流式细胞术或基于荧光显微镜的成像技术来读取测定结果。

70. 发明申请

WO2006130347A2 CREATION OF FUNCTIONALIZED MICROPARTICLE LIBRARIES BY OLIGONUCLEOTIDE LIGATION OR ELONGATION 审中-公开
标题翻译：通过寡核苷酸结合或延伸产生功能化的微生物图谱
公开(公告)号：WO2006130347A2
公开(公告)日：2006-12-07
申请号：PCT/US2006/019203
申请日：2006-05-17
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , YANG, Jiacheng , BANERJEE, Sukanta
发明人： SEUL, Michael , YANG, Jiacheng , BANERJEE, Sukanta
CPC分类号： B01J19/0046 , B01J2219/005 , B01J2219/00545 , B01J2219/00576 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C12N15/1093 , C40B20/04 , C40B50/14
摘要： Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5 '-end, (or possibly at the 3' end) to an encoded carrier such as a color-coded microparticle ("bead"). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.
摘要翻译：公开了通过将具有分析物特异性序列的捕获探针连接到所连接的锚定探针上来构建寡核苷酸探针（或序列修饰的捕获部分，例如蛋白质 - 核酸缀合物）的珠显示文库的方法在5'端，（或可能在3'端）与经编码的载体（如着色微粒（“珠”））相连。也可以使用第二探针作为延伸模板，通过锚定探针的伸长来构建这种文库，其中第二探针具有锚特异性亚序列和分析物特异性亚序列。

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