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61. 发明申请

WO2014087408A1 THERAPEUTIC APOPTOTIC CELL PREPARATIONS, METHOD FOR PRODUCING SAME AND USES THEREOF 审中-公开
标题翻译：治疗药物细胞制剂，其生产方法及其用途
公开(公告)号：WO2014087408A1
公开(公告)日：2014-06-12
申请号：PCT/IL2013/051001
申请日：2013-12-05
申请人： ENLIVEX THERAPEUTICS LTD
发明人： MEVORACH, Dror , REINER, Inna
IPC分类号： C12N5/078 , A61K35/14 , A61K35/26 , A61P37/06
CPC分类号： C12N5/0634 , A61K31/194 , A61K31/573 , A61K31/7004 , A61K31/727 , A61K35/17 , A61K45/06 , A61K2300/00
摘要： The present application provides pharmaceutical compositions comprising a population of mononuclear-enriched cells in an early-apoptotic state, methods for the production of said compositions and uses thereof in the treatment of diseases characterized by pathological immune responses. The pharmaceutical compositions may be used in treatment of conditions such as, but not limited to, graft versus host disease (GVHD) and autoimmune diseases including but not limited to inflammatory bowel disease, gout and arthritis.
摘要翻译：本申请提供包含早期凋亡状态的富含单核的细胞群的药物组合物，所述组合物的生产方法及其用于治疗以病理免疫应答为特征的疾病的用途。药物组合物可用于治疗诸如但不限于移植物抗宿主病（GVHD）和自身免疫性疾病，包括但不限于炎症性肠病，痛风和关节炎的病症。

62. 发明申请

WO2013163377A1 HUMAN CD30 LIGAND ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：人类CD30配体抗原结合蛋白
公开(公告)号：WO2013163377A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038135
申请日：2013-04-25
申请人： NOVO NORDISK A/S , AMGEN INC.
发明人： ANDERSEN, Mette, Dahl , DANTZLER, Jeff , ARMITAGE, Richard, J. , CLARK, Rutilio
IPC分类号： C07K16/28
CPC分类号： C07K16/2875 , A61K2039/505 , C07K14/70575 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/21 , C07K2319/43 , C07K2319/50
摘要： Provided are compositions and methods relating to human CD30L antigen binding proteins. Compositions described herein include: human CD30L antigen binding proteins, polynucleotides encoding human CD30L antigen binding proteins, vectors comprising these polynucleotides, host cells, and pharmaceutical compositions. Methods of making and using each of these compositions are also provided.
摘要翻译：提供与人CD30L抗原结合蛋白有关的组合物和方法。本文描述的组合物包括：人CD30L抗原结合蛋白，编码人CD30L抗原结合蛋白的多核苷酸，包含这些多核苷酸的载体，宿主细胞和药物组合物。还提供了制备和使用这些组合物的方法。

63. 发明申请

WO2013112865A1 DIAGNOSIS AND TREATMENT FOR RESPIRATORY TRACT DISEASES 审中-公开
标题翻译：诊断和治疗呼吸道疾病
公开(公告)号：WO2013112865A1
公开(公告)日：2013-08-01
申请号：PCT/US2013/023185
申请日：2013-01-25
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , MONELL CHEMICAL SENSES CENTER
发明人： COHEN, Noam, A. , LEE, Robert, J. , REED, Danielle, R.
IPC分类号： G01N33/566
CPC分类号： A61K36/185 , A61K31/167 , A61K31/365 , A61K31/4709 , A61K31/513 , A61K45/06 , C12Q1/6883 , C12Q2600/156 , G01N33/502 , G01N33/566 , G01N33/6893 , G01N2333/705 , G01N2500/04 , G01N2800/14
摘要： The invention provides methods and compositions for the diagnosis, prognosis and treatment of respiratory tract diseases. Specifically, the invention provides diagnosis, prognosis and treatment of respiratory infections using bitter and sweet taste signal transduction pathways. In one aspect, the invention relates to a method for treating a respiratory infection by administering a composition to the respiratory tract of a subject in an amount capable of activating bitter taste signaling and/or inhibiting sweet taste signaling. The composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract. In another aspect, the invention relates to a composition for treatment of a respiratory infection. Such composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract.
摘要翻译：本发明提供了用于诊断，预后和治疗呼吸道疾病的方法和组合物。具体地说，本发明提供使用苦味和甜味信号转导途径的呼吸道感染的诊断，预后和治疗。一方面，本发明涉及一种通过向受试者的呼吸道施用能够激活苦味信号传导和/或抑制甜味信号传导的量的组合物来治疗呼吸道感染的方法。组合物包含至少一种苦味受体激动剂和任选的用于将组合物递送至呼吸道的药学上可接受的载体。另一方面，本发明涉及用于治疗呼吸道感染的组合物。这种组合物至少包含苦味受体激动剂和任选的用于将组合物递送至呼吸道的药学上可接受的载体。

64. 发明申请

WO2013043304A1 ESTROGEN RECEPTOR LIGANDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：雌激素受体配体及其使用方法
公开(公告)号：WO2013043304A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/052141
申请日：2012-08-23
申请人： GTX, INC. , DALTON, James , STEINER, Mitchell, S. , COSS, Christopher, C.
发明人： DALTON, James , STEINER, Mitchell, S. , COSS, Christopher, C.
IPC分类号： A01N37/18 , A61K31/165
CPC分类号： A61K31/137 , A61K31/167
摘要： The present invention relates to methods for reducing testosterone levels by reduction of luteinizing hormone (LH) or independent of LH levels in a male subject and methods of treating, suppressing, reducing the incidence, reducing the severity, or inhibiting prostate cancer, advanced prostate (5) cancer, castration resistant prostate cancer (CRPC), metastatic castration resistant prostate cancer (mCRPC) and palliative treatment of prostate cancer, advanced prostate cancer, castration resistant prostate cancer (CRPC) and metastatic castration resistant prostate cancer (mCRPC), and methods of reducing high or increasing PSA levels and/or increasing SHBG levels in a subject suffering from prostate cancer, advanced prostate cancer, castration resistant prostate cancer (CRPC) and metastatic (10) castration resistant prostate cancer (mCRPC). The compounds of this invention suppress free or total testosterone levels despite castrate levels secondary to ADT and reduce high or increasing PSA levels.
摘要翻译：本发明涉及通过降低男性受试者的黄体生成素（LH）或LH水平而降低睾酮水平的方法以及治疗，抑制，降低发病率，降低严重程度或抑制前列腺癌，晚期前列腺（ 5）癌症，阉割抗性前列腺癌（CRPC），转移性阉割抗性前列腺癌（mCRPC）和姑息治疗前列腺癌，晚期前列腺癌，去势抗性前列腺癌（CRPC）和转移性阉割抗性前列腺癌（mCRPC）在前列腺癌，晚期前列腺癌，阉割抗性前列腺癌（CRPC）和转移性（10）抗阉割前列腺癌（mCRPC）的受试者中降低PSA水平升高和/或增加SHBG水平。本发明的化合物尽管阉割水平继发于ADT并降低高水平或增加PSA水平，但抑制游离或总睾丸激素水平。

65. 发明申请

WO2012154962A3 RADIATION PROTECTION DEVICE AND METHODS THEREOF 审中-公开
公开(公告)号：WO2012154962A3
公开(公告)日：2012-11-15
申请号：PCT/US2012/037335
申请日：2012-05-10
申请人： STEMRAD LTD. , MILSTEIN, Oren
发明人： MILSTEIN, Oren
IPC分类号： A42B3/00 , A41D13/00 , A41F9/00
摘要： A radiation protection device for providing protection of a body part that includes active bone marrow from ionizing radiation may include a radiation protection component configured to be placed adjacent to and externally cover the body part so as to reduce a radiation dose absorbed in that body part.

66. 发明申请

WO2012068229A1 COMPOSITIONS AND METHODS FOR TREATING ALPHAVIRUS INFECTION 审中-公开
标题翻译：用于治疗ALVHAVIRUS感染的组合物和方法
公开(公告)号：WO2012068229A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/060952
申请日：2011-11-16
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , CHERRY, Sara , ROSE, Patrick
发明人： CHERRY, Sara , ROSE, Patrick
IPC分类号： A61K39/193
CPC分类号： A61K31/713 , A61K33/26 , C07K14/705 , C12Q1/6876 , G01N33/502
摘要： Provided herein are compositions and methods for treating a disease or disorder associated with an alphavirus infection. Specifically, the invention relates to administering a Natural Resistance-Associated Macrophage Protein (NRAMP) antagonist to prevent binding or infection of an alphavirus to its host.
摘要翻译：本文提供了用于治疗与甲病毒感染相关的疾病或病症的组合物和方法。具体地，本发明涉及施用天然抗性相关巨噬细胞蛋白（NRAMP）拮抗剂以防止甲病毒与其宿主的结合或感染。

67. 发明申请

WO2011109059A1 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的化合物
公开(公告)号：WO2011109059A1
公开(公告)日：2011-09-09
申请号：PCT/US2010/062418
申请日：2010-12-29
申请人： GTX, INC. , UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , AHN, Sunjoo , CHEN, Jianjun , DUKE, Charles , LI, Chien-ming , LI, Wei , LU, Yan , WANG, Zhao
发明人： DALTON, James, T. , MILLER, Duane, D. , AHN, Sunjoo , CHEN, Jianjun , DUKE, Charles , LI, Chien-ming , LI, Wei , LU, Yan , WANG, Zhao
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D233/64 , A61K31/4164 , A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译：本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如，黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。

68. 发明申请

WO2011100754A1 LIVE LISTERIA-BASED VACCINES FOR CENTRAL NERVOUS SYSTEM THERAPY 审中-公开
标题翻译：用于中央神经系统治疗的基于LISTERIA的疫苗
公开(公告)号：WO2011100754A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024918
申请日：2011-02-15
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ADVAXIS , SHAHABI, Vafa , SEAVEY, Matthew , PATERSON, Yvonne
发明人： SHAHABI, Vafa , SEAVEY, Matthew , PATERSON, Yvonne
IPC分类号： A61K39/00 , A01N63/02 , A61K38/16
CPC分类号： A61K39/0011 , A61K2039/523 , A61K2039/55527 , A61K2039/6068 , C07K2319/00
摘要： This invention is directed to methods for treating a central nervous system (CNS) tumor or cancer using live Listeria -based recombinant vaccines.
摘要翻译：本发明涉及使用活的利斯特氏菌基重组疫苗来治疗中枢神经系统（CNS）肿瘤或癌症的方法。

69. 发明申请

WO2011097615A1 SHOULDER TORQUE AND RANGE OF MOTION DEVICE 审中-公开
标题翻译：肩袖扭矩和运动装置范围
公开(公告)号：WO2011097615A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/024022
申请日：2011-02-08
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SARVER, Joseph, J. , SOSLOWSKY, Louis, J.
发明人： SARVER, Joseph, J. , SOSLOWSKY, Louis, J.
IPC分类号： A61B5/11
CPC分类号： A61B5/1121 , A61B5/1124 , A61B5/4528 , A61B5/6824
摘要： The invention relates to a device for measuring shoulder stiffness and range of motion. Specifically, the invention relates to a device for measuring shoulder stiffness and range of motion in human subjects, and methods for making and using thereof.
摘要翻译：本发明涉及一种用于测量肩部刚度和运动范围的装置。具体地，本发明涉及一种用于测量人体受试者的肩部刚度和运动范围的装置及其制造和使用方法。

70. 发明申请

WO2011085385A1 METHODS OF TREATING MEIBOMIAN GLAND DYSFUNCTION 审中-公开
标题翻译：治疗脑血管功能障碍的方法
公开(公告)号：WO2011085385A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020871
申请日：2011-01-11
申请人： GTX, INC. , DALTON, James, T. , ESWARAKA, Jeetendra
发明人： DALTON, James, T. , ESWARAKA, Jeetendra
IPC分类号： A01N43/40
CPC分类号： A61K31/277
摘要： The present invention includes methods for treating Meibomian gland dysfunctions. The invention also includes methods for improving tear lipid composition, for treating abnormal Meibomian gland secretion and for normalizing Meibomian gland secretions.
摘要翻译：本发明包括治疗睑板腺功能障碍的方法。本发明还包括改善泪液脂质组成，治疗异常睑板腺分泌物和使睑板腺分泌物正常化的方法。

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