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61. 发明专利

JPH02240020A ANTI-TUMOR RELAPSE AGENT AFTER SURGICAL INCISION 失效
公开(公告)号：JPH02240020A
公开(公告)日：1990-09-25
申请号：JP1379290
申请日：1990-01-25
申请人： CHILDRENS MEDICAL CENTER
发明人： JIYAIRUZU EFU FUEEREN , DONARUDO II INGUBAA
IPC分类号： A61K31/00 , A61K31/395 , A61K31/715 , A61K31/77 , A61K31/78 , A61K38/00 , A61K38/04 , A61K38/39 , A61K38/46 , A61K38/48 , A61K45/00 , A61P35/00 , A61P43/00
摘要： PURPOSE: To provide an agent for inhibiting the relapse of tumor after surgical excision operation composed of a composition containing a compound inhibiting the adhesion of tumor cell in a region of the tissue to be excised (e.g. protease). CONSTITUTION: Relapse of tumor in a local tissue of a mammal is prevented by applying a composition containing a compound capable of inhibiting the adhesion of tumor cell in the region of the tissue. The compound is e.g. (A) an agent for regulating extracellular substrate metabolism such as heparin or hydrocortisone-21-phosphate disodium salt, (B) a protease such as trypsin, dispase or pancreatin, (C) a polymer having high molecular weight such as dextran or polycarboxylic acid having a molecular weight of >=10,000 or (D) a synthetic peptide or saccharide containing a cell condensation sequence of a specific extracellular substrate molecule such as a synthetic fibronectin peptide containing Arg-Gly-Asp sequence.

62. 发明专利

JPH0256437A ARYLSULFATASE INHIBITOR AND ACTION ENHANCER OF ANGIOGENESIS INHIBITING STEROIDS 失效
公开(公告)号：JPH0256437A
公开(公告)日：1990-02-26
申请号：JP13168789
申请日：1989-05-26
申请人： CHILDRENS MEDICAL CENTER , UNIV HARVARD
发明人： MOOZESU JIYUUDA FUOOKUMAN , NAIRU TEII CHIEN , ERIASU JIEE KOOREI
IPC分类号： A61K31/185 , A61K31/215 , A61K31/22 , A61K31/255 , A61K45/06 , A61P7/02 , A61P9/00
摘要： PURPOSE: To effectively treat/prevent diseases advancing due to angiogenesis by administering a mammal with an arylsulfatase inhibitor to restrain angiogenesis. CONSTITUTION: A mammal is administered with an effective amount of an arylsulfatase inhibitor, pref. a carboxylate or sulfate or benzyl alcohol compound, esp. a compound of the formula [R1 is a 1-2C alkylene; X is SO3 , OSO3 or O-COR (R7 is an alkyl); R2 to R6 are each H, an alkyl, NO2 or OH], e.g. sodium 2-hydroxy-5-nitro-α-toluenesulfonate. Combinational use of the inhibitor with an angiogenesis-restraining steroid (e.g. cortisone, epicortisol, 17α- hydroxyprogesterone) potentiates the steroid; and combinational use of the inhibitor with heparin potentiates the anticoagulant effect of the heparin.

63. 发明申请

US20110071088A1 METHOD FOR TREATING NEUROLOGICAL DISORDERS 有权
标题翻译：治疗神经疾病的方法
公开(公告)号：US20110071088A1
公开(公告)日：2011-03-24
申请号：US12790515
申请日：2010-05-28
申请人： Larry I. Benowitz
发明人： Larry I. Benowitz
IPC分类号： A61K38/16 , A61P25/28 , A61P25/02 , C12N5/0793
CPC分类号： A61K38/1709 , A61K31/7076 , A61K48/00 , A61K48/005 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , A61K2300/00
摘要： The present invention is based on the discovery that suppressing the activity of the Nogo receptor (NgR) alone does not result in extensive axon regeneration unless the intrinsic growth program of neurons is also activated. Accordingly, the present invention is directed to methods of stimulating axon regeneration using a combination therapy wherein agents that inhibit NgR activity or downstream pathways activated by inhibitory signals are combined with agents that activate the growth pathway of neurons (e.g. polypeptide growth factors, activators of macrophages, purine nucleosides, or hexoses).
摘要翻译：本发明基于以下发现：除非神经元的内在生长程序也被激活，否则单独抑制Nogo受体（NgR）的活性不会导致广泛的轴突再生。因此，本发明涉及使用组合疗法刺激轴突再生的方法，其中抑制NgR活性的药物或通过抑制性信号激活的下游途径的药剂与激活神经元生长途径的试剂（例如多肽生长因子，巨噬细胞的激活剂，嘌呤核苷或己糖）。

64. 发明申请

US20080102456A1 Compositions and Methods for Obesity Screening Using Polymorphisms in Npy2r 失效
标题翻译：在Npy2r中使用多态性进行肥胖筛查的组合物和方法
公开(公告)号：US20080102456A1
公开(公告)日：2008-05-01
申请号：US11663052
申请日：2005-09-19
申请人： Joel Hirschhorn , Catarina deHaseth Campbell , Kristin Ardlie
发明人： Joel Hirschhorn , Catarina deHaseth Campbell , Kristin Ardlie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： Methods and constructs are provided that are predictive of a subject's susceptibility to developing a metabolic disorder, such as obesity. The disclosed naturally-occurring SNPs located upstream of the NPY2R gene can be used as targets for the design of diagnostic reagents and the development of therapeutic agents, as well as for disease association and linkage analysis. In particular, the SNPs of the present invention are useful for identifying an individual who is at an increased or decreased risk of developing metabolic disorders, such as obesity and diabetes, and for early detection of the disease, for providing clinically important information for the prevention and/or treatment of metabolic disorder, and for screening and selecting therapeutic agents. The SNPs disclosed herein are also useful for human identification applications. Methods, assays, kits, and reagents for detecting the presence of these polymorphisms and their encoded products are provided.
摘要翻译：提供了预测受试者对发展代谢性疾病如肥胖症的易感性的方法和构建体。位于NPY2R基因上游的公开的天然存在的SNP可以用作诊断试剂的设计和治疗剂的开发的目标，以及疾病关联和连锁分析。特别地，本发明的SNP可用于鉴定发生代谢紊乱（例如肥胖症和糖尿病）的风险增加或降低的个体以及用于早期发现疾病的个体，以提供用于预防的临床重要信息和/或代谢紊乱的治疗，以及筛选和选择治疗剂。本文公开的SNP也可用于人类鉴定应用。提供了用于检测这些多态性及其编码产物的存在的方法，测定，试剂盒和试剂。

65. 发明申请

US20110230568A1 HEATING OF POLYMERS AND OTHER MATERIALS USING RADIATION FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：加热聚合物和其他材料，使用辐射进行药物递送和其他应用
公开(公告)号：US20110230568A1
公开(公告)日：2011-09-22
申请号：US13055177
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Jesus Santamaria Ramiro
发明人： Todd R. Hoare , Daniel S. Kohane , Jesus Santamaria Ramiro
IPC分类号： A61K47/30 , A61P35/00 , A61P25/00 , A61P3/10 , A61P9/00 , A61P37/06 , A61P29/00
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using infrared or near-infrared radiation. Such systems and methods may be useful, for example in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation-sensitive material to radiation such as infrared or near-infrared radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna may be used to focus infrared or near- infrared radiation on an article. For instance, the receive antenna may focus infrared or near-infrared radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器例如使用红外或近红外辐射从制品中释放可释放物质的系统和方法。这样的系统和方法可能是有用的，例如在生物应用中（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于诸如红外或近红外辐射的辐射可能导致材料的温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，接收天线可用于将红外或近红外辐射聚焦在物品上。例如，接收天线可以将红外或近红外辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

66. 发明授权

US09629821B2 Treatment and prevention of liver disease associated with parenteral nutrition (PN) 有权
公开(公告)号：US09629821B2
公开(公告)日：2017-04-25
申请号：US12165785
申请日：2008-07-01
申请人： Mark Puder , Kathleen M. Gura
发明人： Mark Puder , Kathleen M. Gura
IPC分类号： A61K31/20 , A61K31/23 , A61K9/00 , A61K9/107 , A61K31/202 , A23L33/00 , A23L33/12
CPC分类号： A61K31/202 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K9/0029 , A61K9/107 , A61K31/23 , A61K35/60 , A61K47/24
摘要： The present invention is based on the discovery that parenteral nutrition (PN) induced liver disease, e.g. fatty liver disease, can be prevented and even reversed by administration of primarily omega-3-fatty acid with PN rather than the administration of the standard intravenous lipid emulsions that contain primarily plant derived omega-6 fatty acid. Thus, the present invention provides a method for treating or preventing liver disease in a human patient obtaining nutritional support through PN. The method comprises intravenous administration of an effective amount of an omega-3-fatty acid emulsion to the patient, wherein the patient is not administered phytosterols or plant derived fatty acids, e.g. omega-6 fatty acids derived from a plant source, and wherein the administration of the omega-3-fatty acid emulsion to the patient is for a period greater than three weeks. Preferably, the administration is for a period of greater than six weeks. More preferably, the administration is for a period greater than three months.

67. 发明申请

US20090143765A1 Device for Mixing and Delivering Fluids for Tissue Repair 有权
标题翻译：用于组织修复的混合和输送流体的装置
公开(公告)号：US20090143765A1
公开(公告)日：2009-06-04
申请号：US11883985
申请日：2006-02-09
申请人： Alexander Slocum , Matthew R. Carvey , Alexey Salamini , Daniel G. Walker , Ying-Chih Wang , Martha M. Murray
发明人： Alexander Slocum , Matthew R. Carvey , Alexey Salamini , Daniel G. Walker , Ying-Chih Wang , Martha M. Murray
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61B17/00491 , A61B2017/00495 , A61B2017/3445 , B01F7/0005 , B01F7/00408 , B01F13/002 , B01F13/0023 , B01F15/0279 , B33Y80/00
摘要： A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site.
摘要翻译：用于将流体混合并输送到目标地点的装置包括用于容纳混合物的管。用于混合流体的可压缩螺旋钻可移动地设置在管内，螺旋钻的一端在管的远端处是自由的。柱塞也可以在管内与螺旋钻的另一端连通。当柱塞在管内轴向移动时，螺旋钻也轴向移动，并且螺旋钻被压缩以分配流体。混合和递送装置可用于关节镜将组织修复材料递送至修复部位的装置。该装置包括可移除地附接到第一护套的第一护套和第二护套，用于将组织修复材料输送到修复部位。

68. 发明申请

US20090042229A1 PLATELET BIOMARKERS FOR CANCER 失效
标题翻译：癌症生物标志物
公开(公告)号：US20090042229A1
公开(公告)日：2009-02-12
申请号：US11658377
申请日：2005-04-22
申请人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
发明人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
IPC分类号： C12Q1/37 , G01N33/00 , G01N31/22 , G01N33/566
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染以及与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

69. 发明授权

US5106610A Method for determining the diuretic potency of candidate drugs as inhibitors of the antidiuretic hormone-elicited water channel 失效
标题翻译：用于确定作为抗细胞激素水通道的抑制剂的候选药物的溶解度的方法
公开(公告)号：US5106610A
公开(公告)日：1992-04-21
申请号：US458591
申请日：1989-12-29
申请人： H. William Harris , Mark L. Zeidel
发明人： H. William Harris , Mark L. Zeidel
IPC分类号： A61K45/00 , A61P7/10 , G01N33/15 , G01N33/50 , G01N33/543 , G01N33/74
CPC分类号： G01N33/5436 , G01N33/5008 , G01N33/743 , Y10S514/836 , Y10S514/869
摘要： A method for determining the diuretic potency of candidate drugs as inhibitors of ADH-elicited water channels is disclosed. In a preferred embodiment, such diuretic potency of candidate drugs is determined by suspending vesicles containing ADH water channels in an aqueous suspending medium, incorporating the candidate into the suspension, rapidly changing the pH of the suspending medium and thereafter detecting the proton permeability of the water channels. The proton permeability in the presence of the candidate drug can then be compared to the proton permeability of water channels under similar conditions without the presence of the candidate drug to determine the diuretic potency of the candidate drug to inhibit ADH-elicited water channels.
摘要翻译：公开了一种确定候选药物作为ADH引发的水通道抑制剂的利尿效能的方法。在优选的实施方案中，通过将含有ADH水通道的囊泡悬浮在含水悬浮介质中，将候选物掺入悬浮液中，迅速改变悬浮培养基的pH值，然后检测水的质子渗透性来确定候选药物的利尿效力频道然后可以在候选药物存在下的质子渗透性与类似条件下水通道的质子渗透性相比较，而不存在候选药物以确定候选药物抑制ADH引发的水通道的利尿效力。

70. 发明授权

US5811393A Heparin binding mitogen with homology to epidermal growth factor (EGF) 失效
标题翻译：肝素结合丝裂原与表皮生长因子（EGF）具有同源性
公开(公告)号：US5811393A
公开(公告)日：1998-09-22
申请号：US39364
申请日：1993-06-15
申请人： Michael Klagsbrun , Judith A. Abraham , Shigeki Higashiyama , Gail E. Besner
发明人： Michael Klagsbrun , Judith A. Abraham , Shigeki Higashiyama , Gail E. Besner
IPC分类号： A61K38/22 , A61K38/00 , A61P43/00 , C07K14/475 , C07K16/22 , C12N15/09 , C12N15/18 , C12P21/02 , A61K38/18
CPC分类号： C07K16/22 , C07K14/475 , A61K38/00
摘要： Disclosed are heparin binding mitogens which include an epidermal growth factor-homologous segment (HB-EHM). These factors stimulate proliferation of fibroblast cells, epithelial cells, and smooth muscle cells, but not endothelial cells. Also disclosed are isolated antibodies that recognize, and purified nucleic acids that encode, the above growth factors as well as isolated polypeptides, vectors containing such nucleic acids, and cells harboring such vectors. Growth factors of this invention may be used for accelerating the rate of wound healing, for the in vitro culture of HB-EHM-responsive cells, and for the identification of antagonists to HB-EHM.
摘要翻译： PCT No.PCT / US91 / 07691 Sec。 371日期：1993年6月15日 102（e）1993年6月15日PCT 1991年10月16日PCT被公开是包括表皮生长因子同源片段（HB-EHM）的肝素结合有丝分裂原。这些因素刺激成纤维细胞，上皮细胞和平滑肌细胞，而不是内皮细胞的增殖。还公开了分离的抗体，其识别和纯化上述生长因子以及分离的多肽，含有此类核酸的载体的纯化核酸和含有这些载体的细胞。本发明的生长因子可用于加速伤口愈合的速率，用于HB-EHM反应性细胞的体外培养，以及用于鉴定HB-EHM的拮抗剂。

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