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1. 发明申请

US20080102456A1 Compositions and Methods for Obesity Screening Using Polymorphisms in Npy2r 失效
标题翻译：在Npy2r中使用多态性进行肥胖筛查的组合物和方法
公开(公告)号：US20080102456A1
公开(公告)日：2008-05-01
申请号：US11663052
申请日：2005-09-19
申请人： Joel Hirschhorn , Catarina deHaseth Campbell , Kristin Ardlie
发明人： Joel Hirschhorn , Catarina deHaseth Campbell , Kristin Ardlie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： Methods and constructs are provided that are predictive of a subject's susceptibility to developing a metabolic disorder, such as obesity. The disclosed naturally-occurring SNPs located upstream of the NPY2R gene can be used as targets for the design of diagnostic reagents and the development of therapeutic agents, as well as for disease association and linkage analysis. In particular, the SNPs of the present invention are useful for identifying an individual who is at an increased or decreased risk of developing metabolic disorders, such as obesity and diabetes, and for early detection of the disease, for providing clinically important information for the prevention and/or treatment of metabolic disorder, and for screening and selecting therapeutic agents. The SNPs disclosed herein are also useful for human identification applications. Methods, assays, kits, and reagents for detecting the presence of these polymorphisms and their encoded products are provided.
摘要翻译：提供了预测受试者对发展代谢性疾病如肥胖症的易感性的方法和构建体。位于NPY2R基因上游的公开的天然存在的SNP可以用作诊断试剂的设计和治疗剂的开发的目标，以及疾病关联和连锁分析。特别地，本发明的SNP可用于鉴定发生代谢紊乱（例如肥胖症和糖尿病）的风险增加或降低的个体以及用于早期发现疾病的个体，以提供用于预防的临床重要信息和/或代谢紊乱的治疗，以及筛选和选择治疗剂。本文公开的SNP也可用于人类鉴定应用。提供了用于检测这些多态性及其编码产物的存在的方法，测定，试剂盒和试剂。

2. 发明授权

US07829281B2 Compositions and methods for obesity screening using polymorphisms in NPY2R 失效
标题翻译： NPY2R多态性肥胖筛查的组成和方法
公开(公告)号：US07829281B2
公开(公告)日：2010-11-09
申请号：US11663052
申请日：2005-09-19
申请人： Joel Hirschhorn , Catarina deHaseth Campbell , Kristin Ardlie
发明人： Joel Hirschhorn , Catarina deHaseth Campbell , Kristin Ardlie
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： Methods and constructs are provided that are predictive of a subject's susceptibility to developing a metabolic disorder, such as obesity. The disclosed naturally-occurring SNPs located upstream of the NPY2R gene can be used as targets for the design of diagnostic reagents and the development of therapeutic agents, as well as for disease association and linkage analysis. In particular, the SNPs of the present invention are useful for identifying an individual who is at an increased or decreased risk of developing metabolic disorders, such as obesity and diabetes, and for early detection of the disease, for providing clinically important information for the prevention and/or treatment of metabolic disorder, and for screening and selecting therapeutic agents. The SNPs disclosed herein are also useful for human identification applications. Methods, assays, kits, and reagents for detecting the presence of these polymorphisms and their encoded products are provided.
摘要翻译：提供了预测受试者对发展代谢性疾病如肥胖症的易感性的方法和构建体。位于NPY2R基因上游的公开的天然存在的SNP可以用作诊断试剂的设计和治疗剂的开发的目标，以及疾病关联和连锁分析。特别地，本发明的SNP可用于鉴定发生代谢紊乱（例如肥胖症和糖尿病）的风险增加或降低的个体以及用于早期发现疾病的个体，以提供用于预防的临床重要信息和/或代谢紊乱的治疗，以及筛选和选择治疗剂。本文公开的SNP也可用于人类鉴定应用。提供了用于检测这些多态性及其编码产物的存在的方法，测定，试剂盒和试剂。

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