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51. 发明申请

US20100129788A1 METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) 失效
标题翻译：用于评估个体对I型干扰素（IFN）的治疗反应的方法
公开(公告)号：US20100129788A1
公开(公告)日：2010-05-27
申请号：US12522623
申请日：2008-01-24
申请人： Patrick Stordeur , Mathieu Vokaer , Annick Ocmant , Michel Goldman
发明人： Patrick Stordeur , Mathieu Vokaer , Annick Ocmant , Michel Goldman
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably M×A, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
摘要翻译：描述了用于评估在I型干扰素治疗的个体中预防I型（IFN）的生物学作用的因子的体内存在的方法。在用I型干扰素治疗的个体中评估针对I型干扰素（IFN）的抗体的体内存在。该方法包括将体外血液样品与适量的I型干扰素孵育合适的时间，并测定血液样品中IFN活性，优选M×A的生物学标志物的mRNA水平。该治疗可涉及使用I型干扰素治疗多发性硬化症，HCV或HBV。

52. 发明申请

US20100120891A1 USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权
标题翻译：使用GALECTIN-1靶向基于RNAi的方法治疗癌症
公开(公告)号：US20100120891A1
公开(公告)日：2010-05-13
申请号：US11911342
申请日：2006-03-09
申请人： Isabelle Camby , Patrick Henriet , Florence Lefranc , Pierre Courtoy , Robert Kiss
发明人： Isabelle Camby , Patrick Henriet , Florence Lefranc , Pierre Courtoy , Robert Kiss
IPC分类号： A61K31/7105 , C12N5/071 , C12N15/74 , A61K31/711 , A61P35/00 , A61P35/04
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译：本发明涉及适于降低含有SEQ ID NO：1-33的任何序列，优选SEQ ID NO：2,3或4的序列的半乳凝素-1的表达的RNAi分子，并且涉及或用于制备用于治疗和/或延迟癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤。本发明还涉及用于治疗和延迟癌症，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法，用于减少肿瘤细胞，优选胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症的功效，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，选自化疗，放射治疗，免疫治疗和/或基因治疗。

53. 发明授权

US07565037B2 Reducing depolarisation 失效
标题翻译：减少去极化
公开(公告)号：US07565037B2
公开(公告)日：2009-07-21
申请号：US11660059
申请日：2005-08-12
申请人： Sandu Popescu , Serge Alexandre Massar
发明人： Sandu Popescu , Serge Alexandre Massar
IPC分类号： G02F1/01
CPC分类号： G02B6/278 , G02B6/105
摘要： The present invention provides a method for reducing spreading of a pulse in a transmission line, said spreading being as a result of polarization mode dispersion, comprising inducing predetermined polarization rotations of particle or wave components of the pulse in the transmission line.
摘要翻译：本发明提供一种减少传输线中的脉冲扩展的方法，所述扩展是偏振模色散的结果，包括在传输线中引起脉冲的粒子或波分量的预定偏振旋转。

54. 发明授权

US07463366B2 Digital holographic microscope 有权
标题翻译：数字全息显微镜
公开(公告)号：US07463366B2
公开(公告)日：2008-12-09
申请号：US11284768
申请日：2005-11-22
申请人： Franck Dubois , Catherine Yourassowsky
发明人： Franck Dubois , Catherine Yourassowsky
IPC分类号： G01B9/02
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/365 , G03H1/0005 , G03H1/041 , G03H1/0443 , G03H1/0465 , G03H1/0866 , G03H2001/005 , G03H2001/0452 , G03H2001/0456 , G03H2001/0458 , G03H2222/24 , G03H2223/14 , G03H2223/26
摘要： A method and device for obtaining a sample with three-dimensional microscopy, in particular a thick biological sample and the fluorescence field emitted by the sample. One embodiment includes obtaining interferometric signals of a specimen, obtaining fluorescence signals emanating from the specimen, recording these signals, and processing these signals so as to reconstruct three-dimensional images of the specimen and of the field of fluorescence emitted by the specimen at a given time. Another embodiment includes a digital holography microscope, a fluorescence excitation source illuminating a specimen, where the microscope and the fluorescence excitation source cooperate to obtain interferometric signals of the specimen and obtain fluorescence signals emanating from the specimen, means for recording the interferometric signals and fluorescence signals, and means for processing the interferometric signals and the fluorescence signals so as to reconstruct three-dimensional images of the specimen and of the field of fluorescence emitted by the specimen at a given time.
摘要翻译：一种利用三维显微镜获得样品的方法和装置，特别是厚的生物样品和由样品发射的荧光场。一个实施例包括获得样本的干涉信号，获得从样本发出的荧光信号，记录这些信号，以及处理这些信号，以便重建样本的三维图像和由给定的样本发射的荧光场时间。另一个实施例包括数字全息显微镜，照射样本的荧光激发源，其中显微镜和荧光激发源协作以获得样本的干涉信号并获得从样本发出的荧光信号，用于记录干涉信号和荧光信号的装置以及用于处理干涉信号和荧光信号的装置，以便重建样本的三维图像和在给定时间由样本发射的荧光场。

55. 发明授权

US07206079B2 Apparatus and process for characterizing samples 有权
标题翻译：用于表征样品的装置和方法
公开(公告)号：US07206079B2
公开(公告)日：2007-04-17
申请号：US10861673
申请日：2004-06-04
申请人： Luc Joannes
发明人： Luc Joannes
IPC分类号： G01N21/45
CPC分类号： G02B27/54 , G01N21/455
摘要： An apparatus and method for measuring by the Schlieren technique light beam deviations generated by a sample (EV) includes a source (S) of light beam for illuminating the sample (EV) therewith so as to have a transmitted beam. An imaging means is provided (L2, L3) for forming an image of the sample from the transmitted beam. A filtering means acts as a Schlieren filter (SF) for obtaining “Schlieren fringes” from the image. The Schlieren filter (SF) comprises a periodic structure (SFP) of a defined period. A detecting means (CCD) is provided for detecting the Schlieren fringes under operating conditions. The apparatus can also include means to shift the filtering means with a shift φ by a fraction of the period of the periodic structure thereby shifting the Schlieren fringes, means to acquire a set of at least three successive phase-shifted images; means for reconstructing a mean image of the sample from said collected phase-shifted images using a phase-shifting algorithm used in interferometry, and processing means to calculate by said phase-shifting analysis the optical characteristics, angle and phase of the transmitted beam from said reconstructed image so as to determine the beam deviation angle generated by the sample.
摘要翻译：用于通过施利伦技术测量的装置和方法由样品（EV）产生的光束偏差包括用于照射样品（EV）的光束源（S）以具有透射束。提供了一种成像装置（L 2，L 3），用于从透射光束形成样品的图像。过滤装置用作Schlieren过滤器（SF），用于从图像中获得“Schlieren条纹”。 Schlieren滤波器（SF）包括定义周期的周期性结构（SFP）。提供检测装置（CCD），用于在操作条件下检测施莱伦条纹。该装置还可以包括用移位装置移动滤波装置的装置，该移动装置以周期性结构周期的一小部分移动，从而移动施伦瑞条纹，用于获取一组至少三个连续的相移图像的装置; 用于使用在干涉测量中使用的相移算法从所述收集的相移图像重建样本的平均图像的装置，以及通过所述相移分析来计算所述透射光束的光学特性，角度和相位的处理装置重建图像，以便确定样本产生的光束偏移角。

56. 发明授权

US07183097B1 Cytotoxin-based biological containment 有权
标题翻译：基于细胞毒素的生物遏制
公开(公告)号：US07183097B1
公开(公告)日：2007-02-27
申请号：US09700130
申请日：1999-05-07
申请人： Kenn Gerdes , Marie Mikkelsen , Hugo Grønlund , Kim Pedersen , Peter Kristofferson
发明人： Kenn Gerdes , Marie Mikkelsen , Hugo Grønlund , Kim Pedersen , Peter Kristofferson
IPC分类号： C12N1/20
CPC分类号： C12N15/74 , C12N15/635 , C12N15/68
摘要： Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollulant degrading organisms or as biogical pest control organisms e.g. expressing B. thuringiensis crystalline proteins.
摘要翻译：有条件地控制重组细胞群的生存能力和将这些细胞包含在宿主细胞环境或含有复制子中的方法是基于使用包括大肠杆菌relBE基因座在内的蛋白质杀伤系统和在革兰氏阴性菌中发现的类似系统和革兰氏阳性菌和古菌。这种系统通常基于细胞毒素多肽和与细胞毒素相反的抗毒素或解毒剂多肽可被蛋白酶降解。重组细胞可用作疫苗，污染物降解生物体或作为生物传播的有害生物控制生物体。表达苏云金芽孢杆菌结晶蛋白。

57. 发明申请

US20060099219A1 Mutated hpv-16e7 polypeptide, pharmaceutical composition comprising it and its preparation process 审中-公开
标题翻译：突变的hpv-16e7多肽，包含其的药物组合物及其制备方法
公开(公告)号：US20060099219A1
公开(公告)日：2006-05-11
申请号：US10512190
申请日：2003-04-24
申请人： Sophie Hallez , Arsene Burny , Alain Jacquet , Alex Bollen
发明人： Sophie Hallez , Arsene Burny , Alain Jacquet , Alex Bollen
IPC分类号： A61K39/12 , C12Q1/70 , C07H21/04 , C12N15/86 , C07K14/025
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K2319/00 , C12N2710/20022 , C12N2740/16322 , C12N2770/20022
摘要： The present invention is related to a mutated E7 polypeptide obtained from the human Papillomavirus HPV-16 as well as the pharmaceutical composition comprising it and its preparation process.
摘要翻译：本发明涉及从人乳头瘤病毒HPV-16获得的突变的E7多肽以及包含其的药物组合物及其制备方法。

58. 发明授权

US5985272A Human myeloperoxidase and its therapeutic application 失效
标题翻译：人髓过氧化物酶及其治疗应用
公开(公告)号：US5985272A
公开(公告)日：1999-11-16
申请号：US775745
申请日：1996-12-31
申请人： Carol Deby , Joel Pincemail , Alex Bollen
发明人： Carol Deby , Joel Pincemail , Alex Bollen
IPC分类号： A61K38/00 , A61P37/04 , C12N9/08 , C12N15/53 , C12N15/55 , A61K38/44 , A61K9/127
CPC分类号： C12N9/0065 , A61K38/00
摘要： Human myeloperoxidase produced by culturing prokaryotic or eukaryotic cells transformed by a vector for the expression of human myeloperoxidase in said cells.
摘要翻译：通过培养通过载体转化的原核或真核细胞产生的人髓过氧化物酶，用于在所述细胞中表达人髓过氧化物酶。

59. 发明授权

US4157285A Method for preparing manganese chloride and manganese by igneous electrolysis of the manganese chloride obtained 失效
标题翻译：通过火成电解制备氯化锰和锰的方法
公开(公告)号：US4157285A
公开(公告)日：1979-06-05
申请号：US808179
申请日：1977-06-20
申请人： Rene F. P. Winand
发明人： Rene F. P. Winand
IPC分类号： C01G45/06 , C22B47/00 , C25C3/30 , C25C5/04 , C25C3/00
CPC分类号： C01G45/06 , C22B47/00 , C25C3/30 , C25C5/04 , Y02P10/214
摘要： Manganese is recovered from its oxides by reacting a manganese oxide with fused calcium chloride or fused magnesium chloride to provide a liquid phase containing manganese chloride and fused chloride, and a solid phase containing reaction residue, the temperature of the reaction being above the melting point of the calcium or magnesium chloride but below the boiling point of manganese chloride in the reaction mixture. The liquid phase containing the manganese chloride is then subjected to electrolysis to deposit manganese metal upon the cathode and release elemental chlorine at the anode.
摘要翻译：通过使锰氧化物与熔融氯化钙或熔融氯化镁反应从而提供含有氯化锰和氯化聚氯乙烯的液相以及含有固相的反应残余物，从其氧化物中回收锰，反应温度高于氯化钙或氯化镁，但低于反应混合物中氯化锰的沸点。然后对含有氯化锰的液相进行电解，在阴极上沉积锰金属，并在阳极释放元素氯。

60. 发明授权

US4107006A Electrolysis cell 失效
标题翻译：电解池
公开(公告)号：US4107006A
公开(公告)日：1978-08-15
申请号：US703007
申请日：1976-07-06
申请人： Rene Fernand Paul Winand
发明人： Rene Fernand Paul Winand
IPC分类号： C25C3/30 , C25C7/00 , C25C1/10 , C25C7/04
CPC分类号： C25C7/00 , C25C3/30
摘要： There is described an electrolysis cell which comprises an anode formed by said solid material which contacts directly an anode current supply made of a substantially inert material, said cell being divided into at least one anode compartment and at least one cathode compartment by means allowing the flow of the electrolyte from the cathode compartment to the anode compartment but which however prevent the passage of said solid material from one compartment to another one, other means being provided to cause a substantially continuous flow of electrolyte from the cathode compartment to the anode compartment.
摘要翻译：描述了一种电解池，其包括由所述固体材料形成的阳极，其直接接触由基本上惰性的材料制成的阳极电流源，所述电池通过允许流动的装置被分成至少一个阳极室和至少一个阴极室的电解质从阴极室转移到阳极室，但是防止所述固体材料从一个隔室通到另一个室，而提供其它装置以使电解质从阴极室到阳极室基本连续地流动。

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