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1. 发明申请

US20100129788A1 METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) 失效
标题翻译：用于评估个体对I型干扰素（IFN）的治疗反应的方法
公开(公告)号：US20100129788A1
公开(公告)日：2010-05-27
申请号：US12522623
申请日：2008-01-24
申请人： Patrick Stordeur , Mathieu Vokaer , Annick Ocmant , Michel Goldman
发明人： Patrick Stordeur , Mathieu Vokaer , Annick Ocmant , Michel Goldman
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably M×A, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
摘要翻译：描述了用于评估在I型干扰素治疗的个体中预防I型（IFN）的生物学作用的因子的体内存在的方法。在用I型干扰素治疗的个体中评估针对I型干扰素（IFN）的抗体的体内存在。该方法包括将体外血液样品与适量的I型干扰素孵育合适的时间，并测定血液样品中IFN活性，优选M×A的生物学标志物的mRNA水平。该治疗可涉及使用I型干扰素治疗多发性硬化症，HCV或HBV。

2. 发明申请

US20120190031A1 MARKER FOR DIAGNOSIS OF ACTIVE MULTIPLE SCLEROSIS 审中-公开
标题翻译：主动多发性硬化症诊断标记
公开(公告)号：US20120190031A1
公开(公告)日：2012-07-26
申请号：US13203531
申请日：2010-03-25
申请人： Patrick Stordeur , Françoise Villée , Mathieu Vokaer , Annick Ocmant , Michel Goldman
发明人： Patrick Stordeur , Françoise Villée , Mathieu Vokaer , Annick Ocmant , Michel Goldman
IPC分类号： C12Q1/68
CPC分类号： G01N33/6869 , G01N33/6896 , G01N2333/545 , G01N2800/285
摘要： The invention provides an improved method for monitoring the course of the MS disease and to predict, diagnose or prognosticate whether a subject is in an active or non-active period of MS. The method is based on determining the ratio of the expression levels of two cytokines, measured before and after stimulation of the subject by an immunomodulator.
摘要翻译：本发明提供了一种用于监测MS疾病进程并预测，诊断或预测受试者是否处于MS的活动期或非活动期的改进方法。该方法基于通过免疫调节剂测定受试者刺激之前和之后测量的两种细胞因子的表达水平的比例。

3. 发明授权

US08426170B2 Method for evaluating the response of an individual to a treatment with a type I interferon (IFN) 失效
标题翻译：评价个体对I型干扰素（IFN）治疗反应的方法
公开(公告)号：US08426170B2
公开(公告)日：2013-04-23
申请号：US12522623
申请日：2008-01-24
申请人： Patrick Stordeur , Mathieu Vokaer , Annick Ocmant , Michel Goldman
发明人： Patrick Stordeur , Mathieu Vokaer , Annick Ocmant , Michel Goldman
IPC分类号： C12P19/34
CPC分类号： C12Q1/707 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably MxA, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
摘要翻译：描述了用于评估在I型干扰素治疗的个体中预防I型（IFN）的生物学作用的因子的体内存在的方法。在用I型干扰素治疗的个体中评估针对I型干扰素（IFN）的抗体的体内存在。该方法包括将体外血液样品与合适量的I型干扰素孵育合适的时间，并测定血液样品中IFN活性生物学标志物，优选MxA的mRNA水平。该治疗可涉及使用I型干扰素治疗多发性硬化症，HCV或HBV。

4. 发明授权

US08206916B2 Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed 失效
标题翻译：用药剂脉冲生物样品的装置，试剂盒和方法，并将样品稳定化，使其脉动
公开(公告)号：US08206916B2
公开(公告)日：2012-06-26
申请号：US13088135
申请日：2011-04-15
申请人： Patrick Stordeur , Michel Goldman , Marius Tuijnder
发明人： Patrick Stordeur , Michel Goldman , Marius Tuijnder
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/02 , C07H21/04
CPC分类号： B01L3/502 , A61B5/15003 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150251 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/153 , A61B5/41 , A61B5/411 , A61B5/413 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology.
摘要翻译：公开了一种用于用脉动剂脉冲生物样品的装置和试剂盒。如此脉冲的生物样品随后稳定，装置或试剂盒提供对照反应。在医疗诊断领域，特别是免疫学领域，可以找到所描述的器件和试剂盒的应用。

5. 发明申请

US20050153292A1 Method to determine in vivo nucleic acid levels 审中-公开
标题翻译：确定体内核酸水平的方法
公开(公告)号：US20050153292A1
公开(公告)日：2005-07-14
申请号：US10501666
申请日：2003-01-20
申请人： Patrick Stordeur , Michel Goldman
发明人： Patrick Stordeur , Michel Goldman
IPC分类号： C12N15/09 , C12N15/10 , C12Q1/68 , C12Q1/6806 , C12N1/08
CPC分类号： C12N15/1003 , C12Q1/6806
摘要： The invention in particular relates to a method for the quantification of in vivo RNA from a biological sample comprising the steps of: collecting said biological sample in a tube comprising a compound inhibiting RNA degradation and/or gene induction; forming a precipate comprising nucleic acids; separating said precipate from the supernatant; dissolving said precipitate using a buffer, forming a suspension; isolating nucleic acids from said suspension using an automated device; dispersing/distributing a reagent mix for RT-PCR using an automated device; dispersing/distributing the isolated nucleic acids within the dispersed reagent mix using an automated device, and determining the in vivo levels of transcripts using the nucleic acid/RT-PCR reagent mix in an automated setup. The present invention also relates to the quantitatification of DNA from a biological sample. The present invention further elucidates a kit for isolating quantifiable nucleic acids from a biological sample. Applications of the method according to present invention are aldo disclosed.
摘要翻译：本发明特别涉及一种用于从生物样品中定量体内RNA的方法，包括以下步骤：在包含抑制RNA降解和/或基因诱导的化合物的管中收集所述生物样品; 形成包含核酸的沉淀物; 将上述沉淀物与上清液分离; 用缓冲液溶解所述沉淀物，形成悬浮液; 使用自动化装置从所述悬浮液中分离核酸; 使用自动化装置分散/分配用于RT-PCR的试剂混合物; 使用自动化装置将分离的核酸分散/分散在分散的试剂混合物中，并且在自动设置中使用核酸/ RT-PCR试剂混合物确定转录物的体内水平。本发明还涉及来自生物样品的DNA的定量化。本发明进一步阐明了用于从生物样品中分离可量化核酸的试剂盒。根据本发明的方法的应用是公开的。

6. 发明申请

US20110263007A1 DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED 失效
标题翻译：装置，套件和方法，用于使用药剂脉冲生物样品并稳定样品
公开(公告)号：US20110263007A1
公开(公告)日：2011-10-27
申请号：US13088135
申请日：2011-04-15
申请人： Patrick Stordeur , Michel Goldman , Marius Tuijnder
发明人： Patrick Stordeur , Michel Goldman , Marius Tuijnder
IPC分类号： C12M1/34 , B01L3/00
CPC分类号： B01L3/502 , A61B5/15003 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150251 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/153 , A61B5/41 , A61B5/411 , A61B5/413 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology.
摘要翻译：公开了一种用于用脉动剂脉冲生物样品的装置和试剂盒。如此脉冲的生物样品随后稳定，装置或试剂盒提供对照反应。在医疗诊断领域，特别是免疫学领域，可以找到所描述的器件和试剂盒的应用。

7. 发明申请

US20090117646A1 DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED 失效
标题翻译：装置，套件和方法，用于使用药剂脉冲生物样品并稳定样品
公开(公告)号：US20090117646A1
公开(公告)日：2009-05-07
申请号：US12253539
申请日：2008-10-17
申请人： Patrick Stordeur , Michel Goldman , Marius Tuijnder
发明人： Patrick Stordeur , Michel Goldman , Marius Tuijnder
IPC分类号： C12M1/00
CPC分类号： B01L3/502 , A61B5/15003 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150251 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/153 , A61B5/41 , A61B5/411 , A61B5/413 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology.
摘要翻译：公开了一种用于用脉动剂脉冲生物样品的装置和试剂盒。如此脉冲的生物样品随后稳定，装置或试剂盒提供对照反应。在医疗诊断领域，特别是免疫学领域，可以找到所描述的器件和试剂盒的应用。

8. 发明申请

US20070065825A1 Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed 失效
标题翻译：用药剂脉冲生物样品的装置，试剂盒和方法，并将样品稳定化，使其脉动
公开(公告)号：US20070065825A1
公开(公告)日：2007-03-22
申请号：US10563503
申请日：2003-07-10
申请人： Patrick Stordeur , Michel Goldman
发明人： Patrick Stordeur , Michel Goldman
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34 , A61M31/00
CPC分类号： A61B5/411 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150755 , A61B5/413 , B01L3/502 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.
摘要翻译：本发明涉及用脉冲发生脉冲生物样品并随后稳定生物样品如此脉冲的装置，试剂盒和方法。本发明在医学诊断领域中的应用，特别是涉及免疫的领域。

9. 发明授权

US08067172B2 Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed 失效
标题翻译：用药剂脉冲生物样品的装置，试剂盒和方法，并将样品稳定化，使其脉动
公开(公告)号：US08067172B2
公开(公告)日：2011-11-29
申请号：US12701101
申请日：2010-02-05
申请人： Patrick Stordeur , Michel Goldman
发明人： Patrick Stordeur , Michel Goldman
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00 , C12M1/34 , C12M3/08 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/00
CPC分类号： A61B5/411 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150755 , A61B5/413 , B01L3/502 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.
摘要翻译：本发明涉及用脉冲发生脉冲生物样品并随后稳定生物样品如此脉冲的装置，试剂盒和方法。本发明在医学诊断领域中的应用，特别是涉及免疫的领域。

10. 发明申请

US20110129839A1 DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED 失效
标题翻译：装置，套件和方法，用于使用药剂脉冲生物样品并稳定样品
公开(公告)号：US20110129839A1
公开(公告)日：2011-06-02
申请号：US12701101
申请日：2010-02-05
申请人： Patrick Stordeur , Michel Goldman
发明人： Patrick Stordeur , Michel Goldman
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/16
CPC分类号： A61B5/411 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150755 , A61B5/413 , B01L3/502 , B01L3/5082 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/044 , B01L2300/048 , B01L2300/0672 , B01L2300/0832 , B01L2400/0478
摘要： The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.
摘要翻译：本发明涉及用脉冲发生脉冲生物样品并随后稳定生物样品如此脉冲的装置，试剂盒和方法。本发明在医学诊断领域中的应用，特别是涉及免疫的领域。

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