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1. 发明授权

US07362449B2 Digital holographic microscope for 3D imaging and process using it 有权
标题翻译：数字全息显微镜，用于3D成像和使用它的过程
公开(公告)号：US07362449B2
公开(公告)日：2008-04-22
申请号：US10557240
申请日：2005-11-16
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G01B11/02
CPC分类号： G01B9/021 , G01B9/04 , G02B21/16 , G02B21/22 , G02B21/36 , G03H1/0005 , G03H1/0443 , G03H1/0493 , G03H1/0866 , G03H2001/005 , G03H2001/0454 , G03H2222/24
摘要： The present invention is related to a compact microscope able to work in digital holography for obtaining high quality 3D images of samples, including fluorescent samples and relatively thick samples such as biological samples, said microscope comprising illumination means (1,41) at least partially spatially coherent for illuminating a sample (2) to be studied and a differential interferometer (5) for generating interfering beams from said sample (2) on the sensor (33) of an electronic imaging device(7), said interferometer (5) comprising namely tilting means (17) for tilting by a defined angle one the interfering beams (28 or 29) relatively to the other, said tilting resulting into a defined shift (27) of said interfering beam on the sensor of the electronic imaging device (7), said shift (27) being smaller than spatial coherence width of each beam, said microscope being able to be quasi totally preadjusted independently from the samples so that minimum additional adjustments are required for obtaining reliable 3D images of samples.
摘要翻译：本发明涉及能够在数字全息术中工作以获得样品的高质量3D图像的紧凑型显微镜，包括荧光样品和相对较厚的样品例如生物样品，所述显微镜包括至少部分空间上的照明装置（1,41）用于照射要研究的样品（2）的相干性和用于在电子成像装置（7）的传感器（33）上产生来自所述样品（2）的干扰光束的差分干涉仪（5），所述干涉仪（5）包括倾斜装置（17），用于相对于另一个倾斜定影角度的一个干涉光束（28或29），所述倾斜导致所述干涉光束在电子成像装置（7）的传感器上的限定位移（27）），所述偏移（27）小于每个光束的空间相干宽度，所述显微镜能够独立于样本被准全部预调整，使得最小加法为了获得样品的可靠3D图像，需要进行调整。

2. 发明申请

US20130308135A1 OPTICAL METHOD FOR CHARACTERISING TRANSPARENT PARTICLES 有权
标题翻译：用于表征透明颗粒的光学方法
公开(公告)号：US20130308135A1
公开(公告)日：2013-11-21
申请号：US13884508
申请日：2011-11-09
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G01B9/021 , G01N21/59
CPC分类号： G01B9/021 , G01N21/59 , G03H1/00 , G03H1/0005 , G03H2001/0033 , G03H2001/005 , G03H2001/0445 , G03H2210/55 , G03H2222/24
摘要： The present invention is related to a method for characterising transparent objects (2, 3) in a transparent medium (1), said transparent objects (2, 3) presenting an optical focal area (5, 6) said method comprising the steps of: illuminating a sample comprising the objects (2, 3) to be characterised by means of a directional light (7) source, thereby inducing light intensity peaks (5, 6) at the focal area of said transparent objects; determining at least one characteristic of the light intensity peak (5, 6) induced by said object to be characterised, determining from said light intensity peak (5, 6) at least one property of said object.
摘要翻译：本发明涉及一种用于表征透明介质（1）中的透明物体（2,3）的方法，所述透明物体（2,3）具有光焦点区域（5,6），所述方法包括以下步骤：照亮包含通过定向光（7）源表征的物体（2,3）的样品，从而在所述透明物体的聚焦区域处引起光强度峰值（5,6）; 确定由所述待表征的物体感应的光强度峰值（5,6）的至少一个特性，从所述光强度峰值（5,6）确定所述物体的至少一个性质。

3. 发明申请

US20080018966A1 DIGITAL HOLOGRAPHIC MICROSCOPE FOR 3D IMAGING AND PROCESS USING IT 有权
标题翻译：用于3D成像的数字全息显微镜和使用它的过程
公开(公告)号：US20080018966A1
公开(公告)日：2008-01-24
申请号：US10557240
申请日：2004-05-17
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G03H1/08
CPC分类号： G01B9/021 , G01B9/04 , G02B21/16 , G02B21/22 , G02B21/36 , G03H1/0005 , G03H1/0443 , G03H1/0493 , G03H1/0866 , G03H2001/005 , G03H2001/0454 , G03H2222/24
摘要： The present invention is related to a compact microscope able to work in digital holography for obtaining high quality 3D images of samples, including fluorescent samples and relatively thick samples such as biological samples, said microscope comprising illumination means (1,41) at least partially spatially coherent for illuminating a sample (2) to be studied and a differential interferometer (5) for generating interfering beams from said sample (2) on the sensor (33) of an electronic imaging device (7), said interferometer (5) comprising namely tilting means (17) for tilting by a defined angle one the interfering beams (28 or 29) relatively to the other, said tilting resulting into a defined shift (27) of said interfering beam on the sensor of the electronic imaging device (7), said shift (27) being smaller than spatial coherence width of each beam, said microscope being able to be quasi totally preadjusted independently from the samples so that minimum additional adjustments are required for obtaining reliable 3D images of samples.
摘要翻译：本发明涉及能够在数字全息术中工作以获得样品的高质量3D图像的紧凑型显微镜，包括荧光样品和相对较厚的样品例如生物样品，所述显微镜包括至少部分空间上的照明装置（1,41）用于照射要研究的样品（2）的相干性和用于在电子成像装置（7）的传感器（33）上产生来自所述样品（2）的干扰光束的差分干涉仪（5），所述干涉仪（5）包括倾斜装置（17），用于相对于另一个倾斜定影角度的一个干涉光束（28或29），所述倾斜导致所述干涉光束在电子成像装置（7）的传感器上的限定位移（27）），所述偏移（27）小于每个光束的空间相干宽度，所述显微镜能够独立于样品被准全部预调整，使得最小加法为了获得样品的可靠3D图像，需要进行调整。

4. 发明授权

US09476694B2 Optical method for characterizing transparent particles 有权
标题翻译：用于表征透明颗粒的光学方法
公开(公告)号：US09476694B2
公开(公告)日：2016-10-25
申请号：US13884508
申请日：2011-11-09
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G01N21/59 , G01B9/021 , G03H1/00 , G03H1/04
CPC分类号： G01B9/021 , G01N21/59 , G03H1/00 , G03H1/0005 , G03H2001/0033 , G03H2001/005 , G03H2001/0445 , G03H2210/55 , G03H2222/24
摘要： The present invention is related to a method for characterizing transparent objects (2, 3) in a transparent medium (1), said transparent objects (2, 3) presenting an optical focal area (5, 6) said method comprising the steps of: illuminating a sample comprising the objects (2, 3) to be characterized by means of a directional light (7) source, thereby inducing light intensity peaks (5, 6) at the focal area of said transparent objects; determining at least one characteristic of the light intensity peak (5, 6) induced by said object to be characterized, determining from said light intensity peak (5, 6) at least one property of said object.
摘要翻译：本发明涉及一种用于表征透明介质（1）中的透明物体（2,3）的方法，所述透明物体（2,3）具有光焦点区域（5,6），所述方法包括以下步骤：照亮包含通过定向光（7）源表征的物体（2,3）的样品，从而在所述透明物体的聚焦区域处引起光强度峰值（5,6）; 确定由所述待表征的物体感应的光强度峰值（5,6）的至少一个特性，从所述光强度峰值（5,6）确定所述物体的至少一个性质。

5. 发明授权

US09207638B2 Off-axis interferometer 有权
标题翻译：离轴干涉仪
公开(公告)号：US09207638B2
公开(公告)日：2015-12-08
申请号：US13498299
申请日：2010-10-05
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G02B5/32 , G02B21/00 , G02B5/18 , G01B9/021 , G03H1/08 , G03H1/02 , G03H1/04 , G03H1/00
CPC分类号： G03H1/08 , G02B21/00 , G03H1/02 , G03H1/0443 , G03H2001/005 , G03H2001/0212 , G03H2001/0456 , G03H2222/13 , G03H2222/18 , G03H2222/23 , G03H2222/24
摘要： An Interferometer for off-axis digital holographic microscopy includes a recording plane, and a grating located in a plane optically conjugated with the recording plane. The grating defining a first and a second optical path, the optical path corresponding to different diffraction order.
摘要翻译：用于离轴数字全息显微镜的干涉仪包括记录平面和位于与记录平面光学共轭的平面中的光栅。光栅限定第一和第二光路，光路对应于不同的衍射级。

6. 发明申请

US20120200901A1 OFF-AXIS INTERFEROMETER 有权
标题翻译：离轴干涉仪
公开(公告)号：US20120200901A1
公开(公告)日：2012-08-09
申请号：US13498299
申请日：2010-10-05
申请人： Frank Dubois , Catherine Yourassowsky
发明人： Frank Dubois , Catherine Yourassowsky
IPC分类号： G02B5/32
CPC分类号： G03H1/08 , G02B21/00 , G03H1/02 , G03H1/0443 , G03H2001/005 , G03H2001/0212 , G03H2001/0456 , G03H2222/13 , G03H2222/18 , G03H2222/23 , G03H2222/24
摘要： An Interferometer for off-axis digital holographic microscopy includes a recording plane, and a grating located in a plane optically conjugated with the recording plane. The grating defining a first and a second optical path, the optical path corresponding to different diffraction order.
摘要翻译：用于离轴数字全息显微镜的干涉仪包括记录平面和位于与记录平面光学共轭的平面中的光栅。光栅限定第一和第二光路，光路对应于不同的衍射级。

7. 发明授权

US07463366B2 Digital holographic microscope 有权
标题翻译：数字全息显微镜
公开(公告)号：US07463366B2
公开(公告)日：2008-12-09
申请号：US11284768
申请日：2005-11-22
申请人： Franck Dubois , Catherine Yourassowsky
发明人： Franck Dubois , Catherine Yourassowsky
IPC分类号： G01B9/02
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/365 , G03H1/0005 , G03H1/041 , G03H1/0443 , G03H1/0465 , G03H1/0866 , G03H2001/005 , G03H2001/0452 , G03H2001/0456 , G03H2001/0458 , G03H2222/24 , G03H2223/14 , G03H2223/26
摘要： A method and device for obtaining a sample with three-dimensional microscopy, in particular a thick biological sample and the fluorescence field emitted by the sample. One embodiment includes obtaining interferometric signals of a specimen, obtaining fluorescence signals emanating from the specimen, recording these signals, and processing these signals so as to reconstruct three-dimensional images of the specimen and of the field of fluorescence emitted by the specimen at a given time. Another embodiment includes a digital holography microscope, a fluorescence excitation source illuminating a specimen, where the microscope and the fluorescence excitation source cooperate to obtain interferometric signals of the specimen and obtain fluorescence signals emanating from the specimen, means for recording the interferometric signals and fluorescence signals, and means for processing the interferometric signals and the fluorescence signals so as to reconstruct three-dimensional images of the specimen and of the field of fluorescence emitted by the specimen at a given time.
摘要翻译：一种利用三维显微镜获得样品的方法和装置，特别是厚的生物样品和由样品发射的荧光场。一个实施例包括获得样本的干涉信号，获得从样本发出的荧光信号，记录这些信号，以及处理这些信号，以便重建样本的三维图像和由给定的样本发射的荧光场时间。另一个实施例包括数字全息显微镜，照射样本的荧光激发源，其中显微镜和荧光激发源协作以获得样本的干涉信号并获得从样本发出的荧光信号，用于记录干涉信号和荧光信号的装置以及用于处理干涉信号和荧光信号的装置，以便重建样本的三维图像和在给定时间由样本发射的荧光场。

8. 发明申请

US20060132799A1 Digital holographic microscope 有权
标题翻译：数字全息显微镜
公开(公告)号：US20060132799A1
公开(公告)日：2006-06-22
申请号：US11284768
申请日：2005-11-22
申请人： Franck Dubois , Catherine Yourassowsky
发明人： Franck Dubois , Catherine Yourassowsky
IPC分类号： G01B11/02
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/365 , G03H1/0005 , G03H1/041 , G03H1/0443 , G03H1/0465 , G03H1/0866 , G03H2001/005 , G03H2001/0452 , G03H2001/0456 , G03H2001/0458 , G03H2222/24 , G03H2223/14 , G03H2223/26
摘要： A method and device for obtaining a sample with three-dimensional microscopy, in particular a thick biological sample and the fluorescence field emitted by the sample. One embodiment includes obtaining interferometric signals of a specimen, obtaining fluorescence signals emanating from the specimen, recording these signals, and processing these signals so as to reconstruct three-dimensional images of the specimen and of the field of fluorescence emitted by the specimen at a given time. Another embodiment includes a digital holography microscope, a fluorescence excitation source illuminating a specimen, where the microscope and the fluorescence excitation source cooperate to obtain interferometric signals of the specimen and obtain fluorescence signals emanating from the specimen, means for recording the interferometric signals and fluorescence signals, and means for processing the interferometric signals and the fluorescence signals so as to reconstruct three-dimensional images of the specimen and of the field of fluorescence emitted by the specimen at a given time.
摘要翻译：一种利用三维显微镜获得样品的方法和装置，特别是厚的生物样品和由样品发射的荧光场。一个实施例包括获得样本的干涉信号，获得从样本发出的荧光信号，记录这些信号，以及处理这些信号，以便重建样本的三维图像和由给定的样本发射的荧光场时间。另一个实施例包括数字全息显微镜，照射样本的荧光激发源，其中显微镜和荧光激发源协作以获得样本的干涉信号并获得从样本发出的荧光信号，用于记录干涉信号和荧光信号的装置以及用于处理干涉信号和荧光信号的装置，以便重建样本的三维图像和在给定时间由样本发射的荧光场。

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