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51. 发明申请

US20060100427A1 Novel Gamma Secretase inhibitors 审中-公开
标题翻译：新型Gamma分泌酶抑制剂
公开(公告)号：US20060100427A1
公开(公告)日：2006-05-11
申请号：US11242337
申请日：2005-10-03
申请人： Dmitri Pissarnitski , Hubert Josien , Elizabeth Smith , John Clader , Theodros Asberom , Tao Guo , Douglas Hobbs
发明人： Dmitri Pissarnitski , Hubert Josien , Elizabeth Smith , John Clader , Theodros Asberom , Tao Guo , Douglas Hobbs
IPC分类号： A61K31/5377 , C07D413/02 , C07D401/14
CPC分类号： C07D401/12 , C07D211/96 , C07D401/14 , C07D409/12 , C07D471/10
摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, —X(CO)Y, or alkylene-X(CO)Y wherein X and Y are as defined herein; each R3 and each R3A are independently H, or alkyl; R11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.
摘要翻译：本发明公开了下式的新型γ分泌酶抑制剂：其中：R 1是取代的芳基或取代的杂芳基; R 2是R 1基团，烷基，-X（CO）Y或亚烷基-X（CO）Y，其中X和Y如本文所定义; 每个R 3和R 3各自独立地为H或烷基; R 11是芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基或烷氧基烷基。还公开了使用一种或多种本发明化合物治疗阿尔茨海默病的方法。

52. 发明授权

US06887889B2 Aryl and biaryl piperdines with MCH modulatory activity 失效
标题翻译：具有MCH调节活性的芳基和联芳基哌啶
公开(公告)号：US06887889B2
公开(公告)日：2005-05-03
申请号：US10120080
申请日：2002-04-10
申请人： Douglas W. Hobbs , Tao Guo , Rachael C. Hunter , Huizhong Gu , Suresh D. Babu , Yuefei Shao
发明人： Douglas W. Hobbs , Tao Guo , Rachael C. Hunter , Huizhong Gu , Suresh D. Babu , Yuefei Shao
IPC分类号： A61K31/438 , A61K31/4433 , A61K31/445 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K45/00 , A61P3/04 , A61P5/14 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/64 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D471/10 , C07D221/26
CPC分类号： C07D401/10 , C07D211/26 , C07D405/04 , C07D405/10 , C07D405/12 , C07D471/10
摘要： In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration or one or more of diseases associated with the MCH receptor. An illustrative inventive compound is shown below:
摘要翻译：在一个实施方案中，本发明提供了一类新颖的化合物作为MCH受体的拮抗剂，制备此类化合物的方法，含有一种或多种化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗，预防或改善或与MCH受体相关的一种或多种疾病。示例性的本发明化合物如下所示：

53. 发明申请

US20050085506A1 Novel gamma secretase inhibitors 失效
标题翻译：新型γ分泌酶抑制剂
公开(公告)号：US20050085506A1
公开(公告)日：2005-04-21
申请号：US10941440
申请日：2004-09-15
申请人： Dmitri Pissarnitski , Hubert Josien , Elizabeth Smith , John Clader , Theodros Asberom , Tao Guo , Douglas Hobbs
发明人： Dmitri Pissarnitski , Hubert Josien , Elizabeth Smith , John Clader , Theodros Asberom , Tao Guo , Douglas Hobbs
IPC分类号： A61K31/445 , C07D211/60 , C07D43/02
CPC分类号： C07D401/14 , C07D211/96 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/10 , C07D491/10
摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, —XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X—C(O)—Y, —CH—X—C(O)—NR3—Y or —CH—X—C(O)—Y, wherein X and Y are as defined herein; each R3 and each R3A are independently H, or alkyl; R11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.
摘要翻译：本发明公开了下式的新型γ分泌酶抑制剂：其中：R 1是取代的芳基或取代的杂芳基; R 2是R 1基团，烷基，-XC（O）Y，亚烷基-XC（O）Y，亚环烷基-XC（O）-Y，-CH -XC（O）-NR 3 -Y或-CH-XC（O）-Y，其中X和Y如本文所定义; 每个R 3和R 3各自独立地为H或烷基; R 11是芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基或烷氧基烷基。还公开了使用一种或多种本发明化合物治疗阿尔茨海默病的方法。

54. 发明授权

US08666170B2 Computer system and method of matching for images and graphs 有权
标题翻译：计算机系统和匹配图像和图形的方法
公开(公告)号：US08666170B2
公开(公告)日：2014-03-04
申请号：US13030428
申请日：2011-02-18
申请人： Tao Guo
发明人： Tao Guo
IPC分类号： G06K9/62 , G06K9/74 , G06K9/64 , G06K9/32
CPC分类号： G06K9/6212 , G06K9/6204
摘要： It is provided a computer system for matching between images/graphs comprising a processing unit, a storage unit, an input unit and a data recording unit, wherein the computer system includes a feature pattern generating unit for generating a set of feature patterns of the image and the graph from the received image and the received graph, segmenting each of the image and the graph into a plurality of regions centered on a sample point, and determining characteristics of the plurality of regions; a correspondence computing unit for computing correspondence between the image and the graph to be matched by comparing the generated feature patterns; a transform unit for transforming a coordinate system of at least one of the image and the graph to be matched; and a combination unit for combining the image and the graph that have been subjected to the transform of the coordinate system.
摘要翻译：提供了一种用于在包括处理单元，存储单元，输入单元和数据记录单元的图像/图形之间进行匹配的计算机系统，其中计算机系统包括特征图案生成单元，用于生成图像的特征图案集合以及来自接收图像和接收图的曲线图，将图像和图形中的每一个分割成以采样点为中心的多个区域，并且确定多个区域的特征; 对应计算单元，用于通过比较所生成的特征图案来计算图像和要匹配的图形之间的对应关系; 用于变换要匹配的图像和图形中的至少一个的坐标系的变换单元; 以及用于组合已经经过坐标系变换的图像和图形的组合单元。

55. 发明授权

US08513232B2 Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands 失效
标题翻译：取代的螺环哌啶衍生物作为组胺-3（H3）受体配体
公开(公告)号：US08513232B2
公开(公告)日：2013-08-20
申请号：US12846100
申请日：2010-07-29
申请人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
发明人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
IPC分类号： C07D491/10 , C07D401/14 , C07D471/10 , A61K31/397 , A61K31/438 , A61K31/506 , A61P11/00 , A61P1/00 , A61P25/00 , A61P29/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译：本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。

56. 发明授权

US08359156B2 Map generation system and map generation method by using GPS tracks 有权
标题翻译：使用GPS轨迹的地图生成系统和地图生成方法
公开(公告)号：US08359156B2
公开(公告)日：2013-01-22
申请号：US12068296
申请日：2008-02-05
申请人： Tao Guo , Masashi Koga
发明人： Tao Guo , Masashi Koga
IPC分类号： G06F19/00
CPC分类号： G01C21/32
摘要： A map generation system comprising: a mobile device for acquiring location data of a vehicle and a status of the vehicle at a time of acquisition of the location; and a server for processing the acquired location data of the vehicle. The server comprises an input interface, a first storage unit, a processor and a second storage unit. The server includes a management unit for collecting a plurality of pieces of the track data obtained by a motion of the vehicle, an extraction unit for extracting feature points of the plurality of pieces of the track data on a road from which the plurality of pieces of the track data are collected to calculate a Spline curve satisfying the extracted feature points, and an update unit for adding the calculated Spline curve as a lane central line to the digital road map to update map data.
摘要翻译：一种地图生成系统，包括：在获取所述位置时获取车辆的位置数据和所述车辆的状态的移动装置; 以及用于处理所获取的车辆位置数据的服务器。服务器包括输入接口，第一存储单元，处理器和第二存储单元。服务器包括：管理单元，用于收集通过车辆的运动获得的多条轨道数据;提取单元，用于从道路上提取多条轨迹数据的特征点，该道路上的多条收集轨道数据以计算满足所提取的特征点的样条曲线，以及更新单元，用于将所计算的样条曲线作为车道中心线添加到数字路线图以更新地图数据。

57. 发明申请

US20120130076A1 Synthetic Multimerizing Agents 失效
标题翻译：合成多元化剂
公开(公告)号：US20120130076A1
公开(公告)日：2012-05-24
申请号：US13361082
申请日：2012-01-30
申请人： Dennis A. Holt , Terence P. Keenan , Tao Guo , Edgardo Laborde , Wu Yang
发明人： Dennis A. Holt , Terence P. Keenan , Tao Guo , Edgardo Laborde , Wu Yang
IPC分类号： C07D401/12
CPC分类号： C07D401/14 , C07D207/16 , C07D211/60 , C07D401/12 , C07D405/12
摘要： New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.
摘要翻译：公开了用于多聚化免疫亲和素和含有免疫亲和素相关结构域的蛋白质的新化合物。该化合物具有式M-L-Q，其中M是FKBP蛋白质的合成配体。

58. 发明申请

US20120123696A1 METHOD AND SYSTEM FOR STEAM QUALITY MONITORING 有权
标题翻译：蒸汽质量监测方法与系统
公开(公告)号：US20120123696A1
公开(公告)日：2012-05-17
申请号：US12945680
申请日：2010-11-12
申请人： Binayak Roy , Tao Guo
发明人： Binayak Roy , Tao Guo
IPC分类号： G06F19/00
CPC分类号： G01N15/0205 , F01D21/003 , F22B35/16 , G01N21/534
摘要： A method of determining a steam quality of a wet steam located in an interior of a steam turbine includes emitting from an optical probe a plurality of wavelengths through the wet steam, measuring with the optical probe a wet steam intensity corresponding to each of the plurality of wavelengths emitted through the wet steam, determining an intensity ratio vector by dividing the wet steam intensity by a corresponding dry steam intensity for each of the plurality of wavelengths, successively applying scaling factors to the intensity ratio vector to obtain a scaled intensity ratio vector, calculating a suitable value for each of the scaling factors to obtain a plurality of residuals, determining a minimum residual of the plurality of residuals, determining a droplet size distribution by calculating the droplet number density corresponding to the minimum residual, and determining the steam quality based on the droplet size distribution.
摘要翻译：确定位于蒸汽涡轮机内部的湿蒸汽的蒸汽质量的方法包括通过湿蒸汽从光学探针发射多个波长，用光学探针测量与多个通过湿蒸汽发射的波长，通过将湿蒸汽强度除以对于多个波长中的每一个的相应的干蒸汽强度来确定强度比矢量，连续地将比例因子应用于强度比矢量以获得比例的强度比矢量，计算用于获得多个残差的每个缩放因子的合适值，确定多个残差的最小残差，通过计算对应于最小残差的液滴数密度来确定液滴尺寸分布，以及基于液滴尺寸分布。

59. 发明申请

US20120043728A1 TURBINE ENGINE SEALS 有权
标题翻译：涡轮发动机密封
公开(公告)号：US20120043728A1
公开(公告)日：2012-02-23
申请号：US12858701
申请日：2010-08-18
申请人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
发明人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
IPC分类号： F16J15/447
CPC分类号： F01D11/001 , F01D11/02 , F05D2250/232 , F16J15/441 , F16J15/4472
摘要： A seal is provided for preventing axial leakage through a radial gap between a stationary structure and a rotating structure. The radial gap is defined by an inner radial surface opposing an outer radial surface across the radial gap. The seal includes at least one land disposed on one of the inner radial surface and outer radial surface. At least one first tooth and at least one second tooth project from the other of the radial surfaces. The second tooth is shorter than the first tooth. At least one of the first tooth and second tooth, is configured to extend at an angle upstream. This angle is defined between a radial surface from which the first or second tooth projects and an upstream surface of the same tooth. The angle is less than or equal to about 80 degrees.
摘要翻译：提供密封件以防止通过固定结构和旋转结构之间的径向间隙的轴向泄漏。径向间隙由跨越径向间隙的与外径向表面相对的内径向表面限定。密封件包括设置在内径向表面和外径向表面中的一个上的至少一个区域。至少一个第一齿和至少一个第二齿从另一个径向表面突出。第二个齿比第一个牙齿短。第一齿和第二齿中的至少一个构造成在上游以一定角度延伸。该角度限定在第一或第二齿突出的径向表面与同一牙齿的上游表面之间。该角度小于或等于约80度。

60. 发明申请

US20110071131A1 Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands 失效
标题翻译：取代的螺环哌啶衍生物作为组胺-3（H3）受体配体
公开(公告)号：US20110071131A1
公开(公告)日：2011-03-24
申请号：US12846100
申请日：2010-07-29
申请人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
发明人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
IPC分类号： A61K31/397 , C07D471/10 , A61K31/438 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/506 , A61P25/00 , A61P1/00 , A61P11/00 , A61P9/00 , A61P29/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译：本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。

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