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51. 发明申请

US20110202105A1 BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
标题翻译：用于可植入器件应用的BIOELECTRIC BATTERY
公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , H01M8/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

52. 发明申请

US20100114236A1 HYBRID BATTERY SYSTEM WITH BIOELECTRIC CELL FOR IMPLANTABLE CARDIAC THERAPY DEVICE 审中-公开
标题翻译：具有用于可植入心脏治疗装置的生物电池的混合电池系统
公开(公告)号：US20100114236A1
公开(公告)日：2010-05-06
申请号：US12263348
申请日：2008-10-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore
IPC分类号： A61N1/362 , H01M10/36
CPC分类号： A61N1/378 , A61N1/3956 , A61N1/3981 , H01M8/16 , H01M10/0525 , H01M10/425 , H01M10/44 , H01M16/006 , H02J7/0054 , H02J7/0063 , Y02E60/527
摘要： A system and method for powering an implantable cardiac therapy device (ICTD) via a hybrid battery system. The hybrid battery is comprised of a low voltage and low current bioelectric cell, a high voltage and high current rechargeable cell, and a charging means. Via the charging means, the bioelectric cell maintains the rechargeable cell at or near full power. The rechargeable cell is configured to power some or all operations of the ICTD. Some ICTD operations may be powered directly by the bioelectric cell. The rechargeable cell is further configured to be charged via a continuous charging process, reducing the complexity of the charging circuitry. In an embodiment, at least the bioelectric cell is external to the ICTD, enabling easy replacement of this power source. In an embodiment, a consumable anode of the bioelectric cell is external to the ICTD, enabling replacement of the power source by replacing only the anode.
摘要翻译：通过混合电池系统为植入式心脏治疗装置（ICTD）供电的系统和方法。混合电池包括低电压和低电流生物电池，高电压和高电流可再充电电池以及充电装置。通过充电装置，生物电池将可再充电电池维持在或接近全功率。可充电电池被配置为为ICTD的一些或所有操作供电。一些ICTD操作可以由生物电池直接供电。可再充电电池还被配置为经由连续充电过程进行充电，从而降低充电电路的复杂性。在一个实施例中，至少生物电池在ICTD的外部，使得能够容易地更换该电源。在一个实施例中，生物电池的消耗性阳极在ICTD的外部，能够通过仅替换阳极来替换电源。

53. 发明授权

US06804556B1 Methods and apparatus for overdrive pacing heat tissue using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置的超速起搏热组织的方法和装置
公开(公告)号：US06804556B1
公开(公告)日：2004-10-12
申请号：US10036026
申请日：2001-12-21
申请人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
发明人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
IPC分类号： A61N1365
CPC分类号： A61N1/368
摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.
摘要翻译：描述了使用起搏器超速起搏心脏的技术，其中在确定的搜索周期内检测到至少两个固有节拍时，超速起搏速率仅增加。在一种特定技术中，只有在X个心动周期内检测到两个P波时，起搏速率才会增加。在另一个具体技术中，只有在N个心动周期的块内检测到至少两个P波时，才能增加超速起搏速率。在两种技术中，如果在最后Z个心动周期中没有发生增加，则超速起搏速率将降低。通过仅在确定的心跳周期内响应于至少两个P波的检测来增加超速起搏速率，避免了过高的超速起搏速率。描述了用于自适应地调节过驱动起搏参数的其它技术，以便实现例如95％起搏节拍的确定的目标起搏程度。通过自适应地调整过驱动参数以保持目标起搏程度，平均超速起搏速度最小化，同时仍然保持大量的起搏节奏，从而降低患者内出现快速性心律失常的风险。

54. 发明授权

US06766195B1 Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon 有权
标题翻译：用于检测心脏内的自然电相干性并用于基于其进行治疗的方法和装置
公开(公告)号：US06766195B1
公开(公告)日：2004-07-20
申请号：US09686630
申请日：2000-10-10
申请人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
发明人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
IPC分类号： A61N0118
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.
摘要翻译：提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。描述了方法和设备实施例。

55. 发明授权

US06731985B2 Implantable cardiac stimulation system and method for automatic capture verification calibration 有权
标题翻译：植入式心脏刺激系统和自动捕获验证校准方法
公开(公告)号：US06731985B2
公开(公告)日：2004-05-04
申请号：US09981555
申请日：2001-10-16
申请人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
发明人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
IPC分类号： A61N1362
CPC分类号： A61N1/3712
摘要： An implantable cardiac stimulation device and associated method perform an automatic calibration procedure for evaluating whether automatic capture verification can be recommended. The calibration procedure calculates and displays a number of variables for use by a medical practitioner in programming automatic capture operating parameters. An average paced depolarization integral (PDI) is determined from the cardiac signals following delivery of multiple stimulation pulse below and above capture threshold such that both pure lead polarization signals and evoked response signals may be analyzed. From the paced depolarization integral data, a capture threshold, a stimulation response curve, a minimum evoked response, a maximum lead polarization, an evoked response sensitivity, an evoked response safety margin, and a polarization safety margin are determined. Based on these variables, the calibration procedure determines if automatic capture verification can be recommended. If so, the stimulation device calculates a capture detection threshold. The automatic capture verification recommendation and the estimated calibration variables are displayed.
摘要翻译：可植入心脏刺激装置和相关方法执行自动校准程序，以评估是否可以推荐自动捕获验证。校准程序计算并显示许多变量，供医生在编程自动捕获操作参数时使用。平均节奏去极化积分（PDI）是在多次刺激脉冲传递后低于和高于捕获阈值的心脏信号确定的，以便可以分析纯铅极化信号和诱发响应信号。从起搏去极化积分数据中，确定捕获阈值，刺激响应曲线，最小诱发响应，最大引线极化，诱发响应灵敏度，诱发响应安全裕度和极化安全裕度。基于这些变量，校准过程确定是否可以推荐自动捕获验证。如果是，则刺激装置计算捕获检测阈值。显示自动捕获验证建议和估计的校准变量。

56. 发明申请

US20130116740A1 SINGLE-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH DUAL-CHAMBER FUNCTIONALITY AND SHAPED STABILIZATION INTRA-CARDIAC EXTENSION 有权
标题翻译：具有双室功能和形状稳定的单室无胸腔内科医疗设备心脏扩张
公开(公告)号：US20130116740A1
公开(公告)日：2013-05-09
申请号：US13352101
申请日：2012-01-17
申请人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/05 , A61N1/362
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/3684 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) configured to be implanted entirely within a heart of a patient includes a housing configured to be securely attached to an interior wall portion of a chamber of the heart, and a stabilizing intra-cardiac (IC) device extension connected to the housing. The stabilizing IC device extension may include a stabilizer arm, and/or an appendage arm, or an elongated body or a loop member configured to be passively secured within the heart.
摘要翻译：被配置为完全植入患者心脏的无引线心脏内心脏医疗装置（LIMD）包括被构造成可靠地附接到心脏室的内壁部分的壳体，以及稳定心脏内（IC）设备扩展连接到外壳。稳定IC装置延伸部可以包括稳定器臂和/或附肢臂，或者被配置为被动地固定在心脏内的细长主体或环形构件。

57. 发明申请

US20130116529A1 LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH BUILT-IN TELEMETRY SYSTEM 有权
标题翻译：无内置医疗设备与内置远程系统
公开(公告)号：US20130116529A1
公开(公告)日：2013-05-09
申请号：US13352147
申请日：2012-01-17
申请人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
发明人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
IPC分类号： A61B5/042 , A61N1/372
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/042 , A61B5/686 , A61N1/362 , A61N1/368 , A61N1/3756 , A61N1/3787 , A61N1/3956 , A61N1/3968
摘要： A leadless intra-cardiac medical device is configured to be implanted entirely within a heart of a patient. The device includes an intra-cardiac extension and a housing. The intra-cardiac extension includes a loop body having at least one loop segment retaining at least one coil group that is configured to one or both of receive and transmit radio frequency (RF) energy, wherein the loop body is configured to extend into a first chamber of the heart. The housing is in electrical communication within the loop body, and includes a transceiver, control logic and an energy source. The housing is configured to be securely attached to an interior wall portion of a second chamber of the heart, wherein the transceiver is configured to communicate with an external device through the RF energy.
摘要翻译：无引线心脏内心脏医疗设备被配置为完全植入患者的心脏内。该装置包括心脏内延伸部和壳体。心脏内延伸包括环体，其具有至少一个环段，保留至少一个线圈组，该线圈组配置为接收和发射射频（RF）能量中的一个或两个，其中该环体被配置为延伸到第一心脏室。壳体在环体内部电气通信，并且包括收发器，控制逻辑和能量源。壳体构造成牢固地附接到心脏的第二腔室的内壁部分，其中收发器被配置为通过RF能量与外部设备通信。

58. 发明申请

US20100331921A1 NEUROSTIMULATION DEVICE AND METHODS FOR CONTROLLING SAME 审中-公开
标题翻译：神经病学装置及其控制方法
公开(公告)号：US20100331921A1
公开(公告)日：2010-12-30
申请号：US12491101
申请日：2009-06-24
申请人： Gene A. Bornzin , John W. Poore , Rupinder Bharmi
发明人： Gene A. Bornzin , John W. Poore , Rupinder Bharmi
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61N1/36071 , A61N1/36082 , A61N1/362
摘要： A stimulation device that includes a housing, a neuro lead configured to be coupled to the housing and to be located proximate to a neurostimulation site of interest, a neuro pulse generator, in the housing, configured to generate multi-polar neuro modulation (NM) pulses for delivery by the lead to the neuromodulation site of interest and the neuro pulse generator generating the NM pulses utilizing a waveform, with the frequency components of the ICMD compatible waveform in a range of 0 to 225 Hz having substantially limited NM energy content to avoid interference with sensing operation of the ICMD. A method for managing a neuromodulation (NM) device to avoid interference with an implantable medical device (ICMD) providing an ICMD having electrodes configured based on ICMD sensing parameters that define an ICMD sensing frequency range, providing an NM device having NM electrodes to be located proximate a region of interest, the NM electrodes delivering NM pulses based on NM pulse parameters, setting at least one NM pulse parameter in a manner that limits an amount of NM energy content that propagates beyond an active area surrounding the site of interest within the ICMD sensing frequency range.
摘要翻译：一种刺激装置，其包括壳体，神经导线，被配置为耦合到所述壳体并且位于靠近感兴趣的神经刺激部位的神经脉冲发生器，被配置为产生多极神经调制（NM）用于通过引线输送到感兴趣的神经调节部位的脉冲，以及使用波形产生NM脉冲的神经脉冲发生器，其中ICMD兼容波形的频率分量在0至225Hz的范围内具有基本上有限的NM能量含量以避免干扰ICMD的感测操作。一种用于管理神经调节（NM）装置以避免与可植入医疗装置（ICMD）的干涉的方法，所述可植入医疗装置（ICMD）提供具有基于定义ICMD感测频率范围的ICMD感测参数配置的电极的ICMD，提供具有待定位的NM电极的NM装置靠近感兴趣的区域，NM电极基于NM脉冲参数传送NM脉冲，以限制NM能量含量的量超出ICMD内的感兴趣位置周围的有效区域的方式设置至少一个NM脉冲参数感应频率范围。

59. 发明授权

US07043302B1 Methods and apparatus for overdrive pacing heart tissue using an implantable cardiac stimulation device 有权
公开(公告)号：US07043302B1
公开(公告)日：2006-05-09
申请号：US10323380
申请日：2002-12-18
申请人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
发明人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
IPC分类号： A61N1/08
CPC分类号： A61N1/368
摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.

60. 发明授权

US09265436B2 Leadless intra-cardiac medical device with built-in telemetry system 有权
标题翻译：无内置心内膜医疗设备内置遥测系统
公开(公告)号：US09265436B2
公开(公告)日：2016-02-23
申请号：US13352147
申请日：2012-01-17
申请人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
发明人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
IPC分类号： A61B5/0408 , A61N1/05 , A61B5/042 , A61N1/375 , A61N1/372 , A61N1/368 , A61N1/39 , A61B5/00
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/042 , A61B5/686 , A61N1/362 , A61N1/368 , A61N1/3756 , A61N1/3787 , A61N1/3956 , A61N1/3968
摘要： A leadless intra-cardiac medical device is configured to be implanted entirely within a heart of a patient. The device includes an intra-cardiac extension and a housing. The intra-cardiac extension includes a loop body having at least one loop segment retaining at least one coil group that is configured to one or both of receive and transmit radio frequency (RF) energy, wherein the loop body is configured to extend into a first chamber of the heart. The housing is in electrical communication within the loop body, and includes a transceiver, control logic and an energy source. The housing is configured to be securely attached to an interior wall portion of a second chamber of the heart, wherein the transceiver is configured to communicate with an external device through the RF energy.
摘要翻译：无引线心脏内心脏医疗设备被配置为完全植入患者的心脏内。该装置包括心脏内延伸部和壳体。心脏内延伸包括环体，其具有至少一个环段，保留至少一个线圈组，该线圈组配置为接收和发射射频（RF）能量中的一个或两个，其中该环体被配置为延伸到第一心脏室。壳体在环体内部电气通信，并且包括收发器，控制逻辑和能量源。壳体构造成牢固地附接到心脏的第二腔室的内壁部分，其中收发器被配置为通过RF能量与外部设备通信。

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