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51. 发明申请

US20050142600A1 Protein modification and maintenance molecules 审中-公开
标题翻译：蛋白质修饰和维持分子
公开(公告)号：US20050142600A1
公开(公告)日：2005-06-30
申请号：US11046868
申请日：2005-02-01
申请人： Bridget Warren , Cynthia Honchell , Yan Lu , Narinder Chawla , Neil Burford , Angelo Delegeane , Ameena Gandhi , Mariah Baughn , Jennifer Griffin , Kimberly Gietzen , Dyung Lu , Craig Ison , Jayalaxmi Ramkumar , Y. Tang , Preeti Lal , Mark Borowsky , Brendan Duggan , April Hafalia , Chandra Arvizu , Kavitha Thangavelu , Monique Yao , Vicki Elliott , Li Ding , Henry Yue , Sally Lee , Anita Swarnakar , Uyen Tran , Yuming Xu
发明人： Bridget Warren , Cynthia Honchell , Yan Lu , Narinder Chawla , Neil Burford , Angelo Delegeane , Ameena Gandhi , Mariah Baughn , Jennifer Griffin , Kimberly Gietzen , Dyung Lu , Craig Ison , Jayalaxmi Ramkumar , Y. Tang , Preeti Lal , Mark Borowsky , Brendan Duggan , April Hafalia , Chandra Arvizu , Kavitha Thangavelu , Monique Yao , Vicki Elliott , Li Ding , Henry Yue , Sally Lee , Anita Swarnakar , Uyen Tran , Yuming Xu
IPC分类号： A61K38/00 , C07H21/04 , C12N9/64 , C12Q1/68
CPC分类号： C12N9/6421 , A01K2217/05 , A61K38/00 , C07H21/04 , C12N9/64
摘要： The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.
摘要翻译：本发明提供了鉴定和编码PMMM的人蛋白质修饰和维持分子（PMMM）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与PMMM的异常表达相关的紊乱的方法。

52. 发明申请

US20050069876A1 Secreted proteins 审中-公开
标题翻译：分泌蛋白
公开(公告)号：US20050069876A1
公开(公告)日：2005-03-31
申请号：US10473519
申请日：2002-03-29
申请人： Mariah Baughn , Neil Burford , Li Ding , Brendan Duggan , Vicki Elliott , Ian Forsythe , Ameena Gandhi , Kimberly Gietzen , Jennifer Griffin , Ann He , Cynthia Honchell , Craig Ison , Preeti Lal , Ernestine Lee , Sally Lee , Dyung Alina Lu , Patricia Mason , Madhusudan Sanjanwala , Anita Swarnakar , Jayalaxmi Ramkumar , Y Tom Tang , Kavitha Thangavelu , Uyen Tran , Narinder Chawla , Bridget Warren , Monique Yao , Yuming Xu , Henry Yue
发明人： Mariah Baughn , Neil Burford , Li Ding , Brendan Duggan , Vicki Elliott , Ian Forsythe , Ameena Gandhi , Kimberly Gietzen , Jennifer Griffin , Ann He , Cynthia Honchell , Craig Ison , Preeti Lal , Ernestine Lee , Sally Lee , Dyung Alina Lu , Patricia Mason , Madhusudan Sanjanwala , Anita Swarnakar , Jayalaxmi Ramkumar , Y Tom Tang , Kavitha Thangavelu , Uyen Tran , Narinder Chawla , Bridget Warren , Monique Yao , Yuming Xu , Henry Yue
IPC分类号： G01N33/50 , A01K67/00 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/16 , A61P7/00 , A61P7/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/04 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/00 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/08 , C07H21/04 , C07K14/47 , C07K16/18 , C07K16/46 , C07K19/00 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译：本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。

53. 发明授权

US06319507B1 Agar gel bead composition and method 失效
标题翻译：琼脂凝胶珠组成及方法
公开(公告)号：US06319507B1
公开(公告)日：2001-11-20
申请号：US09431742
申请日：1999-11-01
申请人： Pascal E. Delrieu , Li Ding
发明人： Pascal E. Delrieu , Li Ding
IPC分类号： A61K914
CPC分类号： A61K8/042 , A61K8/025 , A61K8/11 , A61K8/365 , A61K8/645 , A61K8/676 , A61K8/73 , A61K8/731 , A61K8/735 , A61K2800/56 , A61Q19/00 , Y10S514/937 , Y10S514/944
摘要： Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.
摘要翻译：由琼脂复合物形成的可破碎的凝胶珠10提供用于局部递送生物或化妆活性剂的新型化妆品，药物等输送载体。优选的琼脂珠10是具有抑制性聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。包埋并随机分散在每个琼脂珠10中是水溶性的，优选极性的，约束聚合物14，优选季铵化阳离子聚合物，例如聚季铵盐24或羟乙基纤维素。各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸或木瓜蛋白酶。还描述了制造方法。

54. 发明授权

US06255095B1 Human diacylglycerol kinase iota 有权
标题翻译：人二酰甘油激酶
公开(公告)号：US06255095B1
公开(公告)日：2001-07-03
申请号：US09412545
申请日：1999-10-05
申请人： Stephen M. Prescott , Li Ding , Elie Traer
发明人： Stephen M. Prescott , Li Ding , Elie Traer
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： Diacylglycerol (DAG) plays a central role in both the synthesis of complex lipids and in intracellular signaling; diacylglycerol kinase (DGK) catalyzes the phosphorylation of DAG, which yields phosphatidic acid. A family of DGKs has been identified in multicellular organisms over the past few years, but the physiological function(s) of this diversity is not clear. One clue has come from the Drosophila DGK2, rdgA, since mutations in this gene cause retinal degeneration. The present invention relates to a novel DGK, designated DGK&igr;, which was isolated from human retina and brain libraries. DGK&igr; contains two cysteine-rich repeats, a region similar to the phosphorylation site domain of MARCKS, a conserved catalytic domain, and four ankyrin repeats at its C-terminus. By primary structure, DGK&igr; is most similar to human DGK&zgr; and Drosophila rdgA. A>12 kb mRNA for DGK&igr; was detected only in brain and retina among the tissues examined. In cells transfected with the DGK&igr; cDNA, an approximately 130 kDa protein was detected by immunoassay, and activity assays demonstrated that it encodes a functional DAG kinase. The protein was found to be in both the cytoplasm and nucleus, with this localization controlled by PKC isoforms &agr; and &ggr;. The gene encoding DGK&igr; was localized to human chromosome 7q32.3-33, which is known to be a locus for an inherited form of retinitis pigmentosa. These results have defined a novel isoform of DAG kinase, which may have important cellular functions in the retina and brain.
摘要翻译：二酰基甘油（DAG）在复合脂质的合成和细胞内信号传导中起重要作用; 二酰基甘油激酶（DGK）催化DAG的磷酸化，其产生磷脂酸。过去几年，DGKs家族已被鉴定为多细胞生物，但这种多样性的生理功能尚不清楚。一个线索来自果蝇DGK2，rdgA，因为该基因的突变导致视网膜变性。本发明涉及一种从人视网膜和脑文库中分离得到的一种称为DGK和igr的新型DGK。 DGK＆igr 含有两个富含半胱氨酸的重复序列，一个与MARCKS的磷酸化位点结构域相似的区域，一个保守的催化结构域，在其C-末端有四个锚蛋白重复序列。通过主要结构，DGK＆igr; 最类似于人类DGK＆zgr; 和果蝇rdgA。 A> 12 kb的mRNA用于DGK和igr; 在所检查的组织中仅在脑和视网膜中检测到。在用DGK和igr转染的细胞中 cDNA通过免疫测定检测到约130kDa的蛋白质，活性测定证明它编码功能性DAG激酶。发现蛋白质在细胞质和细胞核两者中，其定位受PKC同种型α和γ的控制。编码DGK和igr的基因被定位于人染色体7q32.3-33，其被认为是色素性视网膜炎的遗传形式的基因座。这些结果定义了DAG激酶的新型同工型，其可能在视网膜和脑中具有重要的细胞功能。

55. 发明授权

US6013284A Synthetic particulate vectors and preparation process 失效
标题翻译：合成颗粒载体及其制备方法
公开(公告)号：US6013284A
公开(公告)日：2000-01-11
申请号：US513853
申请日：1996-05-01
申请人： Daniel Samain , Pascal Delrieu , Joelle Gibilaro , Roselyne Dirson , Monique Cervilla , Ignacio De Miguel , Li Ding , Frederique Nguyen , Nadine Soulet , Corinne Soler
发明人： Daniel Samain , Pascal Delrieu , Joelle Gibilaro , Roselyne Dirson , Monique Cervilla , Ignacio De Miguel , Li Ding , Frederique Nguyen , Nadine Soulet , Corinne Soler
IPC分类号： A23L27/00 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/36 , A61K8/42 , A61K8/64 , A61K8/66 , A61K8/68 , A61K8/73 , A61K8/92 , A61K8/97 , A61K8/99 , A61K9/16 , A61K9/50 , A61K9/51 , A61Q19/00 , A61Q90/00
CPC分类号： A61K9/5123 , A23L27/70 , A23L27/72 , A61K8/11 , A61K8/14 , A61K8/66 , A61K8/97 , A61K9/1652 , A61K9/5015 , A61K9/5161 , A61Q19/00 , B82Y5/00 , A61K2800/412 , A61K2800/413 , Y10S514/951 , Y10S514/952 , Y10T428/2991
摘要： A synthetic particulate vector comprising a non-liquid hydrophilic nucleus and an outer layer at least partially consisting of amphiphilic compounds, which is combined with the nucleus by hydrophobic interactions and/or ionic bonds. A process for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtained according to such a process, and pharmaceutical, cosmeticological and food compositions comprising such vectors are also disclosed.
摘要翻译： PCT No.PCT / FR94 / 00228 Sec。 371日期：1996年5月1日 102（e）日期1996年5月1日PCT 1994年3月1日PCT公布。 WO94 / 20078 PCT公开号日期1994年9月15日一种包含非液体亲水核和至少部分由两亲化合物组成的外层的合成颗粒载体，其通过疏水相互作用和/或离子键与核结合。还公开了通过包封可离子化活性成分，根据这种方法获得的载体以及包含这种载体的药物，美容和食用组合物来制备颗粒载体的方法。

56. 发明授权

US09105456B2 Tandem mass spectrum analysis device and mass spectrum analysis method 有权
标题翻译：串联质谱分析装置和质谱分析方法
公开(公告)号：US09105456B2
公开(公告)日：2015-08-11
申请号：US13576294
申请日：2011-01-26
申请人： Gongyu Jiang , Hui Mu , Li Ding
发明人： Gongyu Jiang , Hui Mu , Li Ding
IPC分类号： H01J49/06 , H01J49/00 , H01J49/42 , G01N30/72
CPC分类号： H01J49/063 , G01N30/7206 , H01J49/004 , H01J49/062 , H01J49/4215 , H01J49/4225
摘要： A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.
摘要翻译：在本发明中提供串联质谱仪。质谱仪包括离子源，位于离子源下游侧的四极质量过滤器，设置在质量过滤器下游侧的线性离子阱和置于离子阱侧面的离子检测器置于真空环境中。仪器可以通过与线性离子阱配合的四极质谱仪获得满足标准光谱库检索标准的MS，实现轴向碰撞和共振激励两种模式下的任何多级MS，并预测和优化样品的流入量和类型在离子阱分析模式下由四极杆。还提供串联质谱分析方法，可重复提供前体离子选择，离子加速，实现高能碰撞解离，低离子质量鉴定效应。

57. 发明申请

US20140032184A1 PROCESS AND APPARATUS FOR GENERATING A THREE-DIMENSIONAL SWEPT ENVELOPE OF A VEHICLE 有权
标题翻译：用于产生车辆三维开关的过程和装置
公开(公告)号：US20140032184A1
公开(公告)日：2014-01-30
申请号：US14110703
申请日：2012-04-05
申请人： Milton Santano Elias Carrasco , Daniel Akwera Shihundu , Billy Siu Fai Chan , Steven Kin-Shing Cheng , Christian Grant Milne , Guanggui Pei , Darren Earl Brown , Li Ding
发明人： Milton Santano Elias Carrasco , Daniel Akwera Shihundu , Billy Siu Fai Chan , Steven Kin-Shing Cheng , Christian Grant Milne , Guanggui Pei , Darren Earl Brown , Li Ding
IPC分类号： G06F17/50
CPC分类号： G06F17/5009 , G06F17/5095
摘要： A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.
摘要翻译：公开了一种用于产生具有可操作以支撑车身沿着地形运动的轮式底盘的车辆的三维扫掠包络的计算机表示的方法，装置，介质和信号。该方法包括接收表示3D地形的地形数据，接收定义车辆参数的数据，以及接收定义用于使车辆从地形上的初始位置移动到地形上的位移位置的路径的数据。该方法还涉及使用参数在路径的连续位置处将车辆的计算机表示设置在地形的3D表示上。处置涉及确定轮式底盘的车轮与地形的3D表示之间的接合点，以相对于地形布置底盘，以及相对于地形确定车体的对应3D位置。该方法还包括在连续位置处产生车辆的多个空间范围，当在初始位置和位移位置之间移动时，空间范围限定车辆的3D扫描包络线。在另一方面，公开了一种用于生成沿着相对于地形的3D表示布置的导轨移动的物体的三维扫描包络的计算机表示的方法。

58. 发明授权

US08507848B1 Wire electrode based ion guide device 有权
标题翻译：线电极离子导向装置
公开(公告)号：US08507848B1
公开(公告)日：2013-08-13
申请号：US13357470
申请日：2012-01-24
申请人： Li Ding , Gongyu Jiang , Wenjian Sun
发明人： Li Ding , Gongyu Jiang , Wenjian Sun
IPC分类号： H01J49/42 , H01J49/34 , H01J49/04
CPC分类号： H01J49/065 , H01J49/066
摘要： This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.
摘要翻译：本发明提供了一种离子导向装置，其包括在空间上交叉的多层拉伸线电极。这些线电极沿离子导向装置中限定的离子引导轴分布。每层线电极包含至少两根与引导轴距离一定距离的线电极，并相对于相邻层上的线电极以一定角度旋转。离子导向器包含多层线电极以形成笼状离子导向通道，并将这些线电极的安装框架保持在离子引导通道外部，从而减少离子导向装置的气流的干扰。电源为每层线电极提供电压，产生将离子聚焦到引导轴的电场。

59. 发明授权

US08478573B2 Modeling circuit cells for waveform propagation 有权
标题翻译：建模用于波形传播的电路单元
公开(公告)号：US08478573B2
公开(公告)日：2013-07-02
申请号：US11166659
申请日：2005-06-23
申请人： Li Ding , Peivand Fallah-Tehrani , Alireza Kasnavi
发明人： Li Ding , Peivand Fallah-Tehrani , Alireza Kasnavi
IPC分类号： G06F17/50
CPC分类号： G06F17/5031
摘要： A model for a circuit cell used in timing and signal integrity analysis in an integrated circuit design is automatically generated. A behavioral model, such as a gate current model is used in which the current in the circuit cell is determined as a function of the input voltage and the output voltage of the circuit cell as well as the history of at least one of the current, voltage, and charge values of the circuit cell. For example, the current in the circuit cell may be a function of the history of the current, which may be calculated incrementally using recursive convolution at each time step when using the model.
摘要翻译：自动生成用于集成电路设计中的时序和信号完整性分析的电路单元的模型。使用诸如栅极电流模型的行为模型，其中电路单元中的电流被确定为电路单元的输入电压和输出电压的函数以及电流单元中的至少一个的历史，电压和电荷值。例如，电路单元中的电流可以是电流的历史的函数，其可以在使用该模型时在每个时间步长处使用递归卷积来逐渐计算。

60. 发明授权

US08384025B2 Device for separating, enriching and detecting ions 有权
标题翻译：用于分离，富集和检测离子的装置
公开(公告)号：US08384025B2
公开(公告)日：2013-02-26
申请号：US13130254
申请日：2009-11-26
申请人： Wenjian Sun , Li Ding
发明人： Wenjian Sun , Li Ding
IPC分类号： H01J49/26 , H01J49/42 , H01J49/10
CPC分类号： G01N27/622 , G01N15/0266
摘要： A device for separating, enriching and detecting ions comprises: a gas tube, in which a carrier gas flows at a uniform rate; an ion source; multiple electrodes provided in the gas tube and applied with electric voltages respectively, so that at least an electric field is produced along the axis of the gas tube; an ion detector; and an ion extraction channel, by which specific enriched ions will be guided across the side wall of the gas tube toward the ion detector and be analyzed. The device enriches ions utilizing the following characteristic: compound ions with specific ion mobility maintain a dynamic balance for a period of time in a flow field under the combination of a carrier gas and a suitable electrical field against the direction of the carrier gas. Simultaneously, multiple compound particles with different ion motilities can be separated and enriched at positions with different electrical field intensities in a flow field in the same manner. The device also comprises synchronously export latitudinally enriched ions at different positions in a flow field, and performs later mass analysis using a mass spectrometer.
摘要翻译：用于分离，富集和检测离子的装置包括：气体管，其中载气以均匀的速率流动; 离子源; 设置在气体管中并分别施加电压的多个电极，使得沿着气体管的轴线产生至少一个电场; 离子检测器和离子提取通道，通过该离子提取通道将特定的富集离子引导穿过气体管的侧壁朝离子检测器进行分析。该装置利用以下特征丰富离子：具有特定离子迁移率的复合离子在载气和合适的电场相对于载气方向的组合下在流场中保持动态平衡一段时间。同时，具有不同离子运动的多种化合物颗粒可以以相同的方式在流场中分离富集在具有不同电场强度的位置。该装置还包括在流场中同步输出纬向富集的离子，并使用质谱仪进行质量分析。

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