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51. 发明申请

US20090227902A1 GUIDE WIRE WITH CORE HAVING WELDED WIRE SEGMENTS 有权
标题翻译：带有焊接线段的芯线指导线
公开(公告)号：US20090227902A1
公开(公告)日：2009-09-10
申请号：US12405971
申请日：2009-03-17
申请人： John A. Simpson , Michael Plattner , Frank Manning , Ryan Grandfield , Wayne E. Cornish
发明人： John A. Simpson , Michael Plattner , Frank Manning , Ryan Grandfield , Wayne E. Cornish
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61M25/0009 , A61M2025/09083 , A61M2025/09108 , A61M2025/09133 , A61M2025/09141 , B23K11/02 , B23K15/0046 , B23K20/129 , B23K26/26 , B23K26/282 , Y10T29/49826
摘要： An intravascular guide wire having two core materials joined together without the use of a connector tube or sleeve, the core materials being stainless steel and psuedoelastic metal alloy, nitinol. The core materials are joined to each other through an intermediate transition piece made essentially of nickel, which is welded on either side to the two core materials. In a multi-segment intravascular guide wire, discrete, high modulus and medium modulus core portions of different materials are welded to a shapeable, low modulus distal core portion made of a third material having a flattened, shapeable section at a most distal end that is not welded to but made from the distal core portion, so the flattened, shapeable section can be deformed to create a steerable tip. Processes such as simultaneous resistance and friction welding can be used to join the core portions.
摘要翻译：一种血管内导丝，其两芯结合在一起，而不使用连接管或套筒，芯材为不锈钢和伪弹性金属合金，镍钛诺。核心材料通过基本上由镍制成的中间过渡件相互连接，该中间过渡件在两侧焊接到两个芯材上。在多段血管内引导线中，将不同材料的离散，高模量和中等模量和中等模量的芯部分焊接到由第三材料制成的可成形的低模量的远端芯部分，该第三材料在最远端具有扁平的，可成形的截面，未被焊接到远端芯部制成，因此可以使扁平的可成形部分变形以产生可转向的尖端。可以使用诸如同时电阻和摩擦焊接的工艺来连接芯部。

52. 发明授权

US06494891B1 Ultrasonic angioplasty transmission member 有权
标题翻译：超声波血管成形术传播部件
公开(公告)号：US06494891B1
公开(公告)日：2002-12-17
申请号：US09474953
申请日：1999-12-30
申请人： Wayne E. Cornish , Robert C. Esselstein , Sepehr Fariabi , Henry Nita
发明人： Wayne E. Cornish , Robert C. Esselstein , Sepehr Fariabi , Henry Nita
IPC分类号： A61B1732
CPC分类号： A61B17/22012 , A61B2017/22015 , A61B2017/22018
摘要： The ultrasonic angioplasty transmission wire has regions of reduced cross-sectional diameter to improve flexibility of the ultrasonic angioplasty transmission wire and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the ultrasonic angioplasty transmission wire. One or more constraining members are disposed on the ultrasonic angioplasty transmission wire at one or more of the regions of reduced cross-sectional diameter where transverse vibration of ultrasonic energy transmitted by the ultrasound transmission wire is amplified, to constrain transverse vibration at these areas to reduce stress and reduce fracturing, while allowing longitudinal movement. The transmission wire has an elongated shaft including, in atomic percent, from about 28 to about 52 percent nickel, from about 48 to about 52 percent titanium, and up to about 20 percent of at least one alloying element selected from the group consisting of palladium, chromium, and hafnium.
摘要翻译：超声波血管成形术传输线具有减小的横截面直径的区域，以改善超声波血管成形术传输线的柔性，并且补偿由于沿着超声波血管成形术传输线的长度的声学损失引起的纵向位移的退化。一个或多个约束构件设置在超声波血管成形术传输线上的一个或多个减小横截面直径的区域中，其中由超声波传输线传输的超声能量的横向振动被放大，以限制这些区域的横向振动，以减少应力和减少压裂，同时允许纵向移动。传输线具有细长轴，原子百分比包括约28至约52％的镍，约48至约52％的钛，以及至多一种选自钯的至少一种合金元素的至多约20％，铬和铪。

53. 发明授权

US06494847B1 Guide wire with multiple polymer jackets over distal and intermediate core sections 有权
标题翻译：导丝与多个聚合物外套在远端和中间芯部分之间
公开(公告)号：US06494847B1
公开(公告)日：2002-12-17
申请号：US09796777
申请日：2001-02-28
申请人： Mark Richardson , Emmanuel C. Biagtan , Wayne E. Cornish
发明人： Mark Richardson , Emmanuel C. Biagtan , Wayne E. Cornish
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133
摘要： The invention is directed to a guide wire having at least two different polymeric jackets that impart different handling characteristics to the portions of the guide wire they surround. Preferably, the guide wire may have jackets of different grades of polymer, such as polyurethane 55D and 90A. Alternatively, the guide wire may have jackets of different types of polymers such as polyurethane and polytetrafluoroethylene, or may have a single polymeric jacket with continuously varying properties along its length. The invention also comprises methods of making such guide wires.
摘要翻译：本发明涉及一种导丝，其具有至少两种不同的聚合物夹克，其赋予它们围绕的导丝的部分不同的处理特性。优选地，导丝可以具有不同等级的聚合物的夹克，例如聚氨酯55D和90A。或者，导丝可以具有不同类型聚合物的夹克，例如聚氨酯和聚四氟乙烯，或者可以具有沿其长度连续变化的特性的单一聚合物护套。本发明还包括制造这种导丝的方法。

54. 发明授权

US08613712B1 Textured polymer coated guide wire and method of manufacture 有权
标题翻译：纹理聚合物涂层导丝及其制造方法
公开(公告)号：US08613712B1
公开(公告)日：2013-12-24
申请号：US10664004
申请日：2003-09-16
申请人： David H. Burkett , Kevin Britton , Ryan Grandfield , Peter J. D'Aquanni , David Wrolstad , Edwin P. Mahieu , Wayne E. Cornish , Mark T. Richardson
发明人： David H. Burkett , Kevin Britton , Ryan Grandfield , Peter J. D'Aquanni , David Wrolstad , Edwin P. Mahieu , Wayne E. Cornish , Mark T. Richardson
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61B17/12145 , A61F2/95 , A61F2/958 , A61M25/0043 , A61M2025/006 , A61M2025/0062 , A61M2025/09108 , A61M2025/09133 , B29C47/0014 , B29C47/003 , B29C47/026
摘要： A guide wire for advancing a medical device such as a catheter through a patient's body lumen which has an elongated core with proximal and distal core section, a flexible tubular member such as a coil on the distal end. The wire core includes surface textures that are translated into the overlying coating. Alternatively, the coating has its own surface texture. The surface textures include randomly or non-randomly spaced bumps, divots, ridges, helical grooves, longitudinal grooves, undulations, etc.
摘要翻译：一种用于使诸如导管的医疗装置通过患者体腔前进的导丝，所述导管具有具有近端和远侧芯部的细长芯，在远端上具有诸如线圈的柔性管状构件。线芯包括被翻译成上覆涂层的表面纹理。或者，涂层具有其自己的表面纹理。表面纹理包括随机或非随机间隔的凸块，凸纹，凸脊，螺旋槽，纵向凹槽，起伏等。

55. 发明授权

US08500658B2 Nickel-titanium core guide wire 有权
标题翻译：镍钛芯导丝
公开(公告)号：US08500658B2
公开(公告)日：2013-08-06
申请号：US12914049
申请日：2010-10-28
申请人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
发明人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09175 , Y10T29/49986 , Y10T29/5187
摘要： A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.
摘要翻译：一种用于医疗过程的导丝，其具有与引导线的超弹性镍钛诺远端部分的远端一体并由远端制成的可成形尖端，其中可成形尖端可以被扭曲。这种导丝包括在远端由超弹性镍钛诺合金制成的细长芯，细长芯的远端具有通向可成形的远端的锥形部分。可成形尖端是镍钛诺骨远端部分的远端的延伸部，并且包括从至少两个不同径向方向的永久性应变硬化，其赋予径向方向上的结晶学结构，从而消除超弹性，从而可以用手指压力实现永久变形。

56. 发明申请

US20120109108A1 NICKEL-TITANIUM CORE GUIDE WIRE 有权
标题翻译：镍铁芯指导线
公开(公告)号：US20120109108A1
公开(公告)日：2012-05-03
申请号：US12914049
申请日：2010-10-28
申请人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
发明人： William J. Boyle , Wayne E. Cornish , Raleigh A. Purtzer
IPC分类号： A61M25/09 , B21C1/00 , B23P17/00
CPC分类号： A61M25/09 , A61M2025/09175 , Y10T29/49986 , Y10T29/5187
摘要： A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.
摘要翻译：一种用于医疗过程的导丝，其具有与引导线的超弹性镍钛诺远端部分的远端一体并由远端制成的可成形尖端，其中可成形尖端可以被扭曲。这种导丝包括在远端由超弹性镍钛诺合金制成的细长芯，细长芯的远端具有通向可成形的远端的锥形部分。可成形尖端是镍钛诺骨远端部分的远端的延伸部，并且包括从至少两个不同径向方向的永久性应变硬化，其赋予径向方向上的结晶学结构，从而消除超弹性，从而可以用手指压力实现永久变形。

57. 发明授权

US07815660B2 Guide wire with embolic filtering attachment 有权
标题翻译：导丝与栓塞过滤附件
公开(公告)号：US07815660B2
公开(公告)日：2010-10-19
申请号：US12025404
申请日：2008-02-04
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

58. 发明申请

US20090131971A1 GUIDE WIRE WITH EMBOLIC FILTERING ATTACHMENT 有权
标题翻译：导线与导线连接
公开(公告)号：US20090131971A1
公开(公告)日：2009-05-21
申请号：US12025404
申请日：2008-02-04
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

59. 发明申请

US20090131913A1 COMPOSITE GUIDE WIRE WITH DRAWN AND FILLED TUBE CONSTRUCTION 有权
标题翻译：复合导线与抽屉和填充管道结构
公开(公告)号：US20090131913A1
公开(公告)日：2009-05-21
申请号：US12046183
申请日：2008-03-11
申请人： Ryan Grandfield , Mark T. Richardson , Peter D'Aquanni , Wayne E. Cornish , Jonathan M. Howland
发明人： Ryan Grandfield , Mark T. Richardson , Peter D'Aquanni , Wayne E. Cornish , Jonathan M. Howland
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/09175
摘要： The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.
摘要翻译：本发明涉及体内装置，优选导丝，以及制造该装置的方法。本发明的导丝至少部分地形成有至少部分由沉淀硬化材料形成的复合细长芯。对于由超弹性NITINOL单独形成的相同尺寸的细长构件，本发明的细长芯构件将具有大于相同尺寸的极限拉伸强度和弹性模量。

60. 发明授权

US06524301B1 Guidewire with an intermediate variable stiffness section 有权
标题翻译：导丝具有中间可变刚度部分
公开(公告)号：US06524301B1
公开(公告)日：2003-02-25
申请号：US09748294
申请日：2000-12-21
申请人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
发明人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133
摘要： The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a “nodding” motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.
摘要翻译：本发明涉及一种用于在患者体内腔内部署医疗装置的导丝，所述导丝具有细长的芯部件，所述细长的芯部件具有中间的芯部分，所述中间纤芯部分包括与所述芯部件的纵向轴线对准的多个连续部分，柔性和刚性的芯段，使得铰接部分在通过患者体内的弯曲血管或其他体腔前进时以不连续的离散方式弯曲。当血管壁上的阻塞物导致导管或其它同轴装置被阻碍时，引导线和中间芯部分可以交替地前进并缩回穿过导管远端的短距离，导致导管末端的“点头”运动，同时导管被推过血管，以避免和绕过血管阻塞。

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