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    • 53. 发明申请
    • PERFLUOROELASTOMER COMPOSITIONS AND METHODS OF PREPARING SAME
    • 全氟聚合物组合物及其制备方法
    • US20110086229A1
    • 2011-04-14
    • US12969463
    • 2010-12-15
    • Tsuyoshi NoguchiJiazhong LuoTatsuya MorikawaHirokazu KomoriTakafumi YamatoMeiten Koh
    • Tsuyoshi NoguchiJiazhong LuoTatsuya MorikawaHirokazu KomoriTakafumi YamatoMeiten Koh
    • C08L27/22C08L27/18B32B15/08
    • C08L27/18C08K5/18C08L2205/02Y10T428/3154C08L2666/04
    • The present invention includes crosslinked perfluoroelastomeric compositions and molded articles formed from a cross-linkable perfluoroelastomeric composition having a first curable perfluoropolymer having a cure site monomer and a second perfluoropolymer having a cure site monomer. The molar ratio of the tetrafluoroethylene monomer to perfluoroalkylvinyl ether in one perfluoropolymer is about 0 to 100 to about 65 to 35 in the perfluoropolymer. The molar ratio of the tetrafluoroethylene monomer to the perfluoroalkylvinyl ether monomer in the second polymer is about 65:35 to about 95:5 in the second perfluoropolymer. The composition further includes a curative. One fluorine-containing elastomer composition herein, having a short crosslinking time, has perfluoroelastomers (A) having a tetrafluoroethylene unit, a perfluoralkylvinyl ether unit (a) and a monomer unit (b) having at least one kind selected from the group consisting of a nitrile group, a carboxyl group and an alkoxycarbonyl group, wherein the composition has two or more kinds of perfluoroelastomers (A) having differing contents of perfluoroalkylvinyl ether unit (a).
    • 本发明包括交联的全氟弹性体组合物和由可交联的全氟弹性体组合物形成的模塑制品,其具有具有固化部位单体的第一可固化全氟聚合物和具有固化部位单体的第二全氟聚合物。 全氟聚合物中四氟乙烯单体与全氟烷基乙烯基醚的摩尔比在全氟聚合物中为约0至约100至约65至35。 第二聚合物中四氟乙烯单体与全氟烷基乙烯基醚单体的摩尔比在第二全氟聚合物中为约65:35至约95:5。 组合物还包括治疗剂。 具有交联时间短的一种含氟弹性体组合物具有全氟弹性体(A),其具有四氟乙烯单元,全氟烷基乙烯基醚单元(a)和单体单元(b),所述单体单元具有选自以下的至少一种: 腈基,羧基和烷氧基羰基,其中所述组合物具有两种或更多种具有不同全氟烷基乙烯基醚单元(a)含量的全氟弹性体(A)。
    • 59. 发明授权
    • Dust-free rubber mixer
    • 无尘橡胶搅拌机
    • US06527429B1
    • 2003-03-04
    • US09890062
    • 2001-07-26
    • Hiroyuki TanakaTsuyoshi Noguchi
    • Hiroyuki TanakaTsuyoshi Noguchi
    • B29B786
    • B29B7/7495B29B7/52
    • To provide a dust-free rubber mixer which does not release contaminants such as dusts generated in the rubber mixer into a working room. In the dust-free rubber mixer comprising a rubber mixing section having a plurality of rubber mixing rolls and a driving section having a motor, the whole parts of the rubber mixer except the rubber mixing rolls are covered with a casing, air intakes are provided on the casing in a periphery of rotation shafts of the rubber mixing rolls, an exhaust duct is provided on the casing and air suction means for making the inside pressure of the casing reduced is provided on the exhaust duct.
    • 提供一种不会将橡胶混合器中产生的灰尘等污染物排放到工作室的无尘橡胶混合器。 在包括具有多个橡胶混合辊的橡胶混合部分和具有马达的驱动部分的无尘橡胶混合机中,除了橡胶混合辊之外的橡胶混合器的整个部分被壳体覆盖,进气口设置在 橡胶混合辊的旋转轴周围的壳体,在壳体上设置有排气管道,并且在排气管道上设置用于使壳体内部压力降低的空气抽吸装置。
    • 60. 发明授权
    • Indoloylguanidine derivatives
    • 吲哚酰胍衍生物
    • US06169107A
    • 2001-01-02
    • US08544292
    • 1995-10-17
    • Masahumi KitanoKazuhiro NakanoHideki YagiNaohito OhashiAtsuyuki KojimaTsuyoshi NoguchiAkira Miyagishi
    • Masahumi KitanoKazuhiro NakanoHideki YagiNaohito OhashiAtsuyuki KojimaTsuyoshi NoguchiAkira Miyagishi
    • A61K31404
    • C07D209/08C07D209/42
    • Novel indoloylguanidine derivatives shown by formula (1), wherein R1 represents one or more, the same or different substituent(s) which is selected from the group consisting of a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a halogen atom, nitro group, an acyl group, carboxyl group, an alkoxycarbonyl group, an aromatic group, and a group shown by formula: —OR3, —NR6R7, —SO2NR6R7 or —S(O)nR40; and R2 represents a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group, hydroxy group, an alkoxy group or a group shown by formula: —CH2R20; and which inhibit the Na+/H+ exchanger activity and are useful for the treatment and prevention of a disease caused by increased Na+/H+ exchanger activity, such as hypertension, arrhythmia, angina pectoris, cardiac hypertrophy, diabetes, disorders associated with ischemia or ischemic reperfusion, cerebro-ischemic disorders; or diseases caused by excessive cell proliferation.
    • 式(1)所示的新型吲哚酰基胍衍生物,其中R1表示一个或多个选自氢原子,烷基,取代的烷基,烯基, 炔基,环烷基,卤素原子,硝基,酰基,羧基,烷氧基羰基,芳香族基团和由下式表示的基团:-OR3,-NR6R7,-SO2NR6R7或-S(O )nR40; R2表示氢原子,烷基,取代的烷基,环烷基,羟基,烷氧基或由式-CH2R20表示的基团; 并且其抑制Na + / H +交换活性,并且可用于治疗和预防由升高的Na + / H +交换活性引起的疾病,例如高血压,心律失常,心绞痛,心脏肥大,糖尿病,与缺血或缺血再灌注相关的疾病 ,脑缺血障碍; 或由过度细胞增殖引起的疾病。