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51. 发明授权

US08283443B2 Method for purifying protein 失效
标题翻译：蛋白质纯化方法
公开(公告)号：US08283443B2
公开(公告)日：2012-10-09
申请号：US12500526
申请日：2009-07-09
申请人： Akio Kuroda , Takeshi Ikeda
发明人： Akio Kuroda , Takeshi Ikeda
IPC分类号： C07K1/22
CPC分类号： C07K1/14 , C07K1/22
摘要： The present invention provides a method for purifying a protein, includes the step of: contacting a fusion protein of a first protein and a second protein with a bivalent cation-containing solution, the fusion protein being adsorbed to a silicon oxide-containing substance, the first protein being capable of binding to the silicon oxide-containing substance in a solution containing 0.1M sodium chloride. With this arrangement, it is possible to easily produce large quantity of proteins which are high in purity without sacrificing activity of the proteins.
摘要翻译：本发明提供一种纯化蛋白质的方法，包括以下步骤：将第一蛋白质和第二蛋白质的融合蛋白质与二价阳离子溶液接触，所述融合蛋白质被吸附到含氧化硅的物质上，第一种蛋白质能够在含有0.1M氯化钠的溶液中与含氧化硅物质结合。通过这种布置，可以容易地产生大量纯度高且不牺牲蛋白质活性的蛋白质。

52. 发明申请

US20110207729A1 BICYCLIC ACYLGUANIDINE DERIVATIVE 审中-公开
标题翻译：双酚ACYLGUANIDINE DERIVATIVE
公开(公告)号：US20110207729A1
公开(公告)日：2011-08-25
申请号：US12672277
申请日：2008-08-07
申请人： Isao Kinoyama , Satoshi Miyamoto , Takehiro Miyazaki , Yohei Koganemaru , Yuichiro Kawamoto , Nobuyuki Shiraishi , Hiroaki Hoshii , Akio Kuroda , Mayako Yamazaki , Minoru Yasuda , Hiroaki Mizuno
发明人： Isao Kinoyama , Satoshi Miyamoto , Takehiro Miyazaki , Yohei Koganemaru , Yuichiro Kawamoto , Nobuyuki Shiraishi , Hiroaki Hoshii , Akio Kuroda , Mayako Yamazaki , Minoru Yasuda , Hiroaki Mizuno
IPC分类号： A61K31/5377 , C07D311/04 , C07D405/12 , C07D413/12 , C07D311/96 , C07D405/04 , C07D407/10 , A61K31/352 , A61K31/4155 , A61K31/496 , A61K31/4433 , A61K31/357 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D295/12 , C07C279/22 , C07C317/44 , C07C2601/02 , C07C2602/10 , C07C2602/12 , C07D213/56 , C07D213/61 , C07D213/64 , C07D215/12 , C07D231/12 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/30 , C07D295/155 , C07D307/52 , C07D307/54 , C07D309/04 , C07D311/04 , C07D311/58 , C07D313/08 , C07D319/18 , C07D333/24 , C07D333/54 , C07D333/56 , C07D335/06 , C07D405/04 , C07D407/04 , C07D409/04 , C07D471/04
摘要： An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia, and the like, based on the serotonin 5-HT5A receptor modulating action.It was confirmed that a bicyclic acylguanidine derivative which has a characteristic structure that guanidine is bonded to one ring of a bicyclic structure such as chromene and dihydronaphthalene through a carbonyl group and a cyclic group is bonded on the other ring, has a potent 5-HT5A receptor modulating action and an excellent pharmacological action based on this mechanism. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder.
摘要翻译：本发明的目的是提供一种用于治疗或预防基于5-羟色胺5-HT5A受体调节作用的痴呆，精神分裂症等的新颖且优异的药剂。证实具有特征性结构的双环酰基胍衍生物具有有效的5-HT5A（其具有通过羰基和环状基团键合在一个双环结构的环上，如色烯和二氢萘结合在另一个环上）受体调节作用和基于该机制的优异的药理作用。本发明可用作治疗或预防痴呆，精神分裂症，双相情感障碍或注意缺陷多动障碍的优良药剂。

53. 发明申请

US20110152268A1 NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN 审中-公开
标题翻译：用于治疗疼痛的新型药物组合物
公开(公告)号：US20110152268A1
公开(公告)日：2011-06-23
申请号：US13061219
申请日：2009-09-10
申请人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
发明人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
IPC分类号： A61K31/5375 , C07D265/30 , A61P29/00
CPC分类号： C07D265/30 , A61K31/5375
摘要： The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
摘要翻译：本发明涉及用于治疗伤害性疼痛的药物组合物，其含有吗啉衍生物或其药学上可接受的盐作为活性成分。本发明可用于提供用于治疗伤害性疼痛的优异药物组合物。此外，本发明特别可用于提供用于治疗伴随选自以下的疾病的药物组合物：选自类风湿性关节炎，类风湿性脊椎炎，骨关节炎，变形性椎关节强硬症，痛风性关节炎，幼年型关节炎，肩周炎性关节炎和子宫颈综合征，腰痛，腰痛伴椎关节僵硬，麻痹症，炎症，手术或损伤后疼痛，咽后切除术后的疼痛，以及癌症疼痛。此外，本发明特别可用于缓解软骨损伤区域的疼痛，特别适用于NSAIDs无效的骨关节炎。

54. 发明申请

US20110111441A1 METHOD AND KIT FOR MEASUREMENT OF ENDOTOXIN LEVEL 有权
标题翻译：用于测量内毒素含量的方法和试剂盒
公开(公告)号：US20110111441A1
公开(公告)日：2011-05-12
申请号：US12734485
申请日：2008-11-11
申请人： Akio Kuroda , Kenichi Noda
发明人： Akio Kuroda , Kenichi Noda
IPC分类号： C12Q1/66
CPC分类号： G01N21/763 , C12Q1/66 , G01N33/56911 , G01N33/579
摘要： The present invention provides a method comprising allowing a reaction of a sample, a reagent containing Factor C, which can be activated by binding with endotoxin, and a synthetic luminescent substrate comprising a luminescent substrate bound to a peptide, for release of the luminescent substrate from the synthetic luminescent substrate, allowing a luminescent enzyme to act on the luminescent substrate released in the luminescent substrate release step, for measurement of the luminescence intensity, and quantifying the level of endotoxin in the sample based on a measured value obtained in the luminescence measuring step, the method enabling endotoxin to be simply and quickly measured at a level that cannot be detected in conventional methods for endotoxin measurement, without use of any dedicated measuring device.
摘要翻译：本发明提供了一种方法，其包括使样品，可通过与内毒素结合而活化的因子C的试剂与包含与肽结合的发光底物的合成发光底物反应，从而将发光底物从所述合成发光基板允许发光酶作用于在所述发光底物释放步骤中释放的所述发光基板，用于测量所述发光强度，并且基于在所述发光测量步骤中获得的测量值来定量所述样品中的内毒素水平，在不使用任何专用测量装置的情况下，能够以常规的内毒素测量方法无法检测的水平简单且快速地测量内毒素的方法。

55. 发明申请

US20100296898A1 Resin-Coated Metal Plate And Drawn Cans Using These Plates 有权
标题翻译：树脂涂层金属板和拉丝罐使用这些板
公开(公告)号：US20100296898A1
公开(公告)日：2010-11-25
申请号：US12847610
申请日：2010-07-30
申请人： Akio Kuroda , Takashi Iwai , Kazuhiro Sato
发明人： Akio Kuroda , Takashi Iwai , Kazuhiro Sato
IPC分类号： B21D51/26 , B05D3/02 , B05D5/00 , B05D1/36
CPC分类号： B32B15/08 , B32B1/02 , B32B7/02 , B32B15/09 , B32B15/18 , B32B15/20 , B32B27/08 , B32B27/28 , B32B27/308 , B32B27/36 , B32B2255/06 , B32B2255/26 , B32B2307/554 , B32B2307/704 , B32B2307/714 , B32B2439/66 , B32B2439/70 , B65D1/28 , Y10T428/1355 , Y10T428/31681 , Y10T428/31786
摘要： The present invention offers resin-coated metal plates and methods of making, in which the resin-coated metal plates prevent wicket scars from occurring during processes of varnish, print and dry, and there are few scars on the resin-coated surface, the inner surface side of the can and that have superior corrosion resistance and workability, and drawn cans using these metal plates. Therefore, resin film that is applied to the metal plates, is comprised of two layers of a crystallized saturated polyester resin layer [A] and a layer composed of resin [B] that is comprised of saturated polyester resin (i) and ionomer resin (ii), wherein the layer composed of resin [B] is laminated on the above-mentioned metal plate to tightly contact with it, and on the polar surface of the saturated polyester resin layer that is crystallized [A] a highly crystallized layer (X) is formed. A drawn can is formed using the resin-coated metal plate.
摘要翻译：本发明提供了树脂涂覆的金属板和制造方法，其中树脂涂覆的金属板防止在清漆，印刷和干燥过程中出现小网痕迹，并且在树脂涂覆表面上几乎没有疤痕罐的表面侧，具有优异的耐腐蚀性和可加工性，以及使用这些金属板的拉伸罐。因此，施加到金属板的树脂膜由两层结晶的饱和聚酯树脂层[A]和由饱和聚酯树脂（i）和离聚物树脂（i）构成的树脂[B]组成的层 ii），其中由树脂[B]组成的层层叠在上述金属板上以紧密接触，并且在结晶的饱和聚酯树脂层的极性表面上[A]高度结晶的层（X ）形成了。使用树脂涂覆的金属板形成拉伸罐。

56. 发明授权

US06262402B1 Method and apparatus for joining metal pieces using induction heating 失效
标题翻译：使用感应加热连接金属件的方法和装置
公开(公告)号：US06262402B1
公开(公告)日：2001-07-17
申请号：US09352164
申请日：1999-07-12
申请人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Toshiaki Amagasa , Nozomu Tamura , Takahiro Yamasaki , Masashi Osada , Hirosuke Yamada , Toshisada Takechi , Norio Takashima , Junzo Nitta , Shuji Amanuma , Kanji Hayashi , Akio Kuroda , Yoshiki Mito , Kunio Miyamoto , Kazuo Morimoto , Ikuo Wakamoto , Kazuya Tsurusaki , Hideo Sakamoto , Michio Hashimoto , Hiroyuki Nakano , Toshinobu Eguchi , Fumihiro Maeda
发明人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Toshiaki Amagasa , Nozomu Tamura , Takahiro Yamasaki , Masashi Osada , Hirosuke Yamada , Toshisada Takechi , Norio Takashima , Junzo Nitta , Shuji Amanuma , Kanji Hayashi , Akio Kuroda , Yoshiki Mito , Kunio Miyamoto , Kazuo Morimoto , Ikuo Wakamoto , Kazuya Tsurusaki , Hideo Sakamoto , Michio Hashimoto , Hiroyuki Nakano , Toshinobu Eguchi , Fumihiro Maeda
IPC分类号： H05B610
CPC分类号： B21B15/0085 , B21B1/26 , B23K13/015 , B23K13/02 , B23K2101/18
摘要： According to the invention, the rear end of a preceding metal piece and a front end of a succeeding metal piece are heated, pressed and joined prior to the finishing hot rolling. An alternating magnetic field running through the metal pieces in the thickness direction thereof is generated in an end region on opposed faces of the respective metal pieces to perform heating. Another alternating magnetic field whose direction is reverse with respect to that of the former alternating magnetic field is partially generated in the end region on the opposed faces of the metal pieces and in either a region where the metal pieces exist or a region outside width ends of the metal pieces. This assures a uniform heating of the end region on the opposed faces of the metal pieces over their full width to reliably join the both metal pieces to each other.
摘要翻译：根据本发明，在精加工热轧之前，先前金属片的后端和后面的金属片的前端被加热，压制和接合。在各个金属片的相对面上的端部区域中产生沿其厚度方向穿过金属片的交变磁场，以进行加热。在金属片的相对面上的端部区域和金属片存在的区域或外侧宽度端部的区域中部分地产生相对于前者的交变磁场的方向相反的另一个交变磁场金属件。这确保了金属片的相对面上的端部区域在其全宽度上的均匀加热，以将两个金属片彼此可靠地接合。

57. 发明授权

US06218649B1 Method and apparatus for joining metal pieces using induction heating 失效
标题翻译：使用感应加热连接金属件的方法和装置
公开(公告)号：US06218649B1
公开(公告)日：2001-04-17
申请号：US09352157
申请日：1999-07-12
申请人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Toshiaki Amagasa , Nozomu Tamura , Takahiro Yamasaki , Masashi Osada , Hirosuke Yamada , Toshisada Takechi , Norio Takashima , Junzo Nitta , Shuji Amanuma , Kanji Hayashi , Akio Kuroda , Yoshiki Mito , Kunio Miyamoto , Kazuo Morimoto , Ikuo Wakamoto , Kazuya Tsurusaki , Hideo Sakamoto , Michio Hashimoto , Hiroyuki Nakano , Toshinobu Eguchi , Fumihiro Maeda
发明人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Toshiaki Amagasa , Nozomu Tamura , Takahiro Yamasaki , Masashi Osada , Hirosuke Yamada , Toshisada Takechi , Norio Takashima , Junzo Nitta , Shuji Amanuma , Kanji Hayashi , Akio Kuroda , Yoshiki Mito , Kunio Miyamoto , Kazuo Morimoto , Ikuo Wakamoto , Kazuya Tsurusaki , Hideo Sakamoto , Michio Hashimoto , Hiroyuki Nakano , Toshinobu Eguchi , Fumihiro Maeda
IPC分类号： H05B610
CPC分类号： B21B15/0085 , B21B1/26 , B23K13/015 , B23K13/02 , B23K2101/18
摘要： Method and apparatus for joining metal pieces using induction heating. Metal pieces to be joined are placed end-to-end with a gap between them and induction heated in the thickness portion. To maximize speed and even heating edge-to-edge of the ends, members of a magnetic substance are provided in a gap between the inductor and the piece to be heated, thereby enhancing local heating effect by increasing magnetic flux density. Once heated, the ends are pressed together end-to-end for joining.
摘要翻译：使用感应加热连接金属件的方法和装置。要连接的金属片端对端放置，并在厚度部分进行感应加热。为了最大化速度，甚至加热端部的边缘到边缘，磁性物质的构件设置在电感器和待加热件之间的间隙中，从而通过增加磁通密度来增强局部加热效果。一旦被加热，端部端对端地被压在一起用于接合。

58. 发明授权

US5753894A Hot rolling method for continuously joining metal blocks and an apparatus for the same 失效
标题翻译：用于连续接合金属块的热轧方法及其装置
公开(公告)号：US5753894A
公开(公告)日：1998-05-19
申请号：US387788
申请日：1995-02-15
申请人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Hirosuke Yamada , Nozomu Tamura , Toshiaki Amagasa , Toshisada Takechi , Kanji Hayashi , Kunio Miyamoto , Akio Kuroda , Kazunori Nagai , Yoshiki Mito
发明人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Hirosuke Yamada , Nozomu Tamura , Toshiaki Amagasa , Toshisada Takechi , Kanji Hayashi , Kunio Miyamoto , Akio Kuroda , Kazunori Nagai , Yoshiki Mito
IPC分类号： B21B1/26 , B21B15/00 , B23K13/00 , B23K13/01 , B23K37/047 , H05B6/02 , B23K20/04
CPC分类号： B23K13/00 , B21B15/0085 , B23K13/015 , B23K37/047 , B21B1/26 , B23K2201/16
摘要： The invention comprises a continuous hot rolling method in which a rear end portion of a preceding metal block and a fore end portion of a succeeding metal block are cut and the metal blocks are joined to each other by heating and pressing followed by a finish rolling. A region of each metal block is restrained from a clamping position to the end portion thereof in order to prevent a change in level of the metal blocks in heating and pressing the piece. The end portions of the metal blocks can be thus prevented from deformation.
摘要翻译： PCT No.PCT / JP94 / 00968 Sec。 371日期1995年2月15日 102（e）日期1995年2月15日PCT提交1994年6月15日PCT公布。第WO94 / 29040号公报日期1994年12月22日本发明包括一个连续热轧方法，其中先前金属块的后端部分和后面的金属块的前端部分被切割，并且金属块通过加热和加压相互连接通过精轧。每个金属块的区域被限制到其端部的夹紧位置，以防止在加热和压制件时金属块的水平的变化。因此可以防止金属块的端部变形。

59. 发明授权

US4916152A Pyrrolidine derivatives as antiasthmatics 失效
标题翻译：吡咯烷衍生物作为抗哮喘药
公开(公告)号：US4916152A
公开(公告)日：1990-04-10
申请号：US187240
申请日：1988-04-28
申请人： Hiroyuki Setoi , Hideo Hirai , Hiroshi Marusawa , Akio Kuroda , Hirokazu Tanaka , Masashi Hashimoto
发明人： Hiroyuki Setoi , Hideo Hirai , Hiroshi Marusawa , Akio Kuroda , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/66 , A61P7/00 , A61P7/02 , A61P11/00 , A61P13/02 , A61P15/00 , C07D207/12 , C07D207/14 , C07D207/16 , C07D409/12 , C07F9/572
CPC分类号： C07D207/16 , C07D207/12 , C07D207/14
摘要： The invention relates to novel compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkoxycarbonyl, phenylsulfonyl, phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, nitro, lower alkoxy, mono (or di or tri)halo(lower)alkyl and lower alkyl, phenylcarbamoyl, lower alkylsulfonyl, benzoyl or thienylsulfonyl;R.sup.2 is phenylsulfonyl or phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl,R.sup.3 is carboxy(lower)alkyl, lower alkyl substituted with carboxy and 1 to 3 halogen atom(s), esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylsulfonylcarbamoyl(lower)alkyl, phenylsulfonylcarbamoyl(lower)alkyl, carboxyphenyl, esterified carboxyphenyl, carboxy, esterified carboxy, hydroxy(lower)alkyl, sulfino(lower)alkyl, phosphono(lower)alkyl, di(lower)alkoxyphosphoryl(lower)alkyl or halo(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is ##STR2## in which R.sup.8 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof, useful as therapeutic agents for thrombosis, asthma and nephritis.

60. 发明授权

US4435389A Composition for promoting growth of bifidobacteria 失效
标题翻译：用于促进双歧杆菌生长的组合物
公开(公告)号：US4435389A
公开(公告)日：1984-03-06
申请号：US166463
申请日：1980-07-07
申请人： Masahiko Mutai , Tsuneo Terashima , Tokutaro Takahashi , Ryuichiro Tanaka , Akio Kuroda , Sadao Ueyama , Keisuke Matsumoto
发明人： Masahiko Mutai , Tsuneo Terashima , Tokutaro Takahashi , Ryuichiro Tanaka , Akio Kuroda , Sadao Ueyama , Keisuke Matsumoto
IPC分类号： A61K35/74 , A61K36/06 , C12N1/38 , C12P19/04 , C12P19/14 , A61K31/71
CPC分类号： C12P19/14 , A61K36/06 , C12N1/38 , C12P19/04
摘要： This invention relates to a composition for promoting growth of Bifidobacteria containing as effective constituent an oligosaccharide represented by the general formula Gal-(gal).sub.n -Glc, wherein Gal denotes a galactose residue, Glc a glucose residue and n an integer of 1 to 4.This invention further relates to a method for manufacture of the material for promoting growth of Bifidobacteria characterized in that lactose or a lactose-containing material is treated with .beta.-galactosidase produced by Aspergillus oryzae.
摘要翻译：本发明涉及一种用于促进双歧杆菌生长的组合物，其含有由通式Gal-（gal）n-Glc表示的寡糖作为有效成分，其中Gal表示半乳糖残基，Glc是葡萄糖残基，n为1至4的整数本发明还涉及一种用于促进双歧杆菌生长的材料的制造方法，其特征在于用米曲霉产生的β-半乳糖苷酶处理乳糖或含乳糖的材料。

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