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51. 发明授权

US07639009B2 3D MR imaging with fat suppression 失效
标题翻译：具有脂肪抑制的3D MR成像
公开(公告)号：US07639009B2
公开(公告)日：2009-12-29
申请号：US11962792
申请日：2007-12-21
申请人： Timothy Hughes , Bernd Kuehn
发明人： Timothy Hughes , Bernd Kuehn
IPC分类号： G01V3/00
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/4828 , G01R33/5602 , G01R33/5607
摘要： In a method for image generation by magnetic resonance with suppression of a spectral component of the magnetic resonance signal during the signal acquisition, k-space is sampled in sub-sections, an excitation pulse for excitation of the spectral component to be suppressed is radiated at a point in time TI before acquisition of each sub-section of k-space, and different TI values are selected for the respective sub-sections.
摘要翻译：在信号采集期间通过抑制磁共振信号的频谱分量的磁共振成像的方法中，在子部分中对k空间进行采样，将要抑制的频谱分量的激励用激励脉冲放射在在获取k空间的每个子部分之前的时间点TI，并且为各个子部分选择不同的TI值。

52. 发明申请

US20090117641A1 Mutated Abl Kinase Domains 审中-公开
标题翻译：突变的Abl激酶结构域
公开(公告)号：US20090117641A1
公开(公告)日：2009-05-07
申请号：US12165217
申请日：2008-06-30
申请人： Christophe Barthe , Susan Bradford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francios-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
发明人： Christophe Barthe , Susan Bradford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francios-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含功能性激酶结构域，所述功能性激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性或其盐使用这样的多肽筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及使用其核酸分子生产这样的多肽用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

53. 发明申请

US20090015257A1 MAGNETIC RESONANCE ANATOMICAL IMAGE GENERATING METHOD AND SYSTEM 有权
标题翻译：磁共振解剖图像生成方法与系统
公开(公告)号：US20090015257A1
公开(公告)日：2009-01-15
申请号：US12125502
申请日：2008-05-22
申请人： Timothy Hughes
发明人： Timothy Hughes
IPC分类号： G01R33/483
CPC分类号： A61B5/055 , A61B5/4514 , G01R33/50 , G01R33/5608 , G01R33/5617
摘要： In a method to generate an anatomical image of an examination area with a magnetic resonance apparatus as well as computer program and magnetic resonance apparatus for implementation of the method, at least one image data set of the examination area and a parameter value map are loaded. The at least one loaded image data set and the loaded parameter value map are processed into an anatomical image. The processing includes a weighting of elements of the at least one image data set with a weighting factor. The weighting factor depends on a parameter value of the parameter value map corresponding to the respective element of the image data set. The generated weighted anatomical image is displayed and/or stored.
摘要翻译：在使用磁共振装置产生检查区域的解剖图像的方法以及用于实现该方法的计算机程序和磁共振装置的方法中，加载了检查区域和参数值映射的至少一个图像数据集。将至少一个加载的图像数据集和加载的参数值图处理成解剖图像。该处理包括利用加权因子加权至少一个图像数据集的元素。权重因子取决于与图像数据集的各个元素相对应的参数值映射的参数值。产生的加权解剖图像被显示和/或存储。

54. 发明申请

US20080224699A1 MAGNETIC RESONANCE METHOD AND APPARATUS WITH NUCLEAR SPINS TYPE-SPECIFIC SIGNAL SUPPRESSION 有权
标题翻译：磁性共振方法和装置，具有核心转子类型特异性信号抑制
公开(公告)号：US20080224699A1
公开(公告)日：2008-09-18
申请号：US12046807
申请日：2008-03-12
申请人： Timothy Hughes
发明人： Timothy Hughes
IPC分类号： G01R33/32
CPC分类号： G01R33/5613 , G01R33/4828 , G01R33/5607 , G01R33/5676
摘要： A method in the form of a sequence for magnetic resonance imaging with which image data of a subject to be examined are acquired and with which signals of nuclear spins of a specific type are suppressed, includes the steps of (a) application of a suppression module to suppress signals of the nuclear spins of the specific type, (b) application of an acquisition module after a wait time to acquire measurement data, (c) repetition of the steps (a) and (b) one or more times, respectively after a repetition time and, (d) before the steps (a), (b) and (c), application of a spin preparation module that shifts a magnetization of the nuclear spins of the specific type into a steady state condition that is maintained through the application of the subsequent steps (a), (b) and (c). Alternatively, instead of the spin preparation module the first suppression module can be fashioned such that it has an RF pulse with a flip angle selected such that the magnetization of the nuclear spins of the specific type is shifted into a steady state condition.
摘要翻译：一种用于磁共振成像的序列形式的方法，其中获取被检查对象的图像数据并且抑制特定类型的核自旋的信号，包括以下步骤：（a）应用抑制模块抑制特定类型的核自旋的信号，（b）在等待时间之后采集采集模块以获取测量数据，（c）分别在步骤（a）和（b）之后重复一次或多次重复时间，（d）在步骤（a），（b）和（c）之前，应用将特定类型的核自旋的磁化转移到稳定状态的自旋制备模块，后续步骤（a），（b）和（c）的应用。或者，代替旋转制备模块，第一抑制模块可以被形成为使得其具有选择的翻转角的RF脉冲，使得特定类型的核自旋的磁化转移到稳态条件。

55. 发明申请

US20050228120A1 Polymer having charged units 失效
标题翻译：具有带电单元的聚合物
公开(公告)号：US20050228120A1
公开(公告)日：2005-10-13
申请号：US10515218
申请日：2003-05-21
申请人： Timothy Hughes , Grace Chan
发明人： Timothy Hughes , Grace Chan
IPC分类号： G02C7/02 , A61F2/14 , A61F2/16 , A61L24/00 , A61L24/04 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/34 , C08F220/28 , C08F230/08 , C08F255/02 , C08F259/08 , C08F283/06 , C08F283/12 , C08F290/00 , C08F290/06 , C09J11/06 , C09J171/02 , C09J201/00 , C08L83/00
CPC分类号： C08F290/062 , A61F2/14 , A61L27/18 , A61L27/34 , A61L2430/16 , C08F290/02 , C08L71/02
摘要： A polymer comprising one or more macromonomer units selected from the group consisting of polysiloxane, perfluoroalkylpolyether (PFPE), fluorinated poly(meth)acrylate, polyalkyl (meth)acrylate, polyolefin and fluorinated polyolefin, and one or more charged units (such as an anionic, cationic or zwitter-ionic monomer), formed from a polymerization medium containing an aqueous solution of charged units and use of this polymer as an intraocular lens for the implantation into or onto the cornea. Another aspects relates to a process for coating the above polymer with an adhesive comprising covalently coupling co-reactive surface functional groups of a natural or synthetic polymer with functional groups present (or introduced) on the surface of the macromonomer containing polymer, followed by covalently coupling a multifunctionally activated compound having at least one functional group that is co-reactive to the reactive groups of the natural or synthetic polymer.
摘要翻译：包含选自聚硅氧烷，全氟烷基聚醚（PFPE），氟化聚（甲基）丙烯酸酯，聚（甲基）丙烯酸烷基酯，聚烯烃和氟化聚烯烃等）中的一种或多种大分子单体的聚合物和一种或多种带电单元，阳离子或两性离子单体），其由含有带电单元的水溶液的聚合介质形成，并且使用该聚合物作为人工晶状体用于植入角膜或其上。另一方面涉及一种用粘合剂涂覆上述聚合物的方法，包括将天然或合成聚合物的共反应性表面官能团与存在（或引入）的含大分子单体的聚合物的表面共价偶联，然后共价偶联具有至少一个与天然或合成聚合物的反应性基团共反应的官能团的多功能活化化合物。

56. 发明授权

US09662036B2 Method and apparatus for generating a tomographic image 有权
公开(公告)号：US09662036B2
公开(公告)日：2017-05-30
申请号：US12704684
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G06K9/00 , A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00
CPC分类号： A61B5/055 , A61B5/4514 , A61B6/032 , A61B6/5235
摘要： In a method for generating a tomographic image, at a first point in time, a first tomographic image is acquired of a layer of a patient and the region of cartilaginous tissue is determined in the first tomographic image. At a later second point in time a second tomographic image is acquired of the layer of the patient and the region of the cartilaginous tissue is determined in the second tomographic image. The tomographic image is generated from the first tomographic image and the second tomographic image, in which every pixel of the tomographic image is assigned a difference value between a corresponding pixel of the first tomographic image and a corresponding pixel of the second tomographic image. The validation number is determined by adding all the pixels in the region of the cartilaginous tissue in the tomographic image.

57. 发明授权

US09659738B2 X-ray source and the use thereof and method for producing X-rays 有权
公开(公告)号：US09659738B2
公开(公告)日：2017-05-23
申请号：US14407504
申请日：2012-06-15
申请人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
发明人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
IPC分类号： H01J35/08 , H01J35/18 , H05G2/00
CPC分类号： H01J35/08 , H01J35/18 , H01J2235/082 , H01J2235/18 , H05G2/005
摘要： An x-ray source comprising a housing, in which a target in the form of an ionized cloud based on metal vapor is provided. The ionized cloud can be excited by means of an electron beam for emitting monochromatic x-rays. The low atom density advantageously produces only a little braking radiation. The robustness of the plasma with respect to the inevitable thermal energy input is also advantageous with respect to the solid target materials. The cloud can be filled at any time with target material which can be vaporized by means of an electric arc. A method for producing x-rays with the above-mentioned x-ray source is also provided. The use of an x-ray source for emitting monochromatic x-rays for x-raying a body is further provided.

58. 发明授权

US09576692B2 Method and device for producing 99mTc 有权
标题翻译：生产99mTc的方法和装置
公开(公告)号：US09576692B2
公开(公告)日：2017-02-21
申请号：US13576475
申请日：2011-01-20
申请人： Arnd Baurichter , Oliver Heid , Timothy Hughes
发明人： Arnd Baurichter , Oliver Heid , Timothy Hughes
IPC分类号： G21G1/10 , A61K51/02 , C01G99/00 , G21G1/00
CPC分类号： G21G1/10 , A61K51/025 , C01G99/003 , G21G1/001 , G21G2001/0042
摘要： A method for producing 99mTc may include: providing a solution comprising 100Mo-molybdate-ions; providing a proton beam having an energy suitable for inducing a 100Mo(p,2n)99mTc-nuclear reaction when exposing 100Mo-molybdate-ions; exposing the solution to the proton beams and inducing a 100Mo(p,2n)99mTc-nuclear reaction; and applying an extraction method for extracting the 99mTc from the solution. Further, a device for producing 99mTc may include: a solution with 100Mo-molybdate-ions; an accelerator for providing a proton beam with energy which is suitable for inducing a 100Mo(p,2n)99mTc-nuclear reaction when exposing 100Mo-molybdate-ions, for exposing the solution and for inducing a 100Mo(p,2n)99mTc-nuclear reaction; and an extraction step for extracting 99mTc from the solution.
摘要翻译：制备99mTc的方法可以包括：提供包含100M钼酸盐离子的溶液; 提供具有适于在暴露100M钼酸盐离子时诱导100Mo（p，2n）99mTc-核反应的能量的质子束; 将溶液暴露于质子束并诱导100Mo（p，2n）99m Tc核反应; 并从溶液中提取提取99mTc的提取方法。此外，用于制备99mTc的装置可以包括：具有100M钼酸根离子的溶液; 用于提供质子束具有能量的加速器，其适于在暴露100M钼酸盐离子时诱导100Mo（p，2n）99mTc-核反应，用于暴露溶液和诱导100Mo（p，2n）99mTc-核反应; 以及从溶液中提取99mTc的提取步骤。

59. 发明授权

US09287015B2 Method and device for producing two different radioactive isotopes 有权
标题翻译：用于生产两种不同放射性同位素的方法和装置
公开(公告)号：US09287015B2
公开(公告)日：2016-03-15
申请号：US13576446
申请日：2011-01-26
申请人： Arnd Baurichter , Oliver Heid , Timothy Hughes
发明人： Arnd Baurichter , Oliver Heid , Timothy Hughes
IPC分类号： G21G1/00 , G21G1/10 , H05H6/00
CPC分类号： G21G1/10 , G21G2001/0015 , G21G2001/0036 , G21G2001/0042 , H05H6/00
摘要： A method is provided for producing first and second radioactive isotopes using an accelerated particle beam that is directed to a first material and the first radioactive isotope is produced by a first nuclear reaction based on the interaction of the particle beam with the first material, said particle beam is also slowed down and subsequently directed to a second material, and the second radioactive isotope is produced by a second nuclear reaction based on the interaction of the particle beam with the second material. The effective cross-section for the induction of the first nuclear reaction at a first peak for a first particle energy is higher than an effective cross-section for the induction of the second nuclear reaction at a second peak for a second particle energy. A corresponding device includes an acceleration unit, a first exposure target having the first material and a second exposure target having the second material.
摘要翻译：提供了一种使用引导到第一材料的加速粒子束来产生第一和第二放射性同位素的方法，并且基于粒子束与第一材料的相互作用，通过第一核反应产生第一放射性同位素，所述粒子梁也被放慢并且随后被引导到第二材料，并且第二放射性同位素是通过基于粒子束与第二材料的相互作用的第二核反应产生的。用于第一粒子能量的第一个峰值处的第一次核反应的有效截面高于用于第二个粒子能量的第二个峰值处的第二次核反应的有效截面。对应的装置包括加速单元，具有第一材料的第一曝光目标和具有第二材料的第二曝光对象。

60. 发明申请

US20150249322A1 SPARK GAP COMPRISING A CAPACITIVE ENERGY STORE 有权
标题翻译：包容电能储存的SPARK差距
公开(公告)号：US20150249322A1
公开(公告)日：2015-09-03
申请号：US14412703
申请日：2012-07-11
申请人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
发明人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
IPC分类号： H01T15/00 , H01J35/22
CPC分类号： H01T15/00 , H01G4/02 , H01J35/22 , H01J2235/166 , H01T1/20 , H01T2/00 , H05G1/24
摘要： A spark gap including a capacitive energy store is provided. The spark gap is fed via a multiplicity of capacitors arranged in a form of a ring, wherein the capacitors are electrically connected to the anode and the cathode via ring-shaped and conical or funnel-shaped conductors. As a result, sudden changes in impedance can be avoided. At the same time, it is possible to realize as large a cross-sectional area of the conductor as possible within a very small space. Therefore, the spark gap has a switching response with a high rate of rise of the voltage pulse as soon as the spark gaps flash over. This results in an easily predictable switching response of the spark gap. The spark gap can be used, for example, to generate pulses of monochromatic X-ray radiation.
摘要翻译：提供了包括电容性能量储存器的火花隙。火花间隙通过以环形形式布置的多个电容器馈送，其中电容器通过环形和锥形或漏斗形导体电连接到阳极和阴极。结果，可以避免阻抗的突然变化。同时，可以在非常小的空间内实现尽可能大的导体横截面面积。因此，一旦火花隙闪过，火花隙就具有电压脉冲高速率的开关响应。这导致火花隙的容易预测的切换响应。火花隙可以用于例如产生单色X射线辐射的脉冲。

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