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51. 发明申请

US20080109017A1 Barrier layer with underlying medical device and one or more reinforcing support structures 有权
标题翻译：具有底层医疗装置和一个或多个加强支撑结构的阻隔层
公开(公告)号：US20080109017A1
公开(公告)日：2008-05-08
申请号：US11701799
申请日：2007-02-02
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。

52. 发明申请

US20070202149A1 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
标题翻译：用于生物可吸收药物载体涂层的疏水交联凝胶
公开(公告)号：US20070202149A1
公开(公告)日：2007-08-30
申请号：US11582135
申请日：2006-10-16
申请人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
发明人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
IPC分类号： A61F2/00 , A61F2/02
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

53. 发明申请

US20060067983A1 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US20060067983A1
公开(公告)日：2006-03-30
申请号：US11237264
申请日：2005-09-28
申请人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K31/355 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

54. 发明申请

US20060058737A1 Catheter treatment stylet 审中-公开
标题翻译：导管治疗探针
公开(公告)号：US20060058737A1
公开(公告)日：2006-03-16
申请号：US10944393
申请日：2004-09-16
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Joseph Ferraro
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Joseph Ferraro
IPC分类号： A61M5/178
CPC分类号： A61M25/00
摘要： A therapeutic agent-eluting stylet treats a catheter by at least temporarily locating the stylet in a lumen of an indwelling catheter placed into a patient. The therapeutic agent-carrying stylet provides a localized therapeutic effect to the catheter and patient by eluting one or more therapeutic agents directly into the lumen of the catheter, into the fluid within the catheter, into the fluid and tissue in contact with the catheter, and onto the surface of the catheter. By removal and replacement of the temporary stylet from the catheter, renewable therapeutic agent doses can be provided to a component, such as the lumen, of the catheter while the catheter remains within in a patient. One or more therapeutically effective doses of medicated agents can be tailored along the length of the stylet and controlled by the length of time by which the stylet remains installed in the catheter.
摘要翻译：治疗剂洗脱的管心针通过至少临时将探针置于置于患者体内的留置导管的内腔中来治疗导管。治疗剂携带管心针通过将一种或多种治疗剂直接洗脱到导管的内腔，导管内的流体中，与导管接触的流体和组织中，向导管和患者提供局部治疗效果，以及到导管的表面。通过从导管中移除和替换临时探针，当导管保持在患者体内时，可将可再生治疗剂剂量提供给导管的部件（例如内腔）。一个或多个治疗有效剂量的药剂可以沿着探针的长度进行调整，并由探针保持安装在导管中的时间长度来控制。

55. 发明授权

US09801913B2 Barrier layer 有权
公开(公告)号：US09801913B2
公开(公告)日：2017-10-31
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K38/13 , A61L27/36 , A61L27/52 , A61K9/00 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L31/10 , A61L27/54 , A61F13/02 , A61L2/07 , A61L2/08 , A61L2/20 , A61L31/00 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.

56. 发明授权

US08124127B2 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
标题翻译：用于生物可吸收药物载体涂层的疏水交联凝胶
公开(公告)号：US08124127B2
公开(公告)日：2012-02-28
申请号：US11582135
申请日：2006-10-16
申请人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
发明人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

57. 发明申请

US20080206305A1 Implantable barrier device 有权
标题翻译：植入式屏障装置
公开(公告)号：US20080206305A1
公开(公告)日：2008-08-28
申请号：US12075223
申请日：2008-03-10
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/00 , A61K47/12
CPC分类号： A61L31/10 , A61F2/0063 , A61F2/06 , A61F2250/0067 , A61L31/145
摘要： A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：屏障装置由能够表现出抗炎性质，非炎症性质和/或粘合限制性能的屏障组分形成，并且对损伤的组织产生调节的愈合作用。阻隔组分可以是至少部分由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。阻挡装置可以具有锚定位置以在阻挡装置上提供与锚定机构相接合的区域。锚固位置可以包括开口和/或锚定元件。阻挡装置还可以包括为屏障部件提供附加强度的桁架结构。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

58. 发明授权

US10322213B2 Compositions and methods for altering the rate of hydrolysis of cured oil-based materials 有权
公开(公告)号：US10322213B2
公开(公告)日：2019-06-18
申请号：US13184512
申请日：2011-07-16
申请人： Keith M. Faucher , Theresa K. Albergo , Paul Martakos
发明人： Keith M. Faucher , Theresa K. Albergo , Paul Martakos
IPC分类号： A61L29/08 , A61L29/14 , A61L31/08 , C08L91/00 , C09D191/00
摘要： Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.

59. 发明授权

US06955661B1 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US06955661B1
公开(公告)日：2005-10-18
申请号：US09411797
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/958 , A61L29/04 , B29C47/00 , B29C55/24 , A61M5/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen. The tubular member includes at least one microporous portion having a porosity sufficient for the pressurized fluid to permeate through the wall. Substantially all of the nodes within the microporous portion are oriented such that spaces between the nodes form micro-channels extending from the inner surface-to the outer surface of the wall.
摘要翻译：公开了一种用于将流体输送到体内的治疗部位的可径向扩张的流体输送装置。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。流体输送装置包括由壁限定的管状构件，其具有横向于管状构件的纵向轴线并在内表面和外表面之间延伸的厚度。壁的特征在于通过纤维互连的节点的微结构。当将加压流体引入内腔时，管状构件可从第一缩径直径构型展开至第二增大直径构型。管状构件包括具有足以使加压流体渗透通过壁的孔隙的至少一个微孔部分。基本上微孔部分内的所有节点被定向成使得节点之间的空间形成从壁的内表面延伸到外表面的微通道。

60. 发明申请

US20050154416A1 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US20050154416A1
公开(公告)日：2005-07-14
申请号：US11068680
申请日：2005-02-28
申请人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/958 , A61L29/04 , B29C47/00 , B29C55/24 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

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