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51. 发明授权

US06562779B2 Preparation of emulsifiable ethylene polymers 失效
标题翻译：乳化乙烯聚合物的制备
公开(公告)号：US06562779B2
公开(公告)日：2003-05-13
申请号：US09782308
申请日：2001-02-14
申请人： Lars Wittkowski , Andreas Deckers , Wilhelm Weber , Stefan Weiss , Michael Ehle , Siegfried Gast
发明人： Lars Wittkowski , Andreas Deckers , Wilhelm Weber , Stefan Weiss , Michael Ehle , Siegfried Gast
IPC分类号： C11D726
CPC分类号： C08F210/02 , C08F8/44 , C08F2810/50 , C08F2/00 , C08F220/06 , C08F2500/17 , C08F2500/23 , C08F220/16 , C08F8/12 , C08F2220/1825
摘要： Emulsifiable ethylene polymers comprising copolymers of from 90 to 95% by weight of ethylene, from 4 to 10% by weight of one or more C3-C12 alkenecarboxylic acids, and from 0 to 1.2% by weight of one or more tertiary esters of the corresponding C3-C12 alkenecarboxylic acids, where the wax has a cinematic melt viscosity of from 800 to 3000 mm2/s, measured at 120° C.; and a process for preparing the novel emulsifiable ethylene polymers, emulsions comprising the novel ethylene polymers, a process for preparing the emulsions from the novel ethylene polymers, and also floor cleaners, car cleaners, leather cleaners and stone cleaners, and coatings for surfaces made from wood, metal, paper, glass or from plastics, comprising aqueous emulsions of the novel emulsifable waxes.
摘要翻译：包含共聚物的可乳化乙烯聚合物为90至95重量％的乙烯，4至10重量％的一种或多种C 3 -C 12烯烃羧酸，和0至1.2重量％的一种或多种相应的C3- C12链烯羧酸，其中在120℃下测量的蜡具有800至3000mm 2 / s的电影熔体粘度;以及制备新型可乳化乙烯聚合物的方法，包含新型乙烯聚合物的乳液，制备方法来自新型乙烯聚合物的乳液，以及地板清洁剂，汽车清洁剂，皮革清洁剂和石材清洁剂以及由木材，金属，纸，玻璃或塑料制成的表面的涂层，其包含新型可乳化蜡的水性乳液。

52. 发明授权

US06451541B1 Chaperones capable of binding to prion proteins and distinguishing the isoforms PrPc and PrPsc 失效
标题翻译：分子伴侣能够结合朊病毒蛋白并区分同种型PrPc和PrPsc
公开(公告)号：US06451541B1
公开(公告)日：2002-09-17
申请号：US09180652
申请日：1998-11-12
申请人： Ernst-Ludwig Winnacker , Stefan Weiss , Frank Edenhofer , Roman Rieger
发明人： Ernst-Ludwig Winnacker , Stefan Weiss , Frank Edenhofer , Roman Rieger
IPC分类号： G01N3353
CPC分类号： C07K14/47 , A61K38/00 , G01N33/6896 , G01N2800/2828
摘要： The present invention relates to methods for the detection or isolation of prion proteins by use of chaperones specifically binding to said proteins. The invention further relates to a method for in vitro diagnosis of a transmissible spongiform encephalopathy and to pharmaceutical compositions, preferably for the prevention or treatment of said disease.
摘要翻译：本发明涉及通过使用与所述蛋白质特异性结合的分子伴侣来检测或分离朊蛋白的方法。本发明还涉及用于体外诊断传染性海绵状脑病和药物组合物的方法，优选用于预防或治疗所述疾病。

53. 发明授权

US06342600B1 Process for preparing 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine 失效
标题翻译： 2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪的制备方法
公开(公告)号：US06342600B1
公开(公告)日：2002-01-29
申请号：US09749302
申请日：2000-12-27
申请人： Stefan Weiss , Helmut Krommer
发明人： Stefan Weiss , Helmut Krommer
IPC分类号： C07D25116
CPC分类号： C07D251/18
摘要： Provided herein is a novel and useful process for preparing 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine that broadly comprises the steps of (a) reacting zinc bis(imino-bis-carbimic acid methyl ester) with acetic anhydride to give 2,4-dimethoxy-6-methyl-1,3,5-triazine and (b) reacting the 2,4-dimethoxy-6-methyl-1,3,5-triazine, formed in step (a), with methylamine to give 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine.
摘要翻译：本文提供了一种用于制备2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪的新颖且有用的方法，其广泛包括以下步骤：（a）使双（亚氨基 - 二 - 碳二氨基甲酸甲酯））与乙酸酐反应，得到2,4-二甲氧基-6-甲基-1,3,5-三嗪和（b）使步骤中形成的2,4-二甲氧基-6-甲基-1,3,5-三嗪（a）与甲胺反应，得到2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪。

54. 发明授权

US5708182A Method for preparation of 2-imino 4-oxo-5-phenyloxazolidine 失效
标题翻译： 2-亚氨基-4-氧代-5-苯基恶唑烷的制备方法
公开(公告)号：US5708182A
公开(公告)日：1998-01-13
申请号：US627951
申请日：1996-04-03
申请人： Stefan Weiss , Martina Lobensommer
发明人： Stefan Weiss , Martina Lobensommer
IPC分类号： C07D263/48 , C07D263/40
CPC分类号： C07D263/48
摘要： A process for the preparation of 2-imino-4-oxo-5-phenyloxazolidine, which is used in medical applications under the name of pemolin, is described. The preparation proceeds by reacting at 10.degree. to 150.degree. C., optionally in the presence of a base catalyst, an aliphatic or an aromatic mandelic acid ester with an alkali or alkaline earth metal hydrogencyanamide, which can be prepared in situ; followed by treating the obtained reaction mixture or the metal salt isolated therefrom with a protonic acid, at temperatures from -30.degree. to 150.degree. C. until a pH value from 2 to 10 is reached.
摘要翻译：描述了用于医学应用中以异戊胎酚名称的2-亚氨基-4-氧代-5-苯基恶唑烷的制备方法。制备通过在10℃至150℃下反应，任选地在碱催化剂，脂族或芳族扁桃酸酯与碱金属或碱土金属氢过酰基胺的存在下反应，其可原位制备; 然后在-30℃至150℃的温度下用质子酸处理得到的反应混合物或金属盐，直到达到pH值为2至10。

55. 发明授权

US5705666A Process for the preparation of crystalline O-isopropylisourea hydrochloride 失效
标题翻译： O-异丙基异脲盐酸盐结晶的制备方法
公开(公告)号：US5705666A
公开(公告)日：1998-01-06
申请号：US665421
申请日：1996-06-19
申请人： Stefan Weiss
发明人： Stefan Weiss
IPC分类号： C07C273/18 , C07C275/70
CPC分类号： C07C273/1836 , C07C273/1809
摘要： Disclosed is a process for the preparation of crystalline O-isopropylisourea hydrochloride, wherein cyanamide, chloroformamidinium chloride and isopropanol are reacted, an aprotic solvent preferably selected from the group consisting of ketones, ethers, esters and acetals, is added to the reaction mixture before, during and/or after the reaction and, optionally after cooling the reaction solution, the crystalline reaction product is separated off. O-isopropylisourea hydrochloride is obtained in a very pure and coarse crystalline form by the process of the invention.
摘要翻译：公开了一种制备结晶O-异丙基异脲盐酸盐的方法，其中使氨基氰，氯化氯甲烷氯化铵和异丙醇反应，在反应混合物中加入优选选自酮，醚，酯和缩醛的非质子溶剂，在反应期间和/或之后，任选地在冷却反应溶液后，分离结晶反应产物。通过本发明的方法以非常纯和粗的结晶形式获得O-异丙基异脲盐酸盐。

56. 发明授权

US5208351A Process for the preparation of N-cyanoimidocarbonates 失效
标题翻译：制备N-氰基碳酸酯的方法
公开(公告)号：US5208351A
公开(公告)日：1993-05-04
申请号：US914268
申请日：1992-07-15
申请人： Franz Thalhammer , Stefan Weiss
发明人： Franz Thalhammer , Stefan Weiss
IPC分类号： C07C261/04 , C07C269/00 , C07C271/68 , C07D317/32 , C07D319/06
CPC分类号： C07D319/06 , C07C261/04 , C07D317/32
摘要： The present invention provides a process for the preparation of N-cyanoimidocarbonates of the general formula: ##STR1## in which R.sup.1 and R.sup.2 are the same and are alkyl radicals containing up to 4 carbon atoms or R.sup.1 and R.sup.2 are joined together to give an ethylene or propylene chain which is optionally substituted by an alkyl radical containing up to 3 carbon atoms, wherein an imidocarbonate obtained in aqueous alkaline solution from the appropriate alcohol and cyanogen chloride is added with an acid to an aqueous solution of cyanamide in such a manner that the reaction mixture has a pH value of from 3 to 8.
摘要翻译：本发明提供了制备通式如下的N-氰酰亚氨基碳酸酯的方法：其中R 1和R 2相同并且是含有至多4个碳原子的烷基，或者R 1和R 2连接在一起，得到乙烯或任选被含有至多3个碳原子的烷基取代的丙烯链，其中将由适当的醇和氯化氰在碱性水溶液中获得的酰亚胺碳酸酯加入到氰胺水溶液中，使得反应混合物的pH值为3-8。

57. 发明授权

US5126269A Spin filter perfusion bioreactor (SFPB) cell culture apparatus 失效
标题翻译：旋转过滤器渗透生物反应器（SFPB）细胞培养装置
公开(公告)号：US5126269A
公开(公告)日：1992-06-30
申请号：US581706
申请日：1990-09-13
申请人： Richard Fike , Stefan Weiss , Patrick Pomeroy
发明人： Richard Fike , Stefan Weiss , Patrick Pomeroy
IPC分类号： C12M3/06
CPC分类号： C12M27/02 , C12M29/04 , C12M29/10
摘要： An apparatus is disclosed that separates and removes to an external source, spent cell culture media from a cell culture media and cell culture mixture. The apparatus generally comprises a culture vessel, a filter member, wherein the filter member is positioned in the culture vessel to form an outside region and an inside region. Further provided is a tube member. The tube member being positioned in the inside region and having an opening therein to thereby remove the spent cell culture media brought into the inside region. Further disclosed is a structure for rotating the filter member around the tube member and a structure for sealing the outside region from the inside region when the filter member is rotating around the tube member.
摘要翻译：公开了一种从细胞培养基和细胞培养物混合物分离和去除外部来源的废细胞培养基的装置。该装置通常包括培养容器，过滤构件，其中过滤构件位于培养容器中以形成外部区域和内部区域。进一步提供一种管件。管构件定位在内部区域中并且在其中具有开口，从而去除进入内部区域的废细胞培养基。进一步公开了一种用于使过滤构件围绕管构件旋转的结构和当过滤构件围绕管构件旋转时用于将外部区域与内部区域密封的结构。

58. 发明授权

US4587337A Process for the preparation of 2-amino-s-triazines 失效
标题翻译： 2-氨基-s-三嗪的制备方法
公开(公告)号：US4587337A
公开(公告)日：1986-05-06
申请号：US715114
申请日：1985-03-25
申请人： Stefan Weiss , Helmut Krommer
发明人： Stefan Weiss , Helmut Krommer
IPC分类号： C07C233/00 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/42
CPC分类号： C07D251/22 , C07C233/00 , C07D251/16 , C07D251/18
摘要： The present invention relates to a process for the preparation of 2-amino-s-triazines in three stages. In the first stage nitriles, alcohols and hydrogen chloride are reacted to form the corresponding imido-ester hydrochlorides. In the second stage, the imido-ester hydrochlorides are reacted with cyanamide in the aqueous phase to form the N-cyanimido-esters, which comprises carrying out the first stage in the presence of acetic acid esters and the second stage in an aqueous solution which has been brought to a pH value of 5-8 by addition of bases, and reacting the N-cyanimido-esters with O-alkylisourea, S-alkylisothiourea, guanidine or amidine salts in the presence of a base in the third stage. The 2-amino-s-triazines can be prepared in a high purity and with good yields in this manner.
摘要翻译：本发明涉及三个阶段制备2-氨基-s-三嗪的方法。在第一阶段中，腈，醇和氯化氢反应形成相应的酰亚胺酯盐酸盐。在第二阶段中，酰亚胺酯盐酸盐与氰胺在水相中反应形成N-氰基亚氨基酯，其包括在乙酸酯存在下进行第一阶段，第二阶段在水溶液中进行通过加入碱使pH值达到5-8，并在第三阶段在碱的存在下使N-氰基亚氨基酯与O-烷基异脲，S-烷基异硫脲，胍或脒盐反应。 2-氨基-s-三嗪可以以高纯度制备，并且以这种方式具有良好的收率。

59. 发明授权

US3931316A Method of preparing O-methyl-isourea hydrogen sulfate and O-methyl-isourea sulfate from cyanamide 失效
标题翻译：从氨腈制备O-甲基 - 异硫脲硫酸盐和O-甲基 - 异硫脲硫酸盐的方法
公开(公告)号：US3931316A
公开(公告)日：1976-01-06
申请号：US533870
申请日：1974-12-18
申请人： Stefan Weiss
发明人： Stefan Weiss
IPC分类号： C07C273/00 , C07C275/70 , C07C123/00
CPC分类号： C07C273/00
摘要： O-Methyl-isourea hydrogen sulfate is prepared from cyanamide, methanol, and sulfuric acid in a yield of better than 90% when crystalline cyanamide is added to a mixture of sulfuric acid and methanol containing 50 - 150 parts by weight methanol per part sulfuric acid and holding the resulting composition at -10.degree. to 20.degree.C. The recovered O-methyl-isourea hydrogen sulfate is further converted to O-methyl-isourea sulfate with yields greatly exceeding 50%, and even 80%, by holding a mixture of approximately equimolar amounts of cyanamide and of the hydrogen sulfate in a liquid medium essentially consisting of methanol at 5.degree. to 40.degree.C until the O-methyl-isourea sulfate is formed and can be recovered.
摘要翻译：当将结晶氰胺加入含有50-150重量份甲醇/硫酸的硫酸和甲醇的混合物中时，由氰胺，甲醇和硫酸制备O-甲基异硫脲硫酸盐，收率高于90％并将所得组合物保持在-10℃至20℃。回收的O-甲基 - 异硫脲硫酸盐进一步转化为O-甲基 - 异硫脲硫酸盐，产率大大超过50％，甚至80％，通过保持在基本上由5至40℃的甲醇组成的液体介质中，大约等摩尔量的氰胺和硫酸氢盐直到形成O-甲基 - 异硫脲硫酸盐并且可以回收。

60. 发明授权

US08818747B2 Calibration of a triaxial magnetic field sensor 有权
标题翻译：三轴磁场传感器的校准
公开(公告)号：US08818747B2
公开(公告)日：2014-08-26
申请号：US13101844
申请日：2011-05-05
申请人： Stefan Weiss , Julian Bartholomeyczik , Sergej Scheiermann
发明人： Stefan Weiss , Julian Bartholomeyczik , Sergej Scheiermann
IPC分类号： G01D18/00 , G01P21/00 , G01R35/00 , G01C25/00
CPC分类号： G01R33/0206 , G01C17/38 , G01C25/00
摘要： A method for calibrating a triaxial magnetic field sensor includes steps for determining an offset of recorded measured values of the magnetic field sensor using a superposed signal and for determining the sensitivity of the magnetic field sensor along the first measuring axes. The determination of the sensitivity includes steps for determining the sensitivity of the magnetic field sensor along a first measuring axis and for determining the sensitivity of the magnetic field sensor along the other measuring axes based on the sensitivity of the first measuring axis and the determined offset.
摘要翻译：用于校准三轴磁场传感器的方法包括以下步骤：使用叠加信号确定磁场传感器记录的测量值的偏移量，并确定磁场传感器沿着第一测量轴的灵敏度。灵敏度的确定包括用于确定磁场传感器沿着第一测量轴的灵敏度并且基于第一测量轴的灵敏度和确定的偏移来确定磁场传感器沿着其它测量轴的灵敏度的步骤。

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