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1. 发明授权

US06297378B1 Process for making 2-(2-hydroxy-4-alkoxyphenyl)-4,6-bisaryl-1,3,5-triazines 失效
标题翻译：制备2-（2-羟基-4-烷氧基苯基）-4,6-二芳基-1,3,5-三嗪的方法
公开(公告)号：US06297378B1
公开(公告)日：2001-10-02
申请号：US09389067
申请日：1999-09-02
申请人： Ram B. Gupta , Dennis J. Jakiela , Sampath Venimadhavan , Russell C. Cappadona , Venkatrao K. Pai
发明人： Ram B. Gupta , Dennis J. Jakiela , Sampath Venimadhavan , Russell C. Cappadona , Venkatrao K. Pai
IPC分类号： C07D25116
CPC分类号： C07D251/24
摘要： The invention relates to a novel process for making 2-(2-hydroxy-4-alkoxyphenyl)-4,6-bisaryl-1,3,5-triazine and 2-(2,4-dialkoxyphenyl)-4,6-bisaryl-1,3,5-triazine compounds directly from 2-chloro-4,6-bisaryl-1,3,5-triazine compounds with 3-alkoxyphenol, 1,3-dialkoxylbenzene compounds or mixtures thereof. The reaction step to prepare 2-chloro-4,6-bisaryl-1,3,5-triazines from the reaction of cyanuric chloride with substituted aromatic compounds can be combined with the addition reaction of 3-alkoxyphenol or 1,3-dialkoxylbenzene in a two-step, one-pot process. The 2-(2-hydroxyl-4-alkoxyphenyl)-4,6-bisaryl-1,3,5-triazine, and 2-(2,4-dialkoxyphenyl)-4,6-bisaryl-1,3,5-triazine compounds, are useful to stabilize materials against damage by light, heat, and oxygen, and as stabilizers for organic material, or mixtures thereof.
摘要翻译：本发明涉及制备2-（2-羟基-4-烷氧基苯基）-4,6-二芳基-1,3,5-三嗪和2-（2,4-二烷氧基苯基）-4,6-二芳基 -1,3,5-三嗪化合物直接由2-氯-4,6-二芳基-1,3,5-三嗪化合物与3-烷氧基苯酚，1,3-二烷氧基苯化合物或其混合物组成。从氰尿酰氯与取代的芳族化合物的反应制备2-氯-4,6-二芳基-1,3,5-三嗪的反应步骤可以与3-烷氧基苯酚或1,3-二烷氧基苯的加成反应一个两步一锅的过程。 2-（2-羟基-4-烷氧基苯基）-4,6-二芳基-1,3,5-三嗪和2-（2,4-二烷氧基苯基）-4,6-二芳基-1,3,5-三嗪，三嗪化合物可用于稳定材料以防止光，热和氧的损伤，以及用作有机材料的稳定剂或其混合物。

2. 发明授权

US06448398B1 Process for preparing acid amides from (Si, Ge, or Sn substituted amino)-1,3,5-triazines and acid halides 失效
标题翻译：（Si，Ge或Sn取代的氨基）-1,3,5-三嗪和酰卤制备酰胺的方法
公开(公告)号：US06448398B1
公开(公告)日：2002-09-10
申请号：US08324549
申请日：1994-10-18
申请人： William Elliott Bay
发明人： William Elliott Bay
IPC分类号： C07D25116
CPC分类号： C07D251/70
摘要： A process is disclosed for preparing acid amides, including isocyanate-functional 1,3,5-triazines and isocyanate-based 1,3,5 triazine derivatives, from the reaction of (Si, Ge or Sn substituted amino)-1,3,5 triazines and acid halides.
摘要翻译：公开了从（Si，Ge或Sn取代的氨基）-1,3的反应制备酰胺，包括异氰酸酯官能的1,3,5-三嗪和异氰酸酯基1,3,5三嗪衍生物的方法， 5种三嗪和酰卤。

3. 发明授权

US06638932B1 2,4-disubstituted triazine derivatives 失效
标题翻译： 2,4-二取代的三嗪衍生物
公开(公告)号：US06638932B1
公开(公告)日：2003-10-28
申请号：US09831808
申请日：2001-08-02
申请人： Bart De Corte , Marc René de Jonge , Jan Heeres , Paul Adriaan Jan Janssen , Robert W. Kavash , Lucien Maria Henricus Koymans , Michael Joseph Kukla , Donald William Ludovici , Koen Jeanne Alfons Van Aken
发明人： Bart De Corte , Marc René de Jonge , Jan Heeres , Paul Adriaan Jan Janssen , Robert W. Kavash , Lucien Maria Henricus Koymans , Michael Joseph Kukla , Donald William Ludovici , Koen Jeanne Alfons Van Aken
IPC分类号： C07D25116
CPC分类号： A61K9/146 , Y10S977/775 , Y10S977/915
摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein —a1═a2—a3═a4— forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl or substituted C1-6alkyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR4, —NH—S(═O)pR4, —C(═O)R4, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R4, —C(═NH)R4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl; X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—; aryl is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.
摘要翻译：本发明涉及配制N-氧化物的化合物，药学上可接受的加成盐，季胺及其立体化学异构形式的用途，其中-a 1 = a 2 -a 3 = a 4 - 与连接的乙烯基形成苯基，吡啶基，嘧啶基，哒嗪基或吡嗪基; n为0〜4; 并在可能的情况下5; R 1是氢，芳基，甲酰基，C 1-6烷基羰基，C 1-6烷基，C 1-6烷氧基羰基或取代的C 1-6烷基; 每个R 2独立地是羟基，卤素，任选取代的C 1-6烷基，C 2-6烯基或C 2-6炔基，C 3-7环烷基，C 1-6烷氧基，C 1-6烷氧基羰基，羧基，氰基，硝基，氨基，单或二（ C 1-6烷基）氨基，多卤代甲基，多卤甲氧基，多卤甲硫基，-S（= O）p R 4，-NH-S（= O）p R 4，-C（= O）R 4， = O）H，-C（= O）NHNH 2，-NHC（= O）R 4，-C（= NH）R 4或5元杂环; p为1或2; L是任选取代的C 1-10烷基，C 2-10烯基，C 2-10炔基或C 3-7环烷基; 或L是-X-R 3，其中R 3是任选取代的苯基，吡啶基，嘧啶基，吡嗪基或哒嗪基; X是-NR 1 - ， - NH-NH-，-N = N-，-O-，-C（= O） - ， - CHOH-，-S-，-S（= O） - 或 - S（= O）2-; 芳基是任选取代的苯基; 用于制造用于治疗患有HIV（人类免疫缺陷病毒）感染的受试者的药物。

4. 发明授权

US06342600B1 Process for preparing 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine 失效
标题翻译： 2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪的制备方法
公开(公告)号：US06342600B1
公开(公告)日：2002-01-29
申请号：US09749302
申请日：2000-12-27
申请人： Stefan Weiss , Helmut Krommer
发明人： Stefan Weiss , Helmut Krommer
IPC分类号： C07D25116
CPC分类号： C07D251/18
摘要： Provided herein is a novel and useful process for preparing 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine that broadly comprises the steps of (a) reacting zinc bis(imino-bis-carbimic acid methyl ester) with acetic anhydride to give 2,4-dimethoxy-6-methyl-1,3,5-triazine and (b) reacting the 2,4-dimethoxy-6-methyl-1,3,5-triazine, formed in step (a), with methylamine to give 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine.
摘要翻译：本文提供了一种用于制备2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪的新颖且有用的方法，其广泛包括以下步骤：（a）使双（亚氨基 - 二 - 碳二氨基甲酸甲酯））与乙酸酐反应，得到2,4-二甲氧基-6-甲基-1,3,5-三嗪和（b）使步骤中形成的2,4-二甲氧基-6-甲基-1,3,5-三嗪（a）与甲胺反应，得到2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪。

5. 发明授权

US06413911B1 Herbicidal sulfonylureas, their preparation and use 有权
标题翻译：除草磺酰脲类，其制备和用途
公开(公告)号：US06413911B1
公开(公告)日：2002-07-02
申请号：US09879900
申请日：2001-06-14
申请人： Horst Mayer , Gerhard Hamprecht , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
发明人： Horst Mayer , Gerhard Hamprecht , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
IPC分类号： C07D25116
CPC分类号： C07D521/00 , A01N47/36
摘要： Sulfonylureas of the general formula I where R1 is a methyl or ethyl group; R2 is C1-C3-alkoxycarbonyl, a C1-C2-alkyl group which carries 1 to 5 fluorine atoms, methylsulfonyl, dimethylaminosulfonyl, thiomethyl, methylsulfinyl, methylsulfonyloxy, trifluoromethoxy, difluoromethoxy, difluorochloromethoxy, difluorochloromethyl or nitro; R3 is hydrogen, methyl, methoxy, ethoxy, fluorine, chlorine or thiomethyl; W is hydrogen or chlorine and Z is CH or N and their agriculturally utilizable salts are described.
摘要翻译：磺酰脲，其通式为I，其中R 1为甲基或乙基; R 2为C 1 -C 3 - 烷氧基羰基，含有1至5个氟原子的C 1 -C 2烷基，甲基磺酰基，二甲基氨基磺酰基，硫代甲基，甲基亚磺酰基，甲基磺酰氧基，三氟甲氧基，二氟甲氧基，二氟氯甲氧基，二氟氯甲基或硝基; R3是氢，甲基，甲氧基，乙氧基，氟，氯或硫代甲基; W是氢或氯，Z是CH或N，并且描述了它们的农业上可用的盐。

6. 发明授权

US06320046B1 Herbicidal sulfonylureas, their preparation and use 失效
标题翻译：除草磺酰脲类，其制备和用途
公开(公告)号：US06320046B1
公开(公告)日：2001-11-20
申请号：US09517112
申请日：2000-03-07
申请人： Horst Mayer , Gerhard Hamprecht , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
发明人： Horst Mayer , Gerhard Hamprecht , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
IPC分类号： C07D25116
CPC分类号： C07D521/00 , A01N47/36
摘要： Sulfonylureas of the general formula I where R1 is a methyl or ethyl group; R2 is C1-C3-alkoxycarbonyl, a C1-C2-alkyl group which carries 1 to 5 fluorine atoms, methylsulfonyl, dimethylaminosulfonyl, thiomethyl, methylsulfinyl, methylsulfonyloxy, trifluoromethoxy, difluoromethoxy, difluorochloromethoxy, difluorochloromethyl or nitro; R3 is hydrogen, methyl, methoxy, ethoxy, fluorine, chlorine or thiomethyl; W is hydrogen or chlorine and Z is CH or N and their agriculturally utilizable salts are described.
摘要翻译：磺酰脲，其通式为I，其中R 1为甲基或乙基; R 2为C 1 -C 3 - 烷氧基羰基，含有1至5个氟原子的C 1 -C 2烷基，甲基磺酰基，二甲基氨基磺酰基，硫代甲基，甲基亚磺酰基，甲基磺酰氧基，三氟甲氧基，二氟甲氧基，二氟氯甲氧基，二氟氯甲基或硝基; R3是氢，甲基，甲氧基，乙氧基，氟，氯或硫代甲基; W是氢或氯，Z是CH或N，并且描述了它们的农业上可用的盐。

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