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51. 发明申请

WO2006069323A1 IMPLANTABLE HERMETICALLY SEALED STRUCTURES 审中-公开
标题翻译：可塑性密封结构
公开(公告)号：WO2006069323A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/046815
申请日：2005-12-22
申请人： PROTEUS BIOMEDICAL, INC. , COSTELLO, Bendict, J. , JENSEN, Marc , ZDEBLICK, Mark , FRANK, Jeremy , GELFANDBEIN, Vladimier
发明人： COSTELLO, Bendict, J. , JENSEN, Marc , ZDEBLICK, Mark , FRANK, Jeremy , GELFANDBEIN, Vladimier
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/05 , A61N1/37205 , A61N1/3756
摘要： Implantable hermetically sealed structures and methods for making the same are provided. Also provided are devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems.
摘要翻译：提供了可植入密封结构及其制造方法。还提供了包括密封结构的装置，系统和试剂盒以及使用这种装置和系统的方法。

52. 发明申请

WO2004066817A2 METHODS AND SYSTEMS FOR MEASURING CARDIAC PARAMETERS 审中-公开
标题翻译：测量心脏参数的方法和系统
公开(公告)号：WO2004066817A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001834
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC. , ZDEBLICK, Mark , RUGGIO, Joseph, M.
发明人： ZDEBLICK, Mark , RUGGIO, Joseph, M.
IPC分类号： A61B
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61B5/1107 , A61B5/1473 , A61B5/6882
摘要： Methods and systems of the present invention provide for measurement of various cardiac parameters. Methods generally involve causing a change in volume and/or pressure in a heart chamber, measuring the change, and calculating at least one cardiac parameter based on the change. Systems typically include at least one actuator, at least one sensor, and a catheter or other device for positioning at least partially in a heart chamber. In some embodiments, the system may also include a controller, such as a computer or other processor, an external actuator, an external sensor, and/or an ECG device. Methods and systems of the invention may be used to more accurately diagnose cardiac conditions in order to make more informed treatment decisions.
摘要翻译：本发明的方法和系统提供各种心脏参数的测量。方法通常包括引起心室中体积和/或压力的变化，测量变化，以及基于变化计算至少一个心脏参数。系统通常包括至少一个致动器，至少一个传感器，以及用于至少部分地定位在心室中的导管或其它装置。在一些实施例中，系统还可以包括诸如计算机或其他处理器的控制器，外部致动器，外部传感器和/或ECG设备。可以使用本发明的方法和系统来更准确地诊断心脏病状，以便做出更明智的治疗决定。

53. 发明申请

WO2012015757A1 METHODS AND APPARATUS FOR TISSUE STIMULATION CONFIGURATION 审中-公开
标题翻译：组织刺激配置的方法和装置
公开(公告)号：WO2012015757A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045233
申请日：2011-07-25
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , LEICHNER, Robert , BERKMAN, Jeffrey
发明人： ZDEBLICK, Mark , LEICHNER, Robert , BERKMAN, Jeffrey
IPC分类号： A61N1/36 , A61N1/362 , A61N1/05 , A61N1/08
CPC分类号： A61N1/056 , A61N1/37205 , A61N1/37264 , A61N1/37288
摘要： Apparatus, methods, and system for stimulating tissue by using one or more individually addressable satellite units on a lead configured by one or more communication units disposed on the lead are described. In one aspect, the apparatus comprises at least one lead configured for insertion into a subject's body and the lead comprises at least one conduction path, one or more of satellite units located at a distal end of the lead, at least one communication unit disposed on the lead, a connector disposed on a proximal end of the lead, wherein the connector is configured to be coupled to an implantable pulse generator. The satellite units comprise one or more electrodes configured to interact with the body and the communication unit comprises control circuitry configured to communicate with an external device and the satellite units.
摘要翻译：描述了通过在一个或多个设置在引线上的通信单元配置的引线上使用一个或多个可单独寻址的卫星单元来刺激组织的装置，方法和系统。在一个方面，该装置包括至少一个引线，其被配置用于插入到被检者的身体中，并且引线包括至少一个传导路径，位于引线远端的一个或多个卫星单元，至少一个通信单元所述引线，设置在所述引线的近端上的连接器，其中所述连接器被配置为耦合到可植入脉冲发生器。卫星单元包括配置成与身体相互作用的一个或多个电极，并且通信单元包括被配置为与外部设备和卫星单元进行通信的控制电路。

54. 发明申请

WO2011014465A2 LEAD FOR USE IN RF FIELD 审中-公开
标题翻译：用于射频场领域
公开(公告)号：WO2011014465A2
公开(公告)日：2011-02-03
申请号：PCT/US2010/043288
申请日：2010-07-27
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , THOMPSON, Todd
发明人： ZDEBLICK, Mark , THOMPSON, Todd
IPC分类号： A61B5/055 , A61B5/0402 , A61B5/0408
CPC分类号： A61N1/05 , A61N1/086
摘要： A lead such as used for pacemaking or neural stimulation has a current block IC which blocks current when RF is detected. In this way problems of tissue heating are reduced or eliminated when the patient carrying such a lead is given an MRI. The lead may also detect localized temperature, to be reported to equipment external to the lead. This may permit more judicious use of the RF energy, for example during an MRI session. Localized and spurious tissue heating nearby to an electrode of a lead, due to RF energy from an MRI, is reduced or eliminated by detecting the RF field, deriving energy from the field, and actively driving a node that is coupled to such an electrode so as to minimize voltage excursions at the electrode. A state is maintained or set within electronics nearby to an electrode of a lead, so that a can which connects with the lead is able to learn whether an MRI event has occurred since the last time that the can had sent commands to the electronics to set particular internal states. For a lead that delivers pacing pulses, a pacing detector is provided in addition to an MRI detector, and the blocking action is carried out most of the time but is disabled briefly for each pacing pulse. During a time of presence of RF energy, a bucking circuit attempts, to the extent possible, to drive a node toward blood potential, the node capacitively coupled with electrodes of the lead.
摘要翻译：诸如用于起搏或神经刺激的导联具有电流阻断IC，其在检测到RF时阻断电流。以这种方式，当携带这样的导线的患者被给予MRI时，组织加热的问题被减少或消除。导联还可以检测局部温度，并将其报告给导联外部的设备。这可以允许更明智地使用RF能量，例如在MRI会话期间。通过检测RF场，从场获得能量并且主动驱动耦合到这样的电极的节点，减少或消除了由于来自MRI的RF能量而导致的导线电极附近的局部和虚假组织加热以最小化电极处的电压偏移。状态被维持或设置在导线的电极附近的电子器件中，使得与导线连接的罐能够获知自上次能够向电子设备发送命令以设定MRI事件是否已经发生特定的内部状态。对于提供起搏脉冲的导线，除MRI检测器外还提供起搏探测器，大部分时间进行阻断动作，但对每个起搏脉冲暂时禁用。在存在RF能量期间，补偿电路尽可能地尝试将节点驱动至血压，节点与引线的电极电容耦合。

55. 发明申请

WO2010057051A2 IMPLANTABLE MICROSTIMULATORS 审中-公开
标题翻译：可植入的微型计算机
公开(公告)号：WO2010057051A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/064474
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , HAFEZI, Hooman
发明人： ZDEBLICK, Mark , HAFEZI, Hooman
IPC分类号： A61N1/36 , A61N1/05 , A61N1/02
CPC分类号： A61N1/3756 , A61N1/3605 , A61N1/37205
摘要： Electrolytic capacitor microstimulators are provided. Microstimulators of the invention are configured to operate, upon implantation into a living body, as an electrolytic capacitor that employs body fluid as its electrolyte. Also provided are methods and systems that include the microstimulators of the invention, as well as methods of using the devices and systems in a variety of different applications.
摘要翻译：提供了电解电容器微型刺激器。本发明的微型刺激器被构造成在植入生物体中时作为采用体液作为其电解质的电解电容器来操作。还提供了包括本发明的微型刺激器的方法和系统，以及在各种不同的应用中使用该设备和系统的方法。

56. 发明申请

WO2004067081A3 METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING 审中-公开
公开(公告)号：WO2004067081A3
公开(公告)日：2004-08-12
申请号：PCT/US2004/001806
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC. , ZDEBLICK, Mark , RUGGIO, Joseph, M.
发明人： ZDEBLICK, Mark , RUGGIO, Joseph, M.
IPC分类号： A61N1/18
摘要： Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device (20). Devices may include at least one catheter (14) (such as a multiplexed catheter with one or more sensors (16, 18) and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.

57. 发明申请

WO2004052182A2 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译：用于监测和处理血液动力学参数的方法和系统
公开(公告)号：WO2004052182A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039524
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL, INC.
发明人： ZDEBLICK, Mark , SAVAGE, George, M.
IPC分类号： A61B
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.
摘要翻译：复用的医疗载体提供用于感测一个或多个患者参数和/或通过单独识别的效应器递送能量。载体包括主体和与至少两个效应器耦合的至少两个电导体。效应器可以是传感器，致动器或两者的任何组合。传感器可以测量诸如压力，氧含量，体积，电导率，流体流速或任何其它化学或物理参数的参数。例如，可以使用致动器来调节心脏，刺激肌肉或神经组织，广播超声能量，发射光，热或其他形式的辐射，或递送任何形式的能量或物质。一种用于从患者收集医学数据的方法包括询问驻留在患者的并行导体上的复用传感器网络，包括寻址网络中的第一可寻址传感器以获得数据并寻址网络中的第二可寻址传感器以获得数据。

58. 发明公开

EP2414036A2 METHOD AND APPARATUS FOR IMPLANTABLE LEAD 审中-公开
标题翻译：方法和设备的可植入引线LINE
公开(公告)号：EP2414036A2
公开(公告)日：2012-02-08
申请号：EP10759498.8
申请日：2010-04-02
申请人： Proteus Biomedical, Inc.
发明人： ZDEBLICK, Mark
IPC分类号： A61N1/05 , A61B18/00 , A61B19/00
CPC分类号： A61N1/0551 , A61N1/36071
摘要： In one embodiment of the invention, an implantable lead is provided. It has a plurality of satellites along its length, each satellite having at least one electrode and having as many as four electrodes at each satellite. Each satellite has a chip which controls the manner in which electrodes are or are not connected with a conductor within the lead. In an embodiment a control signal is transmitted through the connector of the first and along the at least one conductor to the chips of the satellites, thereby configuring at each chip a respective impedance between the at least one conductor and the respective at least one electrode. Subsequently, a pacing current is passed through the connector of the first lead and along the at least one conductor, and at each chip passing a portion of the pacing current through the respective impedance to the respective at least one electrode.

59. 发明公开

EP2358429A2 ANALYZER COMPATIBLE COMMUNICATION PROTOCOL 审中-公开
标题翻译：有分析单元兼容通讯
公开(公告)号：EP2358429A2
公开(公告)日：2011-08-24
申请号：EP09830930.5
申请日：2009-11-30
申请人： Proteus Biomedical, Inc.
发明人： GILMAN, Alexander , ZDEBLICK, Mark , ARNE, Lawrence , JANI, Nilay , LI, Haifeng , WITHRINGTON, Jonathan , COSTELLO, Benedict J. , WHITWORTH, Adam
IPC分类号： A61N1/05 , A61N1/04 , A61N1/36 , A61B5/0402 , A61M1/10
CPC分类号： A61N1/368 , A61B5/0031 , A61B5/0402 , A61B5/4519 , A61N1/025 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N1/37241 , A61N1/37252
摘要： Methods and systems for programming a plurality of leads under at least two distinct modalities are provided. The leads may be grouped within satellites and multiple satellites may be configured within a single lead. Each lead includes a power and communications bus providing commands, and information and pulses to the satellites. The leads may be connected to at least two different command and pulse sources, optionally a cardiac pacemaker and/or a cardiac pulse analyzer system. A command may include or be preceded by a wake-up pulse that facilitates identification of a modality applicable to the associated command and data. A command may further optionally include a reference pulse or series of reference pulses, whereby the satellite references data pulses in relation to one or more aspects of the associated reference pulse. A data pulse may deliver two bits of information.

60. 发明公开

EP2358270A2 EVALUATION OF GASTROINTESTINAL FUNCTION USING PORTABLE ELECTROVISCEROGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：评估胃肠功能的使用手提式ELEKTROVISZEROGRAPHIESYSTEME及使用方法
公开(公告)号：EP2358270A2
公开(公告)日：2011-08-24
申请号：EP09832576.4
申请日：2009-12-10
申请人： Proteus Biomedical, Inc.
发明人： SAVAGE, George , HAFEZI, Hooman , COLLIOU, Olivier , ZDEBLICK, Mark , STRAND, Angela
IPC分类号： A61B5/05 , A61B1/273
CPC分类号： A61B5/053 , A61B5/04884 , A61B5/073 , A61B5/1107 , A61B5/14539 , A61B5/42 , A61B5/6861 , A61B2560/0214 , A61B2560/0242 , G06F19/00
摘要： Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.

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