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51. 发明授权

US07655040B2 Cardiac valve annulus reduction system 有权
标题翻译：心脏瓣膜减压系统
公开(公告)号：US07655040B2
公开(公告)日：2010-02-02
申请号：US10531819
申请日：2004-11-12
申请人： Nareak Douk , Nasser Rafiee , Eliot Bloom , Douglas A. Fogg , Rany Huynh , David D. Barone
发明人： Nareak Douk , Nasser Rafiee , Eliot Bloom , Douglas A. Fogg , Rany Huynh , David D. Barone
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/00234 , A61B17/0401 , A61B2017/00243 , A61B2017/00783 , A61B2017/0414 , A61B2017/0496 , A61B2017/06052 , A61B2017/06176 , A61F2002/30545 , A61F2220/0016 , A61F2250/001
摘要： A catheter-based, annulus reduction device and system for cardiac valve repair and method of using the same. The system is usable for treating mitral valve regurgitation and comprises a catheter, a reduction ring carried within the catheter, the reduction ring including a plurality of exit ports formed in a side wall of the reduction ring and filament received in the reduction ring. The filament includes a plurality of radially extendible barbs corresponding to the sidewall openings. The reduction ring carrying the filament is deployed adjacent a mitral valve annulus and the filament is translated relative to the reduction ring to deploy the barbs through the exit ports and into the annulus and to further translate the reduction ring with deployed barbs to reshape the annulus.
摘要翻译：一种基于导管的减压装置和心脏瓣膜修复系统及其使用方法。该系统可用于治疗二尖瓣反流，并且包括导管，在导管内承载的还原环，所述还原环包括形成在所述还原环的侧壁中的多个出口和容纳在所述还原环中的细丝。灯丝包括对应于侧壁开口的多个可径向延伸的倒钩。承载细丝的还原环被布置在二尖瓣环附近，并且细丝相对于还原环平移，以将倒钩布置在出口端口并进入环形空间中，并且进一步将还原环用展开的倒钩重新平整以环形环。

52. 发明申请

US20070238979A1 Reference Devices for Placement in Heart Structures for Visualization During Heart Valve Procedures 审中-公开
标题翻译：在心脏瓣膜手术期间用于可视化的心脏结构中的放置参考装置
公开(公告)号：US20070238979A1
公开(公告)日：2007-10-11
申请号：US11689961
申请日：2007-03-22
申请人： Rany Huynh , Nasser Rafiee , Alex Hill , Nareak Douk
发明人： Rany Huynh , Nasser Rafiee , Alex Hill , Nareak Douk
IPC分类号： A61B5/05
CPC分类号： A61B5/103 , A61B5/055 , A61B5/6855 , A61B5/6858 , A61B5/6869 , A61B6/12 , A61B8/0833 , A61B90/39 , A61B2017/00243 , A61B2090/063 , A61B2090/3925
摘要： Visualization reference devices to aid in non-direct visualization of heart structure. The devices are positionable in the heat structure and visible with a desired imaging modality. The devices being elastically transformable between delivery configurations and deployment configurations. The devices being used to assist a clinician in mapping the heart structure while implanting therapeutic devices therein. An example would be using the devices disclosed herein to map the size, location, orientation and displacement of a mitral valve annulus for catheter based implantation of a valve repair device.
摘要翻译：可视化参考设备，以帮助心脏结构的非直接可视化。这些装置可以在热结构中定位并且具有期望的成像模态可见。这些设备可在传送配置和部署配置之间弹性转换。所述装置用于帮助临床医生在将治疗装置植入其中时映射心脏结构。一个例子将是使用本文公开的装置来映射用于基于导管的植入瓣膜修复装置的二尖瓣环的尺寸，位置，取向和位移。

53. 发明申请

US20070010878A1 Coronary sinus approach for repair of mitral valve regurgitation 有权
标题翻译：冠状窦方法修复二尖瓣关闭不全
公开(公告)号：US20070010878A1
公开(公告)日：2007-01-11
申请号：US10531833
申请日：2004-11-11
申请人： Nasser Rafiee , Nareak Douk , James Crittenden
发明人： Nasser Rafiee , Nareak Douk , James Crittenden
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： A device and method for treating cardiac valve regurgitation. The device includes a tubular member including a lumen there through and a locking mechanism and a compression device carried on the tubular member. The compression device is transformable to a compression configuration in response to axial displacement and is locked in the compression configuration by the locking mechanism. The method includes positioning the compression device adjacent a cardiac valve and applying an axial displacement to the compression device to transform the compression device into a compression configuration and locking the compression device in the compression configuration to apply a compressive force to the cardiac valve.
摘要翻译：一种用于治疗心脏瓣膜反流的装置和方法。该装置包括管状构件，其包括其中的内腔和锁定机构以及承载在管状构件上的压缩装置。压缩装置可以响应于轴向位移而变形成压缩构型，并且通过锁定机构锁定在压缩构造中。该方法包括将压缩装置定位在心脏瓣膜附近并向压缩装置施加轴向位移，以将压缩装置转换成压缩构型并将压缩装置锁定在压缩构型中以向心脏瓣膜施加压缩力。

54. 发明申请

US20050131520A1 Compliant blood vessel graft 审中-公开
标题翻译：符合血管移植
公开(公告)号：US20050131520A1
公开(公告)日：2005-06-16
申请号：US10987313
申请日：2004-11-12
申请人： Peter Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael Wolf
发明人： Peter Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael Wolf
IPC分类号： A61F2/06 , A61F2/90
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a blood vessel segment, e.g., a vein segment, carried within and having an ablumenal surface in contact with and supported by the tubular support, the graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和血管段，例如静脉段，其承载在并具有与管状支撑件接触并由其支撑的腹膜表面，所述移植物能够弹性径向膨胀模拟动脉的径向顺应性的方式。

55. 发明申请

US20210137579A1 TISSUE EXCISION, CUTTING, AND REMOVAL SYSTEMS AND METHODS 有权
公开(公告)号：US20210137579A1
公开(公告)日：2021-05-13
申请号：US17086431
申请日：2020-11-01
申请人： Nasser Rafiee , Stuart Macdonald , Rany Busold , Alexis Balcom , Morgan House
发明人： Nasser Rafiee , Stuart Macdonald , Rany Busold , Alexis Balcom , Morgan House
IPC分类号： A61B18/08 , A61B18/14 , A61B90/00
摘要： The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

56. 发明授权

US07815673B2 Double-walled stent system 有权
标题翻译：双壁支架系统
公开(公告)号：US07815673B2
公开(公告)日：2010-10-19
申请号：US12060332
申请日：2008-04-01
申请人： Eliot Bloom , Gian Pellegrini , Juan-Pablo Mas , Nasser Rafiee , Morgan House
发明人： Eliot Bloom , Gian Pellegrini , Juan-Pablo Mas , Nasser Rafiee , Morgan House
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/823 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91591 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61F2230/0071 , A61F2230/0076 , A61F2250/0037 , A61F2250/0063 , A61F2250/0082
摘要： A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.
摘要翻译：公开了一种特别适用于治疗右心室流出道异常的双壁支架系统，其具有外部支架部件和内部支架部件。外部支架部件包括多个纵向延伸的连接器，例如直线或正弦带。内部支架部件具有大致管状的圆柱形主体并且在外部支架部件内居中。支架系统具有收缩输送构型和用于接触血管壁的径向扩张构型。当部署时，外部支架部件的纵向延伸的连接器与血管壁接触并将支架系统固定到治疗部位。内部支架部件也径向扩张，但保持在外部部件的中心，并且几乎不与血管壁接触。

57. 发明授权

US07806919B2 Double-walled stent system 有权
标题翻译：双壁支架系统
公开(公告)号：US07806919B2
公开(公告)日：2010-10-05
申请号：US12060340
申请日：2008-04-01
申请人： Eliot Bloom , Nasser Rafiee , Morgan House
发明人： Eliot Bloom , Nasser Rafiee , Morgan House
IPC分类号： A61F2/06 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/823 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91591 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61F2230/0071 , A61F2230/0076 , A61F2250/0037 , A61F2250/0063 , A61F2250/0082
摘要： A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component is secured to the interior stent component in a non-fixed, sliding relationship. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.
摘要翻译：公开了一种特别适用于治疗右心室流出道异常的双壁支架系统，其具有外部支架部件和内部支架部件。外部支架部件以非固定的滑动关系固定到内部支架部件。外部支架部件包括多个纵向延伸的连接器，例如直线或正弦带。内部支架部件具有大致管状的圆柱形主体并且在外部支架部件内居中。支架系统具有收缩输送构型和用于接触血管壁的径向扩张构型。当部署时，外部支架部件的纵向延伸的连接器与血管壁接触并将支架系统固定到治疗部位。内部支架部件也径向扩张，但保持在外部部件的中心，并且几乎不与血管壁接触。

58. 发明申请

US20090248133A1 Double-Walled Stent System 有权
标题翻译：双壁支架系统
公开(公告)号：US20090248133A1
公开(公告)日：2009-10-01
申请号：US12060340
申请日：2008-04-01
申请人： Eliot Bloom , Nasser Rafiee , Morgan House
发明人： Eliot Bloom , Nasser Rafiee , Morgan House
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/823 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91591 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61F2230/0071 , A61F2230/0076 , A61F2250/0037 , A61F2250/0063 , A61F2250/0082
摘要： A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component is secured to the interior stent component in a non-fixed, sliding relationship. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.
摘要翻译：公开了一种特别适用于治疗右心室流出道异常的双壁支架系统，其具有外部支架部件和内部支架部件。外部支架部件以非固定的滑动关系固定到内部支架部件。外部支架部件包括多个纵向延伸的连接器，例如直线或正弦带。内部支架部件具有大致管状的圆柱形主体并且在外部支架部件内居中。支架系统具有收缩输送构型和用于接触血管壁的径向扩张构型。当部署时，外部支架部件的纵向延伸的连接器与血管壁接触并将支架系统固定到治疗部位。内部支架部件也径向扩张，但保持在外部部件的中心，并且几乎不与血管壁接触。

59. 发明申请

US20070203391A1 System for Treating Mitral Valve Regurgitation 审中-公开
标题翻译：二尖瓣反流治疗系统
公开(公告)号：US20070203391A1
公开(公告)日：2007-08-30
申请号：US11678466
申请日：2007-02-23
申请人： Eliot Bloom , Morgan House , Nasser Rafiee , Michael Finney
发明人： Eliot Bloom , Morgan House , Nasser Rafiee , Michael Finney
IPC分类号： A61F2/02 , A61B17/34
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0482 , A61B2017/00247 , A61B2017/00867 , A61B2017/06052 , A61B2018/00392
摘要： A system for treating mitral valve regurgitation comprising at least delivery catheters, puncture catheters, and tensioning devices. The devices include tension members linking a proximal anchor and distal anchor that can be constructed from a tubular braded material and have internal reinforcing members. In some embodiments, the anchors and tension members may flex in response to a heart beat. The system can also include temporary anchors so a clinician can review and adjust the vector of the tension member. Delivery catheters can also include temporary anchors to secure the catheter in position. When positioned across the left ventricle of a heart, the device can reduce the lateral distance between the walls of the ventricle and thus allow better coaption of the mitral valve leaflets thereby reducing heart valve regurgitation.
摘要翻译：一种用于治疗二尖瓣反流的系统，至少包括输送导管，穿刺导管和张紧装置。这些装置包括连接近端锚固件和远端锚固件的张紧构件，其可以由管状胎体材料构造并具有内部加强构件。在一些实施例中，锚和张紧构件可以响应于心跳而弯曲。该系统还可以包括临时锚，所以临床医生可以检查和调整张力构件的矢量。输送导管还可以包括用于将导管固定就位的临时锚。当位于心脏的左心室时，该装置可以减小心室壁之间的横向距离，从而允许二尖瓣小叶更好地分离，从而减少心脏瓣膜反流。

60. 发明申请

US20090248132A1 Double-Walled Stent System 有权
标题翻译：双壁支架系统
公开(公告)号：US20090248132A1
公开(公告)日：2009-10-01
申请号：US12060332
申请日：2008-04-01
申请人： Eliot Bloom , Gian Pellegrini , Juan-Pablo Mas , Nasser Rafiee , Morgan House
发明人： Eliot Bloom , Gian Pellegrini , Juan-Pablo Mas , Nasser Rafiee , Morgan House
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/823 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91591 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61F2230/0071 , A61F2230/0076 , A61F2250/0037 , A61F2250/0063 , A61F2250/0082
摘要： A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.
摘要翻译：公开了一种特别适用于治疗右心室流出道异常的双壁支架系统，其具有外部支架部件和内部支架部件。外部支架部件包括多个纵向延伸的连接器，例如直线或正弦带。内部支架部件具有大致管状的圆柱形主体并且在外部支架部件内居中。支架系统具有收缩输送构型和用于接触血管壁的径向扩张构型。当部署时，外部支架部件的纵向延伸的连接器与血管壁接触并将支架系统固定到治疗部位。内部支架部件也径向扩张，但保持在外部部件的中心，并且几乎不与血管壁接触。

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