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51. 发明授权

US09642658B2 Device and method for delivery of therapeutic agents via internal implants 有权
公开(公告)号：US09642658B2
公开(公告)日：2017-05-09
申请号：US12908464
申请日：2010-10-20
申请人： Lawrence M. Boyd , Samuel B. Adams, Jr. , Matthew R. Penny , Cody Blazek
发明人： Lawrence M. Boyd , Samuel B. Adams, Jr. , Matthew R. Penny , Cody Blazek
IPC分类号： A61B17/80 , A61B17/60 , A61B17/70 , A61F2/30 , A61K9/00 , A61K9/06
CPC分类号： A61B17/80 , A61B17/60 , A61B17/7061 , A61F2002/30677 , A61F2002/3068 , A61F2250/0068 , A61K9/0024 , A61K9/06
摘要： A device is provided for use with a medical implant for delivering an agent to a designated site of action in a body of a patient. The agent-delivery device comprises a body member having an inner surface and a projection on the inner surface of the body member. An agent-delivery medium is associated with the body member. The agent-delivery medium includes a therapeutic agent for treating the body of the patient. The body member is adapted to be secured to the medical implant such that the projection operatively engages the medical implant for spacing the inner surface of the body member from the implant, and the agent-delivery medium is configured to release the therapeutic agent after implantation in the body of the patient. In alternative embodiments, the agent-delivery device comprises a first body member having an inner surface and a second body member having an inner surface. When connected, the inner surfaces of the first body member and the second body member define a cavity adapted to receive the medical implant. The body member may also define an opening therethrough, the opening configured to receive an anchor member for fixing the body member in a body of a patient.

52. 发明授权

US07981156B2 Bone grafts 有权
标题翻译：骨移植
公开(公告)号：US07981156B2
公开(公告)日：2011-07-19
申请号：US10781058
申请日：2004-02-18
申请人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
发明人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
IPC分类号： A61F2/44 , A61F2/28
CPC分类号： A61F2/30767 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2090/034 , A61F2/28 , A61F2/30724 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30075 , A61F2002/30112 , A61F2002/30136 , A61F2002/30153 , A61F2002/30187 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/30772 , A61F2002/30774 , A61F2002/30787 , A61F2002/30797 , A61F2002/30813 , A61F2002/30836 , A61F2002/30841 , A61F2002/30848 , A61F2002/3085 , A61F2002/30866 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/448 , A61F2002/4623 , A61F2002/4627 , A61F2002/4628 , A61F2002/4649 , A61F2210/0004 , A61F2210/0061 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2310/00161 , A61F2310/00293 , A61F2310/00365 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L27/10 , A61L27/12 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/54 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2300/252 , A61L2300/414 , A61L2300/802 , A61L2430/38 , Y10S606/907 , Y10S606/908 , Y10S606/909 , Y10S606/91 , A61L27/227
摘要： Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
摘要翻译：提供脊柱间隔件20用于运动段的融合。间隔件包括具有壁22的承载构件21，该壁22的尺寸设置成用于接合在相邻椎骨之间的空间中，以维持空间和有效量的成骨组合物以刺激骨诱导。成骨组合物包括药学上可接受的载体中基本上纯的成骨因子。在一个实施例中，承载构件包括浸渍在成骨组合物中的骨移植物。在另一个实施方案中，成骨组合物30被包装在限定在移植物中的腔室25内。涵盖骨移植物的任何合适构型，包括骨榫，D形间隔物和皮质环。

53. 发明申请

US20090254123A1 Dynamic Spinal Stabilization System 有权
标题翻译：动态脊柱稳定系统
公开(公告)号：US20090254123A1
公开(公告)日：2009-10-08
申请号：US12432247
申请日：2009-04-29
申请人： John Pafford , Thomas Wilson , Lawrence M. Boyd , Mark D. LoGuidice
发明人： John Pafford , Thomas Wilson , Lawrence M. Boyd , Mark D. LoGuidice
IPC分类号： A61B17/70 , A61B17/88
CPC分类号： A61B17/701 , A61B17/7007
摘要： A dynamic stabilization system includes a stabilization element, such as a spinal rod, a plurality of bone anchors, such as bone bolts, and a like plurality of connectors for connecting the bolts to the spinal rod. At least some of the connectors include a flexible element between the bone anchor and the rod and an adjustment element for adjusting the flexibility of the flexible element, to thereby adjust the dynamic flexibility between the rod and the bone anchor. In one embodiment, the flexible element is a flexible bearing element of a rod end bearing.
摘要翻译：动态稳定系统包括稳定元件，例如脊椎杆，多个骨锚，例如骨螺栓，以及用于将螺栓连接到脊柱杆的多个连接器。至少一些连接器包括在骨锚和杆之间的柔性元件和用于调节柔性元件的柔性的调节元件，从而调节杆和骨锚之间的动态弹性。在一个实施例中，柔性元件是杆端轴承的柔性支承元件。

54. 发明授权

US06761738B1 Reinforced molded implant formed of cortical bone 有权
标题翻译：由皮质骨形成的增强模制植入物
公开(公告)号：US06761738B1
公开(公告)日：2004-07-13
申请号：US09664652
申请日：2000-09-19
申请人： Lawrence M. Boyd
发明人： Lawrence M. Boyd
IPC分类号： A61F244
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/442 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30166 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30405 , A61F2002/30492 , A61F2002/30507 , A61F2002/3051 , A61F2002/30514 , A61F2002/30604 , A61F2002/30616 , A61F2002/30774 , A61F2002/30841 , A61F2002/30848 , A61F2002/448 , A61F2220/0025 , A61F2220/0033 , A61F2230/0028
摘要： This invention relates to arthodesis for stabilizing the spine. More specifically, the present invention is directed to an intervertebral spacer formed of a bone material and to methods of treating patients having spinal deformities. The invention provides a spinal implant assembly comprising bone-derived components. The bone-derived components can be formed into modular units that can be assembled to provide a wide variety of implants configurations. In addition, the bone-derived components can form scaffold that can withstand the shear and impact forces necessary to insert the assembled implant into a disc space between adjacent vertebrae. In preferred forms the implants define an open spacer that serves as a depot for receipt of an osteoconductive material. The ostoegenic material is preferably a moldable filler that can form a molded reinforced implant.
摘要翻译：本发明涉及用于稳定脊椎的方法。更具体地，本发明涉及由骨材料形成的椎间隔件和治疗患有脊柱畸形的患者的方法。本发明提供一种包括骨衍生成分的脊柱植入物组件。骨衍生的组件可以形成为可以组装以提供各种种植体构造的模块单元。此外，骨衍生的组分可以形成能够承受将组装的植入物插入相邻椎骨之间的椎间盘空间所需的剪切力和冲击力的支架。在优选形式中，植入物限定用作接收骨传导材料的贮库的开放间隔物。造口材料优选是可形成模制增强植入物的可成型填料。

55. 发明授权

US06468311B2 Modular interbody fusion implant 失效
公开(公告)号：US06468311B2
公开(公告)日：2002-10-22
申请号：US09766948
申请日：2001-01-22
申请人： Lawrence M. Boyd , Eddie F. Ray, III , Jeffrey Kozak
发明人： Lawrence M. Boyd , Eddie F. Ray, III , Jeffrey Kozak
IPC分类号： A61F244
CPC分类号： A61F2/28 , A61F2/442 , A61F2/4455 , A61F2/4611 , A61F2002/2835 , A61F2002/30004 , A61F2002/30057 , A61F2002/30131 , A61F2002/30133 , A61F2002/30387 , A61F2002/30448 , A61F2002/30507 , A61F2002/30604 , A61F2002/30772 , A61F2002/30828 , A61F2002/30831 , A61F2002/30904 , A61F2002/4485 , A61F2220/0025 , A61F2220/005 , A61F2230/0013 , A61F2230/0015 , A61F2250/0014
摘要： An interbody fusion device for engagement between vertebrae includes a pair of lateral spacers for spacing the vertebrae, and a connecting member adapted to couple together the lateral spacers when inserted between the vertebrae. The connecting member, individual lateral spacers, or the entire spinal spacer can be made of bone in order to promote fusion of the vertebrae. The modular construction permits use of bone segments otherwise unsuitable due to size or strength in stable fusion devices.

56. 发明授权

US06344057B1 Adjustable vertebral body replacement 失效
标题翻译：可调椎体更换
公开(公告)号：US06344057B1
公开(公告)日：2002-02-05
申请号：US09073081
申请日：1998-05-05
申请人： Louis Marie Rabbe , Lawrence M. Boyd
发明人： Louis Marie Rabbe , Lawrence M. Boyd
IPC分类号： A61F244
CPC分类号： A61F2/30744 , A61B17/7059
摘要： An adjustable vertebral body replacement implant and assembly includes a thin-walled cylindrical body configured to span over most of the length between intact vertebrae when damaged or diseased vertebrae have been removed. The cylindrical body defines a hollow interior and includes endplates with end surfaces configured to contact the adjacent vertebra and to engage the cylindrical body therebetween. Said end surface includes a blade or plurality of blades configured to penetrate the adjacent vertebra and to facilitate insertion and removal of the implant. This end surface also defines a bore through said endplate. In one embodiment, an end cap which includes a porous body such as porous tantalum manufactured under the name HEDROCEL® is placed in said bore. The end cap provides strength to carry the vertebral loading while allowing vascularization between the intact vertebral and bone growth material disposed within the implant. In another embodiment, the end cap includes an anchor embedded in the bone growth material. The end cap may also include a positioning surface to align the end cap within the bore.
摘要翻译：可调节的椎体替换植入物和组件包括薄壁圆筒体，其被构造成在已经被去除损伤或患病椎骨时跨越完整椎骨之间的大部分长度。圆柱形主体限定中空的内部并且包括端板，其端面被构造成接触相邻的椎骨并使其与圆柱体接合。所述端面包括构造成穿透相邻椎骨并有助于植入物的插入和移除的叶片或多个叶片。该端面还限定穿过所述端板的孔。在一个实施例中，包括多孔体的端盖，例如以名称HEDROCEL制造的多孔钽被放置在所述孔中。端盖提供承载椎体载荷的强度，同时允许在植入物内设置的完整的椎骨和骨生长材料之间的血管化。在另一个实施例中，端盖包括嵌入在骨生长材料中的锚。端盖还可以包括定位表面以将端盖对准在孔内。

57. 发明授权

US06190388B1 Anterior spinal instrumentation and method for implantation and revision 有权
标题翻译：前路脊髓手术及植入修复方法
公开(公告)号：US06190388B1
公开(公告)日：2001-02-20
申请号：US09487167
申请日：2000-01-19
申请人： Gary K. Michelson , Lawrence M. Boyd
发明人： Gary K. Michelson , Lawrence M. Boyd
IPC分类号： A61B1770
CPC分类号： A61B17/1671 , A61B17/1637 , A61B17/7011 , A61B17/7032 , A61B17/7041 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/4611 , A61F2002/2835 , A61F2002/30224 , A61F2002/30235 , A61F2002/30785 , A61F2002/30787 , A61F2002/30797 , A61F2002/3085 , A61F2002/4475 , A61F2002/448 , A61F2002/449 , A61F2002/4619 , A61F2002/4627 , A61F2002/4681 , A61F2230/0069
摘要： A system and method for anterior fixation of the spine utilizes a cylindrical implant engaged in the a intradiscal space at the cephalad and caudal ends of the construct. The implants are cylindrical fusion devices (10) filled with bone material to promote bone ingrowth and fusion of the disc space. An attachment member (40) is connected to each of the fusion devices (10) and bone screws (30) having similar attachment members (33) are engaged in the vertebral bodies of the intermediate vertebrae. A spinal rod (50) is connected to each of the attachment members using an eyebolt assembly (53, 54, 55). In a further inventive method, a revision of the construct is achieved by removing the fusion devices. Each fusion device is engaged by an elongated guide member (62) over which a cylindrical trephine (70) is advanced. The trephine (70) has an inner diameter larger than the diameter of the fusion implant and includes cutting teeth (72) for extracting a core (84) of bone material around the fusion implant. The trephine (70) and guide member (62) are removed along with the bone core (84) containing the fusion implant (10). The trephine (70) is also used to extract a bone dowel from a solid bone mass to be inserted into the space left by the removed bone core (84).
摘要翻译：用于脊柱前固定的系统和方法利用一种圆柱形植入物，该圆柱形植入物在构造体的头部和尾端处于椎间盘内空间内。植入物是填充有骨材料的圆柱形融合装置（10），以促进椎间盘的向内生长和融合。连接构件（40）连接到每个融合装置（10），并且具有相似附接构件（33）的骨螺钉（30）接合在中间椎骨的椎体中。使用吊环组件（53,54,55）将脊柱杆（50）连接到每个附接构件。在另一发明的方法中，通过去除融合装置来实现构建体的修订。每个融合装置由细长的引导构件（62）接合，圆柱形环钻（70）在该引导构件上前进。环钻（70）的内径大于融合植入物的直径，并且包括切割齿（72），用于提取融合植入物周围的骨材料芯（84）。将环钻（70）和引导构件（62）与含有融合植入物（10）的骨芯（84）一起被移除。环钻（70）还用于从固体骨块提取骨榫，以将其插入被移除的骨芯（84）留下的空间中。

58. 发明授权

US5702453A Adjustable vertebral body replacement 失效
标题翻译：可调椎体更换
公开(公告)号：US5702453A
公开(公告)日：1997-12-30
申请号：US647272
申请日：1996-05-13
申请人： Louis-Marie Rabbe , Lawrence M. Boyd , Jean-Louis Chevalier , Jean-Charles Moreau
发明人： Louis-Marie Rabbe , Lawrence M. Boyd , Jean-Louis Chevalier , Jean-Charles Moreau
IPC分类号： A61B17/02 , A61B17/70 , A61B17/80 , A61B17/86 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44
CPC分类号： A61F2/44 , A61B17/70 , A61F2/30744 , A61B17/7059 , A61B17/8061 , A61B17/86 , A61B2017/0256 , A61F2/4455 , A61F2002/2835 , A61F2002/30158 , A61F2002/30166 , A61F2002/3023 , A61F2002/30235 , A61F2002/30329 , A61F2002/30382 , A61F2002/30383 , A61F2002/30405 , A61F2002/30411 , A61F2002/30438 , A61F2002/30494 , A61F2002/30507 , A61F2002/3051 , A61F2002/3055 , A61F2002/30561 , A61F2002/30574 , A61F2002/30601 , A61F2002/30604 , A61F2002/30772 , A61F2002/30774 , A61F2002/30779 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/30848 , A61F2002/30892 , A61F2002/3092 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0026 , A61F2230/0028 , A61F2230/0069 , A61F2250/0071 , A61F2310/00131
摘要： An adjustable vertebral body replacement implant and assembly includes a thin-walled cylindrical body configured to span over most of the length between intact vertebrae when damaged or diseased vertebrae have been removed. The cylindrical body defines a hollow interior with a plurality of bone-ingrowth apertures communicating with the interior. The replacement assembly further includes endplates configured to contact the adjacent vertebra and to engage the cylindrical body therebetween. The cylindrical body and the endplates include mating threads to permit adjustment of the overall height of the implant. A means for fixing the cylindrical body to the endplates is contemplated, which in one embodiment is a set screw for locking the components in place. In another embodiment, the means for fixing includes a crimping channel and notch defined in the endplates to be crimped onto the cylindrical body. A means for connecting the replacement implant to a longitudinal member is provided, which in one embodiment contemplates a clamp and screw assembly. In another embodiment, the means for connecting includes an arm projecting from the endplates with an opening to receive the longitudinal member therethrough.
摘要翻译：可调节的椎体替换植入物和组件包括薄壁圆筒体，其被构造成在已经被去除损伤或患病椎骨时跨越完整椎骨之间的大部分长度。圆柱体限定了具有与内部连通的多个骨内生孔的中空内部。更换组件还包括端板，其配置成接触相邻的椎骨并使其与圆柱体接合。圆柱体和端板包括配合螺纹以允许调整植入物的整体高度。设想将圆柱形主体固定到端板的装置，在一个实施例中，该装置是用于将部件锁定在适当位置的固定螺钉。在另一个实施例中，用于固定的装置包括限定在端板中的压接通道和凹口，以压接在圆柱体上。提供了用于将替换植入物连接到纵向构件的装置，其在一个实施例中考虑了夹具和螺钉组件。在另一个实施例中，用于连接的装置包括从端板突出的臂和开口以容纳纵向构件。

59. 发明申请

US20170014824A1 APPARATUS AND METHOD FOR SORTING OF CELLS 审中-公开
标题翻译：用于分选细胞的装置和方法
公开(公告)号：US20170014824A1
公开(公告)日：2017-01-19
申请号：US15211565
申请日：2016-07-15
申请人： Lawrence M. Boyd , John J. Ratcliffe, JR. , Andres Jose Garcia , Todd Christopher McDevitt
发明人： Lawrence M. Boyd , John J. Ratcliffe, JR. , Andres Jose Garcia , Todd Christopher McDevitt
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0652 , B01L2200/0689 , B01L2300/043 , B01L2300/0822 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2400/0478 , C12M47/04
摘要： A device for use in sorting cells comprises a first body member having a pair of longitudinally spaced through passages opening to a inner surface. A second body member has an inner surface and a portion defining an opening. The first body member is configured to be mounted to the second body member such that a gasket is disposed between the inner surface of the first body member. The substrate is disposed between the gasket and the inner surface of the second body member for overlying the opening in the second body member. The openings in the first body member open onto an inner surface of the substrate at opposite ends of a channel defined by the inner surface of the first body member, an elongated longitudinal opening in the gasket and the substrate.
摘要翻译：用于分选细胞的装置包括第一主体构件，其具有通向内表面的一对纵向间隔开的通道。第二主体构件具有内表面和限定开口的部分。第一主体构件被构造成安装到第二主体构件，使得垫圈设置在第一主体构件的内表面之间。基板设置在垫圈和第二主体构件的内表面之间，用于覆盖第二主体构件中的开口。第一主体构件中的开口在由第一主体构件的内表面限定的通道的相对端处，衬垫的内表面上开口，衬垫中的细长纵向开口和衬底。

60. 发明授权

US08450288B2 System and method for the pretreatment of the endplates of an intervertebral disc 有权
公开(公告)号：US08450288B2
公开(公告)日：2013-05-28
申请号：US11049820
申请日：2005-02-03
申请人： Lawrence M. Boyd
发明人： Lawrence M. Boyd
IPC分类号： A61K48/00 , A61K38/43 , A61K39/00 , A61F2/28
CPC分类号： A61F2/4675 , A61B17/0218 , A61B17/3472 , A61B17/8811 , A61B2017/00261 , A61B2017/00469 , A61B2017/0256 , A61B2017/564 , A61F2/442 , A61F2002/444 , A61F2002/4635 , A61F2002/4677
摘要： A method for the pre-treatment of an intervertebral disc prior to the introduction of a disc prosthesis or implant includes removing at least a portion of the nucleus pulposus of the intervertebral disc to expose at least a portion of the endplate of an adjacent vertebra to the disc. A fluent treatment material is then injected into the disc space to come into contact with the portion of the endplate. The fluent treatment material is operable to prepare the portion of the endplate to accommodate a disc prosthesis, implant or graft subsequently introduced into the disc space. Different fluent treatment materials are provided that depend upon the condition of the vertebral endplates.

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