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1. 发明授权

US09642658B2 Device and method for delivery of therapeutic agents via internal implants 有权
公开(公告)号：US09642658B2
公开(公告)日：2017-05-09
申请号：US12908464
申请日：2010-10-20
申请人： Lawrence M. Boyd , Samuel B. Adams, Jr. , Matthew R. Penny , Cody Blazek
发明人： Lawrence M. Boyd , Samuel B. Adams, Jr. , Matthew R. Penny , Cody Blazek
IPC分类号： A61B17/80 , A61B17/60 , A61B17/70 , A61F2/30 , A61K9/00 , A61K9/06
CPC分类号： A61B17/80 , A61B17/60 , A61B17/7061 , A61F2002/30677 , A61F2002/3068 , A61F2250/0068 , A61K9/0024 , A61K9/06
摘要： A device is provided for use with a medical implant for delivering an agent to a designated site of action in a body of a patient. The agent-delivery device comprises a body member having an inner surface and a projection on the inner surface of the body member. An agent-delivery medium is associated with the body member. The agent-delivery medium includes a therapeutic agent for treating the body of the patient. The body member is adapted to be secured to the medical implant such that the projection operatively engages the medical implant for spacing the inner surface of the body member from the implant, and the agent-delivery medium is configured to release the therapeutic agent after implantation in the body of the patient. In alternative embodiments, the agent-delivery device comprises a first body member having an inner surface and a second body member having an inner surface. When connected, the inner surfaces of the first body member and the second body member define a cavity adapted to receive the medical implant. The body member may also define an opening therethrough, the opening configured to receive an anchor member for fixing the body member in a body of a patient.

2. 发明申请

US20110178465A1 DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS VIA INTERNAL IMPLANTS 有权
标题翻译：用于通过内部植入物递送治疗剂的装置和方法
公开(公告)号：US20110178465A1
公开(公告)日：2011-07-21
申请号：US12908464
申请日：2010-10-20
申请人： Lawrence M. Boyd , Samuel B. Adams, JR. , Matthew R. Penny , Cody Blazek
发明人： Lawrence M. Boyd , Samuel B. Adams, JR. , Matthew R. Penny , Cody Blazek
IPC分类号： A61M5/00
CPC分类号： A61B17/80 , A61B17/60 , A61B17/7061 , A61F2002/30677 , A61F2002/3068 , A61F2250/0068 , A61K9/0024 , A61K9/06
摘要： A device is provided for use with a medical implant for delivering an agent to a designated site of action in a body of a patient. The agent-delivery device comprises a body member having an inner surface and a projection on the inner surface of the body member. An agent-delivery medium is associated with the body member. The agent-delivery medium includes a therapeutic agent for treating the body of the patient. The body member is adapted to be secured to the medical implant such that the projection operatively engages the medical implant for spacing the inner surface of the body member from the implant, and the agent-delivery medium is configured to release the therapeutic agent after implantation in the body of the patient. In alternative embodiments, the agent-delivery device comprises a first body member having an inner surface and a second body member having an inner surface. When connected, the inner surfaces of the first body member and the second body member define a cavity adapted to receive the medical implant. The body member may also define an opening therethrough, the opening configured to receive an anchor member for fixing the body member in a body of a patient.
摘要翻译：提供了一种用于医疗植入物的装置，用于将药剂递送到患者体内的指定的作用部位。药剂输送装置包括具有内表面和在本体构件的内表面上的突起的主体构件。药剂递送介质与身体成员相关联。药剂递送介质包括用于治疗患者体内的治疗剂。主体构件适于固定到医疗植入物，使得突出部可操作地接合医疗植入物，用于将本体构件的内表面与植入物间隔开，并且药剂输送介质构造成在植入后释放治疗剂病人的身体。在替代实施例中，药剂输送装置包括具有内表面的第一本体构件和具有内表面的第二本体构件。当连接时，第一主体构件和第二主体构件的内表面限定适于接收医用植入物的空腔。主体构件还可以限定穿过其中的开口，该开口构造成接收用于将身体构件固定在患者体内的锚定构件。

3. 发明申请

US20100130959A1 DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS VIA ARTIFICIAL INTERNAL IMPLANTS 审中-公开
标题翻译：通过人造内部植入物输送治疗药物的装置和方法
公开(公告)号：US20100130959A1
公开(公告)日：2010-05-27
申请号：US12580190
申请日：2009-10-15
申请人： Lawrence M. Boyd , Samuel B. Adams, JR. , Matthew R. Penny
发明人： Lawrence M. Boyd , Samuel B. Adams, JR. , Matthew R. Penny
IPC分类号： A61M31/00
CPC分类号： A61B17/80 , A61B17/60 , A61B17/70 , A61F2002/30677 , A61F2002/3068 , A61F2250/0068 , A61K9/0024 , A61L27/14 , A61L27/54 , A61L31/04 , A61L31/16 , A61L2300/00
摘要： A device is provided for use with a medical implant for delivering an agent to a designated site of action in a body of a patient. The agent-delivery device comprises a body member adapted to be secured to the medical implant and an agent-delivery component associated with the body member. The agent-delivery component includes a therapeutic agent for treating the body of the patient. The agent-delivery component is configured to release the therapeutic agent after implantation in the body of the patient.
摘要翻译：提供了一种用于医疗植入物的装置，用于将药剂递送到患者体内的指定的作用部位。药剂递送装置包括适于固定到医疗植入物的主体部件和与主体部件相关联的药剂输送部件。药剂递送组分包括用于治疗患者体内的治疗剂。药剂递送组分配置成在植入患者体内之后释放治疗剂。

4. 发明申请

US20090105621A1 Protective and Cosmetic Covering for External Fixators 失效
标题翻译：外部固定器的保护和化妆品覆盖
公开(公告)号：US20090105621A1
公开(公告)日：2009-04-23
申请号：US12253315
申请日：2008-10-17
申请人： Lawrence M. Boyd , Douglas Kirven , Samuel B. Adams, JR.
发明人： Lawrence M. Boyd , Douglas Kirven , Samuel B. Adams, JR.
IPC分类号： A61F5/00 , A61B17/00
CPC分类号： A61F5/0195
摘要： A removable protective covering is provided that can be secured about an external fixation device on the upper or lower extremity of a patient. The covering includes a fabric form that is sized and configured to accommodate varying sizes of external fixation devices and uses readily engageable/releasable closure elements or fasteners to securely engage the covering about the fixator and the extremity. A drawstring closure may be provided at the open ends of the covering to tighten the end about the patient's limb. Ventilation features may be provided including vents with and without additional devices to generate air flow through the covering. The covering for a lower extremity fixation device may be configured for removably attachment to a foot plate and the foot plate itself may be configured to support or attach to the fixation device.
摘要翻译：提供可移除的保护盖，其可以围绕患者的上肢或下肢上的外部固定装置固定。覆盖物包括织物形式，其尺寸和构造适合不同尺寸的外部固定装置，并且使用易于接合/可释放的封闭元件或紧固件来牢固地接合围绕固定器和末端的覆盖物。可以在覆盖物的开口端处提供束带闭合件，以收紧患者肢体周围的端部。可以提供通风特征，包括具有和不具有附加装置的通风口，以产生通过覆盖物的气流。用于下肢固定装置的覆盖物可以被构造成可移除地附接到脚板，并且脚板本身可被构造成支撑或附接到固定装置。

5. 发明申请

US20090098110A1 INJECTABLE FORMS OF SOLID-FORMING CROSSLINKED BIOELASTIC BIOPOLYMERS FOR LOCAL DRUG DELIVERY 审中-公开
标题翻译：用于局部药物输送的固体生物交联生物降解剂的可注射形式
公开(公告)号：US20090098110A1
公开(公告)日：2009-04-16
申请号：US12129085
申请日：2008-05-29
申请人： Samuel B. Adams, Jr. , Lori A. Setton
发明人： Samuel B. Adams, Jr. , Lori A. Setton
IPC分类号： A61K39/395 , A61K38/02
CPC分类号： A61K38/39 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/406 , A61L2300/41 , A61L2300/602 , A61L2400/06
摘要： A method for delivering a compound of interest to a selected region in a subject is carried out by administering a composition to the region of interest, the composition comprising a cross-linked bioelastomer in combination with the compound of interest non-covalently combined with the cross-linked bioelastomer. In some embodiments, the composition is produced by the process of cross-linking a bioelastomer to produce a cross-linked polymer thereof, and then combining said cross-linked polymer with said compound of interest. Methods of making the compositions, and kits useful for carrying out the method, are also described.
摘要翻译：将感兴趣的化合物递送到受试者中的选定区域的方法通过将组合物施用于目标区域来进行，所述组合物包含交联生物弹性体与未交联的非共价结合的感兴趣的化合物连接的生物弹性体。在一些实施方案中，通过交联生物弹性体的方法制备组合物以产生其交联聚合物，然后将所述交联聚合物与所述感兴趣的化合物组合。还描述了制备组合物的方法和用于实施该方法的试剂盒。

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