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51. 发明授权

US4707295A Bicyclooctane derivatives 失效
标题翻译：双环辛烷衍生物
公开(公告)号：US4707295A
公开(公告)日：1987-11-17
申请号：US843407
申请日：1986-03-24
申请人： Ludwig Pohl , Bernhard Scheuble , Andreas Wachtler , Reinhard Hittich , Peter Fuss
发明人： Ludwig Pohl , Bernhard Scheuble , Andreas Wachtler , Reinhard Hittich , Peter Fuss
IPC分类号： C07C1/00 , C07C13/44 , C07C17/00 , C07C23/10 , C07C23/20 , C07C41/00 , C07C43/115 , C07C43/18 , C07C45/00 , C07C47/34 , C07C49/115 , C07C67/00 , C07C69/608 , C07C253/00 , C07C255/45 , C07C255/46 , C07C313/00 , C07C317/10 , C07C317/18 , C07C317/20 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/06 , C09K19/30 , C09K19/32 , C09K19/44 , C09K19/46 , C09K19/54 , G02F1/13 , C07C23/32 , C07C69/753 , C07C121/46
CPC分类号： C07C255/00 , C07C13/44 , C07C23/20 , C09K19/321
摘要： Bicyclooctane derivatives of the formula IR.sup.1 --A.sup.1 --A.sup.2 --R.sup.2 IwhereinR.sup.1 and R.sup.2 independently of one another are each an alkyl group which has 1-12 C atoms and in which it is also possible for one or two non-adjacent CH.sub.2 groups to be replaced by O atoms and/or CO groups and/or --O13 CO groups and/or --CO--O groups and/or --CH.dbd.CH-- groups, one of the radicals R.sup.1 and R.sup.2 being also --A.sup.3 --R.sup.3,A.sup.1 is a 1,4-cyclohexylene group which is unsubstituted or substituted in the 1-position and/or 2-position and/or 3-position and/or 4-position by alkyl which has in each case 1-5 C atoms and is unsubstituted or substituted or fluorinated, and in which it is also possible for one or two non-adjacent CH.sub.2 groups to be replaced by one or two different groupings from the group --O--, --CO--, --CH.dbd.CH--, --S--, --SO-- or --SO.sub.2 --, or is substituted by F, Cl, Br, CN and/or CHO,A.sup.2 is a 1,4-bicyclo[2.2.2] octylene group,--A.sup.3 --R.sup.3 is --Cy--R.sup.3, --Ph--R.sup.3, --Cy--Ph--R.sup.3 or --Ph--Cy--R.sup.3,Cy is 1,4-cyclohexylene or one of the other groups recited for A.sup.1,Ph is 1,4-phenylene which is unsubstituted or substituted by or one two F atoms and/or CH.sub.3 groups andR.sup.3 is an alkyl group which has 1-12 C atoms and in which it is also possible for one or two non-adjacent CH.sub.2 groups to be replaced by O atoms and/or CO groups and/or O--CO groups and/or --CO--O groups and/or --CH.dbd.CH-- groupsare suitable for use as components of liquid-crystal phases for field effect and/or bistability effect displys.
摘要翻译：式I R1-A1-A2-R2 I的双环辛烷衍生物，其中R 1和R 2彼此独立地是具有1-12个C原子的烷基，并且其中一个或两个不相邻的CH 2基团也是可能的被O原子和/或CO基团和/或-O13CO基团和/或-CO-O基团和/或-CH = CH-基团取代，基团R1和R2之一也是-A3-R3， A1是未取代的或在1位和/或2位和/或3位和/或4位上被烷基取代的1,4-亚环己基，其各自为1-5个C原子和是未取代或取代或氟化的，并且其中一个或两个不相邻的CH 2基团也可以被-O - ， - CO - ， - CH = CH - ， - S，-SO-或-SO 2 - ，或被F，Cl，Br，CN和/或CHO取代，A2是1,4-双环[2.2.2]亚辛基，-A3-R3是-Cy -R3，-Ph-R3，-Cy-Ph-R3或-Ph-Cy-R3，Cy为1,4-亚环己基或为A1所列举的其它基团之一， Ph是未被取代或被两个F原子和/或CH 3基团取代的1,4-亚苯基，R 3是具有1-12个C原子的烷基，并且其中也可以有一个或两个不相邻的被O原子和/或CO基团和/或O-CO基团和/或-CO-O基团和/或-CH = CH-基团取代的CH 2基团适用于现场的液晶相的组分效果和/或双稳性效应不好。

52. 发明授权

US4578210A Carbocyclic six-membered ring compounds 失效
公开(公告)号：US4578210A
公开(公告)日：1986-03-25
申请号：US650015
申请日：1984-09-13
申请人： Klaus Praefcke , Bernd Kohne , Wadi Poules , Rudolf Eidenschink , Bernhard Scheuble
发明人： Klaus Praefcke , Bernd Kohne , Wadi Poules , Rudolf Eidenschink , Bernhard Scheuble
IPC分类号： C07C69/03 , C07C41/00 , C07C43/18 , C07C43/184 , C07C43/205 , C07C67/00 , C07C69/013 , C07C69/75 , C07C69/76 , C07C313/00 , C07C317/00 , C07C317/12 , C07C317/14 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/17 , C07C323/20 , C07C323/61 , C07C323/62 , C07C323/65 , C09K19/00 , C09K19/06 , G02F1/13
CPC分类号： C07C317/00 , C07C43/184 , C07C43/2055 , C09K19/06
摘要： Six-membered ring compounds of the formula I ##STR1## wherein A is a benzene or cyclohexane ring,X.sup.1 to X.sup.6 independently of one another in each case are H, --OR, --COOR, --SR, --SOR, --SO.sub.2 R or, if A is a cyclohexane ring, also --O--COR, andR is in each case an alkyl group which has up to 15 C atoms and in which one or two CH.sub.2 groups can be replaced by O atoms, at least three of the substituents X.sup.1 to X.sup.6 being other than H,can be used as constituents of discotic liquid-crystal phases for liquid-crystal display elements.

53. 发明授权

US06774107B1 Protein for blocking platelet adhesion 失效
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US06774107B1
公开(公告)日：2004-08-10
申请号：US09936737
申请日：2001-09-17
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： A61K3817
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与心脏病和循环系统疾病有关的各种病症。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并阻止细胞的活化。

54. 发明授权

US5188758A Electrooptical display element using a supertwist liquid crystal having specified elastic constants 失效
标题翻译：使用具有特定弹性常数的超扭曲液晶的电光显示元件
公开(公告)号：US5188758A
公开(公告)日：1993-02-23
申请号：US352533
申请日：1989-05-15
申请人： Gunter Baur , Bernhard Scheuble , Waltraud Fehrenbach
发明人： Gunter Baur , Bernhard Scheuble , Waltraud Fehrenbach
IPC分类号： C09K19/02 , C09K19/42
CPC分类号： C09K19/0208 , C09K19/02 , C09K19/42
摘要： The invention relates to an electrooptical display element which can be multiplexed, has two support plates which, with an edging, form a cell containing a pneumatic liquid crystal material with positive dielectric anisotropy, and at least one chiral additive, and has a small surface tilt angle and a twist angle with a value between 150.degree. and 250.degree., wherein the ratio of the elastic constants for bending and twisting K.sub.3 /K.sub.2 of the liquid crystal material and the twist angle are such that when using liquid crystal material with the ratio of the elastic constants K.sub.3 /K.sub.1 for mending and spreading, which is in the order of the maximum possible, the steepness of the characteristic line is approved by the characteristic line is bi-stable or when using liquid crystal material with the ratio of the elastic constants K.sub.3 /K.sub.1 for bending and spreading either small enough or of the smallest order possible, the steepness of the characteristic line is improved but the characteristic line remains stable. The invention furthermore relates to a corresponding supertwist cell.
摘要翻译：本发明涉及一种可以复用的电光显示元件，具有两个支撑板，其具有边缘形成包含具有正介电各向异性的气动液晶材料的单元和至少一种手性添加剂，并且具有小的表面倾斜角度和扭转角度在150°至250°之间的值，其中液晶材料的弯曲和扭曲K 3 / K 2的弹性常数与扭曲角的比值使得当使用比例为用于修补和扩展的弹性常数K3 / K1（由最大可能的数量级）特征线的陡度被特性线所认可是双稳态的，或者当使用具有弹性常数比的液晶材料时 K3 / K1用于弯曲和扩展足够小或尽可能小的顺序，特征线的陡度提高，但特征线保持为st 能够。本发明还涉及相应的超扭转电池。

55. 发明授权

US4970022A Liquid-crystalline mustard oils 失效
标题翻译：液晶芥子油
公开(公告)号：US4970022A
公开(公告)日：1990-11-13
申请号：US110756
申请日：1987-08-19
申请人： Bernhard Scheuble , Rudolf Eidenschink , Joachim Krause , Eike Poetsch , Andreas Wachtler
发明人： Bernhard Scheuble , Rudolf Eidenschink , Joachim Krause , Eike Poetsch , Andreas Wachtler
IPC分类号： C07C67/00 , C07C325/00 , C07C331/04 , C07C331/26 , C07C331/28 , C07D211/00 , C07D213/00 , C07D213/36 , C07D239/26 , C09K19/30 , C09K19/34 , C09K19/42
CPC分类号： C07D239/26 , C07C331/26 , C07C331/28 , C07D213/36 , C09K19/3003 , C09K19/3068 , C09K19/3444 , C09K19/3458 , C07C2101/14 , C09K2019/0444
摘要： Mustard oils of the formula IR--(A.sup.1 --Z.sup.1).sub.n --A.sup.2 --Z.sup.2 --A.sup.3 --NCSin which A.sup.1, A.sup.2, A.sup.3, R, Z.sup.1, Z.sup.2 and n have the meaning specified in claim 1 can be used as components of liquid-crystalline phases.
摘要翻译： PCT No.PCT / EP86 / 00720 Sec。 371日期1987年8月19日 102（e）日期1987年8月19日PCT申请日1986年12月6日PCT公布。公开号WO87 / 03870 日本1987年7月2日。式I R-（A1-Z1）n-A2-Z2-A3-NCS的蓖麻油，其中A1，A2，A3，R，Z1，Z2和n具有权利要求书中规定的含义 1可以用作液晶相的组分。

56. 发明授权

US4886344A Electro-optical display element 失效
标题翻译：电光显示元件
公开(公告)号：US4886344A
公开(公告)日：1989-12-12
申请号：US235753
申请日：1988-08-19
申请人： Bernhard Scheuble , Gunter Baur , Waltraud Fehrenbach
发明人： Bernhard Scheuble , Gunter Baur , Waltraud Fehrenbach
IPC分类号： G02F1/133 , C09K19/02 , C09K19/42 , G02F1/137 , G02F1/139
CPC分类号： G02F1/1396 , C09K19/0208 , C09K19/42
摘要： A suitable choice of the liquid crystal parameters K.sub.3 /K.sub.1 and .DELTA.E/E.sub.1 makes it possible in electrooptical display elements to obtain both a minimum dependence on the angle of observation and, simultaneously, a steep electro-optical characteristic when operated in the first transmission minimum.
摘要翻译：液晶参数K3 / K1和DELTA E / E1的合适选择使得电光显示元件可以获得对观察角度的最小依赖性，同时获得在第一传输中操作时的陡峭的电光特性最低

57. 发明授权

US4719032A Cyclohexane derivatives 失效
标题翻译：环己烷衍生物
公开(公告)号：US4719032A
公开(公告)日：1988-01-12
申请号：US842692
申请日：1986-03-21
申请人： Andreas Wachtler , Joachim Krause , Reinhard Hittich , Bernhard Scheuble
发明人： Andreas Wachtler , Joachim Krause , Reinhard Hittich , Bernhard Scheuble
IPC分类号： C07C49/11 , C07C41/00 , C07C43/184 , C07C45/00 , C07C67/00 , C07C69/013 , C09K19/30 , C09K19/42 , C09K19/44 , C09K19/46 , C09K19/54 , G02F1/13 , C09K19/34
CPC分类号： C09K19/3028 , C07C43/184 , C09K19/3066 , C09K19/42
摘要： Cyclohexane derivatives of formula IR.sup.1 --Cy--CH.sub.2 --Q--(Cy).sub.m --O--(CO).sub.n --CH.sub.2 --R.sup.2 IwhereR.sup.1 denotes alkyl with 1 to 12 C atoms in which also one or two non-adjacent CH.sub.2 groups may be replaced by --O--, --CO--, --O--CO--, --CO--O-- or --CH.dbd.CH--,R.sup.2 denotes H, alkyl with 1 to 12 C atoms in which also one or two non-adjacent CH.sub.2 groups may be replaced by --O--, --CO--, --O--CO-- or --CO--O--,Cy denotes trans-1,4-cyclohexyleneQ denotes --CH.sub.2 -- or --O--,m denotes 1 or 2, andn denotes 0 or 1,are suitable as components of liquid-crystalline phases.
摘要翻译：式I的环己烷衍生物R1-Cy-CH2-Q-（Cy）mO-（CO）n-CH2-R2 I其中R1表示具有1至12个C原子的烷基，其中一个或两个不相邻的CH2基团可以是被-O - ， - CO-，-O-CO-，-CO-O-或-CH = CH-取代，R 2表示H，具有1至12个C原子的烷基，其中还有一个或两个不相邻的CH 2基团可以被-O-，-CO-，-O-CO-或-CO-O-代替，Cy表示反式-1,4-亚环己基，Q表示-CH2-或-O-，m表示1或2， n表示0或1，适合作为液晶相的组分。

58. 发明授权

US07090986B2 Protein for blocking platelet adhesion 有权
公开(公告)号：US07090986B2
公开(公告)日：2006-08-15
申请号：US11153433
申请日：2005-06-16
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/53
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

59. 发明授权

US06962801B2 Protein for blocking platelet adhesion 失效
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US06962801B2
公开(公告)日：2005-11-08
申请号：US10846668
申请日：2004-05-17
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/50 , A61K31/616 , A61K31/727 , A61K38/00 , A61K38/17 , A61K38/46 , A61L27/00 , A61P7/02 , C07K14/435 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/15 , G01N33/566 , C07H21/04 , C12N15/63
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与硬疾病和循环系统疾病有关的各种疾病。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并防止细胞的活化。

60. 发明申请

US20050065084A1 Protein for blocking platelet adhesion 失效
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US20050065084A1
公开(公告)日：2005-03-24
申请号：US10846668
申请日：2004-05-17
申请人： Wolfgan Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgan Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/50 , A61K31/616 , A61K31/727 , A61K38/00 , A61K38/17 , A61K38/46 , A61L27/00 , A61P7/02 , C07K14/435 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/15 , G01N33/566 , C07K14/47
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12 000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12000，是酸性等电点，含有6个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与硬疾病和循环系统疾病有关的各种疾病。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并防止细胞的活化。

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