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1. 发明申请

US20050065084A1 Protein for blocking platelet adhesion 失效
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US20050065084A1
公开(公告)日：2005-03-24
申请号：US10846668
申请日：2004-05-17
申请人： Wolfgan Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgan Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/50 , A61K31/616 , A61K31/727 , A61K38/00 , A61K38/17 , A61K38/46 , A61L27/00 , A61P7/02 , C07K14/435 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/15 , G01N33/566 , C07K14/47
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12 000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12000，是酸性等电点，含有6个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与硬疾病和循环系统疾病有关的各种疾病。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并防止细胞的活化。

2. 发明申请

US20060094079A1 Protein for blocking platelet adhesion 有权
标题翻译：用于阻断血小板粘附的蛋白质
公开(公告)号：US20060094079A1
公开(公告)日：2006-05-04
申请号：US11153433
申请日：2005-06-16
申请人： Wolfgang Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Gussow , Uwe Hofmann , Jurgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： C07H21/04 , C12N9/64
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译：描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。公开了通过重组技术生产这种多肽的方法。重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与心脏病和循环系统疾病有关的各种病症。此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并阻止细胞的活化。

3. 发明授权

US07049124B1 Hyaluronidase from the Hirudinaria manillensis isolation, purification and recombinant method of production 失效
标题翻译：水蛭属透明质酸酶分离纯化及重组生产方法
公开(公告)号：US07049124B1
公开(公告)日：2006-05-23
申请号：US10009500
申请日：2000-06-06
申请人： Maria Kordowicz , Detlef Gussow , Uwe Hofmann , Tadeusz Pacuszka , Andrzej Gardas
发明人： Maria Kordowicz , Detlef Gussow , Uwe Hofmann , Tadeusz Pacuszka , Andrzej Gardas
IPC分类号： C12N9/26 , C12N9/88 , C12N15/56 , C12N15/66 , A61K38/47 , A61K38/51
CPC分类号： C12N9/2408 , A61K38/00
摘要： The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leech Hirudinaria manillensis. Therefore, according to this invention, the enzyme was called “manillase”. The invention is furthermore concerned with the recombinant method of production of manillase which includes the disclosure of DNA and amino acid sequences as well as of expression vectors and host systems. Finally, the invention relates to the use of manillase for therapeutic purposes, for example, for the treatment of myocardial diseases, thrombotic events and tumors.
摘要翻译：本发明涉及从热带水蛭Hirudinaria manillensis得到的透明质酸酶的分离，纯化和表征。因此，根据本发明，酶被称为“芒硝酶”。本发明进一步涉及重组芽胞杆菌的生产方法，其包括DNA和氨基酸序列以及表达载体和宿主系统的公开。最后，本发明涉及用于治疗目的的芒硝酶的用途，例如用于治疗心肌疾病，血栓形成事件和肿瘤。

4. 发明申请

US20050130137A1 Soluble recombinant alphavbeta3 adhesion receptor 有权
标题翻译：可溶性重组脂蛋白3粘附受体
公开(公告)号：US20050130137A1
公开(公告)日：2005-06-16
申请号：US10460672
申请日：2003-10-31
申请人： Simon Goodman , Beate Dieffenbach , Detlef Gussow , Raj Mehta , Eilish Cullen , Alex Brown
发明人： Simon Goodman , Beate Dieffenbach , Detlef Gussow , Raj Mehta , Eilish Cullen , Alex Brown
IPC分类号： C12N15/09 , C07K1/22 , C07K14/705 , C12N15/12 , C12P21/02 , C12R1/91 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/70557 , C12N2799/026
摘要： The invention relates to a novel purified recombinant αVβ3 adhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural αvβ3 adhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the souluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length αVβ3 adhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell.
摘要翻译：本发明涉及一种显示出未受损配体结合活性的新型纯化的重组α3 N 3 3 N 3粘附受体，以及制备所述可溶性非膜结合受体的方法通过使用杆状病毒 - 昆虫细胞表达系统的重组技术获得。如此合成的可溶性受体可以非常容易地用作可能抑制天然α3β3粘附受体的新的治疗化合物的筛选工具。可以通过根据本发明的灵魂受体非常容易，快速且没有健康风险发现的这种治疗化合物可以是例如RGD肽或模仿天然配体表位的非肽化合物。此外，本发明还涉及以优异的产率制备重组全长α1 H 3β3 N粘附受体的相应方法，另外使用洗涤剂将膜结合受体从宿主细胞的表面。

5. 发明申请

US20080299618A1 SINGLE DOMAIN LIGANDS, RECEPTORS COMPRISING SAID LIGANDS, METHODS FOR THEIR PRODUCTION AND USE OF SAID LIGANDS AND RECEPTORS 审中-公开
标题翻译：单一名称，包含该名称的接受者，其生产和使用同类配偶和受体的方法
公开(公告)号：US20080299618A1
公开(公告)日：2008-12-04
申请号：US12127237
申请日：2008-05-27
申请人： Gregory P. WINTER , Elizabeth S. Ward , Detlef Gussow
发明人： Gregory P. WINTER , Elizabeth S. Ward , Detlef Gussow
IPC分类号： C12P21/04 , C07K16/00 , C07K16/28 , C07H21/00 , C07K17/00 , C12P19/34
CPC分类号： C07K16/461 , A61K38/00 , C07K2317/24 , C12Q1/6876
摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the productions of Ig-type molecules and said ligands or receptors, and the use of said ligand or receptors in therapy, diagnosis or catalysis.
摘要翻译：本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应，在Ig型分子和所述配体或受体的产生中使用所述DNA序列，以及所述配体或受体在治疗，诊断或催化中的用途。

6. 发明申请

US20060058516A1 Novel serine-threonine kinase 审中-公开
标题翻译：新型丝氨酸 - 苏氨酸激酶
公开(公告)号：US20060058516A1
公开(公告)日：2006-03-16
申请号：US10257143
申请日：2001-04-09
申请人： Burkhard Scharm , Detlef Gussow
发明人： Burkhard Scharm , Detlef Gussow
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12N9/1205 , C07K2319/00
摘要： STK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing STK3 polypeptides and polynucleotides in diagnostic assays.
摘要翻译：公开了STK3多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在诊断测定中利用STK3多肽和多核苷酸的方法。

7. 发明授权

US5844093A Anti-EGFR single-chain Fvs and anti-EGFR antibodies 失效
标题翻译：抗EGFR单链Fvs和抗EGFR抗体
公开(公告)号：US5844093A
公开(公告)日：1998-12-01
申请号：US553497
申请日：1995-11-17
申请人： A. Cathrine Kettleborough , Mary M. Bendig , Keith H. Ansell , Detlef Gussow , Jaume Adan , Francesc Mitjans , Elisabet Rosell , Francesc Blasco , Jaume Piulats
发明人： A. Cathrine Kettleborough , Mary M. Bendig , Keith H. Ansell , Detlef Gussow , Jaume Adan , Francesc Mitjans , Elisabet Rosell , Francesc Blasco , Jaume Piulats
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/19 , G01N33/563 , C07H21/04 , C12N15/63
CPC分类号： C07K16/00 , C07K16/2863 , A61K38/00 , C07K2319/00
摘要： This invention relates to new anti-EGFR antibodies and single-chain Fvs (scFvs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mouse. Two of the single-chain Fvs isolated from the phage-antibody libraries were engineered to create partially humanized whole antibody molecules. These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins, and can be used as well as the single-chain Fvs as agents for the diagnosis and therapy of human tumors.
摘要翻译： PCT No.PCT / EP95 / 00978 371日期：1995年11月17日 102（e）日期1995年11月17日PCT 1995年3月16日PCT公布。公开号WO95 / 25167 日期1995年9月21日本发明涉及可从免疫的哺乳动物，优选小鼠的细胞构建的噬菌体抗体文库获得的新的抗EGFR抗体及其单链Fvs（scFv）。将从噬菌体 - 抗体文库分离的两条单链Fvs进行工程改造以产生部分人源化的全抗体分子。这些嵌合抗EGFR抗体含有人免疫球蛋白的恒定区域，并且可以用作单链Fvs作为人肿瘤诊断和治疗的试剂。

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