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    • 3. 发明授权
    • Protein for blocking platelet adhesion
    • 用于阻断血小板粘附的蛋白质
    • US06774107B1
    • 2004-08-10
    • US09936737
    • 2001-09-17
    • Wolfgang StrittmatterDetlef GüssowUwe HofmannJürgen HembergerZisi FotevBernhard Scheuble
    • Wolfgang StrittmatterDetlef GüssowUwe HofmannJürgen HembergerZisi FotevBernhard Scheuble
    • A61K3817
    • C07K14/43536A61K38/00
    • A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
    • 描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质,其与胶原强烈结合,从而作为天然血小板粘附到胶原的抑制剂。 蛋白质的分子量约为12,000,是酸性等电点,含有六个半胱氨酸。 对蛋白质进行测序,并从H. medicinalis cDNA文库克隆该基因。 公开了通过重组技术生产这种多肽的方法。 重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂,因此可用于治疗与心脏病和循环系统疾病有关的各种病症。 此外,该蛋白质可用于包被天然或人造胶原表面,以使其对细胞不粘附并阻止细胞的活化。