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51. 发明申请

US20100233288A1 MEDICAL DEVICES CONTAINING NITROPRUSSIDE AND ANTIMICROBIAL AGENTS 审中-公开
标题翻译：含有硝酸和抗微生物剂的医疗器械
公开(公告)号：US20100233288A1
公开(公告)日：2010-09-16
申请号：US12401829
申请日：2009-03-11
申请人： Nisha Gupta , Joel Rosenblatt , Elaine Steinke
发明人： Nisha Gupta , Joel Rosenblatt , Elaine Steinke
IPC分类号： A61K33/26
摘要： A medical device includes a structure configured for introduction to a vascular system of a patient. The structure including a surface having sodium nitroprusside and silver disposed thereupon. The sodium nitroprusside has a concentration sufficient to reduce thrombosis. To make the medical device, a base material is impregnated with sodium nitroprusside, the medical device is formed from the base material, and the medical device is coated with an antimicrobial agent.
摘要翻译：医疗装置包括构造成用于引入患者血管系统的结构。该结构包括具有硝普钠钠和置于其上的银的表面。硝普钠钠具有足以减少血栓形成的浓度。为了制造医疗装置，将基材浸渍在硝普钠中，医疗装置由基材形成，医疗装置涂敷有抗菌剂。

52. 发明申请

US20100191219A1 Bacteriostatic Catheter Lock Containing Glycerol 有权
标题翻译：含有甘油的细菌性导管锁
公开(公告)号：US20100191219A1
公开(公告)日：2010-07-29
申请号：US12693706
申请日：2010-01-26
申请人： Nisha Gupta , Elaine Steinke , Erin Peters , Joel Rosenblatt
发明人： Nisha Gupta , Elaine Steinke , Erin Peters , Joel Rosenblatt
IPC分类号： A61M25/00 , A61K33/14
CPC分类号： A61K45/06 , A61K31/047 , A61K33/14 , A61L29/14 , A61L29/16 , A61L2300/216 , A61L2300/404 , A61L2300/42 , A61K2300/00
摘要： A catheter lock composition for preventing bacterial infection having an effective amount of glycerol and sodium chloride solution. The effective amount of glycerol is between about 35-60% and sodium chloride is in a concentration range between 0.5-0.9%. The composition further includes an anticoagulant and/or an antimicrobial agent.
摘要翻译：一种用于预防细菌感染的导管锁组合物，其具有有效量的甘油和氯化钠溶液。甘油的有效量为约35-60％，氯化钠的浓度范围为0.5-0.9％。组合物还包括抗凝血剂和/或抗微生物剂。

53. 发明申请

US20100082097A1 Article Containing Segregated Biguanide and Lewis Acid 审中-公开
标题翻译：含有分离双胍和路易斯酸的产品
公开(公告)号：US20100082097A1
公开(公告)日：2010-04-01
申请号：US12570707
申请日：2009-09-30
申请人： Joel Rosenblatt , Perry G. Wang , Hiep Do
发明人： Joel Rosenblatt , Perry G. Wang , Hiep Do
IPC分类号： A61L27/50 , A61L29/14 , A61L17/00 , A61L31/14 , B29C47/06
CPC分类号： A61L31/14 , A61L27/50 , A61L29/14 , B29C48/09 , B29C48/151 , B29C48/152 , B29C48/153 , B29C48/18 , B29L2009/00 , B29L2031/7542
摘要： A medical device includes a first region having a biguanide or a pharmaceutically acceptable salt thereof and a second region having a Lewis acid.
摘要翻译：医疗装置包括具有双胍或其药学上可接受的盐的第一区域和具有路易斯酸的第二区域。

54. 发明申请

US20090130171A1 High concentration gentian violet containing medical devices and methods of making same 审中-公开
标题翻译：高浓度龙胆紫含有医疗器械及其制作方法
公开(公告)号：US20090130171A1
公开(公告)日：2009-05-21
申请号：US12286791
申请日：2008-10-02
申请人： Hiep Do , Daniel J. Spangler , Joel Rosenblatt , Barrett Remington , Onajite Okoh
发明人： Hiep Do , Daniel J. Spangler , Joel Rosenblatt , Barrett Remington , Onajite Okoh
IPC分类号： A61F2/04 , A61K31/136
CPC分类号： A61L29/14 , A61L29/06 , A61L29/16 , A61L2300/404 , A61L2300/442 , C08L75/04
摘要： Implantable medical devices, such as catheters, treated with a high concentration of gentian violet, and methods of preparing these medical devices are provided.
摘要翻译：提供了用高浓度的龙胆紫处理的植入式医疗装置，例如导管，以及制备这些医疗装置的方法。

55. 发明授权

US07220433B2 Compositions for parenteral administration and sustained-release of therapeutic agents 有权
标题翻译：用于肠胃外给药和治疗剂缓释的组合物
公开(公告)号：US07220433B2
公开(公告)日：2007-05-22
申请号：US10608507
申请日：2003-06-27
申请人： Han Cui , Joel Rosenblatt , Ram L. Kataria , Chuanbin Wu
发明人： Han Cui , Joel Rosenblatt , Ram L. Kataria , Chuanbin Wu
IPC分类号： A61K9/16
CPC分类号： A61K9/5073 , A61K47/34
摘要： The present invention is directed to parenterally-administrable microparticles for providing sustained-release of a therapeutic agent in the body, where the microparticles include a polymeric core containing a therapeutically effective amount of a therapeutic agent disposed therein, a first film encapsulating the core, the first film prepared from a first biodegradable polymer soluble in an appropriate solvent therefore, and a second film encapsulating the core and the first film, the second film prepared from a biodegradable polymer soluble in an appropriate solvent therefore, wherein the first film is insoluble in the solvent used to prepare the second film, and to parenterally-administrable compositions containing such microparticles dispersed in a suitable carrier therefore.
摘要翻译：本发明涉及用于在体内提供治疗剂持续释放的肠胃外给药微粒，其中微粒包括含有治疗有效量的治疗剂的聚合物芯，其中包含核心的第一膜，因此，由可溶于适当溶剂的第一可生物降解聚合物制备的第一膜以及包封芯和第一膜的第二膜，由可溶于适当溶剂的可生物降解的聚合物制备的第二膜，其中第一膜不溶于因此用于制备第二膜的溶剂，以及含有分散在合适载体中的这种微粒的肠胃外给药组合物。

56. 发明申请

US20060210747A1 Compositions and medical devices utilizing bioabsorbable polymeric waxes 审中-公开
公开(公告)号：US20060210747A1
公开(公告)日：2006-09-21
申请号：US11340882
申请日：2006-05-05
申请人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
IPC分类号： B32B27/08
CPC分类号： A61K9/7007 , A61K9/1647 , A61K9/204 , A61L17/005 , A61L17/145 , A61L27/18 , A61L27/46 , A61L27/58 , A61L31/06 , A61L31/148 , A61L2300/602 , Y10T428/1352 , C08L67/08
摘要： The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

57. 发明授权

US07101566B2 Polymer coated microparticles for sustained release 有权
标题翻译：聚合物涂层微粒用于持续释放
公开(公告)号：US07101566B2
公开(公告)日：2006-09-05
申请号：US10183260
申请日：2002-06-28
申请人： Joel Rosenblatt , Han Cui , Ram L. Kataria , Chuanbin Wu
发明人： Joel Rosenblatt , Han Cui , Ram L. Kataria , Chuanbin Wu
IPC分类号： A61F13/00 , A61F2/00 , A61K9/14 , A61K9/19
CPC分类号： A61K9/5031 , A61K47/34
摘要： The present invention is directed to sustained release microparticle formulation for parenteral administration of biologically active substances, especially drugs. More specifically it relates to coated drug containing microparticles, wherein the coating is a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.
摘要翻译：本发明涉及用于肠胃外给药生物活性物质，特别是药物的持续释放微粒制剂。更具体地说，它涉及含有包衣药物的微粒，其中涂层是合成的，生物可吸收的生物相容性聚合物蜡，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，聚合物蜡的熔点较低如通过差示扫描量热法测定的。

58. 发明授权

US07030127B2 Composition and medical devices utilizing bioabsorbable polymeric waxes 有权
公开(公告)号：US07030127B2
公开(公告)日：2006-04-18
申请号：US09896004
申请日：2001-06-29
申请人： Aruna Nathan , Joel Rosenblatt , Steven C. Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven C. Arnold
IPC分类号： A61K31/505
CPC分类号： A61K9/7007 , A61K9/1647 , A61K9/204 , A61L17/005 , A61L17/145 , A61L27/18 , A61L27/46 , A61L27/58 , A61L31/06 , A61L31/148 , A61L2300/602 , Y10T428/1352 , C08L67/08
摘要： The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

59. 发明授权

US07026374B2 Injectable microdispersions for medical applications 有权
公开(公告)号：US07026374B2
公开(公告)日：2006-04-11
申请号：US10178970
申请日：2002-06-25
申请人： Aruna Nathan , Joel Rosenblatt , Steven C. Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven C. Arnold
IPC分类号： C08L15/00 , A61F2/00
CPC分类号： A61K47/34
摘要： The present invention is directed to microdispersions and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry, and a synthetic, bioabsorbable, biocompatible polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

60. 发明申请

US20050113937A1 Conformable tissue repair implant capable of injection delivery 有权
标题翻译：能够注射输送的适应性组织修复植入物
公开(公告)号：US20050113937A1
公开(公告)日：2005-05-26
申请号：US10723982
申请日：2003-11-26
申请人： Francois Binette , Joseph Hammer , Krish Mukhopadhyay , Joel Rosenblatt
发明人： Francois Binette , Joseph Hammer , Krish Mukhopadhyay , Joel Rosenblatt
IPC分类号： A61L27/00 , A61F2/02 , A61F2/08 , A61F2/10 , A61F2/28 , A61L27/38 , A61L27/58
CPC分类号： A61L27/3604 , A61L27/3683 , A61L27/38 , A61L27/3852 , A61L27/58
摘要： A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
摘要翻译：提供适合组织植入物用于修复或增加组织缺损或损伤部位。组织植入物包含组织载体基质，其包含多个生物相容的生物可再吸收的颗粒和与颗粒结合的至少一个组织片段。组织片段含有一种或多种活细胞，其可以从组织迁移并填充组织载体基质。还提供了用于可注射地递送组织植入物的方法。

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