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51. 发明授权

US08663976B2 Polymerase chain reaction apparatus 有权
标题翻译：聚合酶链反应装置
公开(公告)号：US08663976B2
公开(公告)日：2014-03-04
申请号：US13039630
申请日：2011-03-03
申请人： Won-seok Chung , Kak Namkoong , Joon-ho Kim
发明人： Won-seok Chung , Kak Namkoong , Joon-ho Kim
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L9/527 , B01L3/502715 , B01L7/52 , B01L2200/025 , B01L2200/147 , B01L2300/1827
摘要： A polymerase chain reaction (“PCR”) apparatus includes a PCR chip holder which accommodates and supports a PCR chip, a housing which supports ends of the PCR chip holder, a temperature control element which moves perpendicularly with respect to the PCR chip holder in a space between the housing and the PCR chip holder in the housing, and an elastic unit which elastically biases the temperature control element toward the PCR chip holder, between the temperature control element and the housing. The temperature control element includes a top surface which is selectively contacted to a bottom surface of the PCR chip.
摘要翻译：聚合酶链式反应（“PCR”）装置包括：一个PCR芯片保持器，其容纳和支持PCR芯片;支撑PCR芯片保持器端部的壳体;一个相对于PCR芯片保持器垂直移动的温度控制元件壳体和壳体中的PCR芯片保持器之间的空间以及在温度控制元件和壳体之间弹性地将温度控制元件朝向PCR芯片保持器偏置的弹性单元。温度控制元件包括选择性地接触PCR芯片的底表面的顶表面。

52. 发明授权

US07510865B2 Sensing switch and detecting method using the same 失效
标题翻译：感应开关及使用其的检测方法
公开(公告)号：US07510865B2
公开(公告)日：2009-03-31
申请号：US11347185
申请日：2006-02-03
申请人： Kyu-tae Yoo , Joon-ho Kim , Jun-hong Min , Sung-ouk Jung , Ji-na Namgoong , Kui-hyun Kim , Jeo-young Shim , Kak Namkoong
发明人： Kyu-tae Yoo , Joon-ho Kim , Jun-hong Min , Sung-ouk Jung , Ji-na Namgoong , Kui-hyun Kim , Jeo-young Shim , Kak Namkoong
IPC分类号： C12M1/34
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

53. 发明申请

US20060234379A1 Cell separation method using hydrophobic solid supports 审中-公开
标题翻译：使用疏水性固体支持物的细胞分离方法
公开(公告)号：US20060234379A1
公开(公告)日：2006-10-19
申请号：US11405106
申请日：2006-04-17
申请人： Hee-kyun Lim , Kyu-youn Hwang , Joon-ho Kim , Kak Namkoong , Chin-sung Park
发明人： Hee-kyun Lim , Kyu-youn Hwang , Joon-ho Kim , Kak Namkoong , Chin-sung Park
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： B01L3/502753 , B01L3/502746 , B01L2300/0681 , B01L2400/086 , B82Y30/00 , B82Y40/00 , C12M47/02
摘要： Provided is a method of separating cells using a hydrophobic solid support. The method comprises contacting a solution containing cells with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. By allowing cells to be adsorbed to the hydrophobic solid substrate, the cells can be separated. Thus, the cell separation efficiency can be rapidly and simply increased.
摘要翻译：提供了使用疏水性固体支持物分离细胞的方法。该方法包括将含有细胞的溶液与70-90度的水接触角的疏水性固体支持物接触。通过使细胞被吸附到疏水性固体底物上，可以分离细胞。因此，可以快速且简单地增加细胞分离效率。

54. 发明申请

US20050199917A1 Sensitivity enhanced biomolecule field effect transistor 有权
标题翻译：灵敏度增强的生物分子场效应晶体管
公开(公告)号：US20050199917A1
公开(公告)日：2005-09-15
申请号：US11057642
申请日：2005-02-14
申请人： Kyu-tae Yoo , Geun-bae Lim , Joon-ho Kim , Kak Namkoong
发明人： Kyu-tae Yoo , Geun-bae Lim , Joon-ho Kim , Kak Namkoong
IPC分类号： G01N27/327 , C12Q1/68 , G01N27/414 , G01N33/487 , H01L29/08
CPC分类号： G01N27/4145
摘要： There is provided a biomolecule FET enhancing a sensitivity. The biomolecule FET includes a substrate, first and second impurity regions formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule attached to the gate. A region of the gate adjacent to the first impurity region is wider than a region thereof adjacent to the second impurity region. A density of the probe biomolecule attached to the surface of the gate is increased, and when detecting a level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.
摘要翻译：提供了提高灵敏度的生物分子FET。生物分子FET包括基板，形成在基板两侧的第一和第二杂质区，并且掺杂极性与基板极性相反的杂质;形成在基板上并与第一和第二杂质接触的栅极区域，以及连接到门的探针生物分子。与第一杂质区相邻的栅极的区域比与第二杂质区相邻的区域宽。附着在栅极表面的探针生物分子的密度增加，并且当检测到探针生物分子和靶生物分子的杂交水平时，其灵敏度得到改善。

55. 发明授权

US09187846B2 Microarray package device and method of manufacturing the same 有权
标题翻译：微阵列封装器件及其制造方法
公开(公告)号：US09187846B2
公开(公告)日：2015-11-17
申请号：US12938485
申请日：2010-11-03
申请人： Woochang Lee , Jeo-young Shim , Myo-yong Lee , Kak Namkoong , Won-seok Chung
发明人： Woochang Lee , Jeo-young Shim , Myo-yong Lee , Kak Namkoong , Won-seok Chung
IPC分类号： B01L3/00 , C40B60/12
CPC分类号： C40B60/12 , B01L3/508 , B01L2200/025 , B01L2300/0819
摘要： A microarray package device and a method of manufacturing the same. An effective microarray analyzing reaction is performed by using the microarray package device that provides structural stability and reliable experimental results.
摘要翻译：微阵列包装装置及其制造方法。通过使用提供结构稳定性和可靠的实验结果的微阵列包装装置进行有效的微阵列分析反应。

56. 发明授权

US09044751B2 Gene analysis device 有权
标题翻译：基因分析装置
公开(公告)号：US09044751B2
公开(公告)日：2015-06-02
申请号：US13608533
申请日：2012-09-10
申请人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
发明人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
IPC分类号： C12M1/34 , C12M3/00 , B01L3/00 , G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/6452 , G01N2021/0314 , G01N2021/0325 , G01N2021/058 , G01N2021/6463
摘要： A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.
摘要翻译：一种基因分析装置，包括将激发光照射到样品溶液上的照明光学系统; 微流体装置，用于形成样品溶液的生物反应空间，并且包括至少一个其中形成有反射图案的微室; 以及检测光学系统，用于检测由微室中的生物反应产生的荧光信号，并包括光电检测器。

57. 发明授权

US08664377B2 Method and apparatus for isolating nucleic acids 有权
标题翻译：分离核酸的方法和装置
公开(公告)号：US08664377B2
公开(公告)日：2014-03-04
申请号：US12852824
申请日：2010-08-09
申请人： Kyu-youn Hwang , Joon-ho Kim , Kak Namkoong
发明人： Kyu-youn Hwang , Joon-ho Kim , Kak Namkoong
IPC分类号： C07H21/00
CPC分类号： C12N15/1006 , B01D15/3866
摘要： A method and apparatus for efficiently isolating nucleic acids from a nucleic acid-containing sample.
摘要翻译：一种用于从含核酸样品有效分离核酸的方法和装置。

58. 发明授权

US08044371B2 Surface acoustic wave device and method for signal amplification of surface acoustic wave element 有权
标题翻译：声表面波器件及表面声波元件信号放大方法
公开(公告)号：US08044371B2
公开(公告)日：2011-10-25
申请号：US12396807
申请日：2009-03-03
申请人： Hun Joo Lee , Soosuk Lee , Kak Namkoong , Chinsung Park , Kieun Kim
发明人： Hun Joo Lee , Soosuk Lee , Kak Namkoong , Chinsung Park , Kieun Kim
IPC分类号： G01T1/04 , G01J1/58 , H01J40/14
CPC分类号： G01N29/022 , G01N29/2418 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423
摘要： A surface acoustic wave (“SAW”) device including a SAW element, a first material, a luminescence material and a light source, and a method for signal amplification of a SAW element. The first material may be positioned on the SAW element and bound to a target material in a sample. The luminescence material may be bound to the target material. The light source may apply light to the luminescence material. The SAW device and the method for signal amplification of a SAW element using the same allow amplification of a signal of the SAW element by an electromagnetic wave generated when light is applied to the luminescence material.
摘要翻译：包括SAW元件，第一材料，发光材料和光源的表面声波（“SAW”）器件以及SAW元件的信号放大方法。第一材料可以定位在SAW元件上并且与样品中的目标材料结合。发光材料可能与靶材料结合。光源可以对发光材料施加光。 SAW器件和使用其的SAW元件的信号放大的方法允许通过在将光施加到发光材料时产生的电磁波来放大SAW元件的信号。

59. 发明授权

US07981666B2 Sensing switch and detecting method using the same 有权
标题翻译：感应开关及使用其的检测方法
公开(公告)号：US07981666B2
公开(公告)日：2011-07-19
申请号：US12833095
申请日：2010-07-09
申请人： Kyu-tae Yoo , Joon-ho Kim , Jun-hong Min , Sung-ouk Jung , Ji-na Namgoong , Kui-hyun Kim , Jeo-young Shim , Kak Namkoong
发明人： Kyu-tae Yoo , Joon-ho Kim , Jun-hong Min , Sung-ouk Jung , Ji-na Namgoong , Kui-hyun Kim , Jeo-young Shim , Kak Namkoong
IPC分类号： C12M3/00
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

60. 发明申请

US20050202489A1 Method and apparatus for amplifying nucleic acids 有权
标题翻译：扩增核酸的方法和装置
公开(公告)号：US20050202489A1
公开(公告)日：2005-09-15
申请号：US11071383
申请日：2005-03-03
申请人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
发明人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
IPC分类号： C12N15/09 , B01F5/06 , B01F13/00 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/38 , C12N15/00 , C12Q1/68 , G01N35/00 , G01N35/08 , C12P19/34
CPC分类号： G01N35/08 , B01F5/0646 , B01F5/0647 , B01F5/0654 , B01F13/0071 , B01F2015/0221 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01L3/5027 , B01L3/502715 , B01L2300/0809 , B01L2300/0861 , B01L2300/0883 , G01N2035/00366 , G01N2035/00514
摘要： Provided are a method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.
摘要翻译：提供了用于扩增核酸的方法和装置。该方法包括通过不同的入口通道将含有用于核酸扩增的反应物的反应物水溶液和与反应物水溶液相分离并且不参与扩增反应的流体引入反应容器，形成多个反应物水溶液通过使反应物水溶液与反应容器中的流体接触，并且扩增反应物水溶液液滴中的核酸，由流体包围的液滴。该装置包括基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许将含有用于核酸扩增的反应物的反应物水溶液引入到反应容器，形成在基板内部的第二入口通道，连接到反应容器的端部，并且允许引入与反应物水溶液相分离并且不参与扩增反应的流体进入反应容器，以及加热单元，其以与基板热接触并加热基板的方式安装在基板上。

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