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51. 发明申请

US20110144575A1 METHOD AND APPARATUS FOR MINIMIZING POST-INFARCT VENTRICULAR REMODELING 失效
标题翻译：用于最小化后腹腔镜重建的方法和装置
公开(公告)号：US20110144575A1
公开(公告)日：2011-06-16
申请号：US13034560
申请日：2011-02-24
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/365 , A61M5/00
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译：一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。这种起搏服务器可以预防或最小化梗死后重塑。

52. 发明授权

US07627373B2 Method and apparatus for cell and electrical therapy of living tissue 有权
标题翻译：活体组织细胞和电疗法的方法和装置
公开(公告)号：US07627373B2
公开(公告)日：2009-12-01
申请号：US10723258
申请日：2003-11-25
申请人： Steven D. Girouard , Rodney W. Salo , Bruce H. KenKnight
发明人： Steven D. Girouard , Rodney W. Salo , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译：一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。在一个应用中，可以使用植入式起搏器进行VDD模式，与内在房室延迟相比，房室延迟保持相对较短。

53. 发明申请

US20090254137A1 Temperature Based Systems and Methods for Tachycardia Discrimination and Therapy 有权
标题翻译：基于温度的系统和方法用于心动过速鉴别和治疗
公开(公告)号：US20090254137A1
公开(公告)日：2009-10-08
申请号：US12411157
申请日：2009-03-25
申请人： Rodney W. Salo , Allan Charles Shuros , Dan Li
发明人： Rodney W. Salo , Allan Charles Shuros , Dan Li
IPC分类号： A61N1/05
CPC分类号： A61N1/3622 , A61N1/3962
摘要： Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及可植入医疗系统等。在一个实施例中，本发明包括处理器，电传感器和温度传感器。处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动，用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度，确定心律失常是否为血液动力学稳定或血液动力学不稳定，如果心律失常是血液动力学不稳定的话，开始进行高压休克治疗。本文还包括其它实施例。

54. 发明申请

US20090062895A1 MEDICAL DEVICE ELECTRODES INCLUDING NANOSTRUCTURES 失效
标题翻译：包括纳米结构的医疗器械电极
公开(公告)号：US20090062895A1
公开(公告)日：2009-03-05
申请号：US11846246
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/0565 , A61N1/375 , Y10S977/931
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译：用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。电极对可以彼此靠近放置。当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。此外，电极可以排列成阵列。

55. 发明授权

US07460914B2 Devices and methods to stimulate therapeutic angiogenesis for ischemia and heart failure 失效
标题翻译：用于刺激局部缺血和心力衰竭的治疗性血管发生的装置和方法
公开(公告)号：US07460914B2
公开(公告)日：2008-12-02
申请号：US11244016
申请日：2005-10-05
申请人： Evgenia Mandrusov , Paul Consigny , Rodney W. Salo
发明人： Evgenia Mandrusov , Paul Consigny , Rodney W. Salo
IPC分类号： A61N1/05 , A61N1/372 , A61M25/00
CPC分类号： A61N1/0568 , A61N1/056 , A61N1/306 , A61N1/326 , A61N2001/0585
摘要： A method for stimulating angiogenesis is provided that includes the use of an electrical output channel adapted to deliver a sub-threshold voltage, a lead that includes a proximal end adapted to be electrically connected to the electrical output channel and a distal end adapted to be placed in the blood conduit where the distal end of the lead is adapted to deliver a treatment agent that stimulates therapeutic angiogenesis, and at least one electrode on the distal end of the first lead.
摘要翻译：提供了一种用于刺激血管生成的方法，其包括使用适于递送亚阈值电压的电输出通道，包括适于电连接到电输出通道的近端的引线和适于放置的远端在血液导管中，其中铅的远端适于递送刺激治疗性血管发生的治疗剂，以及在第一引线的远端上的至少一个电极。

56. 发明申请

US20080234772A1 METHOD AND DEVICE FOR MYOCARDIAL STRESS REDISTRIBUTION 有权
标题翻译：用于心肌应激再分配的方法和装置
公开(公告)号：US20080234772A1
公开(公告)日：2008-09-25
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such an the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可用于故意减压可能预期会发生有害重塑的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或故意压迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

57. 发明申请

US20080188730A1 DEVICE FOR MONITORING FLUID STATUS 有权
标题翻译：用于监测流体状态的装置
公开(公告)号：US20080188730A1
公开(公告)日：2008-08-07
申请号：US12098644
申请日：2008-04-07
申请人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
发明人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61B5/05
CPC分类号： A61B5/0538 , A61B5/053 , A61B5/14535 , A61N1/36521
摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.
摘要翻译：描述了通过电阻抗测量来确定患者的血细胞比容的技术。可植入装置可被配置为利用该技术来评估心脏病人的流体状态。为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

58. 发明授权

US07177688B2 Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
标题翻译：心脏节律管理系统使用心率优化心脏性能
公开(公告)号：US07177688B2
公开(公告)日：2007-02-13
申请号：US11018124
申请日：2004-12-21
申请人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
发明人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
IPC分类号： A61N1/18
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译：公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。微控制器可用于调节起搏器的起搏模式和站间延迟，以达到最佳的血流动力学性能。信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

59. 发明授权

US06278894B1 Multi-site impedance sensor using coronary sinus/vein electrodes 有权
标题翻译：多站阻抗传感器使用冠状窦/静脉电极
公开(公告)号：US06278894B1
公开(公告)日：2001-08-21
申请号：US09336449
申请日：1999-06-21
申请人： Rodney W. Salo , V. A. Kadhiresan , Kevin G. Nugent
发明人： Rodney W. Salo , V. A. Kadhiresan , Kevin G. Nugent
IPC分类号： A61B505
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus for performing impedance plethysmography on a living heart for diagnostic and therapy purposes involves placement of plural leads where at least one is disposed within a coronary vein traversing the myocardium on the left side of the heart with another lead having plural electrodes thereon disposed in the right ventricle. By appropriate selection of electrodes on the first and second leads for driving with an AC carrier signal and other such electrodes coupled to a sensing amplifier, an impedance vs. time signal can be derived that when signal processed provides useful information concerning cardiac performance. The multi-site impedance sensing has been found to yield more robust data especially in patients having CHF.
摘要翻译：用于诊断和治疗目的的用于在活的心脏上进行阻抗体积描记术的方法和装置包括放置多个引线，其中至少一个引线设置在穿过心脏左侧的心肌的冠状静脉内，另一引线上设置有多个电极在右心室。通过适当选择第一和第二引线上的电极用AC载波信号进行驱动并且其它这样的电极耦合到感测放大器，可以导出阻抗对时间信号，当信号被处理时提供关于心脏性能的有用信息。已经发现多位点阻抗感测可以产生更强健的数据，特别是在具有CHF的患者中。

60. 发明授权

US5700283A Method and apparatus for pacing patients with severe congestive heart failure 失效
标题翻译：用于起搏患者严重充血性心力衰竭的方法和装置
公开(公告)号：US5700283A
公开(公告)日：1997-12-23
申请号：US754932
申请日：1996-11-25
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/36564 , A61N1/3627 , A61N1/36585 , A61N1/3682
摘要： An implantable cardiac pacemaker especially designed for treatment of CHF includes an accelerometer for sensing heart sounds and processing circuitry for deriving from the heart sound information the mechanical AV delay of the patient's heart. The pacemaker's applied AV delay is then adjusted until the measured mechanical AV delay falls in a range of between 180 ms and 250 ms. Further optimization of the heart as a pump can then be achieved by incrementally adjusting the pacemaker's applied AV delay interval until a point is reached where a measure of cardiac performance such as aortic pulse pressure is optimized.
摘要翻译：特别设计用于治疗CHF的可植入心脏起搏器包括用于感测心脏声音的加速度计和用于从心脏声音信息导出患者心脏的机械AV延迟的处理电路。然后调整起搏器应用的AV延迟，直到所测量的机械AV延迟在180ms和250ms之间的范围内。然后可以通过逐渐调整心脏起搏器应用的AV延迟间隔直到达到如心脏性能测量（例如主动脉脉压）被优化为止的点来实现心脏作为泵的进一步优化。

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