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51. 发明授权

US08478405B2 Optimizing anti-tachycardia pacing for terminating atrial fibrillation 有权
标题翻译：优化抗心动过速起搏用于终止房颤
公开(公告)号：US08478405B2
公开(公告)日：2013-07-02
申请号：US12841012
申请日：2010-07-21
申请人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/08
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395
摘要： An implantable system terminates atrial fibrillation by applying optimized anti-tachycardia pacing (ATP). In one implementation, the system senses and paces at multiple sites on the left atrium. At each site, the system senses reentrant circuits causing the atrial fibrillation. In one implementation, the system applies ATP tuned to the frequency of the reentrant circuit at the electrode that senses the most regular reentrant circuit. In another implementation, the system applies ATP at multiple electrodes, delivering each pulse at each site when the excitable gap is near the site. In other variations, the ATP is optimized for different patterns of sequential, simultaneous, or syncopated delivery to terminate the atrial fibrillation. The system can also monitor multiple heart chambers for cardiac events that favor terminating atrial fibrillation via ATP. The system then times delivery of the ATP according to these cardiac events.
摘要翻译：可植入系统通过应用优化的抗心动过速起搏（ATP）来终止房颤。在一个实施中，系统在左心房的多个位置感觉和步调。在每个部位，系统检测引起房颤的折返回路。在一个实现中，该系统将ATP调谐到感测最常规的可重入电路的电极处的可重入电路的频率。在另一个实施方案中，该系统在多个电极上施加ATP，当可兴奋的间隙在该位置附近时，在每个位置递送每个脉冲。在其他变体中，ATP针对不同的顺序，同时或间歇递送模式进行优化，以终止心房颤动。该系统还可以监测多个心室，用于通过ATP终止心房颤动的心脏事件。然后系统根据这些心脏事件递送ATP。

52. 发明申请

US20100312300A1 OPTIMIZING ANTI-TACHYCARDIA PACING FOR TERMINATING ATRIAL FIBRILLATION 有权
标题翻译：优化抗惊厥药用于终止ATRIAL FIBRILLATION
公开(公告)号：US20100312300A1
公开(公告)日：2010-12-09
申请号：US12841012
申请日：2010-07-21
申请人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395
摘要： An implantable system terminates atrial fibrillation by applying optimized anti-tachycardia pacing (ATP). In one implementation, the system senses and paces at multiple sites on the left atrium. At each site, the system senses reentrant circuits causing the atrial fibrillation. In one implementation, the system applies ATP tuned to the frequency of the reentrant circuit at the electrode that senses the most regular reentrant circuit. In another implementation, the system applies ATP at multiple electrodes, delivering each pulse at each site when the excitable gap is near the site. In other variations, the ATP is optimized for different patterns of sequential, simultaneous, or syncopated delivery to terminate the atrial fibrillation. The system can also monitor multiple heart chambers for cardiac events that favor terminating atrial fibrillation via ATP. The system then times delivery of the ATP according to these cardiac events.
摘要翻译：可植入系统通过应用优化的抗心动过速起搏（ATP）来终止房颤。在一个实施中，系统在左心房的多个位置感觉和步调。在每个部位，系统检测引起房颤的折返回路。在一个实现中，该系统将ATP调谐到感测最常规的可重入电路的电极处的可重入电路的频率。在另一个实施方案中，该系统在多个电极上施加ATP，当可兴奋的间隙在该位置附近时，在每个位置递送每个脉冲。在其他变体中，ATP针对不同的顺序，同时或间歇递送模式进行优化，以终止心房颤动。该系统还可以监测多个心室，用于通过ATP终止心房颤动的心脏事件。然后系统根据这些心脏事件递送ATP。

53. 发明授权

US07826899B1 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for termination of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏以终止房性快速性心律失常
公开(公告)号：US07826899B1
公开(公告)日：2010-11-02
申请号：US11615488
申请日：2006-12-22
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems, and method for use therewith, are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments, as will be described below, are for use with an implantable device that include one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering AATP and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。如下所述，具体实施方案用于可植入装置，其包括一个或多个用于感测心房颤动（AF）和/或递送AATP的心房电极和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

54. 发明授权

US08478403B2 Implantable systems and methods for use therewith for monitoring and modifying arterial blood pressure without requiring an intravascular pressure transducer 有权
标题翻译：可植入的系统和方法，用于监测和改变动脉血压，而不需要血管内压力传感器
公开(公告)号：US08478403B2
公开(公告)日：2013-07-02
申请号：US13033484
申请日：2011-02-23
申请人： Brian Jeffrey Wenzel , Michael E. Benser , Taraneh Ghaffari Farazi , Timothy A. Fayram , Edward Karst , Allen Keel , Wenbo Hou , Jong Gill
发明人： Brian Jeffrey Wenzel , Michael E. Benser , Taraneh Ghaffari Farazi , Timothy A. Fayram , Edward Karst , Allen Keel , Wenbo Hou , Jong Gill
IPC分类号： A61N1/00
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/02125 , A61B5/02158 , A61B5/02416 , A61B5/042 , A61B5/0452 , A61N1/36507 , A61N1/36585
摘要： Embodiments of the present invention are directed to implantable systems, and methods for use therewith, that monitor and modify a patient's arterial blood pressure without requiring an intravascular pressure transducer. In accordance with an embodiment, for each of a plurality of periods of time, there is a determination one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes for the left ventricle to generate a pressure pulsation that travels from the patient's aorta to a location remote from the patient's aorta. Based on the one or more metrics indicative of PAT, the patient's arterial blood pressure is estimated. Changes in the arterial blood pressure are monitored over time. Additionally, the patient's arterial blood pressure can be modified by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient's arterial blood pressure and/or monitored changes therein.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，其不需要血管内压力传感器来监测和修改患者的动脉血压。根据实施例，对于多个时间段中的每一个，存在确定指示脉搏到达时间（PAT）的一个或多个度量，每个指标指示左心室产生多长时间从患者主动脉行进到远离患者主动脉的位置的压力脉动。基于指示PAT的一个或多个指标，估计患者的动脉血压。随着时间的推移监测动脉血压的变化。此外，可以通过基于患者的动脉血压的估计和/或其中监测的变化来启动和/或调整起搏和/或其他治疗来改变患者的动脉血压。

55. 发明申请

US20120215275A1 IMPLANTABLE SYSTEMS AND METHODS FOR USE THEREWITH FOR MONITORING AND MODIFYING ARTERIAL BLOOD PRESSURE WITHOUT REQUIRING AN INTRAVASCULAR PRESSURE TRANSDUCER 有权
标题翻译：不需要输血管压力传感器的可植入式系统和方法，用于监测和修改血管内血压
公开(公告)号：US20120215275A1
公开(公告)日：2012-08-23
申请号：US13033484
申请日：2011-02-23
申请人： Brian Jeffrey Wenzel , Michael E. Benser , Taraneh Ghaffari Farazi , Timothy A. Fayram , Edward Karst , Allen Keel , Wenbo Hou , Jong Gill
发明人： Brian Jeffrey Wenzel , Michael E. Benser , Taraneh Ghaffari Farazi , Timothy A. Fayram , Edward Karst , Allen Keel , Wenbo Hou , Jong Gill
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/02125 , A61B5/02158 , A61B5/02416 , A61B5/042 , A61B5/0452 , A61N1/36507 , A61N1/36585
摘要： Embodiments of the present invention are directed to implantable systems, and methods for use therewith, that monitor and modify a patient's arterial blood pressure without requiring an intravascular pressure transducer. In accordance with an embodiment, for each of a plurality of periods of time, there is a determination one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes for the left ventricle to generate a pressure pulsation that travels from the patient's aorta to a location remote from the patient's aorta. Based on the one or more metrics indicative of PAT, the patient's arterial blood pressure is estimated. Changes in the arterial blood pressure are monitored over time. Additionally, the patient's arterial blood pressure can be modified by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient's arterial blood pressure and/or monitored changes therein.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，其不需要血管内压力传感器来监测和修改患者的动脉血压。根据实施例，对于多个时间段中的每一个，存在确定指示脉搏到达时间（PAT）的一个或多个指标，每个指标指示左心室产生多长时间从患者主动脉行进到远离患者主动脉的位置的压力脉动。基于指示PAT的一个或多个指标，估计患者的动脉血压。随着时间的推移监测动脉血压的变化。此外，可以通过基于患者的动脉血压的估计和/或其中监测的变化来启动和/或调整起搏和/或其他治疗来改变患者的动脉血压。

56. 发明授权

US07627366B1 Analysis of polarization information 有权
标题翻译：极化信息分析
公开(公告)号：US07627366B1
公开(公告)日：2009-12-01
申请号：US11123300
申请日：2005-05-06
申请人： Annapurna Karicherla , Xiaoyi Min , Xiaozheng Zhang , Jong Gill
发明人： Annapurna Karicherla , Xiaoyi Min , Xiaozheng Zhang , Jong Gill
IPC分类号： A61N1/37
CPC分类号： A61N1/36507
摘要： An exemplary method includes providing a first value indicative of electrode polarization, delivering a cardiac stimulus and determining a second value indicative of electrode polarization associated with the cardiac stimulus, comparing the second value to the first value to determine whether a change in cardiac condition has occurred and, based at least in part on the comparing, deciding whether to adjust a cardiac stimulation therapy.
摘要翻译：示例性方法包括提供指示电极极化的第一值，递送心脏刺激并确定指示与心脏刺激相关联的电极极化的第二值，将第二值与第一值进行比较，以确定心脏状态的变化是否已发生并且至少部分地基于比较，决定是否调整心脏刺激疗法。

57. 发明申请

US20070027489A1 Characterization of a patient's condition by evaluating electrical and mechanical properties of the heart 审中-公开
标题翻译：通过评估心脏的电气和机械性质来描述患者状况
公开(公告)号：US20070027489A1
公开(公告)日：2007-02-01
申请号：US11192538
申请日：2005-07-28
申请人： Jong Gill , Xiaoyi Min
发明人： Jong Gill , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0215 , A61B5/0452 , A61N1/36521 , A61N1/36578 , A61N1/3682 , A61N1/3684
摘要： A method and device for evaluating the progression of a patient's condition, which in certain applications can include heart failure, on an ongoing manner which reduces the need for immediate attention from skilled clinicians or expensive diagnostic equipment. The method and device analyze relative timing between electrical and mechanical properties of the heart. Detection of an elongated delay between corresponding electrical and mechanical activity is interpreted as indicating a worsening heart failure condition. The analysis and data corresponding thereto can be stored for further analysis and/or telemetrically communicated to an external device. Therapy provided by the device can be altered based on the evaluation of the patient's condition.
摘要翻译：一种用于评估患者状况进展的方法和装置，其在某些应用中可以包括心力衰竭，以持续的方式减少熟练临床医生或昂贵诊断设备立即关注的需要。该方法和装置分析心脏的电气和机械性质之间的相对时间。在对应的电和机械活动之间的延长延迟的检测被解释为指示恶化的心力衰竭状况。可以存储对应于其的分析和数据用于进一步分析和/或遥测地传送到外部设备。可以根据对患者状况的评估来改变设备提供的治疗。

58. 发明授权

US07437192B2 System and method for detecting heart failure and pulmonary edema based on ventricular end-diastolic pressure using an implantable medical device 有权
标题翻译：基于使用可植入医疗装置的心室舒张末期压力来检测心力衰竭和肺水肿的系统和方法
公开(公告)号：US07437192B2
公开(公告)日：2008-10-14
申请号：US11100008
申请日：2005-04-05
申请人： Jong Gill , Xiaoyi Min
发明人： Jong Gill , Xiaoyi Min
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3627 , A61N1/36521
摘要： Techniques are provided for detecting left ventricular end diastolic pressure (LV EDP) using a pressure sensor implanted within the heart of a patient and for detecting and evaluating heart failure and pulmonary edema based on LV EDP. Briefly, the peak of the R-wave of an intracardiac electrogram (IEGM) is used to trigger the measurement of a pressure value within the left ventricle. This pressure value is deemed to be representative of LV EDP. In this manner, LV EDP is easily detected merely by measuring pressure at one point within the heartbeat—thereby eliminating any need to track ventricular pressure throughout the heartbeat. Techniques for detecting and evaluating heart failure and pulmonary edema based on the R-wave triggered LV EDP measurements are also set forth herein.
摘要翻译：提供了使用植入患者心脏内的压力传感器来检测左心室舒张压（LV EDP）的技术，并且用于基于LV EDP检测和评估心脏衰竭和肺水肿。简而言之，使用心内电描记图（IEGM）的R波的峰值来触发左心室内的压力值的测量。该压力值被认为是LV EDP的代表。以这种方式，仅通过测量心跳内的一点的压力来容易地检测LV EDP，从而消除了跟踪整个心跳期间的心室压力的任何需要。本文还介绍了基于R波触发的LV EDP测量来检测和评估心脏衰竭和肺水肿的技术。

59. 发明申请

US20080086177A1 System and Related Methods for Monitoring Cardiac Disease Using Pacing Latency Measurements 审中-公开
标题翻译：使用起搏延迟测量监测心脏疾病的系统和相关方法
公开(公告)号：US20080086177A1
公开(公告)日：2008-04-10
申请号：US11539824
申请日：2006-10-09
申请人： Xiaoyi Min , Paul A. Levine , Jong Gill
发明人： Xiaoyi Min , Paul A. Levine , Jong Gill
IPC分类号： A61N1/365
CPC分类号： A61N1/37 , A61B5/0452 , A61B5/0809 , A61B5/091 , A61B5/11 , A61N1/3621 , A61N1/3627
摘要： A system and related methods for monitoring cardiac disease. The system includes an implantable medical device having a microcontroller that is configured to measure a pacing latency value for a region of a heart, compare the measured pacing latency value to a previously measured pacing latency value for the region of the heart, and determine a change in an amount of cardiac disease in the region of the heart based on the comparison of the measured pacing latency values.
摘要翻译：用于监测心脏病的系统和相关方法。该系统包括具有微控制器的可植入医疗装置，微控制器被配置为测量心脏区域的起搏延迟值，将测量的起搏延迟值与心脏区域的先前测量的起搏延迟值进行比较，并确定改变基于测量的起搏延迟值的比较，在心脏区域中的心脏病的量。

60. 发明授权

US07856268B2 Ischemia detection for anti-arrhythmia therapy 有权
标题翻译：缺血检测用于抗心律失常治疗
公开(公告)号：US07856268B2
公开(公告)日：2010-12-21
申请号：US12501765
申请日：2009-07-13
申请人： Mark W. Kroll , Peter Boileau , Jong Gill
发明人： Mark W. Kroll , Peter Boileau , Jong Gill
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3962
摘要： An exemplary method includes detecting arrhythmia, detecting myocardial ischemia, determining whether the myocardial ischemia comprises local ischemia or global ischemia and, in response to the determining, calling for delivery of either a local ischemic anti-arrhythmia therapy or a global ischemic anti-arrhythmia therapy. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心律失常，检测心肌缺血，确定心肌缺血是否包括局部缺血或全身缺血，并且响应于确定，要求递送局部缺血性抗心律失常治疗或全身缺血性抗心律失常治疗。还公开了各种其它示例性方法，装置，系统等。

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