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51. 发明授权

US08527049B2 Cardiac resynchronization therapy optimization using vector measurements obtained from realtime electrode position tracking 有权
标题翻译：使用从实时电极位置跟踪获得的矢量测量的心脏再同步治疗优化
公开(公告)号：US08527049B2
公开(公告)日：2013-09-03
申请号：US12621373
申请日：2009-11-18
申请人： Steve Koh , Stuart Rosenberg , Kyungmoo Ryu , Michael Yang , Allen Keel
发明人： Steve Koh , Stuart Rosenberg , Kyungmoo Ryu , Michael Yang , Allen Keel
IPC分类号： A61N1/365 , A61B5/05
CPC分类号： A61N1/3627 , A61B5/0422 , A61B5/0452 , A61N1/36585 , A61N1/3682 , A61N1/3684 , A61N1/3686
摘要： An exemplary method includes selecting multiple electrodes located in a patient; acquiring position information during one or more cardiac cycles for the multiple electrodes where the acquiring includes using each of the electrodes for measuring one or more electrical potentials in an electrical localization field established in the patient; calculating one or more vector metrics based on the acquired position information for one or more vectors, each vector defined by two of the multiple electrodes; and analyzing the one or more vector metrics to assess cardiac performance during the one or more cardiac cycles. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括选择位于患者体内的多个电极; 在所述多个电极的一个或多个心动周期期间获取位置信息，其中所述获取包括使用每个所述电极来测量在所述患者中建立的电定位场中的一个或多个电位; 基于所获取的一个或多个向量的位置信息来计算一个或多个矢量度量，每个矢量由所述多个电极中的两个限定; 以及分析所述一个或多个矢量度量以评估所述一个或多个心动周期期间的心脏性能。还公开了各种其它方法，装置，系统等。

52. 发明授权

US08473055B2 Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device 有权
标题翻译：用于优化与可植入医疗装置一起使用的多部位心脏起搏和感测配置的系统和方法
公开(公告)号：US08473055B2
公开(公告)日：2013-06-25
申请号：US12703094
申请日：2010-02-09
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Xiaoyi Min
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Xiaoyi Min
IPC分类号： A61B5/04
CPC分类号： A61N1/37247 , A61N1/36507 , A61N1/36521 , A61N1/3682 , A61N1/3684 , A61N1/37282
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, referred to herein as QuickStim, cardiac pacing configurations are optimized based on an assessment of hemodynamic benefit and device longevity. In another example, referred to herein as QuickSense, cardiac sensing configurations are optimized based on sensing profiles input by a clinician. Various virtual sensing channels are also described that provide for the multiplexing or gating of sensed signals. Anisotropic oversampling is also described.
摘要翻译：提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。在一个例子中，本文称为QuickStim，基于对血液动力学益处和器械寿命的评估来优化心脏起搏配置。在另一个例子中，本文称为QuickSense，基于由临床医生输入的感测曲线来优化心脏感测配置。还描述了各种虚拟感测通道，其提供感测信号的复用或门控。还描述了各向异性过采样。

53. 发明申请

US20120310296A1 DETERMINATION OF CARDIAC RESYNCHRONIZATION THERAPY SETTINGS 有权
标题翻译：心脏康复治疗方法的确定
公开(公告)号：US20120310296A1
公开(公告)日：2012-12-06
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/365
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译：用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

54. 发明授权

US07903850B2 Method and apparatus for pre-processing scans by combining enhancement and denoising as a preparation for segmenting the same 有权
标题翻译：通过组合增强和去噪作为分割扫描的准备来预处理扫描的方法和装置
公开(公告)号：US07903850B2
公开(公告)日：2011-03-08
申请号：US11488802
申请日：2006-07-18
申请人： Matthias Rasch , Allen Keel , Christine H Lorenz
发明人： Matthias Rasch , Allen Keel , Christine H Lorenz
IPC分类号： G06K9/00
CPC分类号： G06T5/004
摘要： A computer-implemented method for pre-processing image data of a three-dimensional volume includes providing the image data of a vessel, applying a super-sampling filter to the image data to generate super-sampled image data having an increased resolution as compared to the image data, applying an unsharp masking filter to the super-sampled image data for increasing contrast of an edge of the vessel, applying a de-noising filer for removing noise surrounding the edge after applying the unsharp masking filter, and storing the image data after applying the de-noising filter thereto.
摘要翻译：用于预处理三维体积图像数据的计算机实现方法包括提供容器的图像数据，对图像数据应用超采样滤波器以产生具有增加的分辨率的超采样图像数据，与将所述图像数据应用于所述超采样图像数据，以增加所述容器的边缘的对比度;对所述图像数据应用所述图像数据之后，应用去噪滤光器以除去所述边缘周围的噪声;以及存储所述图像数据在其上应用去噪滤波器之后。

55. 发明申请

US20100161006A1 SYSTEM AND METHOD FOR MONITORING DIASTOLIC FUNCTION USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗装置监测脱脂功能的系统和方法
公开(公告)号：US20100161006A1
公开(公告)日：2010-06-24
申请号：US12341355
申请日：2008-12-22
申请人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
发明人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
IPC分类号： A61N1/36
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3712
摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.
摘要翻译：使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。来自这些代理值的度量来表示舒张功能。随着时间的推移跟踪度量以评估舒张功能的变化。在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

56. 发明申请

US20100160993A1 IMPLANTABLE SYSTEMS AND METHODS FOR MONITORING BNP LEVELS, HF AND MI 有权
标题翻译：用于监测BNP水平，HF和MI的可植入系统和方法
公开(公告)号：US20100160993A1
公开(公告)日：2010-06-24
申请号：US12341074
申请日：2008-12-22
申请人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
发明人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/024 , A61B5/0452 , A61B5/0464 , A61B5/053 , A61B5/145 , A61N1/36557 , A61N1/36585 , A61N1/37258
摘要： Methods for monitoring a patient's level of B-type natriuretic peptide (BNP), and implantable cardiac systems capable of performing such methods, are provided. A ventricle is paced for a period of time to provoke a ventricular evoked response, and a ventricular intracardiac electrogram (IEGM) indicative of the ventricular evoked response is obtained. Based on the ventricular IEGM, there is a determination of at least one ventricular evoked response metric (e.g., ventricular evoked response peak-to-peak amplitude, ventricular evoked response area and/or ventricular evoked response maximum slope), and the patient's level of BNP is monitored based on determined ventricular evoked response metric(s). Based on the monitored level's of BNP, the patients heart failure (HF) condition and/or risks and/or occurrences of certain events (e.g., an acute HF exacerbation and/or an acute myocardial infarction) can be monitored.
摘要翻译：提供了用于监测患者B型利钠肽（BNP）水平的方法，以及能够执行这些方法的可植入心脏系统。心室起搏一段时间以引发心室诱发反应，并获得指示心室诱发反应的心室心内电图（IEGM）。基于心室IEGM，确定至少一个心室诱发反应度量（例如，心室诱发反应峰 - 峰幅度，心室诱发反应面积和/或心室诱发反应最大斜率）和患者的水平基于确定的心室诱发反应度量监测BNP。基于监测的BNP水平，可以监测患者的心力衰竭（HF）状况和/或某些事件的风险和/或发生（例如急性HF急性发作和/或急性心肌梗塞）。

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