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51. 发明申请

US20110313395A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 有权
标题翻译：药物递送管理系统和方法
公开(公告)号：US20110313395A1
公开(公告)日：2011-12-22
申请号：US13203707
申请日：2010-01-27
申请人： Peter Krulevitch , Ulrich Kraft , Robert Wilk , Zara Sieh , Mitch Zhao
发明人： Peter Krulevitch , Ulrich Kraft , Robert Wilk , Zara Sieh , Mitch Zhao
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a “smart” drug delivery pen are provided which include a drug delivery pen having an inertial sensor or accelerometer. A system is also provided that includes the smart drug pen in conjunction with a data management unit(s) DMU. Various exemplary methods for use of the pens and systems are also described and illustrated.
摘要翻译：提供了一种“智能”药物递送笔的各种实施例，其包括具有惯性传感器或加速度计的药物输送笔。还提供了一种系统，其包括结合数据管理单元DMU的智能药笔。还描述和示出了用于笔和系统的各种示例性方法。

52. 发明申请

US20110092915A1 PALM ACTIVATED DRUG DELIVERY DEVICE 有权
标题翻译： PALM激活药物递送装置
公开(公告)号：US20110092915A1
公开(公告)日：2011-04-21
申请号：US12905572
申请日：2010-10-15
申请人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
发明人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
IPC分类号： A61M5/32
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译：公开了用于胃肠外递送药物例如药物的装置。该装置包括上壳体和下壳体，其中上壳体构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下壳体移动。

53. 外观设计

USD602586S1 Drug delivery pod 有权
标题翻译：药物输送荚
公开(公告)号：USD602586S1
公开(公告)日：2009-10-20
申请号：US29321752
申请日：2008-07-23
申请人： Nick Foley , James Cunningham Glencross , James Harkness , Martin Crofton , Peter Krulevitch
设计人： Nick Foley , James Cunningham Glencross , James Harkness , Martin Crofton , Peter Krulevitch

54. 发明申请

US20090247982A1 Medical Device Mechanical Pump 审中-公开
标题翻译：医疗器械机械泵
公开(公告)号：US20090247982A1
公开(公告)日：2009-10-01
申请号：US12407173
申请日：2009-03-19
申请人： Peter Krulevitch , Robert Wilk , Sean O'Connor , Mingqi Zhao , Zara Sieh , Donna Savage
发明人： Peter Krulevitch , Robert Wilk , Sean O'Connor , Mingqi Zhao , Zara Sieh , Donna Savage
IPC分类号： A61M1/00 , H04Q5/22
CPC分类号： A61M5/14248 , A61M5/14224 , A61M5/1424 , A61M5/38 , A61M2005/1405 , A61M2005/14252 , A61M2205/0294 , A61M2205/3569 , A61M2205/3592 , A61M2205/825
摘要： A medical device pump with a housing with a compartment for removably receiving a cartridge containing a therapeutic agent, a conduit configured to operatively provide a fluid flow path for therapeutic agent to exit from the cartridge, a user activated delivery button, a trigger mechanism, and a mechanical pump mechanism. The trigger mechanism, user activated delivery button and mechanical pump mechanism of the medical device pump are configured such that the trigger mechanism is activated by a user fully activating the user activated delivery button. Moreover, such full activation generates mechanical power employed by, and sufficient for, the mechanical pump mechanism to pump a predetermined volume of therapeutic agent from the cartridge and through the fluid flow path.
摘要翻译：一种具有壳体的医疗装置泵，具有用于可拆卸地容纳包含治疗剂的药筒的隔室，构造成可操作地提供用于治疗剂从药筒离开的流体流动路径的管道，用户激活的递送按钮，触发机构和机械泵机构。触发机构，用户激活的输送按钮和医疗装置泵的机械泵机构被配置为使得触发机构被用户激活，完全激活用户激活的递送按钮。此外，这种完全激活产生机械功率，并且足以使机械泵机构从盒中泵送预定量的治疗剂并通过流体流动路径。

55. 发明申请

US20090209030A1 Thermal Cycler 审中-公开
标题翻译：热循环仪
公开(公告)号：US20090209030A1
公开(公告)日：2009-08-20
申请号：US12415623
申请日：2009-03-31
申请人： William J. Benett , James B. Richards , Paul L. Stratton , Elizabeth K. Wheeler , Peter Krulevitch , Steve Visuri , John M. Dzenitis
发明人： William J. Benett , James B. Richards , Paul L. Stratton , Elizabeth K. Wheeler , Peter Krulevitch , Steve Visuri , John M. Dzenitis
IPC分类号： C12M1/02 , H05K3/00
CPC分类号： B01L7/52 , B01L3/5082 , B01L2200/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , Y10T29/49124
摘要： A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit material or a circuit board material. The second thermalcycler body section has a second face. A second cavity portion is formed in the second face. When the first cavity portion and the second cavity portion are positioned together they form a cavity. A thermalcycler unit is positioned in the cavity. The first thermalcycler body section and the second thermalcycler body section are connected together with the first face and the face opposed to each other and the thermalcycler unit operatively connected to the first cavity portion and the second cavity portion.
摘要翻译：热循环器正在构造具有柔性电路材料或电路板材料的第一热循环体主体部分。第一热循环体主体部分具有第一面。第一空腔部分形成在第一面中。第二个热循环器主体部分由柔性电路材料或电路板材料构成。第二热循环器本体部分具有第二面。第二空腔部分形成在第二面中。当第一空腔部分和第二空腔部分位于一起时，它们形成空腔。热循环器单元位于空腔中。第一热循环器主体部分和第二热循环器主体部分与第一面和彼此相对的面连接在一起，并且热循环器单元可操作地连接到第一腔部分和第二腔部分。

56. 发明申请

US20080312582A1 METHOD FOR INSERTING A FLEXIBLE MEDICAL DEVICE CONDUIT 审中-公开
标题翻译：插入灵活的医疗设备管道的方法
公开(公告)号：US20080312582A1
公开(公告)日：2008-12-18
申请号：US12138184
申请日：2008-06-12
申请人： Peter Krulevitch , Lorin P. Olson
发明人： Peter Krulevitch , Lorin P. Olson
IPC分类号： A61M39/10
CPC分类号： A61M5/158 , A61M5/3275 , A61M5/329 , A61M25/0009 , A61M25/0068 , A61M25/007 , A61M2005/1585 , A61M2005/1587 , A61M2205/0266
摘要： A method for inserting a flexible medical device conduit includes adhering a flexible conduit insertion medical device, with a flexible medical device conduit and an integrated insertion mechanism, to a target site. Moreover, the flexible medical device conduit has an elongated framework formed from a flexible material (e.g., Nitinol) with a body portion, sharp head, distal end and proximal end. The flexible medical device conduit also has a flexible tube at least partially jacketing the elongated framework between the distal end and the proximal end. In addition, the sharp head is disposed at the distal end and is configured for subcutaneous skin insertion and the elongated framework and flexible tube define at least one conduit between the elongated framework and the flexible tube, the conduit having an opening at the distal end. The insertion mechanism is operatively connected to, and integrated with, the flexible medical device conduit and the insertion mechanism is configured to insert a portion of the flexible medical device conduit, including at least the sharp head and the opening, into a user's skin target site. The method also includes inserting the flexible medical device conduit into the target site by action of the insertion mechanism.
摘要翻译：用于插入柔性医疗装置导管的方法包括将柔性导管插入医疗装置与柔性医疗装置导管和集成插入机构粘合到目标部位。此外，柔性医疗装置导管具有由柔性材料（例如，镍钛诺）形成的细长骨架，其具有主体部分，尖头，远端和近端。柔性医疗装置导管还具有柔性管，至少部分地将细长骨架夹在远端和近端之间。此外，锋利的头部设置在远端并且构造成用于皮下皮肤插入，并且细长骨架和柔性管限定细长框架和柔性管之间的至少一个导管，该导管在远端具有开口。所述插入机构可操作地连接到所述柔性医疗装置导管并与所述柔性医疗装置导管集成，并且所述插入机构构造成将所述柔性医疗装置导管的至少包括所述尖头和所述开口的部分插入使用者的皮肤目标部位。该方法还包括通过插入机构的作用将柔性医疗装置导管插入目标部位。

57. 发明申请

US20080312558A1 FLEXIBLE CONDUIT INSERTION MEDICAL DEVICE 审中-公开
标题翻译：柔性导管插入式医疗装置
公开(公告)号：US20080312558A1
公开(公告)日：2008-12-18
申请号：US12138170
申请日：2008-06-12
申请人： Peter Krulevitch , Lorin P. Olson
发明人： Peter Krulevitch , Lorin P. Olson
IPC分类号： A61B5/00
CPC分类号： A61M5/158 , A61M5/3275 , A61M5/329 , A61M25/0009 , A61M25/0068 , A61M25/007 , A61M2005/1585 , A61M2005/1587 , A61M2205/0266
摘要： A flexible conduit insertion medical device includes a flexible medical device conduit and an insertion mechanism. The flexible medical device conduit includes an elongated framework formed from a flexible material (e.g., Nitinol) with a body portion, sharp head, distal end and proximal end. The flexible medical device conduit also includes a flexible tube at least partially jacketing the elongated framework between the distal end and the proximal end. Moreover, the sharp head is disposed at the distal end and is configured for subcutaneous skin insertion and the elongated framework and flexible tube define at least one conduit between the elongated framework and the flexible tube, the conduit having an opening at the distal end. The insertion mechanism is operatively connected to the flexible medical device conduit and configured to insert a portion of the flexible medical device conduit, including at least the sharp head and the opening, into a user's skin target site.
摘要翻译：柔性导管插入医疗装置包括柔性医疗装置导管和插入机构。柔性医疗器械导管包括由柔性材料（例如镍钛诺）形成的细长骨架，其具有主体部分，尖头，远端和近端。柔性医疗装置导管还包括柔性管，至少部分地将细长骨架夹在远端和近端之间。此外，尖头设置在远端并且构造成用于皮下皮肤插入，并且细长骨架和柔性管在细长框架和柔性管之间限定至少一个导管，该导管在远端具有开口。所述插入机构可操作地连接到所述柔性医疗装置导管并且被配置为将所述柔性医疗装置导管的至少包括所述尖头和所述开口的一部分插入使用者的皮肤目标部位。

58. 发明申请

US20070123963A1 Method for producing flexible, stretchable, and implantable high-density microelectrode arrays 审中-公开
标题翻译：用于生产柔性，可拉伸和可植入的高密度微电极阵列的方法
公开(公告)号：US20070123963A1
公开(公告)日：2007-05-31
申请号：US11288759
申请日：2005-11-29
申请人： Peter Krulevitch
发明人： Peter Krulevitch
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/37205
摘要： A high-density microelectrode array that is flexible and stretchable and can also be implanted within living tissue is provided. The microelectrode array includes at least first and second implantable and biocompatible polymeric layers in which a plurality of patterned conductive features, including metallic contact pads, metallic traces and metallic electrodes are sandwiched therebetween. Each metallic trace is located between a metallic contact pad and a metallic electrode and has substantially rounded corners and a zigzag pattern. The latter features are provided using stent technology. The present invention also provides a method of fabricating such a flexible, stretchable, and implantable microelectrode arrays which combined micromaching technology and stent technology as well as an implantable medical device that includes the inventive microelectrode array.
摘要翻译：提供了柔性和可拉伸并且还可以植入活组织内的高密度微电极阵列。微电极阵列包括至少第一和第二可植入和生物相容的聚合物层，其中包括金属接触焊盘，金属迹线和金属电极的多个图案化导电特征夹在其间。每个金属迹线位于金属接触焊盘和金属电极之间，并且具有大致圆角和锯齿形图案。后者的功能使用支架技术提供。本发明还提供了一种制造这种柔性，可拉伸和可植入的微电极阵列的方法，所述微电极阵列组合微扫描技术和支架技术以及包括本发明的微电极阵列的可植入医疗装置。

59. 发明授权

US09233213B2 Palm activated drug delivery device 有权
标题翻译：棕榈活化药物输送装置
公开(公告)号：US09233213B2
公开(公告)日：2016-01-12
申请号：US13833978
申请日：2013-03-15
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
IPC分类号： A61M5/32 , A61M5/315 , A61M5/31 , A61M5/50 , A61M5/20
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.
摘要翻译：构造成施用药物的装置可以包括下壳体，其包括壳体闩锁。该装置还可以包括针护罩，所述针护罩可沿第一方向相对于所述下壳体从第一位置运动到第二位置，以便露出针头，以及相对于所述下壳体支撑的上壳体。上壳体可以被构造成沿着从预先使用位置到分配位置的第二方向相对于下壳体移动。当上壳体处于使用前位置时，壳体闩锁可以可释放地干扰上壳体，以防止上壳体向分配位置移动，并且针护罩朝向第二位置的运动引起干扰从而允许上壳体朝向第二位置移动。

60. 发明授权

US08556865B2 Medical module for drug delivery pen 有权
标题翻译：用于药物输送笔的医疗模块
公开(公告)号：US08556865B2
公开(公告)日：2013-10-15
申请号：US13203691
申请日：2010-01-27
申请人： Peter Krulevitch , Robert Wilk , Ulrich Kraft , Donna Savage , Nick Foley , James Glencross , David Shepherd , Zara Sieh
发明人： Peter Krulevitch , Robert Wilk , Ulrich Kraft , Donna Savage , Nick Foley , James Glencross , David Shepherd , Zara Sieh
IPC分类号： A61M5/315 , A61M5/178 , A61M5/00
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a medical module are provided which includes a primary module housing, a secondary module housing, a dosage sensor, a power source, and a microcontroller. The module is configured to be attached to a disposable drug delivery pen or a reusable drug delivery pen so that the module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module.
摘要翻译：提供了包括主模块外壳，次模块外壳，剂量传感器，电源和微控制器的医疗模块的各种实施例。模块被配置为附接到一次性药物输送笔或可重复使用的药物递送笔，使得模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，是否已经被注射或摇动彻底混合胰岛素混合物，将与胰岛素剂量和注射相关的信息传输到数据管理单元，提供提醒，错误警告或关于不正当使用或重复使用针头的信息，跟踪笔上留下的药物量或使用持续时间关于药物到期的笔，或提供用于定位放错的笔和模块的声音报警器。

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