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1. 发明授权

US09233213B2 Palm activated drug delivery device 有权
标题翻译：棕榈活化药物输送装置
公开(公告)号：US09233213B2
公开(公告)日：2016-01-12
申请号：US13833978
申请日：2013-03-15
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
IPC分类号： A61M5/32 , A61M5/315 , A61M5/31 , A61M5/50 , A61M5/20
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.
摘要翻译：构造成施用药物的装置可以包括下壳体，其包括壳体闩锁。该装置还可以包括针护罩，所述针护罩可沿第一方向相对于所述下壳体从第一位置运动到第二位置，以便露出针头，以及相对于所述下壳体支撑的上壳体。上壳体可以被构造成沿着从预先使用位置到分配位置的第二方向相对于下壳体移动。当上壳体处于使用前位置时，壳体闩锁可以可释放地干扰上壳体，以防止上壳体向分配位置移动，并且针护罩朝向第二位置的运动引起干扰从而允许上壳体朝向第二位置移动。

2. 发明申请

US20130204229A1 PALM ACTIVATED DRUG DELIVERY DEVICE 有权
标题翻译： PALM激活药物递送装置
公开(公告)号：US20130204229A1
公开(公告)日：2013-08-08
申请号：US13833978
申请日：2013-03-15
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
IPC分类号： A61M5/32 , A61M5/315
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.
摘要翻译：构造成施用药物的装置可以包括下壳体，其包括壳体闩锁。该装置还可以包括针护罩，所述针护罩可沿第一方向相对于所述下壳体从第一位置运动到第二位置，以便露出针头，以及相对于所述下壳体支撑的上壳体。上壳体可以被构造成沿着从预先使用位置到分配位置的第二方向相对于下壳体移动。当上壳体处于使用前位置时，壳体闩锁可以可释放地干扰上壳体，以防止上壳体向分配位置移动，并且针护罩朝向第二位置的运动引起干扰从而允许上壳体朝向第二位置移动。

3. 发明申请

US20160089503A1 PALM ACTIVATED DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20160089503A1
公开(公告)日：2016-03-31
申请号：US14959701
申请日：2015-12-04
申请人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
发明人： Lorin Olson , Vaclav Vojan , Juergen Ernst Pfrang , Peter Krulevitch , Jingli Wang , Nicholas Foley , Mingqi Zhao , Paul Tashjian
IPC分类号： A61M5/32 , A61M5/315 , A61M5/50 , A61M5/31
CPC分类号： A61M5/326 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/3213 , A61M5/3243 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2013 , A61M2005/2026 , A61M2005/2073 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

4. 发明授权

US09216256B2 Palm activated drug delivery device 有权
标题翻译：棕榈活化药物输送装置
公开(公告)号：US09216256B2
公开(公告)日：2015-12-22
申请号：US12905572
申请日：2010-10-15
申请人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
发明人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
IPC分类号： A61M5/00 , A61M5/32 , A61M5/31 , A61M5/315 , A61M5/50 , A61M5/20
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译：公开了用于胃肠外递送药物例如药物的装置。该装置包括上壳体和下壳体，其中上壳体构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下壳体移动。

5. 发明申请

US20110092915A1 PALM ACTIVATED DRUG DELIVERY DEVICE 有权
标题翻译： PALM激活药物递送装置
公开(公告)号：US20110092915A1
公开(公告)日：2011-04-21
申请号：US12905572
申请日：2010-10-15
申请人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
发明人： Lorin P. Olson , Peter Krulevitch , James Glencross , Jingli Wang , Nicholas Foley , Mingqi Zhao
IPC分类号： A61M5/32
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译：公开了用于胃肠外递送药物例如药物的装置。该装置包括上壳体和下壳体，其中上壳体构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下壳体移动。

6. 发明授权

US07666287B2 Method for preparing an electrokinetic element 有权
标题翻译：电动元件的制备方法
公开(公告)号：US07666287B2
公开(公告)日：2010-02-23
申请号：US11614517
申请日：2006-12-21
申请人： Mingqi Zhao , Mark Huang , Stan Thomas , Peter Krulevitch
发明人： Mingqi Zhao , Mark Huang , Stan Thomas , Peter Krulevitch
IPC分类号： G01N27/27
CPC分类号： F04B17/00 , B29C45/14778 , B29C47/0021 , B29C47/065 , B29C47/067 , B29C70/685 , B29K2023/06 , B29K2023/083 , B29K2023/12 , B29K2025/00 , B29K2027/16 , B29K2031/04 , B29K2067/00 , B29K2075/00 , B29K2077/00 , B29K2079/085 , B29K2081/06 , B29L2031/755 , F04B19/006 , Y10T29/49236 , Y10T137/206 , Y10T156/10 , Y10T156/1039 , Y10T156/1052 , Y10T156/1092
摘要： A method for preparing an electrokinetic element is provided and generally includes providing a porous membrane adapted for use in an electrokinetic pump and encapsulating the porous membrane within a polymer substrate to yield an electrokinetic element base member having the porous membrane encapsulated by the polymer. In one embodiment, the method can include laminating the porous membrane between opposed sheets of a polymer before the step of encapsulating. The method can also include cutting the electrokinetic element base member into a plurality of slices and assembling an electrokinetic infusion pump by inserting a slice into a chamber of the pump.
摘要翻译：提供了一种制备电动元件的方法，并且通常包括提供适用于电动泵中的多孔膜并将多孔膜封装在聚合物基底内以产生具有被聚合物包封的多孔膜的电动元件基底构件。在一个实施方案中，该方法可以包括在封装步骤之前将多孔膜层叠在聚合物的相对片之间。该方法还可以包括将动电元件基底部件切割成多个切片，并通过将切片插入泵的腔室来组装电动输注泵。

7. 发明授权

US07654127B2 Malfunction detection in infusion pumps 有权
标题翻译：输液泵故障检测
公开(公告)号：US07654127B2
公开(公告)日：2010-02-02
申请号：US11614211
申请日：2006-12-21
申请人： Peter Krulevitch , Mingqi Zhao , Sebastian Bohm , Deon Anex , Michael Gearhart
发明人： Peter Krulevitch , Mingqi Zhao , Sebastian Bohm , Deon Anex , Michael Gearhart
IPC分类号： G01F25/00 , G01N19/00
CPC分类号： A61M5/14526 , A61M5/14244 , A61M5/14566 , A61M5/16831 , A61M2005/14513 , A61M2205/3317
摘要： The present application is directed to systems and methods associated with infusion pumps, which can optionally utilize an electrokinetic driving mechanism. Infusion pumps, including electrokinetically-driven pumps, are discussed, along with schemes for controlling their operation. As well, systems and methods of detecting malfunctions in infusion pumps are discussed. Any number of malfunctions can be detected including the presence of occlusions and/or leaks. In some instances, a measurement associated with some aspect of electrokinetic phenomena (e.g., an electrode measurement such as voltage or current) is compared with one or more sample values, the comparison allowing an indication of pump malfunction to be determined. A variety of such measurements and comparison techniques are discussed in the present disclosure.
摘要翻译：本申请涉及与输注泵相关联的系统和方法，其可以可选地使用电动驱动机构。讨论了输液泵，包括电动泵，以及控制其操作的方案。此外，还讨论了检测输液泵故障的系统和方法。可以检测到任何数量的故障，包括堵塞和/或泄漏的存在。在一些情况下，将与动电现象的一些方面（例如电极测量例如电压或电流）相关联的测量与一个或多个样本值进行比较，该比较允许确定泵故障的指示。在本公开中讨论了各种这样的测量和比较技术。

8. 发明申请

US20080149268A1 METHOD FOR PREPARING AN ELECTROKINETIC ELEMENT 有权
标题翻译：制备电动元件的方法
公开(公告)号：US20080149268A1
公开(公告)日：2008-06-26
申请号：US11614517
申请日：2006-12-21
申请人： Mingqi Zhao , Mark Huang , Stan Thomas , Peter Krulevitch
发明人： Mingqi Zhao , Mark Huang , Stan Thomas , Peter Krulevitch
IPC分类号： B29C65/54 , B05D5/12
CPC分类号： F04B17/00 , B29C45/14778 , B29C47/0021 , B29C47/065 , B29C47/067 , B29C70/685 , B29K2023/06 , B29K2023/083 , B29K2023/12 , B29K2025/00 , B29K2027/16 , B29K2031/04 , B29K2067/00 , B29K2075/00 , B29K2077/00 , B29K2079/085 , B29K2081/06 , B29L2031/755 , F04B19/006 , Y10T29/49236 , Y10T137/206 , Y10T156/10 , Y10T156/1039 , Y10T156/1052 , Y10T156/1092
摘要： A method for preparing an electrokinetic element is provided and generally includes providing a porous membrane adapted for use in an electrokinetic pump and encapsulating the porous membrane within a polymer substrate to yield an electrokinetic element base member having the porous membrane encapsulated by the polymer. In one embodiment, the method can include laminating the porous membrane between opposed sheets of a polymer before the step of encapsulating. The method can also include cutting the electrokinetic element base member into a plurality of slices and assembling an electrokinetic infusion pump by inserting a slice into a chamber of the pump.
摘要翻译：提供了一种制备电动元件的方法，并且通常包括提供适用于电动泵中的多孔膜并将多孔膜封装在聚合物基底内以产生具有被聚合物包封的多孔膜的电动元件基底构件。在一个实施方案中，该方法可以包括在封装步骤之前将多孔膜层叠在聚合物的相对片之间。该方法还可以包括将动电元件基底部件切割成多个切片，并通过将切片插入泵的腔室来组装电动输注泵。

9. 发明申请

US20070062250A1 Malfunction Detection With Derivative Calculation 有权
标题翻译：导数计算的故障检测
公开(公告)号：US20070062250A1
公开(公告)日：2007-03-22
申请号：US11532691
申请日：2006-09-18
申请人： Peter Krulevitch , Sebastian Bohm , Mingqi Zhao , Deon Anex
发明人： Peter Krulevitch , Sebastian Bohm , Mingqi Zhao , Deon Anex
IPC分类号： G01F25/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中产生阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开也可能导致流体损失，这可能是破坏性的。对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其它算法。

10. 发明申请

US20080154187A1 MALFUNCTION DETECTION IN INFUSION PUMPS 有权
标题翻译：输血泵中的功能异常检测
公开(公告)号：US20080154187A1
公开(公告)日：2008-06-26
申请号：US11614211
申请日：2006-12-21
申请人： Peter Krulevitch , Mingqi Zhao , Sebastian Bohm , Deon Anex , Michael Gearhart
发明人： Peter Krulevitch , Mingqi Zhao , Sebastian Bohm , Deon Anex , Michael Gearhart
IPC分类号： A61M1/00
CPC分类号： A61M5/14526 , A61M5/14244 , A61M5/14566 , A61M5/16831 , A61M2005/14513 , A61M2205/3317
摘要： The present application is directed to systems and methods associated with infusion pumps, which can optionally utilize an electrokinetic driving mechanism. Infusion pumps, including electrokinetically-driven pumps, are discussed, along with schemes for controlling their operation. As well, systems and methods of detecting malfunctions in infusion pumps are discussed. Any number of malfunctions can be detected including the presence of occlusions and/or leaks. In some instances, a measurement associated with some aspect of electrokinetic phenomena (e.g., an electrode measurement such as voltage or current) is compared with one or more sample values, the comparison allowing an indication of pump malfunction to be determined. A variety of such measurements and comparison techniques are discussed in the present disclosure.
摘要翻译：本申请涉及与输注泵相关联的系统和方法，其可以可选地使用电动驱动机构。讨论了输液泵，包括电动泵，以及控制其操作的方案。此外，还讨论了检测输液泵故障的系统和方法。可以检测到任何数量的故障，包括堵塞和/或泄漏的存在。在一些情况下，将与动电现象的一些方面（例如，诸如电压或电流的电极测量）相关联的测量与一个或多个样本值进行比较，所述比较允许确定泵故障的指示。在本公开中讨论了各种这样的测量和比较技术。

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