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51. 发明申请

WO1990009981A1 PREPARATION OF OPTICALLY ACTIVE GLYCEROL DERIVATIVES 审中-公开
标题翻译：光学活性甘油衍生物的制备
公开(公告)号：WO1990009981A1
公开(公告)日：1990-09-07
申请号：PCT/GB1990000278
申请日：1990-02-22
申请人： ISIS INNOVATION LIMITED , WATTS, Anthony , DURALSKI, Andrzej
发明人： ISIS INNOVATION LIMITED
IPC分类号： C07C69/587
CPC分类号： C07D317/22 , C07C41/26 , C07C67/08 , C07C69/587 , C07C43/178
摘要： 1,2-Isopropylidene-3-methoxyethoxymethyl-sn-glycerol is used to access complex polyunsaturated diacylglycerols of high optical purity such as 1,2-dilinoleoyl-sn-glycerol. Using a similar methodology its enantiomer, 2,3-dilinoleoyl-sn-glycerol, can be obtained from 1-methoxyethoxymethyl-2,3,isopropylidene-sn-glycerol.
摘要翻译： 1,2-亚丙基-3-甲氧基乙氧基甲基-sn-甘油用于获得高光学纯度的复合多不饱和二酰基甘油，如1,2-二亚油酰基-sn-甘油。使用类似的方法，其对映体2,3-二亚油酰基-sn-甘油可以从1-甲氧基乙氧基甲基-2,3，异亚丙基-sn-甘油获得。

52. 发明申请

WO1998023960A1 ASSAY METHOD FOR PEPTIDE SPECIFIC T-CELLS 审中-公开
标题翻译：肽特异性T细胞的测定方法
公开(公告)号：WO1998023960A1
公开(公告)日：1998-06-04
申请号：PCT/GB1997003222
申请日：1997-11-25
申请人： ISIS INNOVATION LIMITED , LALVANI, Ajit , BROOKES, Roger, Hamilton
发明人： ISIS INNOVATION LIMITED
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , A61K39/00 , C07K14/35 , G01N33/543 , G01N33/56905 , G01N33/56983 , G01N33/56988 , G01N33/56994 , G01N33/6863 , G01N33/6866 , G01N33/6878 , Y02A50/412
摘要： A method of assaying for peptide-specific T-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon- gamma produced by T-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including Hepatitis B, Hepatitis C, tuberculosis, malaria, HIV and influenza.
摘要翻译：测定肽特异性T细胞的方法包括向新鲜外周血单核细胞的流体样品中加入肽，并检测细胞因子，例如已经对肽预致敏的T细胞产生的干扰素-γ。测定方法快速便宜，预计可用于研究各种疾病状态，包括乙型肝炎，丙型肝炎，结核病，疟疾，艾滋病毒和流行性感冒。

53. 发明申请

WO1998009180A1 METHOD AND APPARATUS FOR DETERMINING INTRACELLULAR pH AND FREE MAGNESIUM ION CONCENTRATION 审中-公开
标题翻译：用于测定细胞内pH和游离镁离子浓度的方法和装置
公开(公告)号：WO1998009180A1
公开(公告)日：1998-03-05
申请号：PCT/GB1997002299
申请日：1997-08-28
申请人： ISIS INNOVATION LIMITED , CLARKE, Kieran , VEECH, Richard, L. , KASHIWAYA, Yoshihiro
发明人： ISIS INNOVATION LIMITED
IPC分类号： G01R33/48
CPC分类号： G01R33/4804 , G01R33/465
摘要： A method for determining pH and free magnesium ion concentration within the range 0.25 to 1.5 mM by P NMR comprises determining delta pi, the chemical shift difference for a composite of all inorganic phosphate species relative to the chemical shift for creatine phosphate, and hx, the peak height ratio of either the beta - and alpha - ATP resonances or the gamma - and alpha - ATP resonances. The values for delta pi and hx are used to calculate pH and free magnesium ion concentration. The method may be carried out using apparatus comprising means for determining delta pi and hx.
摘要翻译：通过P NMR确定0.25至1.5mM范围内的pH和游离镁离子浓度的方法包括确定δpi，所有无机磷酸盐物质的复合物相对于磷酸肌酸的化学位移的化学位移差，以及 hx，β和α-ATP共振或γ和α-ATP共振的峰高比。 delta pi和hx的值用于计算pH和游离镁离子浓度。该方法可以使用包括用于确定delta pi和hx的装置的装置来执行。

54. 发明申请

WO1998008046A1 ATOMIC FORCE MICROSCOPY APPARATUS AND A METHOD THEREOF 审中-公开
标题翻译：原子力显微镜装置及其方法
公开(公告)号：WO1998008046A1
公开(公告)日：1998-02-26
申请号：PCT/GB1997002232
申请日：1997-08-19
申请人： ISIS INNOVATION LIMITED , KOLOSOV, Oleg Victor , BRIGGS, George, Andrew, Davidson
发明人： ISIS INNOVATION LIMITED
IPC分类号： G01B07/34
CPC分类号： G01Q60/32
摘要： The microscopy apparatus comprises a cantilever (10) having an atomically sharp tip (11) and a detector (15) which monitors the deflection of the tip (11) as a measure of the atomic force between the tip and a sample. A piezotransducer (12) is provided on the end of the cantilever (10) distant from the tip (11). The piezotransducer (12) generates high frequency vibrations which are applied to the cantilever. The vibrations transmitted to the tip (11) are modulated using means such as a second piezotransducer (20) in contact with the sample and the movement of the tip (11) is then sampled by the detector (15) at a much lower frequency. The microscopy apparatus and method described is able to maintain sensitivity to the properties of the sample whilst retaining sensitivity to the output of the apparatus. The apparatus and method is particularly suited of the study of time-dependent physico-chemical and physico-mechanical properties up to nanosecond and sub-nanosecond time resolution.
摘要翻译：显微镜装置包括具有原子锋利尖端（11）的悬臂（10）和用于监测尖端（11）的偏转的检测器（15），作为尖端和样品之间的原子力的量度。压电传感器（12）设置在远离尖端（11）的悬臂（10）的端部上。压电传感器（12）产生施加到悬臂的高频振动。传递到尖端（11）的振动使用诸如与样品接触的第二压电传感器（20）的装置进行调制，并且尖端（11）的运动然后由检测器（15）以低得多的频率被采样。所述的显微镜装置和方法能够保持对样品性质的敏感性，同时保持对装置的输出的灵敏度。该装置和方法特别适用于研究纳秒和亚纳秒时间分辨率下的时间依赖性物理化学和物理机械性能。

55. 发明申请

WO1997042507A1 PEPTIDE ARRAY AND METHOD 审中-公开
标题翻译：肽阵列和方法
公开(公告)号：WO1997042507A1
公开(公告)日：1997-11-13
申请号：PCT/GB1997001228
申请日：1997-05-02
申请人： ISIS INNOVATION LIMITED , ESNOUF, Michael, Peter , GAO, Bin
发明人： ISIS INNOVATION LIMITED
IPC分类号： G01N33/68
CPC分类号： G01N33/86 , B01J2219/00659 , B01J2219/00725 , C40B40/10 , G01N33/54306 , G01N2333/96458
摘要： A method of studying a functional protein comprises providing an array of support-bound oligopeptides with different oligopeptides bound in an immunoreactive state at different locations on the support wherein each oligopeptide has defined amino acid residues at two chosen positions and a mixture of amino acid residues at other positions; applying the functional protein in solution to the array; and identifying support-bound oligopeptides that bind to the functional protein. Secondary oligopeptide libraries are used to further elucidate the amino acid sequence of the target protein. The method is used to elucidate the core residues responsible for the binding of a monoclonal antibody to its antigen beta -factor XIIa.
摘要翻译：一种研究功能性蛋白质的方法包括提供支持结合寡肽的阵列，其与在载体上的不同位置处以免疫反应性状态结合的不同寡肽，其中每个寡肽在两个选定位置具有限定的氨基酸残基和氨基酸残基的混合物其他职位; 将溶液中的功能蛋白应用于阵列; 并鉴定结合功能蛋白的支持结合的寡肽。二级寡肽文库用于进一步阐明靶蛋白的氨基酸序列。该方法用于阐明负责单克隆抗体与其抗原β因子XIIa结合的核心残基。

56. 发明申请

WO1996039505A1 AVIAN GHD GENES AND THEIR USE IN METHODS FOR SEX IDENTIFICATION IN BIRDS 审中-公开
标题翻译： AVIAN GHD基因及其在BIRDS中鉴别的方法中的应用
公开(公告)号：WO1996039505A1
公开(公告)日：1996-12-12
申请号：PCT/GB1996001341
申请日：1996-06-05
申请人： ISIS INNOVATION LIMITED , GRIFFITHS, Richard , TIWARI, Bela
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12N15/12
CPC分类号： C12Q1/6879 , C07K14/465
摘要： The invention provides for DNA sequences (introns and exons) encoding two genes located on the Z and W chromosomes of birds. These genes can be used to identify the sex of most birds (Class Aves). In addition, the genes control the sex of the birds, a genetic process which is initiated as an embryo. Nucleic acid fragments, proteins, polypeptides, antibodies and related products and their use in medicine and agriculture are provided. The invention may be used in sex identification or for controlling the sex of adults or the progeny of commercially important animals.
摘要翻译：本发明提供了编码位于鸟的Z和W染色体上的两个基因的DNA序列（内含子和外显子）。这些基因可用于鉴定大多数鸟类（Aves）的性别。此外，这些基因控制着鸟的性别，这是作为胚胎发起的遗传过程。提供核酸片段，蛋白质，多肽，抗体及相关产品及其在医学和农业中的应用。本发明可用于性别鉴定或用于控制成年人的性别或商业上重要的动物的后代。

57. 发明申请

WO1995015513A1 IMPROVEMENTS RELATING TO SPATIAL LIGHT MODULATORS 审中-公开
标题翻译：关于空调光调制器的改进
公开(公告)号：WO1995015513A1
公开(公告)日：1995-06-08
申请号：PCT/GB1994002618
申请日：1994-11-30
申请人： ISIS INNOVATION LIMITED , PAIGE, Edward, George, Sydney , NEIL, Mark, Andrew, Aquilla
发明人： ISIS INNOVATION LIMITED
IPC分类号： G02F01/141
CPC分类号： G02F1/141 , G02F2001/133531 , G02F2203/12
摘要： An arrangement for producing binary, phase or intensity, spatial light modulation uses a controllable two state ferroelectric liquid crystal spatial light modulator (10) (FLC SLM) which can alter the polarisation of input light in one of two ways depending on the state of the SLM (10). The SLM (10) is placed before a retardation plate (15) and a mirror (18). When used in this arrangement the efficiency of the modulation is enhanced by a factor of two for small switching angles o of the FLC SLM (10) when compared with the same SLM (10) used in a conventional transmission mode.
摘要翻译：用于产生二进制，相位或强度的空间光调制的装置使用可控制的两状态铁电液晶空间光调制器（FLC SLM），其可以根据两者的状态以两种方式之一改变输入光的偏振 SLM（10）。 SLM（10）放置在延迟板（15）和反射镜（18）之前。当在这种布置中使用时，与常规传输模式中使用的相同的SLM（10）相比，对于FLC SLM（10）的小切换角度o，调制效率增加了2倍。

58. 发明申请

WO1995003809A2 USE OF GLUCOKINASE INHIBITORS FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING TUMOURS 审中-公开
标题翻译：用于制造治疗肿瘤的药物的GLUCOKINASE抑制剂的使用
公开(公告)号：WO1995003809A2
公开(公告)日：1995-02-09
申请号：PCT/GB1994001676
申请日：1994-08-01
申请人： ISIS INNOVATION LIMITED , BOARD, Mary , NEWSHOLME, Eric, Arthur
发明人： ISIS INNOVATION LIMITED
IPC分类号： A61K31/70
CPC分类号： A61K31/7004 , A61K31/00 , C07D309/10 , C07H7/02 , C07H13/04
摘要： A method of inhibiting the growth of tumour cells is provided, comprising contacting the cells with an inhibitor of glucokinase. The glucokinase enzyme, normally only found in liver and pancreatic beta -cells, is found to be active in tumour cells.
摘要翻译：提供抑制肿瘤细胞生长的方法，包括使细胞与葡萄糖激酶的抑制剂接触。发现通常仅在肝脏和胰腺β细胞中发现的葡糖激酶是在肿瘤细胞中具有活性的。

59. 发明申请

WO1994026890A1 HIV-1 TAR RNA BINDING PROTEIN 审中-公开
标题翻译： HIV-1 TAR RNA结合蛋白
公开(公告)号：WO1994026890A1
公开(公告)日：1994-11-24
申请号：PCT/GB1994001061
申请日：1994-05-18
申请人： ISIS INNOVATION LIMITED , KINGSMAN, Susan, Mary , KINGSMAN, Alan, John , MUCKENTHALER, Martina , BLANCHARD, Andrew , BRADDOCK, Martin , VIVES, Eric
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12N15/12
CPC分类号： C12N15/85 , A61K38/00 , C07K14/47
摘要： A 38kD protein called BBP recognises an RNA element with a primary, secondary or tertiary structure of the HIV-1 TAR RNA element. The protein is therapeutically active against retroviral infections including those caused by human immunodeficiency virus type 1.
摘要翻译：称为BBP的38kD蛋白质识别具有HIV-1TAR RNA元件的一级，二级或三级结构的RNA元件。该蛋白质对抗病毒感染具有治疗活性，包括由1型人类免疫缺陷病毒引起的。

60. 发明申请

WO1994002633A1 DIAGNOSTIC METHOD 审中-公开
标题翻译：诊断方法
公开(公告)号：WO1994002633A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001520
申请日：1993-07-20
申请人： ISIS INNOVATION LIMITED , TARIN, David , MATSUMURA, Yasuhiro
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/58
CPC分类号： G01N33/57492 , A61K51/1027 , A61K2123/00 , C07K14/70585 , C07K16/2884 , C12Q1/6886 , C12Q2600/112 , G01N33/5748 , G01N2333/705
摘要： There is marked over-expression of multiple spliced variants of the CD44 gene in tumour compared to counterpart normal tissue. This observation forms the basis of a method of diagnosing neoplasia by analysis of a sample of body tissue or body fluid or waste product. A new exon 6 of 129 bp has been located and sequenced, and is claimed as such and for use in the diagnostic method.
摘要翻译：与对照正常组织相比，肿瘤中CD44基因的多个剪接变体显着过表达。该观察通过分析身体组织或体液或废物的样品来形成诊断肿瘤的方法的基础。已经定位和测序了129 bp的新外显子6，并且被要求保护，并用于诊断方法。

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