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1. 发明申请

WO1997042507A1 PEPTIDE ARRAY AND METHOD 审中-公开
标题翻译：肽阵列和方法
公开(公告)号：WO1997042507A1
公开(公告)日：1997-11-13
申请号：PCT/GB1997001228
申请日：1997-05-02
申请人： ISIS INNOVATION LIMITED , ESNOUF, Michael, Peter , GAO, Bin
发明人： ISIS INNOVATION LIMITED
IPC分类号： G01N33/68
CPC分类号： G01N33/86 , B01J2219/00659 , B01J2219/00725 , C40B40/10 , G01N33/54306 , G01N2333/96458
摘要： A method of studying a functional protein comprises providing an array of support-bound oligopeptides with different oligopeptides bound in an immunoreactive state at different locations on the support wherein each oligopeptide has defined amino acid residues at two chosen positions and a mixture of amino acid residues at other positions; applying the functional protein in solution to the array; and identifying support-bound oligopeptides that bind to the functional protein. Secondary oligopeptide libraries are used to further elucidate the amino acid sequence of the target protein. The method is used to elucidate the core residues responsible for the binding of a monoclonal antibody to its antigen beta -factor XIIa.
摘要翻译：一种研究功能性蛋白质的方法包括提供支持结合寡肽的阵列，其与在载体上的不同位置处以免疫反应性状态结合的不同寡肽，其中每个寡肽在两个选定位置具有限定的氨基酸残基和氨基酸残基的混合物其他职位; 将溶液中的功能蛋白应用于阵列; 并鉴定结合功能蛋白的支持结合的寡肽。二级寡肽文库用于进一步阐明靶蛋白的氨基酸序列。该方法用于阐明负责单克隆抗体与其抗原β因子XIIa结合的核心残基。

2. 发明公开

EP0656949A1 VACCINIA VIRUS B15R USED IN INTERLEUKIN B1-INVOLVING CONDITION 失效
标题翻译：白细胞介素中引起B1使用的疫苗病毒B15R条件。
公开(公告)号：EP0656949A1
公开(公告)日：1995-06-14
申请号：EP93905517.0
申请日：1993-03-05
申请人： ISIS INNOVATION LIMITED
发明人： ISIS INNOVATION LIMITED
IPC分类号： C07K14 , C12N15 , A61K38
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70503 , C12N2710/24122
摘要： This invention relates to proteins encoded by vaccinia virus and which function to interfere with the host's immune system. In particular, the invention provides for use of the nucleotide sequence designated herein as B15R or of a nucleotide sequence coding for an allele of, or functionally equivalent fragment, derivative or variant of the polypeptide encoded by the B15R nucleotide sequence in a process relating to the manufacture of a medicament for the treatment of a condition in which interleukin-1β is involved in the mediation of one or more symptoms associated with the condition. The invention also provides an anti-fever medicament which comprises a polypeptide which is encoded by the B15R gene product or an allele of, or functionally equivalent fragment, derivative or variant of that product.

3. 发明申请

WO1998026087A1 BACILLUS STRAIN AND ANTIBIOTIC SCREENING METHOD 审中-公开
标题翻译：贝类菌株和抗生素筛选方法
公开(公告)号：WO1998026087A1
公开(公告)日：1998-06-18
申请号：PCT/GB1997003401
申请日：1997-12-10
申请人： ISIS INNOVATION LIMITED , ERRINGTON, Jeffery , WU, Ling, Juan
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12Q01/18
CPC分类号： C12R1/07 , C07K14/32 , C12Q1/18
摘要： A Bacillus strain has a chromosome with the following modifications: a mutation of a spolllE gene which blocks transfer of the prespore chromosome; a mutation which prevents loss of SpoOJ function from blocking sporulation; a first reporter gene dependent on sigma factor and placed at a location where impaired SpoOJ function leads to increased trapping in the prespore; and a second reporter gene having a promoter which is dependent on sigma factor and where impaired SpoOJ function leads to reduced trapping in the prespore. The strain is useful in a method of screening for putative antibiotics.
摘要翻译：芽孢杆菌菌株具有染色体，其具有以下修饰：阻断前体染色体转移的spolllE基因的突变; 防止SpoOJ功能丧失阻止孢子形成的突变; 一个依赖于西格玛因子的第一个报告基因，并被置于受损的SpoOJ功能导致在前体中增加捕获的位置; 和具有依赖于σ因子的启动子的第二报告基因，并且其中受损的SpoOJ功能导致在前体中的捕获减少。该菌株可用于筛选推定抗生素的方法。

4. 发明申请

WO1998016550A1 CHIRAL PEPTIDE NUCLEIC ACIDS 审中-公开
公开(公告)号：WO1998016550A1
公开(公告)日：1998-04-23
申请号：PCT/GB1997002820
申请日：1997-10-13
申请人： ISIS INNOVATION LIMITED , LOWE, Gordon
发明人： ISIS INNOVATION LIMITED
IPC分类号： C07K14/00
CPC分类号： C07D403/04 , C07D207/16 , C07D403/12 , C07D473/18 , C07K14/003
摘要： Chiral peptide nucleic acids are provided which hybridise strongly with complementary nucleic acids and have potential as antigene and antisense agents and as tools in molecular biology. Compounds with cis-stereochemistry and based on proline and a spacer amino acid have structures (II), (III), where n is 1 or 2 - 200, B is a protected or unprotected base, R is H or alkyl, aralkyl or heteroaryl and may be substituted, X may be OH, and Y may be H.
摘要翻译：提供手性肽核酸，其与互补核酸强烈杂交，并且具有作为分子生物学的反义和反义试剂的潜力。具有顺式立体化学和基于脯氨酸和间隔氨基酸的化合物具有结构（II），（III），其中n为1或2〜200，B为受保护或未保护的碱，R为H或烷基，芳烷基或杂芳基并且可以被取代，X可以是OH，Y可以是H.

5. 发明申请

WO1997041606A1 SPIN TRANSISTOR 审中-公开
标题翻译：旋转晶体管
公开(公告)号：WO1997041606A1
公开(公告)日：1997-11-06
申请号：PCT/GB1997001167
申请日：1997-04-28
申请人： ISIS INNOVATION LIMITED , GREGG, John, Francis , SPARKS, Patricia, Dresel
发明人： ISIS INNOVATION LIMITED
IPC分类号： H01L43/00
CPC分类号： H01L29/66984
摘要： The spin transistor is a hybrid magnetic/semiconductor transistor in which a magnetically controllable barrier (5) is provided between a semiconductor base (4) and collector (3) to control the diffusion of charge carriers to the collector (3). With the spin transistor the charge carrier populations are distinguished by the direction of the spin or magnetic moment of the carriers instead of the electronic charge. A spin injector (1) is used to spin polarise the charge carrier population so that the population has a selected magnetic moment which population may or may not be enabled to flow to the collector via the magnetic barrier. The spin transistor utilises the electronic characteristics of a conventional semiconductor transistor in combination with a carrier flow controlled by magnetic moment to maximise gain.
摘要翻译：自旋晶体管是混合磁/半导体晶体管，其中在半导体基底（4）和集电极（3）之间设置有可控制的屏障（5），以控制载流子到集电极（3）的扩散。对于自旋晶体管，载流子群体通过载流子的自旋或磁矩的方向而不是电子电荷来区分。自旋注入器（1）用于使电荷载体群旋转极化，使得群体具有选定的磁矩，其中群体可能或可能不能通过磁屏障流向收集器。旋转晶体管利用常规半导体晶体管的电子特性与由磁矩控制的载流相结合，以使增益最大化。

6. 发明申请

WO1997019681A1 PERFLUOROALKYL SUBSTITUTED METALLO-BETA-LACTAMASE INHIBITORS AND METHOD FOR THE PREPARATION OF TRIFLUOROMETHYLKETONE DERIVATIVES 审中-公开
标题翻译：全氟烷基取代的金属 - β-乳酸酶抑制剂及其制备三氟甲基酮衍生物的方法
公开(公告)号：WO1997019681A1
公开(公告)日：1997-06-05
申请号：PCT/GB1996002922
申请日：1996-11-27
申请人： ISIS INNOVATION LIMITED , SCHOFIELD, Christopher, Joseph , WALTER, Magnus, W. , ADLINGTON, Robert, M. , BALDWIN, Jack, E. , FRERE, Jean-Marie , FELICI, Antonio
发明人： ISIS INNOVATION LIMITED
IPC分类号： A61K31/165
CPC分类号： C07C235/20 , A61K31/16 , A61K31/165 , A61K31/27 , A61K31/43 , C07C221/00 , C07C233/16 , C07C233/30 , C07C233/76 , A61K2300/00
摘要： The invention concerns perfluoro-lower-alkyl derivatives of amino acids. A new synthetic route is provided for preparing alpha -aminotrifluoromethylketones, by converting alpha -amino acids to oxazolidin-5-ones which are then reacted with Ruppert's Reagent. Fluorinated derivatives of amino acids and peptides are shown to have a new property of inhibiting or inactivating metallo- beta -lactamase enzymes, and are thus valuable components of antibacterial formulations. Certain of the trifluoromethyl derivatives of amino acids are new compounds per se.
摘要翻译：本发明涉及氨基酸的全氟低级烷基衍生物。通过将α-氨基酸转化为恶唑烷-5-酮，然后与Ruppert's试剂反应，提供了一种新的合成路线来制备α-氨基三氟甲基酮。显示氨基酸和肽的氟化衍生物具有抑制或灭活金属β-内酰胺酶的新性质，因此是抗菌制剂的有价值的成分。某些氨基酸的三氟甲基衍生物本身是新化合物。

7. 发明申请

WO1997017431A1 CELL LINES EXPRESSING AN ACETYLCHOLINE RECEPTOR, CONTAINING AN EPSILON SUBUNIT 审中-公开
标题翻译：表达包含EPSILON亚基的乙酰胆碱受体的细胞系
公开(公告)号：WO1997017431A1
公开(公告)日：1997-05-15
申请号：PCT/GB1996002725
申请日：1996-11-07
申请人： ISIS INNOVATION LIMITED , BEESON, David, Murray, Wendaver , VINCENT, Angela
发明人： ISIS INNOVATION LIMITED
IPC分类号： C12N05/10
CPC分类号： C07K14/70571 , C07K14/4713 , G01N33/564 , G01N33/944 , G01N2500/00
摘要： Cells of the clones CN21 and DB30S and DB40 express a form of an acetylcholine receptor (AChR) containing an adult epsilon subunit. The AChR is useful in an assay for AChR antibodies which is diagnostic of myasthenia gravis.
摘要翻译：克隆CN21和DB30S和DB40的细胞表达含有成年ε亚基的乙酰胆碱受体（AChR）的形式。 AChR可用于重症肌无力诊断的AChR抗体检测。

8. 发明申请

WO1996028241A1 FILTER COMPRISING ONE OR MORE DUCTS 审中-公开
标题翻译：过滤器包括一个或多个导管
公开(公告)号：WO1996028241A1
公开(公告)日：1996-09-19
申请号：PCT/GB1996000584
申请日：1996-03-11
申请人： ISIS INNOVATION LIMITED , BELLHOUSE, Brian, John
发明人： ISIS INNOVATION LIMITED
IPC分类号： B01D63/06
CPC分类号： B01D65/08 , B01D63/063 , B01D63/066 , B01D2321/08 , B01D2321/16 , B01D2321/2016 , Y10S264/48
摘要： A filter comprising one or more substantially unobstructed ducts (11) with porous walls, each duct having a helical groove (18) in the wall.
摘要翻译：一种过滤器，包括具有多孔壁的一个或多个基本上无障碍的管道（11），每个管道在壁中具有螺旋槽（18）。

9. 发明申请

WO1996027191A1 COVERT IDENTIFICATION 审中-公开
标题翻译：覆盖识别
公开(公告)号：WO1996027191A1
公开(公告)日：1996-09-06
申请号：PCT/GB1996000447
申请日：1996-02-28
申请人： ISIS INNOVATION LIMITED , EDWARDS, David, John , STREET, Andrew, Michael , MOSS, Jonathan, Guy, Owen
发明人： ISIS INNOVATION LIMITED
IPC分类号： G11B20/00
CPC分类号： G06F21/10 , G06F2211/007 , G06F2221/0737 , G11B20/00086 , G11B20/0021 , G11B20/00557 , G11B20/00586 , G11B20/00913
摘要： Apparatus and a method for applying to and retrieving from a work to be protected covert identification consists of a predetermined identification (12) which is encrypted using a pseudorandom code (11). The encrypted identification is then added (14) as a noise-like feature to a signal of the work to be protected. The apparatus and method may be used to introduce covert identification into a music recording for example on a CD, literature or pictures and even into telecommunication signals. As the identification is implemented as a noise-like feature in the work, the identification cannot easily be extracted without knowledge of both the identification and the encryption code employed.
摘要翻译：用于应用于要被保护的工作的隐藏识别的装置和方法包括使用伪随机码（11）加密的预定标识（12）。然后将加密标识作为类似噪声的特征添加（14）到要保护的工作的信号。该装置和方法可用于将隐蔽识别引入音乐记录，例如在CD，文献或图像上甚至电信信号中。由于识别被实现为工作中的类噪声特征，所以在不知道所采用的识别和加密码的情况下，不能容易地提取识别。

10. 发明申请

WO1995033999A1 FLUID VELOCITY MEASUREMENT APPARATUS 审中-公开
标题翻译：流体速度测量装置
公开(公告)号：WO1995033999A1
公开(公告)日：1995-12-14
申请号：PCT/GB1995001278
申请日：1995-06-02
申请人： ISIS INNOVATION LIMITED , AINSWORTH, Roger, William , THORPE, Steven, John
发明人： ISIS INNOVATION LIMITED
IPC分类号： G01P05/00
CPC分类号： G01P5/26 , G01P5/001 , G01S7/4812 , G01S7/497 , G01S17/58 , G01S17/89 , G01S2007/52014
摘要： Fluid velocity measurement apparatus which utilises Doppler-shift spectral analysis includes a narrow line width light source (1), the light from which passes through a beam expander (3) to provide an irradiated region, for example a two-dimensional plane, in which velocity measurements may be taken. Light scattered from small particles in the irradiated region is collected in an imaging system (4) which enables spectral analysis of the scattered light for determining the velocity of the light scattering particles in the irradiated region. A single camera (13) is used in the imaging system (4) to obviate the need for costly electronics to synchronise images obtained. Also to improve the accuracy of measurement, selected parameters of the apparatus may be measured (2,5) to allow for perturbations in the velocity measurements obtained.
摘要翻译：利用多普勒频移分析的流体速度测量装置包括窄线宽度光源（1），来自光束扩展器（3）的光线从光束扩展器（3）提供照射区域，例如二维平面，其中可以进行速度测量。在照射区域的小颗粒散射的光被收集在能够对散射光进行光谱分析以确定照射区域中的光散射粒子的速度的成像系统（4）中。在成像系统（4）中使用单个照相机（13），以避免需要昂贵的电子设备来同步所获得的图像。另外为了提高测量精度，可以测量装置的选定参数（2,5）以允许所获得的速度测量值的扰动。

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