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51. 发明授权

US09597388B2 Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same 有权
公开(公告)号：US09597388B2
公开(公告)日：2017-03-21
申请号：US14391952
申请日：2013-04-12
申请人： David B. Weiner , Devon Shedlock
发明人： David B. Weiner , Devon Shedlock
IPC分类号： A61K39/12 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K38/20 , A61K38/208 , A61K38/2086 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/572 , A61K2039/70 , A61N1/327 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2760/14122 , C12N2760/14134 , C12N2760/14171 , C12N2760/14222 , C12N2760/14234 , C12N2760/14271
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.

52. 发明申请

US20160022796A1 Synthetic Immunogens For Prophylaxis Or Treatment Of Tuberculosis 有权
标题翻译：合成免疫原用于预防或治疗结核病
公开(公告)号：US20160022796A1
公开(公告)日：2016-01-28
申请号：US14774399
申请日：2014-03-17
申请人： David B. WEINER , Daniel VILLARREAL , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： David B. Weiner , Daniel Villarreal
IPC分类号： A61K39/04 , A61K45/06
CPC分类号： A61K39/04 , A61K39/07 , A61K45/06 , A61K2039/53
摘要： Compositions comprising a nucleic acid molecule that encodes TB esat-6 proteins are disclosed. Methods of inducing an immune response against TB an individual are disclosed. Method of treating an individual who has been diagnosed with TB are disclosed. Method of preventing TB infection in an individual are disclosed.
摘要翻译：公开了包含编码TB esat-6蛋白的核酸分子的组合物。公开了诱导个体对TB的免疫应答的方法。公开了治疗已被诊断患有结核病的个体的方法。公开了预防结核病感染个体的方法。

53. 发明申请

US20140127244A1 VACCINES FOR SUPPRESSING IGE-MEDIATED ALLERGIC DISEASE AND METHODS FOR USING THE SAME 审中-公开
标题翻译：用于抑制神经介导的过敏性疾病的疫苗及其使用方法
公开(公告)号：US20140127244A1
公开(公告)日：2014-05-08
申请号：US14054621
申请日：2013-10-15
申请人： Arnold I. Levinson , Sandra Calarota , David B. Weiner , Miguel Otero
发明人： Arnold I. Levinson , Sandra Calarota , David B. Weiner , Miguel Otero
IPC分类号： A61K39/00 , A61K39/08
CPC分类号： A61K39/0005 , A61K39/00 , A61K39/08 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K2317/52 , C07K2318/10 , C07K2319/55
摘要： Nucleic acid molecules that encode a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines, vectors and host cells that comprise such nucleic acid molecules are disclosed. Isolated proteins, including haptenized proteins, comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise and methods of making such proteins and antibodies that specifically bind to such proteins are disclosed. Vaccines that comprise killed or inactivated cells or particles are disclosed. Methods of treating and preventing IgE mediated allergic disease or condition are disclosed.
摘要翻译：公开了编码蛋白质的核酸分子，其包含不含存在于血清IgE上的表位的膜IgE的至少一个表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。公开了包含这种核酸分子的疫苗，载体和宿主细胞。公开了分离的蛋白质，包括半抗原蛋白，其包含至少一个不含存在于血清IgE上的表位的膜IgE表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。公开了包含制备这种蛋白质和特异性结合这些蛋白质的抗体的方法的疫苗。公开了包含杀死或灭活的细胞或颗粒的疫苗。公开了治疗和预防IgE介导的过敏性疾病或病症的方法。

54. 发明申请

US20130273112A1 CONSENSUS ANTIGEN CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING THE SAME TO TREAT MALARIA 审中-公开
标题翻译：共同抗原构建物及其制备方法及其使用方法治疗疟疾
公开(公告)号：US20130273112A1
公开(公告)日：2013-10-17
申请号：US13876148
申请日：2011-09-27
申请人： David B. Weiner , Bernadette Ferraro , Jian Yan , Niranjan Y. Sardesai
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Niranjan Y. Sardesai
IPC分类号： A61K39/015 , A61K38/20
摘要： Provided herein is consensus amino acid sequences of P. falciparum (P.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against P. falciparum using the expression constructs provided herein.
摘要翻译：本文提供恶性疟原虫（P.f.）蛋白及其编码序列的共有氨基酸序列以及表达序列的表达构建体。本文还提供了使用本文提供的表达构建体来产生针对恶性疟原虫的免疫应答的方法。

55. 发明申请

US20130004529A1 VACCINES AND METHODS FOR USING THE SAME 有权
标题翻译：疫苗及其使用方法
公开(公告)号：US20130004529A1
公开(公告)日：2013-01-03
申请号：US13458013
申请日：2012-04-27
申请人： David B. Weiner , Jian Yan , Dominick Laddy
发明人： David B. Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/00 , C07K14/155 , A61P37/04 , A61P31/18 , A61P31/20 , A61P31/14 , A61P31/16 , A61K39/21 , C07K2/00 , C07K14/025 , C07K14/08 , C12N9/12 , C07K14/11 , A61K39/29 , A61K39/145 , A61K39/12 , C12N15/54 , C12N15/37 , C12N15/44 , C12N15/40 , C12N15/63 , C12N7/04 , C12N5/09 , A61P35/00 , C12N15/49
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译：公开了改进的抗HIV免疫原和编码它们的核酸分子。所公开的免疫原包括具有HIV亚型A包膜蛋白的共有序列的那些，对于HIV亚型B包膜蛋白具有共有序列的那些，对于HIV亚型C包膜蛋白具有共有序列的那些，对于HIV亚型D包膜蛋白具有共有序列的那些 HIV亚型B共有序列Nef-Rev蛋白和具有共有序列的序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 公开了改进的抗流感免疫原和编码它们的核酸分子，以及在个体中针对HIV，HPV，HCV，hTERT和流感诱导免疫应答的方法。

56. 发明申请

US20120195852A1 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20120195852A1
公开(公告)日：2012-08-02
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

57. 发明申请

US20110305664A1 NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF INFLUENZA VIRUS 有权
标题翻译：新鲜疫苗对多种流感病毒亚型
公开(公告)号：US20110305664A1
公开(公告)日：2011-12-15
申请号：US13158150
申请日：2011-06-10
申请人： Ruxandra Draghia-Akli , David B. Weiner , Jian Yan , Dominick Laddy
发明人： Ruxandra Draghia-Akli , David B. Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/145 , A61K38/20 , A61P31/16 , A61P37/04 , A61P31/12 , A61K39/395 , C12N15/63
CPC分类号： A61K39/145 , A61K9/0019 , A61K38/208 , A61K38/2086 , A61K39/12 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , A61K2300/00
摘要： An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.
摘要翻译：本发明的一个方面涉及能够在哺乳动物中产生针对多种流感病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达共有流感抗原，其中共有流感抗原包含共有血凝素（HA），神经氨酸酶（NA），基质蛋白，核蛋白，M2胞外域 - 核蛋白（M2e-NP）或其组合。优选地，共有流感抗原包含HA，NA，M2e-NP或其组合。 DNA质粒包含与编码共有流感抗原的编码序列可操作地连接的启动子。此外，本发明的一个方面包括使用提供的DNA质粒疫苗在哺乳动物中引发针对多种流感病毒亚型的免疫应答的方法。

58. 发明授权

US07943587B2 Vaccines and gene therapy compositions and methods of making and using the same 有权
标题翻译：疫苗和基因治疗组合物及其制备和使用方法
公开(公告)号：US07943587B2
公开(公告)日：2011-05-17
申请号：US10139423
申请日：2002-05-06
申请人： David B. Weiner , Jong J. Kim , Michael G. Agadjanyan
发明人： David B. Weiner , Jong J. Kim , Michael G. Agadjanyan
IPC分类号： A61K48/00 , C12N15/63
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , C12N2740/16134
摘要： Methods of inducing an immune response against an immunogen in an individual are disclosed. The methods comprise administering to the individual, one or more nucleic acid molecules that comprise a nucleotide sequence that encodes an immunogen and a nucleotide sequence that encodes an Major Histocompatibility Complex antigen. The nucleotide sequences that encode the immunogen and the Major Histocompatibility Complex antigen are expressed when taken up by cells of the individual and an immune response against the immunogen is induced in the individual. Methods of reducing rejection of unmatched donor cells, tissue or organ in an individual undergoing cell, tissue or organ transplantation are disclosed. The methods comprise administering to the individual, one or more nucleic acid molecules that comprise a nucleotide sequence that encodes a death signal or toxin and a nucleotide sequence that encodes a Major Histocompatibility Complex antigen that is matched to the donor cells, tissue or organ. The nucleotide sequences that encode the Major Histocompatibility Complex antigen and death signal or toxin are expressed when taken up by cells of the individual. T cell death through interaction with the death signal or toxin results in a reduction of rejection of unmatched donor cells, tissue or organ. Methods of reducing a dominant immune response in an individual and methods of expanding a subpopulation of T cells associated with a specific immune response are also described. Plasmids and compositions comprising plasmids useful for practicing the method are described.
摘要翻译：公开了在个体中诱导针对免疫原的免疫应答的方法。所述方法包括向个体施用包含编码免疫原的核苷酸序列的一个或多个核酸分子和编码主要组织相容性复合物抗原的核苷酸序列。编码免疫原和主要组织相容性复合物抗原的核苷酸序列在个体细胞吸收时被表达，并且在个体中诱导针对免疫原的免疫应答。公开了在经历细胞，组织或器官移植的个体中减少不匹配的供体细胞，组织或器官的排斥的方法。所述方法包括向个体施用包含编码死亡信号或毒素的核苷酸序列的一个或多个核酸分子和编码与供体细胞，组织或器官相匹配的主要组织相容性复合物抗原的核苷酸序列。编码主要组织相容性复合物抗原和死亡信号或毒素的核苷酸序列由个体细胞摄取时表达。通过与死亡信号或毒素的相互作用导致的T细胞死亡导致不匹配的供体细胞，组织或器官的排斥减少。还描述了减少个体中显性免疫应答的方法和扩增与特异性免疫应答相关的T细胞亚群的方法。描述了包含用于实施该方法的质粒的质粒和组合物。

59. 发明申请

US20110002956A1 MUTANT HUMAN CD80 AND COMPOSITIONS FOR AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：突变人CD80及其组合物及其制备和使用方法
公开(公告)号：US20110002956A1
公开(公告)日：2011-01-06
申请号：US12211029
申请日：2008-11-10
申请人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
发明人： David B. Weiner , Michael G. Agadjanyan , Rafick P. Sekaly , Mark Holterman
IPC分类号： A61K39/12 , C07H21/04 , A61K38/02 , C07K14/705 , A61P31/12 , A61P37/06
CPC分类号： C07K14/70532 , A61K39/00
摘要： Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.
摘要翻译：公开了改进的疫苗和使用该疫苗的方法。公开了用于治疗患有自身免疫性疾病或移植物的个体的免疫抑制组合物及其使用方法。

60. 发明授权

US07151172B1 Attenuated vif DNA immunization cassettes for genetic vaccines 有权
标题翻译：用于遗传疫苗的减毒vif DNA免疫盒
公开(公告)号：US07151172B1
公开(公告)日：2006-12-19
申请号：US09486625
申请日：1998-09-18
申请人： Velpandi Ayyavoo , Thanadavarayan Nagashunmugam , David B. Weiner
发明人： Velpandi Ayyavoo , Thanadavarayan Nagashunmugam , David B. Weiner
IPC分类号： C07H21/04 , C07K1/00 , C12N15/00 , C12N5/10 , C12P21/06 , A61K31/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K2317/00 , C12N2710/24143 , C12N2740/16322 , Y10S530/826
摘要： The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in order to induce a cellular and humoral immune response to the encoded protein product.
摘要翻译：本发明涉及编码减毒，非功能性病毒粒子感染因子（vif）蛋白的核酸分子。将本发明的核酸分子插入到重组表达载体中并施用于哺乳动物，以诱导编码的蛋白质产物的细胞和体液免疫应答。

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