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51. 发明申请

US20090081293A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
标题翻译：可持续发布的APO A-I型胶原蛋白和治疗方法
公开(公告)号：US20090081293A1
公开(公告)日：2009-03-26
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K9/10 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

52. 发明申请

US20090075933A1 CYTOCOMPATIBLE ALGINATE GELS 有权
标题翻译：可溶性胶原凝胶
公开(公告)号：US20090075933A1
公开(公告)日：2009-03-19
申请号：US11857878
申请日：2007-09-19
申请人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
发明人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC分类号： A61K31/715 , A61P9/00 , C07H1/00 , C12P19/04
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
摘要翻译：本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。

53. 发明授权

US07466985B1 Network element for implementing scheduled high-power PTP and low-power PTMP transmissions 失效
标题翻译：用于实现调度的大功率PTP和低功率PTMP传输的网元
公开(公告)号：US07466985B1
公开(公告)日：2008-12-16
申请号：US11241145
申请日：2005-09-30
申请人： Martin Ridgway Handforth , Anoop Nannra , John Stankus , Larry Marcanti , Brian Vezza
发明人： Martin Ridgway Handforth , Anoop Nannra , John Stankus , Larry Marcanti , Brian Vezza
IPC分类号： H04Q7/20
CPC分类号： H04W72/08 , H04W84/047 , H04W92/12 , Y02D70/142 , Y02D70/146 , Y02D70/22
摘要： A network element is configured to implement scheduled high-power Point-To-Point (PTP) and low-power Point-To-MultiPoint (TMP) transmissions. The high-power PTP and low-power PTMP transmissions may be scheduled as bursts on an 802.16 network to occur in both the downlink subframe and uplink subframe on a given frequency channel in the wireless network. The use of an air interface for both types of communications allows the PTP and PTMP communications to be scheduled relative to each other in a unified manner to increase quality of service and minimize interference between the backhaul PTP and access PTMP networks, even though the PTP and PTMP communications take place on the same channel using the same underlying wireless technology. Buffers may be used to store data received in a PTP downlink burst prior to transmission in a PTMP downlink burst, and may be used to store data received in an uplink PTMP burst prior to transmission in an uplink PTP burst.
摘要翻译：网元被配置为实现调度的高功率点对点（PTP）和低功率点到多点（TMP）传输。高功率PTP和低功率PTMP传输可以被调度为802.16网络上的突发，以在无线网络中的给定频率信道上的下行链路子帧和上行链路子帧中发生。对于两种类型的通信使用空中接口允许以统一的方式相对于彼此进行调度，以增加服务质量并最小化回程PTP和接入PTMP网络之间的干扰，即使PTP和 PTMP通信使用相同的底层无线技术在相同的信道上进行。缓冲器可以用于存储在PTMP下行链路突发中传输之前在PTP下行链路突发中接收的数据，并且可以用于在上行链路PTP突发中传输之前存储在上行链路PTMP突发中接收的数据。

54. 发明申请

US20080131509A1 Methods and Compositions for Treating Tissue Using Silk Proteins 有权
标题翻译：使用丝蛋白处理组织的方法和组合物
公开(公告)号：US20080131509A1
公开(公告)日：2008-06-05
申请号：US11566643
申请日：2006-12-04
申请人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
发明人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
IPC分类号： A61F2/02 , C08L71/00 , C08H1/00 , A61K35/00 , A61K38/18 , A61K38/30 , A61K47/42 , A61P43/00
CPC分类号： A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
摘要翻译：本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。还公开了包括适合递送组合物的递送装置的试剂盒。在一些实施方案中，组合物可以包括至少三种组分。在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

55. 发明授权

US09662677B2 Drug-coated balloon with location-specific plasma treatment 有权
公开(公告)号：US09662677B2
公开(公告)日：2017-05-30
申请号：US12883024
申请日：2010-09-15
申请人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
发明人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
IPC分类号： B05D3/06 , C23C14/02 , A61F2/00 , B05D3/14 , B05D7/02 , C08J7/12 , A61F2/82
CPC分类号： B05D3/144 , A61F2/82 , B05D7/02 , C08J7/123
摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.

56. 发明授权

US09622849B2 Bioerodible wraps and uses therefor 有权
公开(公告)号：US09622849B2
公开(公告)日：2017-04-18
申请号：US13502759
申请日：2010-10-28
申请人： Mohammed El-Kurdi , J. Christopher Flaherty , Yi Hong , Jonathan McGrath , Lorenzo Soletti , John Stankus , David Vorp , William Wagner
发明人： Mohammed El-Kurdi , J. Christopher Flaherty , Yi Hong , Jonathan McGrath , Lorenzo Soletti , John Stankus , David Vorp , William Wagner
IPC分类号： A61F2/06 , A61F2/04 , A61F2/07
CPC分类号： A61F2/06 , A61F2/04 , A61F2/062 , A61F2002/072
摘要： A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

57. 发明授权

US09370306B1 Methods and devices for in vivo targeted light therapy 有权
标题翻译：用于体内靶向光疗法的方法和装置
公开(公告)号：US09370306B1
公开(公告)日：2016-06-21
申请号：US12191200
申请日：2008-08-13
申请人： Kevin J. Ehrenreich , Kyle Klein , John Stankus
发明人： Kevin J. Ehrenreich , Kyle Klein , John Stankus
IPC分类号： A61N5/06 , A61B5/00 , A61B5/1459 , A61B18/14
CPC分类号： A61B5/0084 , A61B5/1459 , A61B18/1492 , A61B2017/00057 , A61B2018/00904 , A61B2562/0233 , A61N5/0603 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Catheter-based systems for in-vivo targeted light therapy include a first type of catheter configured for photo-activating photosensitive substances in tissue, and a second type of catheter configured for photo-degrading photosensitive substances in tissue. The catheters may be configured to produce light using a variety of light sources, such as light emitting diodes (LEDs) and fiber optics. The light transmission is directed to tissue in such a way that only portions of tissue in a treatment area are exposed to light, depending upon whether the tissue is diseased or healthy.
摘要翻译：用于体内靶向光疗法的基于导管的系统包括构造成用于光敏物质在组织中的光激活的第一类型的导管，以及被配置为光降解组织中的光敏物质的第二类导管。导管可以被配置为使用各种光源（例如发光二极管（LED））和光纤来产生光。光透射以这样的方式被引导到组织，使得只有部分处理区域中的组织暴露于光，这取决于组织是否患病或健康。

58. 发明授权

US09249663B2 Impact resistant lagging, method for designing impact resistant lagging, and apparatus for testing impact resistant lagging 有权
标题翻译：抗冲击滞后设计方法，抗冲击滞后设计方法以及抗冲击滞后试验装置
公开(公告)号：US09249663B2
公开(公告)日：2016-02-02
申请号：US12714139
申请日：2010-02-26
申请人： Kevin Jinrong Ma , John Stankus , Robert McGinnis , Dakota Faulkner , Demrey Brandon , John Feyrer
发明人： Kevin Jinrong Ma , John Stankus , Robert McGinnis , Dakota Faulkner , Demrey Brandon , John Feyrer
IPC分类号： E21D11/18 , E21D11/28
CPC分类号： G01N3/30 , E21D11/18 , E21D11/28
摘要： A steel set assembly includes a first pair of legs and a second pair of legs with the first pair of legs being spaced from and positioned opposite the second pair of legs. First and second beams are provided with the first beam being secured to one leg of the first pair of legs and one leg of the second pair of legs. The second beam is secured to the other leg of the first pair of legs and the other leg of the second pair of legs. A panel is secured to the first and second beams and includes a base having a top surface and a bottom surface, a block having a top surface and a bottom surface, and a pad. The block is secured to the base and the pad is positioned between the top surface of the base and the bottom surface of the block.
摘要翻译：钢组件包括第一对腿和第二对腿，其中第一对腿与第二对腿分开并与第二对腿相对定位。第一和第二梁设置有第一梁被固定到第一对腿的一条腿和第二对腿的一条腿。第二梁被固定到第一对腿的另一条腿和第二对腿的另一条腿。面板被固定到第一和第二梁上并且包括具有顶表面和底表面的基部，具有顶表面和底表面的块以及垫。块被固定到基部，并且垫位于基部的顶表面和块的底表面之间。

59. 发明授权

US09205456B2 Modifying polymer properties with penetrants in the fabrication of bioresorbable scaffolds 有权
标题翻译：在生物可吸收支架的制造中，用渗透剂改性聚合物性能
公开(公告)号：US09205456B2
公开(公告)日：2015-12-08
申请号：US13556986
申请日：2012-07-24
申请人： Mikael Trollsas , John Stankus , Michael H. Ngo , Wen Chung Tsai , Thierry Glauser
发明人： Mikael Trollsas , John Stankus , Michael H. Ngo , Wen Chung Tsai , Thierry Glauser
IPC分类号： B05D5/00 , A61L31/06 , A61L31/14
CPC分类号： A61L31/148 , A61L31/06 , A61L31/08 , A61L31/141 , A61L2420/02 , B05D5/00 , C08L67/04
摘要： Methods of fabricating a bioresorbable polymer scaffold are disclosed including a step of inducing crystallization in a bioresorbable polymer construct through exposure to a liquid penetrant.
摘要翻译：公开了制备生物可再吸收的聚合物支架的方法，包括通过暴露于液体渗透剂在生物可再吸收的聚合物构造体中诱导结晶的步骤。

60. 发明授权

US08951595B2 Coatings with tunable molecular architecture for drug-coated balloon 有权
标题翻译：涂层具有可调分子结构的药物涂层球囊
公开(公告)号：US08951595B2
公开(公告)日：2015-02-10
申请号：US12636079
申请日：2009-12-11
申请人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
发明人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
IPC分类号： A61L33/00 , A61F2/958 , A61L29/08 , A61L29/16 , A61M25/10
CPC分类号： A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
摘要翻译：提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。

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