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1. 发明授权

US09370306B1 Methods and devices for in vivo targeted light therapy 有权
标题翻译：用于体内靶向光疗法的方法和装置
公开(公告)号：US09370306B1
公开(公告)日：2016-06-21
申请号：US12191200
申请日：2008-08-13
申请人： Kevin J. Ehrenreich , Kyle Klein , John Stankus
发明人： Kevin J. Ehrenreich , Kyle Klein , John Stankus
IPC分类号： A61N5/06 , A61B5/00 , A61B5/1459 , A61B18/14
CPC分类号： A61B5/0084 , A61B5/1459 , A61B18/1492 , A61B2017/00057 , A61B2018/00904 , A61B2562/0233 , A61N5/0603 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Catheter-based systems for in-vivo targeted light therapy include a first type of catheter configured for photo-activating photosensitive substances in tissue, and a second type of catheter configured for photo-degrading photosensitive substances in tissue. The catheters may be configured to produce light using a variety of light sources, such as light emitting diodes (LEDs) and fiber optics. The light transmission is directed to tissue in such a way that only portions of tissue in a treatment area are exposed to light, depending upon whether the tissue is diseased or healthy.
摘要翻译：用于体内靶向光疗法的基于导管的系统包括构造成用于光敏物质在组织中的光激活的第一类型的导管，以及被配置为光降解组织中的光敏物质的第二类导管。导管可以被配置为使用各种光源（例如发光二极管（LED））和光纤来产生光。光透射以这样的方式被引导到组织，使得只有部分处理区域中的组织暴露于光，这取决于组织是否患病或健康。

2. 发明授权

US08500687B2 Stent delivery system having a fibrous matrix covering with improved stent retention 失效
标题翻译：支架输送系统具有纤维基质覆盖，具有改善的支架保留
公开(公告)号：US08500687B2
公开(公告)日：2013-08-06
申请号：US13069020
申请日：2011-03-22
申请人： Kevin J. Ehrenreich , Richard Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9583 , A61L29/16 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： The present invention provides an intraluminal stent delivery catheter device having improved stent retention. Particularly, the present invention is directed to a catheter having an expandable member and a fibrous matrix positioned over the expandable member and a stent mounted on the outer surface of the fibrous matrix. The fibrous matrix provides mechanical interface for improved stent retention, delivery and deployment.
摘要翻译：本发明提供了具有改善的支架保留的管腔内支架输送导管装置。特别地，本发明涉及一种导管，其具有位于可扩张部件上方的可扩张部件和纤维矩阵，以及安装在纤维基质外表面上的支架。纤维基质提供机械界面，用于改进支架保留，递送和部署。

3. 发明申请

US20110230948A1 STENT DELIVERY SYSTEM HAVING A FIBROUS MATRIX COVERING WITH IMPROVED STENT RETENTION 失效
标题翻译：具有改进的保持性的纤维矩阵覆盖的STENT传送系统
公开(公告)号：US20110230948A1
公开(公告)日：2011-09-22
申请号：US13069020
申请日：2011-03-22
申请人： Kevin J. Ehrenreich , Richard Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9583 , A61L29/16 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： The present invention provides an intraluminal stent delivery catheter device having improved stent retention. Particularly, the present invention is directed to a catheter having an expandable member and a fibrous matrix positioned over the expandable member and a stent mounted on the outer surface of the fibrous matrix. The fibrous matrix provides mechanical interface for improved stent retention, delivery and deployment.
摘要翻译：本发明提供了具有改善的支架保留的管腔内支架输送导管装置。特别地，本发明涉及一种导管，其具有位于可扩张部件上方的可扩张部件和纤维矩阵，以及安装在纤维基质外表面上的支架。纤维基质提供机械界面，用于改进支架保留，递送和部署。

4. 发明申请

US20100081992A1 Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权
标题翻译：用于腔内药物递送的纤维基质形成的可膨胀构件
公开(公告)号：US20100081992A1
公开(公告)日：2010-04-01
申请号：US12238627
申请日：2008-09-26
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。治疗剂可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

5. 发明申请

US20100076377A1 Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权
标题翻译：具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件
公开(公告)号：US20100076377A1
公开(公告)日：2010-03-25
申请号：US12238026
申请日：2008-09-25
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/606 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。水凝胶聚合物可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到所需治疗部位。一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。

6. 发明授权

US08076529B2 Expandable member formed of a fibrous matrix for intraluminal drug delivery 有权
标题翻译：由用于管腔内药物递送的纤维基质形成的可膨胀构件
公开(公告)号：US08076529B2
公开(公告)日：2011-12-13
申请号：US12238627
申请日：2008-09-26
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61F13/15 , A61F13/20 , A61M31/00 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。治疗剂可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

7. 发明授权

US08049061B2 Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery 有权
标题翻译：由具有用于管腔内药物递送的水凝胶聚合物的纤维基质形成的可膨胀构件
公开(公告)号：US08049061B2
公开(公告)日：2011-11-01
申请号：US12238026
申请日：2008-09-25
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61F13/15 , A61F13/20 , A61M31/00 , A61M37/00 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/606 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。水凝胶聚合物可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件的基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到所需治疗部位。一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。

8. 发明授权

US09173890B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

9. 发明授权

US08961589B2 Bioabsorbable coating with tunable hydrophobicity 有权
公开(公告)号：US08961589B2
公开(公告)日：2015-02-24
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
IPC分类号： A61F2/82 , A61L31/16 , A61L31/10 , A61L31/14
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.

10. 发明申请

US20120276152A1 SYSTEMS AND METHODS OF USING ZINC-CHELATOR TO TREAT MYOCARDIAL INFARCTION 审中-公开
标题翻译：使用锌化合物治疗心肌梗塞的系统和方法
公开(公告)号：US20120276152A1
公开(公告)日：2012-11-01
申请号：US13366841
申请日：2012-02-06
申请人： Syed Hossainy , John Stankus , Mikael Trollsas , Dariush Davalian
发明人： Syed Hossainy , John Stankus , Mikael Trollsas , Dariush Davalian
IPC分类号： A61K9/00 , A61K31/351 , A61K31/4412 , A61K31/44 , A61K38/02 , A61K31/734 , A61K31/045 , A61K33/26 , A61K31/04 , A61K31/519 , A61K31/4985 , A61K31/352 , A61K38/22 , A61K31/198 , A61K33/00 , A61K31/502 , A61K47/30 , A61P9/10 , A61K31/16
CPC分类号： A61K31/16 , A61K31/04 , A61K31/045 , A61K31/198 , A61K31/351 , A61K31/352 , A61K31/44 , A61K31/4412 , A61K31/4985 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： Methods and systems for treating an infarct by delivery of zinc chelator to modulate tissue.
摘要翻译：通过递送锌螯合剂来调节组织来治疗梗死的方法和系统。

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