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    • 54. 发明申请
    • TUNING BIOLOGICAL SYSTEM PROPERTIES FOR OPTIMIZED TREATMENT EFFICACY
    • 调节生物系统性能优化治疗效果
    • US20160263150A1
    • 2016-09-15
    • US15067010
    • 2016-03-10
    • Nadia C. LaraAndrew R. BarronStuart CorrSteven Curley
    • Nadia C. LaraAndrew R. BarronStuart CorrSteven Curley
    • A61K33/00
    • A61K33/44A61K9/14A61K33/10A61K33/24
    • Various embodiments of the present disclosure pertain to methods of optimizing a treatment efficacy of a biological system by tuning a property of the biological system through the addition of an optimizing agent to the biological system. The tuning can include: (a) determining a property parameter of the biological system; (b) selecting an optimizing agent to be added to the biological system based on the determined property parameter; and (c) adding the optimizing agent to the biological system. The optimizing agent can include a kosmotropic material. The biological system can include a tissue, such as a tumor. The methods of the present disclosure can be utilized to enhance the efficacy of various treatments, such as the heat treatment of a biological system exposed to a radiofrequency field. The methods of the present disclosure can also include a step of treating the biological system.
    • 本公开的各种实施方案涉及通过通过向生物系统添加优化剂来调节生物系统的性质来优化生物系统的治疗功效的方法。 调整可以包括:(a)确定生物系统的属性参数; (b)基于所确定的属性参数选择要添加到所述生物系统的优化剂; 和(c)将优化剂加入到生物系统中。 优化剂可以包括一种感光性材料。 生物系统可以包括诸如肿瘤的组织。 本公开的方法可以用于增强各种治疗的功效,例如暴露于射频场的生物系统的热处理。 本公开的方法还可以包括处理生物系统的步骤。
    • 56. 发明授权
    • Analyzing the transport of plasmonic particles through mineral formations
    • 通过矿物地层分析等离子体激元粒子的运输
    • US08575548B2
    • 2013-11-05
    • US13701769
    • 2011-06-02
    • Andrew R. BarronSamuel J. Maguire-BoyleAlvin White Orbaek
    • Andrew R. BarronSamuel J. Maguire-BoyleAlvin White Orbaek
    • H01J37/05H01J37/28G01N33/62
    • G01V8/02G01N30/74G01N33/24G01N2015/0693G01N2021/258
    • A transport of plasmonic particles through a mineral formation is analyzed by flowing a plasmonic particles solution through an immobile phase (e.g., a mineral formation), determining an absorbance of the plasmonic particles solution subsequent to flowing the plasmonic particles solution through the immobile phase, comparing the determined absorbance of the plasmonic particles solution with an absorbance of the plasmonic particles solution determined previous to flowing the plasmonic particles solution through the immobile phase, and determining an absorbance of the plasmonic particles to the immobile phase as a function of the comparison. The plasmonic particles solution may be produced by dissolving or suspending plasmonic particles in a mobile phase. Flowing the plasmonic particles solution through the immobile phase may include injecting the plasmonic particles solution into the immobile phase, and then flushing the plasmonic particles solution through the immobile phase.
    • 通过使等离子体颗粒溶液流过固定相(例如矿物形成)来分析通过矿物形成的等离子体激元粒子的运输,确定等离子体激元粒子溶液在使等离子体激元粒子溶液流过固定相后的吸光度,比较 所述等离子体激元粒子溶液的吸光度与先前将等离子体激元粒子溶液流过固定相所确定的等离子体激元粒子溶液的吸光度,以及根据比较确定等离子体激元粒子与固定相的吸光度。 等离子体颗粒溶液可以通过将等离子体激元粒子溶解或悬浮在流动相中来制备。 将等离子体激元颗粒溶液流过固定相可包括将等离子体激元颗粒溶液注入固定相,然后通过固定相冲洗等离子体颗粒溶液。