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51. 发明申请

US20050225839A1 Optical switch using rare earth doped glass 失效
标题翻译：使用稀土掺杂玻璃的光开关
公开(公告)号：US20050225839A1
公开(公告)日：2005-10-13
申请号：US10820098
申请日：2004-04-07
申请人： Falgun Patel , Jeffrey Miller
发明人： Falgun Patel , Jeffrey Miller
IPC分类号： G02B6/34 , H01S3/00 , H01S3/067
CPC分类号： H01S3/06754 , H01S3/10007
摘要： The present invention provides an optical switch including a loss element having a signal loss, and a rare earth doped gain element optically connected in series with the loss element. The rare earth doped gain element is operable to produce a signal gain. The signal gain and the signal loss are about equal. The present invention also provides a method of optical switching including optically connecting a loss element in series with a rare earth doped gain element and passing an optical signal through the loss element and the gain element. The loss element attenuates the optical signal by a first amount. The method further includes selectively applying an optical pump to the gain element to perform the switching, the gain element amplifying the optical signal by the first amount in response to the optical pump.
摘要翻译：本发明提供了一种光开关，其包括具有信号损耗的损耗元件和与损耗元件串联光学连接的稀土掺杂增益元件。稀土掺杂增益元件可操作以产生信号增益。信号增益和信号损耗大致相等。本发明还提供一种光学切换的方法，包括将稀土元素与稀土掺杂的增益元件串联光学连接并使光信号通过损耗元件和增益元件。损耗元件将光信号衰减第一量。该方法还包括选择性地将光泵施加到增益元件以执行切换，增益元件响应光泵将光信号放大第一量。

52. 发明申请

US20050225815A1 Compact optical amplifier 有权
标题翻译：紧凑型光放大器
公开(公告)号：US20050225815A1
公开(公告)日：2005-10-13
申请号：US10819827
申请日：2004-04-07
申请人： Falgun Patel , Jeffrey Miller
发明人： Falgun Patel , Jeffrey Miller
IPC分类号： G02B6/122 , G03H1/00 , H01S3/063 , H01S3/16
CPC分类号： G02B6/122 , H01S3/0632 , H01S3/0637 , H01S3/1608 , H01S3/1618 , H01S3/2308
摘要： The optical amplifier has a waveguide including a core and a cladding. The cladding at least partially surrounds the core and is doped with at least one species of rare earth ion in the range of 5 to 75 wt %. In another embodiment, the core is doped with Er3+ in the range of 7 to 9 wt % and with Yb3+ in the range of 11 to 13 wt %.
摘要翻译：光放大器具有包括芯和包层的波导。所述包层至少部分地包围所述芯并且掺杂有至少一种在5至75重量％范围内的稀土离子。在另一个实施方案中，核心掺杂有7至9重量％范围内的Er 3+和11至13重量％的Yb 3+。

53. 发明申请

US20050202535A1 Bacterial expression of protease inhibitors and variants thereof 有权
标题翻译：蛋白酶抑制剂及其变体的细菌表达
公开(公告)号：US20050202535A1
公开(公告)日：2005-09-15
申请号：US10984514
申请日：2004-11-08
申请人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
发明人： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
IPC分类号： A61K38/08 , A61K38/54 , A61K38/55 , C07H21/04 , C07K7/06 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/62 , C12N15/74 , C12P21/06
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides compositions and methods related to expression of protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the protease inhibitors.
摘要翻译：本发明提供了与细菌种中的蛋白酶抑制剂及其变体的表达相关的组合物和方法。本发明进一步提供融合核酸，载体，融合多肽以及获得蛋白酶抑制剂的方法。

54. 发明申请

US20050064474A1 Methods and compositions for targeted cleavage and recombination 有权
标题翻译：用于靶向切割和重组的方法和组合物
公开(公告)号：US20050064474A1
公开(公告)日：2005-03-24
申请号：US10912932
申请日：2004-08-06
申请人： Fyodor Urnov , Michael Holmes , Jeffrey Miller , Carl Pabo
发明人： Fyodor Urnov , Michael Holmes , Jeffrey Miller , Carl Pabo
IPC分类号： C07K14/435 , C07K14/47 , C07K14/715 , C12N9/14 , C12N9/22 , C12N15/62 , C12P19/34 , C12Q1/68
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。用于靶向切割的方法包括将这种融合蛋白或其编码的多核苷酸引入细胞。用于靶向重组的方法另外包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。

55. 发明授权

US06249990B1 Method and apparatus for transporting articles 失效
标题翻译：用于运输物品的方法和装置
公开(公告)号：US06249990B1
公开(公告)日：2001-06-26
申请号：US09275359
申请日：1999-03-23
申请人： Adel George Tannous , Jeffrey Miller , Khalid Makhamreh
发明人： Adel George Tannous , Jeffrey Miller , Khalid Makhamreh
IPC分类号： F26B504
CPC分类号： H01L21/67386 , F26B21/14 , F26B25/063 , H01L21/67393 , H01L21/67396 , H01L21/67724
摘要： In one embodiment, a cart (5) having a first vessel (10) which fits within a second vessel (90) is used to transport and store an integrated circuit substrate. The integrated circuit substrate is placed within the first vessel (10) and the door (18) of the first vessel (10) is closed and sealed against a door seal (24). The first vessel (10) is then purged with nitrogen to expel moisture and reactive gases from the interior of the first vessel (10). After purging, the first vessel (10) is then placed within the second vessel (90). The door (102) of the second vessel (90) is then closed and sealed against a door seal (104). The second vessel (90) is then purged with nitrogen to expel moisture and reactive gases from the interior of the second vessel (90). The cart (5) containing the integrated circuit substrate is then transported to the next manufacturing area. Integrated circuits and other articles may be manufacturing using the cart system of the present invention.
摘要翻译：在一个实施例中，具有装配在第二容器（90）内的第一容器（10）的推车（5）用于运输和存储集成电路基板。集成电路基板被放置在第一容器（10）内，并且第一容器（10）的门（18）被封闭并相对于门密封件（24）密封。然后用氮气吹扫第一容器（10）以从第一容器（10）的内部排出水分和反应性气体。清洗后，将第一容器（10）放置在第二容器（90）内。然后，第二容器（90）的门（102）被封闭并相对于门密封件（104）密封。然后用氮气吹扫第二容器（90）以从第二容器（90）的内部排出水分和反应性气体。然后将包含集成电路基板的推车（5）运送到下一个制造区域。集成电路和其它制品可以使用本发明的推车系统进行制造。

56. 发明授权

US06101740A Method and apparatus for transporting articles 失效
标题翻译：用于运输物品的方法和装置
公开(公告)号：US06101740A
公开(公告)日：2000-08-15
申请号：US275359
申请日：1999-03-23
申请人： Adel George Tannous , Jeffrey Miller , Khalid Makhamreh
发明人： Adel George Tannous , Jeffrey Miller , Khalid Makhamreh
IPC分类号： B65G1/00 , F26B21/14 , F26B25/06 , H01L21/02 , H01L21/673 , H01L21/677 , F26B5/04
CPC分类号： H01L21/67386 , F26B21/14 , F26B25/063 , H01L21/67393 , H01L21/67396 , H01L21/67724
摘要： In one embodiment, a cart (5) having a first vessel (10) which fits within a second vessel (90) is used to transport and store an integrated circuit substrate. The integrated circuit substrate is placed within the first vessel (10) and the door (18) of the first vessel (10) is closed and sealed against a door seal (24). The first vessel (10) is then purged with nitrogen to expel moisture and reactive gases from the interior of the first vessel (10). After purging, the first vessel (10) is then placed within the second vessel (90). The door (102) of the second vessel (90) is then closed and sealed against a door seal (104). The second vessel (90) is then purged with nitrogen to expel moisture and reactive gases from the interior of the second vessel (90). The cart (5) containing the integrated circuit substrate is then transported to the next manufacturing area. Integrated circuits and other articles may be manufacturing using the cart system of the present invention.
摘要翻译：在一个实施例中，具有装配在第二容器（90）内的第一容器（10）的推车（5）用于运输和存储集成电路基板。集成电路基板被放置在第一容器（10）内，并且第一容器（10）的门（18）被封闭并相对于门密封件（24）密封。然后用氮气吹扫第一容器（10）以从第一容器（10）的内部排出水分和反应性气体。清洗后，将第一容器（10）放置在第二容器（90）内。然后，第二容器（90）的门（102）被封闭并相对于门密封件（104）密封。然后用氮气吹扫第二容器（90）以从第二容器（90）的内部排出水分和反应性气体。然后将包含集成电路基板的推车（5）运送到下一个制造区域。集成电路和其它制品可以使用本发明的推车系统进行制造。

57. 发明授权

US5273741A Packaged anti-plaque oral compositions 失效
标题翻译：包装的抗斑块口服组合物
公开(公告)号：US5273741A
公开(公告)日：1993-12-28
申请号：US922252
申请日：1992-07-30
申请人： Abdul Gaftar , Richard S. Robinson , Jeffrey Miller , Chimpiramma Potini , Michael A. Collins , Theresa G. Shackil
发明人： Abdul Gaftar , Richard S. Robinson , Jeffrey Miller , Chimpiramma Potini , Michael A. Collins , Theresa G. Shackil
IPC分类号： A61K8/34 , A61Q11/00 , A61K7/16 , A61K7/18 , A61K7/26
CPC分类号： A61Q11/00 , A61K8/347 , A61K2800/87 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.
摘要翻译：包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少牙齿包装在分配容器或瓶子中，该分配容器或瓶子包括与抗菌剂相容的诸如聚氟乙烯的固体聚合物材料，从而避免了这种药剂在储存时过度的抗斑块活性损失。或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用通过稳定剂如萜烯的存在来抵消，例如苎烯，在口服组合物配方中。还描述了抑制牙齿斑块发展的方法。

58. 发明授权

US5167951A Article comprising a dispensing container that includes solid polymeric material in contact with an antiplaque oral composition with which it is compatible 失效
标题翻译：一种包含分配容器的制品，其包括与可与其兼容的抗牙釉质口服组合物接触的固体聚合物材料
公开(公告)号：US5167951A
公开(公告)日：1992-12-01
申请号：US505628
申请日：1990-04-06
申请人： Abdul Gaffar , Richard S. Robinson , Jeffrey Miller , Chimpiramma Potini , Michael A. Collins , Theresa G. Shackil
发明人： Abdul Gaffar , Richard S. Robinson , Jeffrey Miller , Chimpiramma Potini , Michael A. Collins , Theresa G. Shackil
IPC分类号： A61K8/34 , A61K8/81 , A61Q11/00
CPC分类号： A61K8/347 , A61K8/81 , A61K8/8164 , A61Q11/00 , A61K2800/87 , Y10S514/90 , Y10S514/901
摘要： An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition, but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.
摘要翻译：包含基本上不溶于水的非阳离子抗菌剂（例如三氯生）的口服组合物，例如糊剂或凝胶洁齿剂或液体漱口剂，其用于清洁牙齿或冲洗口腔时起作用以减少牙齿被包装在分配容器中，该分配容器包括与抗菌剂相容的固体聚合物材料，例如聚氟乙烯，从而避免了这种药剂在储存时过度的抗斑块活性损失。或者，可以使用各种其它聚合物作为容器部件，其通常将导致组合物中抗菌剂的抗斑块作用的过度损失，但是这种作用由稳定剂如萜烯的存在来抵消，例如，柠檬烯，口服组合物配方。口服组合物优选含有聚乙烯基醚 - 马来酸酐共聚物的氟化物离子源，多磷酸盐的抗牙垢比例，多磷酸盐的稳定化比例（与氟化物源结合）的牙齿硬化比例，和用于口服制剂的正常佐剂。抑制牙齿斑块发展的方法也在本发明的范围内，含有有效量的本发明洁牙剂的清洁用品也是如此。

59. 发明授权

US5123915A Medicated pacifier 失效
标题翻译：药膏安抚奶嘴
公开(公告)号：US5123915A
公开(公告)日：1992-06-23
申请号：US515614
申请日：1990-04-27
申请人： Lawrence E. Miller , Jeffrey Miller
发明人： Lawrence E. Miller , Jeffrey Miller
IPC分类号： A61J7/00 , A61J17/00
CPC分类号： A61J7/0046 , A61J17/006 , A61J7/0007 , A61J7/0053 , A61J17/001
摘要： The present invention pertains to a device for the oral administration of a medication. The device comprises a pierced nipple having a nipple chamber and an open base, a medication reservoir having an outer wall member defining a reservoir chamber, a first end opening into the reservoir chamber, and a closable second end opening into the reservoir chamber. There is means to connect the reservoir to the base of the nipple in fluid-tight relationship with the nipple chamber communicating with the reservoir chamber through the open base. There are closing means for sealing the second end of the reservoir.
摘要翻译：本发明涉及用于口服给药的装置。该装置包括具有乳头腔室和开口底座的穿孔乳头，具有限定储存室的外壁构件的药物储存器，进入储存室的第一端开口和通向储存室的可封闭的第二端开口。存在将储存器与乳头基部以与流体密封的关系连接的装置，该乳头腔通过开口底座连通储存室。存在用于密封储存器的第二端的封闭装置。

60. 发明授权

US10688219B2 Quilted implantable graft 有权
公开(公告)号：US10688219B2
公开(公告)日：2020-06-23
申请号：US12482002
申请日：2009-06-10
申请人： Umesh H. Patel , Jeffrey Miller
发明人： Umesh H. Patel , Jeffrey Miller
IPC分类号： A61L27/36 , A61L27/50 , A61L27/38 , A61L27/56 , A61L27/14 , B32B5/26 , B32B5/06 , B32B7/08
摘要： Described are embodiments of a multilaminate or multiple layer implantable surgical graft comprising remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

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