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51. 发明申请

US20110009774A1 BODY FLUID SAMPLING DEVICE 有权
标题翻译：身体液体取样装置
公开(公告)号：US20110009774A1
公开(公告)日：2011-01-13
申请号：US12879500
申请日：2010-09-10
申请人： Irio Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/151
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。孔尺寸可以较小，例如具有0.01至0.5mm的直径。这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。在一些实施例中，孔的深度为50至500μm。在其它实施方案中，收集区是多孔的，或者是粗糙区域。收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

52. 发明申请

US20100286564A1 TEST MEDIA CASSETTE FOR BODILY FLUID TESTING DEVICE 有权
公开(公告)号：US20100286564A1
公开(公告)日：2010-11-11
申请号：US12840352
申请日：2010-07-21
申请人： Jeffrey N. Roe , Steven N. Roe
发明人： Jeffrey N. Roe , Steven N. Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/1411 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/150419 , A61B5/150473 , A61B5/150503 , A61B5/150633 , A61B5/150702 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/157 , A61B10/0045 , A61B2562/0295 , G01N33/48 , G01N33/48764 , G01N2001/028 , G01N2035/00019 , Y10T436/25
摘要： A bodily fluid sampling device includes a piercing device and a sensor enclosed in a housing. A cassette, which contains test media, is positioned proximal to the sensor so that the sensor is able to analyze a bodily fluid sample collected on the test media. The cassette includes a supply portion from which unused test media is supplied and a storage portion in which contaminated test media is stored after exposure to the bodily fluid. The cassette is adapted to collect a series of bodily fluid samples without requiring disposal of the test media.

53. 发明授权

US07819822B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US07819822B2
公开(公告)日：2010-10-26
申请号：US11470368
申请日：2006-09-06
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilfried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilfried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid, and the device further comprising a fluid receiving means remote spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially. The collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0.5 seconds. The fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from the collection zone is automatically or manually transported to the fluid receiving means to contact the fluid with the test zone.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件，并且该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液不会接触流体接收装置原来。收集区在小于0.5秒的非常短的时间段内占据非常小体积的体液约10至500nl。流体接收装置可以具有用于进行分析反应的测试区域。来自收集区的流体样品被自动或手动地输送到流体接收装置以使流体与测试区接触。

54. 发明授权

US07708703B2 Integrated analytical test element 有权
标题翻译：综合分析测试元件
公开(公告)号：US07708703B2
公开(公告)日：2010-05-04
申请号：US11691674
申请日：2007-03-27
申请人： Charles C. Raney , Steven N. Roe
发明人： Charles C. Raney , Steven N. Roe
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00
CPC分类号： A61B5/150458 , A61B5/150022 , A61B5/150061 , A61B5/150282 , A61B5/150358 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15194 , A61B5/157 , A61B2562/0295
摘要： A lancet integrated test element (LIT) includes an incision forming member that has a cutting end configured to form an incision in tissue. A test element is attached to the incision forming member to test fluid from the incision. The test element has a sampling end with a sample opening through which the fluid is collected. The test element is bendable from a first state where the cutting end of the incision forming member is retracted from the sampling end of the test element to a second state where at least a portion of the cutting extends past the sampling end of the test element to form the incision in the tissue.
摘要翻译：柳叶刀集成测试元件（LIT）包括切口形成构件，其具有构造成在组织中形成切口的切割端。将测试元件附接到切口形成构件以测试来自切口的流体。测试元件具有采样端，其具有采样流体的采样开口。测试元件可从第一状态弯曲，其中切口形成构件的切割端从测试元件的采样端缩回到第二状态，其中至少一部分切割延伸穿过测试元件的采样端到在组织中形成切口。

55. 发明申请

US20100069943A1 MAGNETIC POWERED LANCING DRIVE 失效
标题翻译：磁力驱动
公开(公告)号：US20100069943A1
公开(公告)日：2010-03-18
申请号：US12211408
申请日：2008-09-16
申请人： Steven N. Roe
发明人： Steven N. Roe
IPC分类号： A61B17/32
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150167 , A61B5/150183 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15123 , A61B5/1519
摘要： A self-powered lancing drive system and lancing technique uses permanent magnets to initially store the potential energy that is converted to kinetic energy for extending a lancet during lancing. This self-powered lancing drive system is a pure permanent magnet drive that is highly reliable under numerous operating conditions. Permanent magnets can produce stronger magnetic fields at smaller sizes as compared to electromagnets. In one form, the lancing system has a drive permanent magnet that is kept fixed or stationary while the lancet magnet travels along the firing path. With the drive magnet being stationary, the lancet experiences fewer fluctuations in the magnetic field. The lancet vibrates less and is driven straighter into the tissue. In another form, a retraction magnet is positioned at the end of the firing path of the lancet, near the tissue, to enhance retraction of the lancet. In another form, a mechanical structure keeps the magnets in close proximity so that the strength of the magnetic propulsion force is maintained. The mechanical structure in one example is a crank mechanism that confines magnet movement to a circular path. The crank mechanism provides a smooth lancing profile as well as facilitates adjustments to the lancing profile.
摘要翻译：自动牵引驱动系统和穿刺技术使用永久磁铁来初始储存转换为动能的势能，以便在穿刺期间延长刺血针。这种自供电的牵引驱动系统是一种纯永磁驱动器，在许多操作条件下都是高度可靠的。与电磁铁相比，永磁体可以以较小的尺寸产生更强的磁场。在一种形式中，穿刺系统具有驱动永磁体，其在柳叶刀磁体沿着击发路径行进时保持固定或静止。在驱动磁体静止的情况下，刺血针的磁场波动较少。柳叶刀振动较小，并且更直接地驱动到组织中。在另一种形式中，收缩磁体位于柳叶刀的靠近组织的射击路径的末端，以增强刺血针的收缩。在另一种形式中，机械结构保持磁体紧密接近，从而保持磁推进力的强度。一个示例中的机械结构是将磁体运动限制到圆形路径的曲柄机构。曲柄机构提供平滑的穿刺剖面，并且便于对穿刺剖面进行调整。

56. 发明申请

US20100069793A1 DEVICE FOR SAMPLING BODILY FLUIDS 有权
标题翻译：用于取样体液的装置
公开(公告)号：US20100069793A1
公开(公告)日：2010-03-18
申请号：US12624060
申请日：2009-11-23
申请人： Steven N. Roe
发明人： Steven N. Roe
IPC分类号： A61B5/151
CPC分类号： A61B5/15163 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15107 , A61B5/15117 , A61B5/15146 , A61B5/15151 , A61B2562/0295
摘要： A bodily fluid sampling device comprising a lancet which can be advanced against a skin-piercing site to produce a droplet of bodily fluid. A transport medium is positioned sufficiently close to the lancing medium to retain a droplet of bodily fluid therebetween by capillary action. One of the two mediums has hydrophobic material on its surface and the other hydrophilic. Various mechanisms are provided for relatively displacing the lancing and transport medium to move the droplet of bodily fluid away from the skin-piercing end. Furthermore, multiple lancet assemblies may be provided in a barrel or disk configuration and indexed to the displacing mechanisms for sampling a skin site.
摘要翻译：一种体液采样装置，其包括刺血针，所述刺血针可以抵靠皮肤刺穿部位前进以产生体液滴。运输介质被定位成足够靠近穿刺介质，以通过毛细作用在其间保持体液滴。两种介质中的一种在其表面上具有疏水性材料，而另一种具有亲水性。提供了各种机构用于使穿刺和输送介质相对移位以使体液的液滴远离皮肤刺穿端。此外，多个柳叶刀组件可以以桶或盘构造提供并且被索引到用于取样皮肤部位的移位机构。

57. 发明申请

US20090124994A1 MINIATURE DRUG DELIVERY PUMP WITH A PIEZOELECTRIC DRIVE SYSTEM 有权
标题翻译：具有压电驱动系统的微型药液输送泵
公开(公告)号：US20090124994A1
公开(公告)日：2009-05-14
申请号：US11936813
申请日：2007-11-08
申请人： Steven N. Roe
发明人： Steven N. Roe
IPC分类号： A61M1/00 , F04B35/04 , H01L41/09
CPC分类号： F04B43/095 , A61M5/14248 , A61M5/1452 , A61M2005/14573 , H02N2/101
摘要： A drug delivery pump which uses a piezoelectric drive system to advance a small syringe piston to deliver a liquid drug and a method thereof are disclosed. The present invention has a cost and size advantage compared to traditional pumps and is a very compact and potentially disposable pump device design.
摘要翻译：公开了一种使用压电驱动系统推进小注射器活塞以输送液体药物的药物输送泵及其方法。与传统泵相比，本发明具有成本和尺寸优点，并且是非常紧凑且潜在的一次性泵装置设计。

58. 发明申请

US20080147107A1 PRECISION DEPTH CONTROL LANCING TIP 有权
标题翻译：精密深度控制系统
公开(公告)号：US20080147107A1
公开(公告)日：2008-06-19
申请号：US12038302
申请日：2008-02-27
申请人： Steven N. Roe , Chris Wiegel
发明人： Steven N. Roe , Chris Wiegel
IPC分类号： A61B5/151
CPC分类号： A61B5/150717 , A61B5/150022 , A61B5/150068 , A61B5/15019 , A61B5/150358 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/1519 , A61B5/15194
摘要： A bodily fluid sampling device is operable to lance with a precise depth and express fluid from both fingertip and alternate sites. In one form, the device is operable to adjust the penetration depth of the lancet into the skin. The bodily fluid sampling device includes a lancet adapted to form an incision in skin. A skin contacting member has an orifice through which the lancet extends when lancing the skin. The orifice has a first opening size that is sized to flatten the skin around the lancet during lancing. The orifice has a second opening size that is larger than the first opening size after the incision is formed to express fluid from the incision.
摘要翻译：体液采样装置可操作以用精确的深度喷枪并从指尖和替代部位表达流体。在一种形式中，该装置可操作以调节刺血针进入皮肤的穿透深度。体液取样装置包括适于在皮肤中形成切口的刺血针。皮肤接触构件具有孔，当穿刺皮肤时柳叶刀延伸穿过该孔。孔口具有第一开口尺寸，其尺寸适于在穿刺期间使柳叶刀周围的皮肤变平。在形成切口以从切口表达流体之后，孔口具有大于第一开口尺寸的第二开口尺寸。

59. 发明授权

US06866675B2 Lancet device having capillary action 有权
标题翻译：具有毛细作用的柳叶刀装置
公开(公告)号：US06866675B2
公开(公告)日：2005-03-15
申请号：US10054270
申请日：2002-01-22
申请人： Edward P. Perez , Steven N. Roe
发明人： Edward P. Perez , Steven N. Roe
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/15 , A61B5/151 , A61B5/157 , A61B10/00 , G01N1/00 , G01N33/487 , G01N33/66 , A61B17/34
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/150022 , A61B5/150175 , A61B5/150358 , A61B5/150389 , A61B5/150419 , A61B5/150511 , A61B5/15087 , A61B5/15117 , A61B5/15144 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/008 , A61B2562/0295 , G01N35/1079
摘要： A device for sampling body fluid, the device comprising, a main body, a lancet disposed within the main body, a carrier disposed within the main body fixedly attached to the lancet, a spring in communication with the lancet and the carrier, an annular space disposed within the main body adjacent the lancet, and a testing device for measuring a body fluid. The testing device may include micro-porous test strips, an electronic testing device, an optical/reflectance testing measuring device, or a visual inspection.
摘要翻译：一种用于体液取样的装置，该装置包括：主体，设置在主体内的柳叶刀，设置在固定在刺血针上的主体内的载体，与柳叶刀和载体连通的弹簧，环形空间设置在与身体相邻的主体内，以及用于测量体液的检查装置。测试装置可以包括微孔测试条，电子测试装置，光学/反射测试测量装置或目视检查。

60. 发明授权

US06719777B2 Closure device and methods for making and using them 有权
标题翻译：关闭装置及其制造和使用的方法
公开(公告)号：US06719777B2
公开(公告)日：2004-04-13
申请号：US09732178
申请日：2000-12-07
申请人： Richard S. Ginn , William N. Aldrich , W. Martin Belef , Steven N. Roe
发明人： Richard S. Ginn , William N. Aldrich , W. Martin Belef , Steven N. Roe
IPC分类号： A61B1708
CPC分类号： H03K3/356156 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/0641
摘要： A vascular clip includes a peripheral body defining a plane, and tines extending from the body transversely with respect to the plane, the tines biased towards a planar configuration. The clip includes expandable elements disposed along its periphery that are biased to expand from compressed to expanded states for increasing a diameter of the clip upon deployment. The clip is provided within a housing slidably mounted on an introducer sheath. The sheath is introduced through a puncture into a blood vessel, and after a procedure is performed via the sheath, the housing is advanced into the puncture and the clip deployed until the tines engage tissue adjacent the opening in the vessel wall. The sheath is withdrawn from the patient, leaving the clip in place. The tines at least partially move towards the planar configuration to pull the engaged tissue together and close the opening.
摘要翻译：血管夹包括限定平面的周边主体和从身体相对于平面横向延伸的齿，所述尖被偏向平面构型。夹子包括沿着其周边布置的可膨胀元件，其被偏压以从压缩膨胀到膨胀状态，以在展开时增加夹子的直径。夹子设置在可滑动地安装在引导器护套上的壳体内。护套通过穿刺引入血管中，并且在通过护套进行手术之后，将壳体推进到穿刺中并且夹持器展开，直到尖齿与容器壁中的开口相邻的组织接合。将鞘从病人身上取出，将夹子放在适当位置。尖齿至少部分地朝向平面构型移动以将被接合的组织拉到一起并关闭开口。

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