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51. 发明专利

DE69929264D1 未知
公开(公告)号：DE69929264D1
公开(公告)日：2006-03-30
申请号：DE69929264
申请日：1999-01-12
申请人： AJINOMOTO KK
发明人： SUGA MIKIKO , SUGIMOTO MASAKAZU , OSUMI TSUYOSHI , NAKAMATSU TSUYOSHI , HIBINO WATARU , ITO MIKA
IPC分类号： C12N15/09 , C12N15/53 , C12N1/20 , C12N1/21 , C12N9/04 , C12P13/06 , C12R1/13 , C12R1/15
摘要： Disclosed is a coryneform bacterium having resistance to azaserine or beta -(2-thienyl)-DL-alanine and having L-serine productivity. Also, disclosed are D-3-phosphoglycerate dehydrogenase derived from a coryneform bacterium, in which feedback inhibition by L-serine is desensitized; the D-3-phosphoglycerate dehydrogenase, which is obtainable from a coryneform bacterium having resistance to azaserine or beta -(2-thienyl)-DL-alanine and having L-serine productivity; the D-3-phosphoglycerate dehydrogenase having an amino acid sequence depicted in SEQ ID NO : 12 in Sequence Listing or the sequence including substitution, addition or deletion of one or more amino acids, wherein an amino acid residue corresponding to the 325th glutamic acid residue of the amino acid sequence in the SEQ ID NO : 12 is replaced with an amino acid other than glutamic acid; the D-3-phosphoglycerate dehydrogenase that has an amino acid sequence depicted in SEQ ID NO : 11 in Sequence Listing; a DNA coding for the D-3-phosphoglycerate dehydrogenase described above; the DNA that has a base sequence depicted in SEQ ID NO : 13 in Sequence Listing; a coryneform bacterium which harbors a recombinant DNA containing the DNA; and a method of producing L-serine, comprising the steps of cultivating the bacterium described above in a medium to allow accumulation of L-serine in the medium, and collecting the L-serine from the medium.

52. 发明专利

DE69928845D1 未知
公开(公告)号：DE69928845D1
公开(公告)日：2006-01-19
申请号：DE69928845
申请日：1999-01-12
申请人： AJINOMOTO KK
发明人： SUGA MIKIKO , SUGIMOTO MASAKAZU , OSUMI TSUYOSHI , NAKAMATSU TSUYOSHI , HIBINO WATARU , ITO MIKA
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/04 , C12N15/53 , C12P13/06 , C12R1/13 , C12R1/15
摘要： L-serine is produced by cultivating in a medium a coryneform bacterium having L-serine productivity in which an activity of at least one of phosphoserine phosphatase and phosphoserine transaminase is enhanced, preferably, further having introduced therein a gene coding for D-3-phosophoglycerate dehydrogenase in which feedback inhibition by L-serine is desensitizied, allowing L-serine to accumulate in the medium, and collecting the L-serine from the medium.

53. 发明专利

ES2214567T3 未知
公开(公告)号：ES2214567T3
公开(公告)日：2004-09-16
申请号：ES97108764
申请日：1997-06-02
申请人： AJINOMOTO KK
发明人： HIRANO SEIKO , SUGIMOTO MASAKAZU , NAKANO EIICHI , IZUI MASAKO , HAYAKAWA ATSUSHI , YOSHIHARA YASUHIKO
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/06 , C12N9/88 , C12N15/77 , C12P13/08 , C12R1/13
摘要： A coryneform bacterium in which a DNA coding for a diaminopimelate decarboxylase and a DNA coding for a diaminopimelate dehydrogenase are enhanced is cultivated in a medium to allow L-lysine to be produced and accumulated in a culture, and L-lysine is collected from the culture.

54. 发明专利

PL186081B1 METHOD OF OBTAINING L-LYSINE 未知
公开(公告)号：PL186081B1
公开(公告)日：2003-10-31
申请号：PL32032497
申请日：1997-06-03
申请人： AJINOMOTO KK
发明人： HIRANO SEIKO , SUGIMOTO MASAKAZU , NAKANO EIICHI , IZUI MASAKO , HAYAKAWA ATSUSHI , YOSHIHARA YASUHIKO , NAKAMATSU TSUYOSHI
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/06 , C12N9/88 , C12N15/77 , C12P13/08 , C12R1/13 , C12N15/10 , C12N15/54
摘要： A coryneform bacterium in which a DNA coding for a diaminopimelate decarboxylase and a DNA coding for a diaminopimelate dehydrogenase are enhanced is cultivated in a medium to allow L-lysine to be produced and accumulated in a culture, and L-lysine is collected from the culture.

55. 发明专利

BR0016656A 未知
公开(公告)号：BR0016656A
公开(公告)日：2002-11-05
申请号：BR0016656
申请日：2000-12-22
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , NAKAI YUTA , ITO HISAO , KURAHASHI OSAMU
IPC分类号： C12N1/21 , C12N9/12 , C12N15/54 , C12P13/08 , C12P13/14 , C12N1/20 , C12P13/04
摘要： A gene coding for fructose phosphotransferase is introduced into a coryneform bacterium having an ability to produce an L-amino acid such as L-lysine or L-glutamic acid to enhance fructose phosphotransferase activity and thereby improve the L-amino acid producing ability.

56. 发明专利

DE69430919D1 未知
公开(公告)号：DE69430919D1
公开(公告)日：2002-08-08
申请号：DE69430919
申请日：1994-08-17
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , SUZUKI TOMOKO , MATSUI HIROSHI , IZUI KATSURA
IPC分类号： C12N9/88 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/14 , C12P13/20
摘要： A variant phosphoenolpyruvate carboxylase that is not substantially inhibited by aspartic acid is produced by introducing a variant phosphoenolpyruvate carboxylase gene, such as one wherein the 625th glutamic acid residue from the N-terminus of the carboxylase has been replaced by a lysine residue or one wherein the 438th arginine residue has been replaced by a cysteine residue, into Escherichia coli or a coryneform bacterium. An amino acid can efficiently be produced by using this carboxylase.

57. 发明专利

BR0012020A 未知
公开(公告)号：BR0012020A
公开(公告)日：2002-07-02
申请号：BR0012020
申请日：2000-06-30
申请人： AJINOMOTO KK
发明人： IZUI MASAKO , SUGIMOTO MASAKAZU , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N9/12 , C12N15/54

58. 发明专利

DE10103509A1 未知
公开(公告)号：DE10103509A1
公开(公告)日：2001-09-27
申请号：DE10103509
申请日：2001-01-26
申请人： AJINOMOTO KK
发明人： SUGA MIKIKO , ASAKURA YOKO , SUGIMOTO MASAKAZU , ITO HISAO
IPC分类号： C12N1/21 , C12N9/16 , C12N15/54 , C12N15/55 , C12P13/06 , C12N9/14 , C12N15/63 , C07H21/04
摘要： The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open reading frame in the DNA fragment. (A) A protein which comprises an amino acid sequence of SEQ ID: 2 in Sequence Listing; or (B) A protein which comprises an amino acid sequence including substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence of SEQ ID NO: 2 in Sequence Listing, and which has phosphoserine phosphatase activity.

59. 发明专利

PL181380B1 MUTATED PHOSPHOENOLOPYROGRONIANIC CARBOXYLASE, ITS GENE AND METHOD OF OBTAINING AMINO ACID 未知
公开(公告)号：PL181380B1
公开(公告)日：2001-07-31
申请号：PL31311994
申请日：1994-08-17
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , SUZUKI TOMOKO , MATSUI HIROSHI , IZUI KATSURA
IPC分类号： C12N9/88 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/14 , C12P13/20 , C12N15/60 , C12N15/77
摘要： A variant phosphoenolpyruvate carboxylase that is not substantially inhibited by aspartic acid is produced by introducing a variant phosphoenolpyruvate carboxylase gene, such as one wherein the 625th glutamic acid residue from the N-terminus of the carboxylase has been replaced by a lysine residue or one wherein the 438th arginine residue has been replaced by a cysteine residue, into Escherichia coli or a coryneform bacterium. An amino acid can efficiently be produced by using this carboxylase.

60. 发明专利

AU5707200A Process for producing l-amino acid 未知
公开(公告)号：AU5707200A
公开(公告)日：2001-01-22
申请号：AU5707200
申请日：2000-06-30
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , ITO HISAO , KURAHASHI OSAMU
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/02 , C12N15/53 , C12P13/06 , C12P13/08 , C12P13/14 , C12P13/04

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