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51. 发明授权

US06040325A Triazole derivative or salt thereof preparation process thereof, and pharmaceutical containing said compound as an effective ingredient 失效
标题翻译：三唑衍生物或其盐的制备方法，以及含有所述化合物作为有效成分的药物
公开(公告)号：US06040325A
公开(公告)日：2000-03-21
申请号：US235320
申请日：1999-01-22
申请人： Sunao Takeda , Yasushi Kaneko , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
发明人： Sunao Takeda , Yasushi Kaneko , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
IPC分类号： C07C323/07 , C07C323/22 , C07D249/08 , C07D303/34 , C07D521/00 , A61K31/41
CPC分类号： C07D231/12 , C07C323/22 , C07D233/56 , C07D249/08 , C07D303/34 , C07C2101/02
摘要： Described is a triazole derivative represented by the formula (1): wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient.The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
摘要翻译：描述了由式（1）表示的三唑衍生物：其中R1表示氢原子，低级烷基或芳烷基，X1和X2相同或不同，并且各自独立地表示氢原子，卤素原子或卤代烷基，n表示0〜2的整数，或其盐; 所述化合物的制备方法和包含所述化合物作为有效成分的药物。上述化合物具有高抗真菌活性，可用于预防和治疗哺乳动物真菌感染。

52. 发明授权

US5945438A Triazole derivative and pharmaceutical comprising the same as an effective ingredient 失效
标题翻译：三唑衍生物和包含与有效成分相同的药物
公开(公告)号：US5945438A
公开(公告)日：1999-08-31
申请号：US767694
申请日：1996-12-17
申请人： Minoru Tokizawa , Sunao Takeda , Yasushi Kaneko , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato , Hideaki Matsuda
发明人： Minoru Tokizawa , Sunao Takeda , Yasushi Kaneko , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato , Hideaki Matsuda
IPC分类号： C07D249/08 , C07D303/34 , C07D521/00 , A61K31/41
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D303/34
摘要： Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.
摘要翻译：描述由式（1）表示的三唑衍生物或其盐，其制备方法，由式（2）和（3）表示的制备中间体，以及包含式（1）表示的化合物或其盐的药物。其中n表示0,1或2，X 1表示H或F，Y 1和Y 2各自独立地表示H，卤素或CF 3。

53. 发明授权

US5385900A Quinoline carboxylic acid derivatives 失效
公开(公告)号：US5385900A
公开(公告)日：1995-01-31
申请号：US149134
申请日：1993-11-08
申请人： Fujiko Konno , Akihiro Shibata , Hideaki Matsuda , Takemitsu Asaoka , Ryuichi Kawahara , Naokata Taido , Tadayuki Kuraishi , Sunao Takeda
发明人： Fujiko Konno , Akihiro Shibata , Hideaki Matsuda , Takemitsu Asaoka , Ryuichi Kawahara , Naokata Taido , Tadayuki Kuraishi , Sunao Takeda
IPC分类号： A61K31/55 , A61P31/04 , C07D215/56 , C07D401/04 , C07D413/04 , C07D417/04 , C07D243/08
CPC分类号： C07D215/56 , C07D401/04 , C07D413/04 , C07D417/04
摘要： A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in living bodies, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatments and prevention of various infectious diseases in clinics.

54. 发明授权

US5255686A Continuous noninvasive blood pressure measuring apparatus and method 失效
标题翻译：连续无创血压测量仪及方法
公开(公告)号：US5255686A
公开(公告)日：1993-10-26
申请号：US907795
申请日：1992-07-02
申请人： Sunao Takeda , Hideo Ozawa , Mitsushi Hyogo , Yoshinobu Nakae
发明人： Sunao Takeda , Hideo Ozawa , Mitsushi Hyogo , Yoshinobu Nakae
IPC分类号： A61B5/022 , A61B5/0225 , A61B5/00
CPC分类号： A61B5/0225
摘要： In a continuous noninvasive blood pressure measuring apparatus, a systolic pressure, diastolic pressure, and mean arterial pressure for calibration are measured according to the output of a pressure sensor, a cuff pressure is set lower than the diastolic pressure by a cuff pressure control section, and a reference pulse wave is obtained from the arithmetic means of a plurality of cuff pulse waves. A CPU calculates the peak value and the bottom value of the reference pulse wave, and a cuff pressure mean value corresponding to the D.C. component of the reference pulse wave, and further calculates coefficients which are used to allow the peak value, bottom value and cuff pressure mean value thus obtained to correspond to correspond to the systolic pressure, diastolic pressure, and mean arterial pressure, respectively. The CPU calculates according to the output of a temperature sensor a cuff pressure temperature compensation value for compensating for an amount of variation of the cuff pressure which varies with the temperature of the cuff. In addition, the CPU, while compensating the cuff pressure, which is read continuously, with the cuff pressure temperature compensation value, continuously calculates a blood pressure by utilizing the cuff pressure thus compensated, and the coefficients provided by the coefficient calculating section, and the cuff pulse waves read continuously.
摘要翻译：在连续无创血压测定装置中，根据压力传感器的输出来测量收缩压，舒张压和用于校准的平均动脉压，通过袖带压力控制部将袖带压设定为低于舒张压，并且从多个袖带脉冲波的运算装置获得参考脉搏波。 CPU计算参考脉搏波的峰值和底值，以及与参考脉搏波的直流分量对应的袖带压力平均值，并进一步计算用于允许峰值，底值和袖带由此获得的压力平均值分别对应于收缩压，舒张压和平均动脉压。 CPU根据温度传感器的输出计算袖带压力温度补偿值，用于补偿袖带压力的变化量随袖带的温度而变化。此外，CPU在通过袖带压力温度补偿值连续读取补偿袖带压力的同时，通过利用这样补偿的袖带压力连续计算血压，并且由系数计算部提供的系数和袖带脉搏波连续读取。

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