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51. 发明公开

EP1957982A2 PARTICLE-BASED ANALYTE CHARACTERIZATION 审中-公开
标题翻译：基于颗粒的分析物的表征
公开(公告)号：EP1957982A2
公开(公告)日：2008-08-20
申请号：EP06848541.6
申请日：2006-12-05
申请人： Guava Technologies, Inc.
发明人： TYAGARAJAN, Kamala , FISHWILD, Dianne, M. , KING, David, A.
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/54346 , G01N33/582
摘要： Methods for assaying a sample for an analyte are provided. In various embodiments, the methods comprise contacting a sample suspected of containing the analyte with a non-uniform particle comprising a capture molecule, and further contacting the particle with a detection moiety comprising a label that permits detection of the analyte when associated with the particle. The methods may be performed to detect and/or quantitate analyte in the sample. In some embodiments, the methods may be performed in an automated manner, and may use an optical and/or cytometric apparatus for performing the method(s). The methods may further be performed with automated vessel-processing apparatus(es), such as plate loaders, plate washers, etc. Also provided are complexes containing the described materials formed by an assay of the invention, including excited state complexes. Kits useful for performing such methods are also provided.

52. 发明公开

EP1664784A1 COMPOSITIONS AND METHODS FOR ANALYSIS OF TARGET ANALYTES 审中-公开
标题翻译：程序胰岛素分析
公开(公告)号：EP1664784A1
公开(公告)日：2006-06-07
申请号：EP04784342.0
申请日：2004-09-17
申请人： Guava Technologies, Inc.
发明人： DANIELZADEH, Robert , OLSON, Keith R.
IPC分类号： G01N33/566
CPC分类号： G01N33/54306 , G01N33/54366 , G01N33/569 , G01N33/56983 , G01N33/582 , G01N33/585 , G01N33/6863 , G01N33/74
摘要： Compositions and methods are provided for analyzing a sample for the presence or absence of one or more target analytes.

53. 发明公开

EP1334346A2 PARTICLE OR CELL ANALYZER AND METHOD 审中-公开
标题翻译：颗粒或细胞分析仪及方法
公开(公告)号：EP1334346A2
公开(公告)日：2003-08-13
申请号：EP01968506.4
申请日：2001-09-05
申请人： Guava Technologies, Inc.
发明人： GOIX, Philippe, J. , LINGANE, Paul, J. , PHI-WILSON, Janette, T.
IPC分类号： G01N15/14 , B01L3/02 , G01N1/14
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.

54. 发明公开

EP2005141A2 ASYMMETRIC CAPILLARY FOR CAPILLARY-FLOW CYTOMETERS 审中-公开
标题翻译：非对称毛细管毛细流式细胞仪
公开(公告)号：EP2005141A2
公开(公告)日：2008-12-24
申请号：EP07760400.7
申请日：2007-04-10
申请人： Guava Technologies, Inc.
发明人： ILKOV, Fedor, A.
IPC分类号： G01N21/00
CPC分类号： G01N15/1404 , G01N2015/0053 , G01N2015/1415
摘要： The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.

55. 发明公开

EP0988523A1 METHOD AND APPARATUS FOR DETECTING MICROPARTICLES IN FLUID SAMPLES 失效
标题翻译：方法及器具的微粒在液体样品检测
公开(公告)号：EP0988523A1
公开(公告)日：2000-03-29
申请号：EP98926490.8
申请日：1998-06-09
申请人： Guava Technologies, Inc.
发明人： GOIX, Philippe
IPC分类号： G01N21/64
CPC分类号： G01N15/1484 , G01N15/1456 , G01N21/64 , G01N2021/0346
摘要： A method and apparatus for detecting a fluorescent substance tagged to a microparticle are described. The device comprises a single capillary flow carrier system for transporting the microparticle past a a selected location, a source of electromagnetic radiation for irradiating the substance tagged to the microparticle, and a detection system for measuring fluorescent light emitted from the substance at the selected location. The method comprises transporting the microparticle to a selected location, irradiating a fluorescent substance tagged to the microparticle, and measuring the fluorescent light emitted from the fluorescent substance at the selected location.

56. 发明申请

US20090220989A1 Particle-Based Analyte Characterization 审中-公开
标题翻译：基于粒子的分析物表征
公开(公告)号：US20090220989A1
公开(公告)日：2009-09-03
申请号：US12096342
申请日：2006-12-05
申请人： Kamala Tyagarajan , Dianne M. Fishwild , David A. King
发明人： Kamala Tyagarajan , Dianne M. Fishwild , David A. King
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54346 , G01N33/582
摘要： Methods for assaying a sample for an analyte are provided. In various embodiments, the methods comprise contacting a sample suspected of containing the analyte with a non-uniform particle comprising a capture molecule, and further contacting the particle with a detection moiety comprising a label that permits detection of the analyte when associated with the particle. The methods may be performed to detect and/or quantitate analyte in the sample. In some embodiments, the methods may be performed in an automated manner, and may use an optical and/or cytometric apparatus for performing the method(s). The methods may further be performed with automated vessel-processing apparatus(es), such as plate loaders, plate washers, etc. Also provided are complexes containing the described materials formed by an assay of the invention, including excited state complexes. Kits useful for performing such methods are also provided.
摘要翻译：提供了用于分析样品的分析物的方法。在各种实施方案中，所述方法包括将怀疑含有分析物的样品与包含捕获分子的非均匀颗粒接触，并且使颗粒与包含标记的检测部分接触，所述标记允许在与颗粒相关联时检测分析物。可以执行该方法以检测和/或定量样品中的分析物。在一些实施例中，可以以自动方式执行所述方法，并且可以使用用于执行所述方法的光学和/或细胞计数装置。这些方法可以进一步用自动容器处理设备（例如平板装载机，板式洗涤器等）进行。还提供了含有通过本发明的测定形成的所述材料的复合物，包括激发态复合物。还提供了用于执行这些方法的套件。

57. 发明授权

US07485888B2 Single detector multicolor particle analyzer and method 失效
标题翻译：单检测器多色粒子分析仪及方法
公开(公告)号：US07485888B2
公开(公告)日：2009-02-03
申请号：US10821727
申请日：2004-04-08
申请人： Philippe Goix , Paul J. Lingane
发明人： Philippe Goix , Paul J. Lingane
IPC分类号： G01N15/06 , G01N21/00 , F21V9/16 , C02F1/40
CPC分类号： G01N15/147 , G01N15/1434 , G01N21/645 , G01N2021/6421
摘要： A multicolor particle analyzer and method is described. The particles each of which either naturally fluoresce or are tagged to fluoresce at distinctive wavelengths are caused to flow through an analyzing volume where fluorescence is excited by an impinging light beam. A tunable optical filter repetitively and sequentially passes emitted light at each of the characteristic wavelengths as each particle travels through the analyzing volume and the light transmitted through the optical filter is received by single detector which provides output signals representative of each distinct wavelength of light emitted by the particle.
摘要翻译：描述了一种多色粒子分析仪和方法。天然荧光或被标记以在特定波长发荧光的颗粒被引导流过分析体积，其中荧光被入射光束激发。可调谐滤光器每个粒子通过分析体积重复地依次通过发射的每个特征波长的光，并且通过光学滤波器传输的光被单个检测器接收，该检测器提供表示由颗粒。

58. 发明申请

US20080283773A1 Particle or Cell Analyzer and Method 有权
标题翻译：粒子或细胞分析仪和方法
公开(公告)号：US20080283773A1
公开(公告)日：2008-11-20
申请号：US12183301
申请日：2008-07-31
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
IPC分类号： G01J1/58 , C12M1/34
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

59. 发明授权

US07410809B2 Particle or cell analyzer and method 有权
标题翻译：粒子或细胞分析仪和方法
公开(公告)号：US07410809B2
公开(公告)日：2008-08-12
申请号：US10410230
申请日：2003-04-08
申请人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson , Kenneth F. Uffenheimer
IPC分类号： G01N33/543
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

60. 发明授权

US5798222A Apparatus for monitoring substances in organisms 失效
标题翻译：用于监测生物体内物质的装置和方法
公开(公告)号：US5798222A
公开(公告)日：1998-08-25
申请号：US503095
申请日：1995-07-17
申请人： Philippe J. Goix
发明人： Philippe J. Goix
IPC分类号： C12Q1/04 , G01N33/18 , G01N33/58 , C12Q1/02 , C12Q1/00 , C12Q1/22
CPC分类号： C12Q1/04 , G01N33/186 , G01N33/582 , Y10S435/808 , Y10S435/968
摘要： An apparatus for monitoring a substance in a living organism. The apparatus can be used to provide an assessment of the feeding rate of the organism and can be used to measure water toxicity.
摘要翻译：一种用于监测活体内物质的装置。该装置可用于提供生物体的进料速率的评估，并可用于测量水的毒性。

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