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41. 发明授权

US06706949B1 RuvB orthologues and uses thereof 有权
标题翻译： RuvB直向同源物及其用途
公开(公告)号：US06706949B1
公开(公告)日：2004-03-16
申请号：US09589510
申请日：2000-06-07
申请人： Pramod B. Mahajan
发明人： Pramod B. Mahajan
IPC分类号： C12N1509
CPC分类号： C12N9/14 , C07K14/415 , C12N9/90 , C12N15/8213
摘要： The invention provides isolated RuvB nucleic acids and their encoded protiens. The present invention provides methods and compositions relating to altering RuvB levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants.
摘要翻译：本发明提供分离的RuvB核酸及其编码的质子。本发明提供了关于改变植物中RuvB水平的方法和组合物。本发明还提供了重组表达盒，宿主细胞和转基因植物。

42. 发明授权

US06696295B2 Transducing phages 有权
标题翻译：转化噬菌体
公开(公告)号：US06696295B2
公开(公告)日：2004-02-24
申请号：US09796318
申请日：2001-02-28
申请人： Janet Westpheling , Julie A. Burke
发明人： Janet Westpheling , Julie A. Burke
IPC分类号： C12N1509
CPC分类号： C12R1/465 , C12N15/76 , C12R1/91
摘要： The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient microbe, and producing a secondary metabolite from a microbe. The transducing phages typically have a broad host range, and transduce microbes in the Order Actinomycetales, in particular in the Family Streptomycetaceae, including Streptomyces coelicolor, Streptomyces lividans, Streptomyces venezuelae, Streptomyces avermitilis, and Saccharopolyspora erythraea. The transducing phages can be specialized transducing phages or generalized transducing phages.
摘要翻译：本发明涉及分离的转导噬菌体，分离转导噬菌体的方法，以及使用转导性噬菌体的方法，包括例如将至少一种核酸片段从供体微生物转移至受体微生物，以及从微生物。转导噬菌体通常具有广泛的宿主范围，并且在放线菌纲中转导微生物，特别是在家族链霉菌科，包括天蓝色链霉菌（Streptomyces coelicolor），变形链霉菌（Streptomyces lividans），维生素链霉菌（Streptomyces venezuelae），阿维链霉菌（Streptomyces avermitilis）和糖酵母（Saccharopolyspora erythraea）中。转导噬菌体可以是专门的转化噬菌体或广泛转导的噬菌体。

43. 发明授权

US06586209B1 Xylanase production 失效
标题翻译：木聚糖酶生产
公开(公告)号：US06586209B1
公开(公告)日：2003-07-01
申请号：US07955726
申请日：1993-02-18
申请人： Robert F. M. van Gorcom , Johanna G. M. Hessing , Jan Maat , Martinus Roza , Johannes Maria A. Verbakel
发明人： Robert F. M. van Gorcom , Johanna G. M. Hessing , Jan Maat , Martinus Roza , Johannes Maria A. Verbakel
IPC分类号： C12N1509
CPC分类号： C12Y302/01032 , A21D8/042 , C12N9/248 , C12Y302/01008
摘要： An isolated DNA with a nucleotide sequence encoding a ripening form of a xylanase fungal origin having bread improving activity. Cells are transformed with this DNA and used to produce the ripening form of xylanase which itself is suitable for use in flour and dough.
摘要翻译：具有编码具有面包改良活性的木聚糖酶真菌来源的成熟形式的核苷酸序列的分离的DNA。细胞用该DNA转化并用于产生本身适用于面粉和面团的木聚糖酶的成熟形式。

44. 发明授权

US06576814B1 Manipulation of Mlo genes to enhance disease resistance in plants 有权
标题翻译：操纵Mlo基因以增强植物的抗病性
公开(公告)号：US06576814B1
公开(公告)日：2003-06-10
申请号：US09347650
申请日：1999-07-06
申请人： Steven Briggs , Carl R. Simmons
发明人： Steven Briggs , Carl R. Simmons
IPC分类号： C12N1509
CPC分类号： C07K14/415 , C12N15/8279 , C12N15/8282
摘要： Compositions and methods for enhancing disease resistance in plants are provided. The method involves modulating the activity of Mlo sequences in the plant. Particular Mlo sequences are provided that can be manipulated to enhance pathogen resistance in modified plants. Transformed plants, plant cells, tissues, and seed are also provided having enhanced disease resistance.
摘要翻译：提供了增强植物抗病性的组合物和方法。该方法涉及调节植物中Mlo序列的活性。提供特定的Mlo序列，其可以被操纵以增强修饰植物中的病原体抗性。还提供了具有增强的抗病性的转化植物，植物细胞，组织和种子。

45. 发明授权

US06489538B1 Method for regulation of plant lignin composition 有权
标题翻译：调节植物木质素组成的方法
公开(公告)号：US06489538B1
公开(公告)日：2002-12-03
申请号：US09387663
申请日：1999-08-31
申请人： Clint Chapple
发明人： Clint Chapple
IPC分类号： C12N1509
CPC分类号： C12N9/0071 , C12N9/0077 , C12N15/8255
摘要： A method is disclosed for the regulation of lignin composition in plant tissue. Plants are transformed with a gene encoding an active F5H gene. The expression of the F5H gene results in increased levels of syringyl monomer providing a lignin composition more easily degraded with chemicals and enzymes.
摘要翻译：公开了用于调节植物组织中木质素组成的方法。用编码活性F5H基因的基因转化植物。 F5H基因的表达导致更高水平的丁香基单体，提供更容易用化学品和酶降解的木质素组合物。

46. 发明授权

US06468770B1 Nucleic acids and proteins of D. melanogaster insulin-like genes and uses thereof 有权
标题翻译：黑腹果蝇胰岛素样基因的核酸和蛋白质及其用途
公开(公告)号：US06468770B1
公开(公告)日：2002-10-22
申请号：US09201227
申请日：1998-11-30
申请人： Linda Nolan Keyes , Stephen Kohl Doberstein , Andrew Roy Buchman , Bindu Priya Reddy , David Andrew Ruddy
发明人： Linda Nolan Keyes , Stephen Kohl Doberstein , Andrew Roy Buchman , Bindu Priya Reddy , David Andrew Ruddy
IPC分类号： C12N1509
CPC分类号： C07K14/43581 , A01K2217/075
摘要： The present invention relates to D. melangaster insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of D. melangaster insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a D. melangaster insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a D. melangaster gene which modifies the function of, and/or functions in a signaling pathway with an insulin-like gene are provided. The invention further provides uses of Drosophila insulin-like nucliec acids and proteins, e.g., as media additives, and as pesticides.
摘要翻译：本发明涉及D. melangaster胰岛素样基因和鉴定胰岛素样基因的方法。该方法提供了D.瓜瓜那胰岛素样基因的核苷酸序列，其编码的蛋白质的氨基酸序列及其衍生物（例如片段）及其类似物。本发明还涉及包含胰岛素样蛋白的一个或多个结构域的胰岛素样蛋白的片段（及其衍生物和类似物）。提供了胰岛素样蛋白的抗体及其衍生物和类似物。提供了胰岛素样蛋白质的生产方法（例如，通过重组方法）及其衍生物和类似物。此外，提供了鉴定一种D.瓜兰特氏胰岛素样基因的生物学功能的方法，包括同时进行一个或多个基因的功能修饰（例如，过表达，低表达，突变，敲除）的各种方法。此外，提供了鉴定修饰胰岛素样基因的信号传导途径的功能和/或功能的D.瓜兰加斯特基因的方法。本发明还提供了果蝇胰岛素样核糖酸和蛋白质的用途，例如作为培养基添加剂和农药。

47. 发明授权

US06455282B1 Cells, vectors and methods for producing biologically active TSH 失效
标题翻译：用于生产生物活性TSH的细胞，载体和方法
公开(公告)号：US06455282B1
公开(公告)日：2002-09-24
申请号：US07970227
申请日：1992-11-02
申请人： Anton Beck , Edward Bernstine , Nancy Hsiung , Vermuni B. Reddy
发明人： Anton Beck , Edward Bernstine , Nancy Hsiung , Vermuni B. Reddy
IPC分类号： C12N1509
CPC分类号： C12N15/85 , A61K38/00 , C12N2830/002 , C12N2830/85 , C12N2840/20
摘要： Biologically active heteropolymeric protein composed of a plurality of subunits, both subunits being synthesized in a single cell having an expression vector comprising heterologous DNA encoding the subunits. Preferably the protein is similar to the human or ungulate fertility hormones, LH and FSH.
摘要翻译：由多个亚基组成的生物活性杂聚蛋白，两个亚单位均在具有包含编码亚基的异源DNA的表达载体的单个细胞中合成。优选地，蛋白质类似于人或有蹄类生育激素LH和FSH。

48. 发明授权

US06391587B1 Peptides which mimic candida carbohydrate epitopes and their use in a vaccine 失效
标题翻译：模仿念珠糖碳水化合物表位的肽及其在疫苗中的应用
公开(公告)号：US06391587B1
公开(公告)日：2002-05-21
申请号：US09334921
申请日：1999-06-17
申请人： Jim E. Cutler , Pati M. Glee , Bruce L. Granger
发明人： Jim E. Cutler , Pati M. Glee , Bruce L. Granger
IPC分类号： C12N1509
CPC分类号： B82Y5/00 , A61K9/127 , A61K9/1271 , A61K39/00 , A61K39/0002 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/40 , C07K16/14
摘要： A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
摘要翻译：用于治疗由白色念珠菌感染引起的弥漫性念珠菌病的组合物，药物组合物，疫苗和方法。该组合物包括白色念珠菌的磷酸甘露聚糖，磷酸甘露糖表位的肽模拟表位，或编码肽模拟表位的多核苷酸。还提供了用于针对念珠菌感染的被动免疫的单克隆抗体。

49. 发明授权

US06387662B1 Synthesis and purification of hepatitis C virus-like particles 失效
标题翻译：丙型肝炎病毒样颗粒的合成和纯化
公开(公告)号：US06387662B1
公开(公告)日：2002-05-14
申请号：US09296441
申请日：1999-04-21
申请人： T. Jake Liang , Thomas F. Baumert
发明人： T. Jake Liang , Thomas F. Baumert
IPC分类号： C12N1509
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/14143 , C12N2770/24222 , C12N2770/24223 , Y02A50/388 , Y10S977/802
摘要： Production of enveloped RNA virus-like particles intracellularly in vitro in insect cells using a recombinant baculovirus vector containing a cDNA coding for viral structural proteins is disclosed. In vitro production and purification of hepatitis C virus (HCV)-like particles containing HCV core protein, E1 protein and E2 protein is disclosed. Production of antibodies in vivo to the purified HCV-like particles is disclosed.
摘要翻译：公开了使用含有编码病毒结构蛋白的cDNA的重组杆状病毒载体在昆虫细胞中细胞内包膜的RNA病毒样颗粒的生产。公开了含有HCV核心蛋白，E1蛋白和E2蛋白的丙型肝炎病毒（HCV）样颗粒的体外生产和纯化。公开了体内抗体与纯化的HCV样颗粒的产生。

50. 发明授权

US06376747B1 Plant-derived map kinase kinase 失效
标题翻译：植物衍生的地图激酶激酶
公开(公告)号：US06376747B1
公开(公告)日：2002-04-23
申请号：US09384162
申请日：1999-08-27
申请人： Ti Xing , Kamal Malik , Teresa Martin-Heller , Brian L. Miki
发明人： Ti Xing , Kamal Malik , Teresa Martin-Heller , Brian L. Miki
IPC分类号： C12N1509
CPC分类号： C12N9/1205 , C12N15/8271 , C12N15/8281
摘要： A mitogen-activated protein (MAP) kinase kinase gene, tMEK2, was isolated from tomato cv. Bonny Best. By mutagenesis, a permanently-active variant, tMEK2MUT, was created. Both wild type tMEK2 and mutant tMEK2MUT were driven by a strong constitutive promoter, tCUP&Dgr;, in a tomato protoplast transient expression system. Pathogenesis-related genes, PR1b1 and PR3, and a wound-inducible gene, ER5, were activated by tMEK2MUT expression revealing the convergence of the signal transduction pathways for pathogen attack and mechanical stress at the level of MAPKK. Activation of biotic and abiotic stress response genes downstream of tMEK2 occurred through divergent pathways involving at least two classes of mitogen-activated protein kinase. This study shows that tMEK2 may play an important role in the interaction of signal transduction pathways that mediate responses to both biotic (eg disease) and abiotic (wound responsiveness) stresses.
摘要翻译：从番茄cv中分离出丝裂原活化蛋白（MAP）激酶激酶基因tMEK2。邦尼最好的通过诱变，创建了永久活跃的变体tMEK2MUT。野生型tMEK2和突变体tMEK2MUT均在番茄原生质体瞬时表达系统中由强组成型启动子tCUPDELTA驱动。发病相关基因PR1b1和PR3以及伤口诱导基因ER5被tMEK2MUT表达活化，表明MAPKK水平的病原体攻击和机械应激信号转导通路的收敛。通过涉及至少两类丝裂原活化蛋白激酶的分歧途径，激活tMEK2下游的生物和非生物胁迫反应基因。这项研究表明，tMEK2可能在介导生物（如疾病）和非生物（伤口反应））应激反应的信号转导途径的相互作用中起重要作用。

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