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41. 发明申请

US20130180217A1 Sandwich Separator Container 审中-公开
标题翻译：三明治分离器容器
公开(公告)号：US20130180217A1
公开(公告)日：2013-07-18
申请号：US13350766
申请日：2012-01-14
申请人： Ronda Brubaker
发明人： Ronda Brubaker
IPC分类号： B65B5/00 , B65D81/38 , B65D25/04
CPC分类号： G01R33/4633 , A45C11/20 , A47J47/14 , G01N24/081
摘要： A container for storing a sandwich comprising a plurality of individual compartments for storing sandwich items individually; wherein all the individual compartments of the container are joinable into a single container for ease of transportation. The individual compartments prevent the items of the sandwich from intermixing and affecting the taste, consistency, and integrity of each of the other elements. Included in the container are all utensils for preparing the sandwich. Individual compartments may be insulated and thus may be kept warmer or cooler than other compartments.
摘要翻译：一种用于存储夹层的容器，包括多个单独的隔间，用于分别存储夹心物品; 其中容器的所有单个隔室可连接成单个容器以便于运输。单独的隔间防止三明治物品混合并影响每个其他元件的味道，一致性和完整性。容器内装有三明治准备的器具。单独的隔间可以是绝缘的，因此可以比其他隔室保持更暖或更冷。

42. 发明申请

US20120237937A1 METHODS TO DETECT CANCER IN ANIMALS 审中-公开
标题翻译：检测动物癌症的方法
公开(公告)号：US20120237937A1
公开(公告)日：2012-09-20
申请号：US13377560
申请日：2010-06-11
申请人： Teresa Whei-Mei Fan , Andrew Nicholas Lane , Michael Bousamra , Donald M. Miller , Richard M. Higashi
发明人： Teresa Whei-Mei Fan , Andrew Nicholas Lane , Michael Bousamra , Donald M. Miller , Richard M. Higashi
IPC分类号： G01N24/08 , G01N33/574 , G01N21/64 , G01N27/62
CPC分类号： G01R33/46 , A61K49/10 , G01N24/08 , G01N33/57423 , G01N33/6848 , G01R33/4633
摘要： Some embodiments of the invention include methods for detecting the presence of cancer in animal tissue in an animal that was administered a labeled molecule. Some of the methods disclosed comprise obtaining an NMR spectrum, an MS spectrum, or both. In some instances, spectra can be taken of a cancer cell extract of the tissue and of a non-cancer cell extract of the tissue. In some embodiments, the amounts of at least one resultant labeled molecule (e.g., a molecule resulting from transformation of the administered labeled molecule) from each extract can be compared to detect the presence of cancer.
摘要翻译：本发明的一些实施方案包括用于检测给予标记分子的动物中动物组织中癌症存在的方法。公开的一些方法包括获得NMR光谱，MS光谱或两者。在一些情况下，可以拍摄组织的癌细胞提取物和组织的非癌细胞提取物的光谱。在一些实施方案中，可以比较来自每个提取物的至少一个所得标记分子（例如由所施用的标记分子转化产生的分子）的量以检测癌症的存在。

43. 发明授权

US08072213B2 NMR measurement method 有权
标题翻译： NMR测定法
公开(公告)号：US08072213B2
公开(公告)日：2011-12-06
申请号：US12561484
申请日：2009-09-17
申请人： Yusuke Nishiyama
发明人： Yusuke Nishiyama
IPC分类号： G01V3/00
CPC分类号： G01R33/4641 , G01N24/08 , G01R33/4608 , G01R33/4633 , G01R33/50 , G01R33/5602 , G01R33/5605
摘要： An NMR measurement method adapted for measurements on solid mixture samples starts with irradiating a pulse sequence to the sample in order to measure the longitudinal magnetization relaxation times of nuclei possessing homogeneous longitudinal magnetization relaxation times (step 1). After a lapse of a given period of time t, a high-resolution NMR spectrum is acquired by nullifying spin diffusion across the nuclei (step 2). The steps 1 and 2 are repeated while varying the period of time t. The high-resolution NMR spectra are classified according to value of longitudinal magnetization relaxation time by inverse Laplace transform.
摘要翻译：适用于固体混合物样品测量的NMR测量方法开始于向样品照射脉冲序列，以测量具有均匀纵向磁化弛豫时间的核的纵向磁化松弛时间（步骤1）。在经过给定时间段t之后，通过使跨越核的自旋扩散无效获得高分辨率NMR光谱（步骤2）。重复步骤1和2，同时改变时间段t。通过反拉普拉斯变换，高分辨NMR谱根据纵向磁化弛豫时间的值进行分类。

44. 发明授权

US07920972B2 G-matrix Fourier transformation (GFT) nuclear magnetic resonance (NMR) experiments for resonance assignment and structure determination of organic molecules 失效
标题翻译：用于共振分配和有机分子结构测定的G-基质傅里叶变换（GFT）核磁共振（NMR）实验
公开(公告)号：US07920972B2
公开(公告)日：2011-04-05
申请号：US11253262
申请日：2005-10-18
申请人： Thomas A. Szyperski , Hanudatta S. Atreya
发明人： Thomas A. Szyperski , Hanudatta S. Atreya
IPC分类号： G06F19/00 , G01N33/48 , G01N31/00 , C12Q1/00
CPC分类号： G01R33/4633 , G01N24/087 , G01R33/465 , G06F19/16
摘要： The present invention discloses a suite of G2FT and GFT NMR experiments that can be used for complete resonance assignments of proteins and for obtaining structural (conformational and orientational) constraints for determining high resolution three-dimensional structures of biomolecules.
摘要翻译：本发明公开了一套G2FT和GFT NMR实验，可用于蛋白质的完全共振分配，并用于获得用于确定生物分子的高分辨率三维结构的结构（构象和取向）约束。

45. 发明申请

US20100225314A1 NUCLEAR MAGNETIC RESONANCE MEASURING METHOD 有权
标题翻译：核磁共振测量方法
公开(公告)号：US20100225314A1
公开(公告)日：2010-09-09
申请号：US12676239
申请日：2008-09-08
申请人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
发明人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
IPC分类号： G01R33/44
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.
摘要翻译：本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以将空间位置信息附加到上述核磁共振信号，因此装置。

46. 发明申请

US20100188084A1 COMPARATIVE ANALYSIS OF PROTEIN CONFORMATIONS BY USING 2D NOESY NMR SPECTRA 有权
标题翻译：使用二维核磁共振谱对蛋白质结构进行比较分析
公开(公告)号：US20100188084A1
公开(公告)日：2010-07-29
申请号：US12595867
申请日：2008-04-15
申请人： Ian Christopher Parsons , Jonathan Lansing , Carlos J. Bosques , Daniela Beccati
发明人： Ian Christopher Parsons , Jonathan Lansing , Carlos J. Bosques , Daniela Beccati
IPC分类号： G01R33/48
CPC分类号： G01R33/4633 , G01N24/08 , G01N24/087 , G01R33/1269 , G01R33/465 , G01R33/48 , G01R33/5605
摘要： The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.
摘要翻译：本公开提供了用于确定不同蛋白质制剂中提供的蛋白质的相对构象的方法，包括以下步骤：（i）获得第一蛋白质制剂的第一2D NOESY NMR光谱; （ii）获得第二种蛋白质制剂的第二种二维核磁共振谱; 和（iii）; 通过将第一2D NOESY NMR光谱中的一个或多个交叉峰与第二2D NOESY NMR光谱中的一个或多个相应的交叉峰进行比较来确定蛋白质在第一和第二蛋白质制剂中是否具有不同的构象。

47. 发明授权

US07550970B2 Multidimensional NMR spectroscopy of a hyperpolarized sample 有权
标题翻译：超极化样品的多维NMR光谱
公开(公告)号：US07550970B2
公开(公告)日：2009-06-23
申请号：US10553381
申请日：2004-04-13
申请人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
发明人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
IPC分类号： G01V3/00
CPC分类号： G01R33/4633 , G01R33/62
摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.
摘要翻译：本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。

48. 发明申请

US20080317307A1 Systems and methods for alignment of objects in images 失效
标题翻译：图像中对象对齐的系统和方法
公开(公告)号：US20080317307A1
公开(公告)日：2008-12-25
申请号：US11820939
申请日：2007-06-21
申请人： Peng Lu , Ming Zheng , Guochun Liao
发明人： Peng Lu , Ming Zheng , Guochun Liao
IPC分类号： G06K9/00
CPC分类号： G01R33/46 , G01N24/08 , G01R33/4633 , G01R33/465 , G01R33/5608 , G06T7/30 , G06T2207/10088
摘要： Systems and methods for aligning objects in object sets are provided. An object set has objects that are in a corresponding image in a plurality of images. For each respective object in a first object set, a corresponding object group is constructed that contains the respective object, thereby constructing a plurality of object groups. Similarity metrics are computed between object groups and objects in objects sets in order to assign the objects to object groups. The object groups are then refined in order to align objects in the object sets.
摘要翻译：提供了对象集中对象对齐的系统和方法。对象集合具有在多个图像中的对应图像中的对象。对于第一对象集合中的每个对象，构造包含相应对象的对应对象组，从而构造多个对象组。在对象集中的对象组和对象之间计算相似性度量，以便将对象分配给对象组。然后对对象组进行细化，以便对齐对象中的对象。

49. 发明授权

US07365539B2 Method of using G-matrix fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins 失效
标题翻译：使用G矩阵傅里叶变换核磁共振（GFT NMR）光谱法进行蛋白质快速化学位移分配和二级结构测定的方法
公开(公告)号：US07365539B2
公开(公告)日：2008-04-29
申请号：US10973807
申请日：2004-10-26
申请人： Thomas A. Szyperski , Seho Kim , Hanudatta S. Atreya
发明人： Thomas A. Szyperski , Seho Kim , Hanudatta S. Atreya
IPC分类号： G01V3/00
CPC分类号： G01R33/4633 , G01R33/465 , Y10T436/24
摘要： The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named “GFT NMR spectroscopy”, which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the “sampling limited” data collection regime. Concomitantly, the analysis of the resulting checmical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.
摘要翻译：本发明提出了一种快速获得精确的高维NMR光谱信息的新方法，命名为“GFT NMR光谱”，其基于跨过常规NMR实验的子空间的间接尺寸的相敏联合采样。与FT NMR相比，高维NMR实验的几个间接尺寸的相敏联合取样导致最大测量时间大大降低。这样可以避免“采样受限”的数据收集制度。伴随地，通过G矩阵变换编辑的所得到的移动多重点的分析产生了用于化学位移测量的增加的精度。此外，公开了进行特定GFT NMR实验的方法以及进行GFT NMR实验的组合以快速获得精确的化学位移分配和确定蛋白质或其他分子的结构的方法。

50. 发明申请

US20080081375A1 Metabolite detection using magnetic resonance 审中-公开
标题翻译：使用磁共振的代谢物检测
公开(公告)号：US20080081375A1
公开(公告)日：2008-04-03
申请号：US11906650
申请日：2007-10-03
申请人： Yasvir A. Tesiram , Rheal A. Towner
发明人： Yasvir A. Tesiram , Rheal A. Towner
IPC分类号： G01N23/00 , C12Q1/68
CPC分类号： G01N33/574 , G01N24/08 , G01N33/57438 , G01R33/4633 , G01R33/465 , G01R33/485
摘要： Methods using magnetic resonance, such as nuclear magnetic resonance (NMR) spectroscopy or magnetic resonance imaging (MRI), are provided for detecting metabolites in a sample. The methods are useful for the diagnosis or prognosis of a disease such as cancer and can also be used to determine or monitor a treatment protocol. The methods are useful in characterizing speciation in biological samples where mixtures are often encountered and chemical shifts of the same structural group of similar molecules can produce complicated overlapping resonances.
摘要翻译：提供使用核磁共振（NMR）光谱或磁共振成像（MRI）的磁共振的方法来检测样品中的代谢物。这些方法对于诸如癌症的疾病的诊断或预后是有用的，并且还可以用于确定或监测治疗方案。该方法可用于表征生物样品中的物种形态，其中经常遇到混合物，相同分子的相同结构基团的化学位移可产生复杂的重叠共振。

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